A. Beck

发表

Analysis of recombinant monoclonal antibodies in hydrophilic interaction chromatography: A generic method development approach

D. Guillarme, Balázs Bobály, V. D’Atri, 2017, Journal of pharmaceutical and biomedical analysis.

Strategies and challenges for the next generation of antibody–drug conjugates

C. Dumontet, A. Beck, L. Goetsch, 2017, Nature Reviews Drug Discovery.

Tuning selectivity in cation-exchange chromatography applied for monoclonal antibody separations, part 2: Evaluation of recent stationary phases.

D. Guillarme, A. Beck, S. Fekete, 2019, Journal of pharmaceutical and biomedical analysis.

Capture of the human IgG1 antibodies by protein A for the kinetic study of h-IgG/FcγR interaction using SPR-based biosensor technology.

A. Beck, T. Champion, 2013, Methods in molecular biology.

Rapid and improved characterization of therapeutic antibodies and antibody related products using IdeS digestion and subunit analysis.

A. Beck, Jonathan Sjögren, F. Olsson, 2016, The Analyst.

A. Beck, 2011, mAbs.

8th Annual European Antibody Congress 2012

P. Carter, T. Wurch, R. Kontermann, 2013, mAbs.

Glycosylation of biosimilars: Recent advances in analytical characterization and clinical implications.

J. Veuthey, D. Guillarme, W. Jiskoot, 2019, Analytica chimica acta.

Antibody–Drug Conjugates: The Last Decade

C. Dumontet, A. Beck, Nicolas Joubert, 2020, Pharmaceuticals.

[Antibody-drug conjugates in oncology. New strategies in development].

C. Dumontet, A. Beck, Nicolas Joubert, 2019, Medecine sciences : M/S.

State-of-the-Art Native Mass Spectrometry and Ion Mobility Methods to Monitor Homogeneous Site-Specific Antibody-Drug Conjugates Synthesis

D. Guillarme, S. Cianférani, V. D’Atri, 2021, Pharmaceuticals.

Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates

S. Cianférani, A. Beck, P. Drake, 2017, mAbs.

Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates

François Debaene, S. Cianférani, J. Marcoux, 2016, Expert review of proteomics.

Antibody-drug conjugates

J. Reichert, A. Beck, 2013, mAbs.

World Antibody-Drug Conjugate Summit, October 15–16, 2013, San Francisco, CA

P. Strop, D. Shah, A. Beck, 2013, mAbs.

Correct primary structure assessment and extensive glyco-profiling of cetuximab by a combination of intact, middle-up, middle-down and bottom-up ESI and MALDI mass spectrometry techniques

D. Suckau, C. Baessmann, A. Beck, 2013, mAbs.

Extending mass spectrometry contribution to therapeutic monoclonal antibody lead optimization: characterization of immune complexes using noncovalent ESI-MS.

S. Sanglier-Cianférani, A. van Dorsselaer, A. Robert, 2009, Analytical chemistry.

2nd PEGS Annual Symposium on Antibodies for Cancer Therapy

Mitchell Ho, A. Beck, I. Royston, 2012, mAbs.

NanoLC Chips MS/MS for the characterization of N-glycopeptides generated from trypsin digestion of a monoclonal antibody.

A. van Dorsselaer, A. Beck, Christine Schaeffer‐Reiss, 2013, Methods in molecular biology.

Identification of B- and T-Cell Epitopes of BB, a Carrier Protein Derived from the G Protein of Streptococcus Strain G148

A. Beck, L. Goetsch, T. Champion, 2003, Clinical Diagnostic Laboratory Immunology.

Passive transfer of serum antibodies induced by BBG2Na, a subunit vaccine, in the elderly protects SCID mouse lungs against respiratory syncytial virus challenge.

J. Bonnefoy, A. Beck, T. Nguyen, 2002, Virology.

Gamma Interferon-Dependent Protection of the Mouse Upper Respiratory Tract following Parenteral Immunization with a Respiratory Syncytial Virus G Protein Fragment

J. Bonnefoy, A. Beck, T. Nguyen, 2002, Journal of Virology.

Development of a quantitative assay for residual host cell proteins in a recombinant subunit vaccine against human respiratory syncytial virus.

T. Nguyen, J. Bonnefoy, A. Beck, 2001, Journal of immunological methods.

Lipophilic quaternary ammonium salt acts as a mucosal adjuvant when co-administered by the nasal route with vaccine antigens.

T. Nguyen, J. Bonnefoy, A. Beck, 2001, Vaccine.

A novel bipolar mode of attachment to aluminium-containing adjuvants by BBG2Na, a recombinant subunit hRSV vaccine.

T. Nguyen, J. Bonnefoy, A. Beck, 2001, Vaccine.

Influence of live respiratory syncytial virus priming on the immune response generated by a recombinant vaccine candidate, BBG2Na.

T. Nguyen, J. Bonnefoy, A. Beck, 2000, Vaccine.

Influence of administration dose and route on the immunogenicity and protective efficacy of BBG2Na, a recombinant respiratory syncytial virus subunit vaccine candidate.

T. Nguyen, J. Bonnefoy, S. Ståhl, 2000, Vaccine.

Synthesis and characterization of Respiratory Syncytial Virus protein G related peptides containing two disulfide bridges.

T. Nguyen, A. van Dorsselaer, J. Bonnefoy, 2000, The journal of peptide research : official journal of the American Peptide Society.

6th Annual European Antibody Congress 2010

T. Wurch, A. Beck, 2011, mAbs.

Combination of intact, middle-up and bottom-up levels to characterize 7 therapeutic monoclonal antibodies by capillary electrophoresis - Mass spectrometry.

Yannis-Nicolas François, A. Beck, E. Leize‐Wagner, 2020, Journal of pharmaceutical and biomedical analysis.

Insights from capillary electrophoresis approaches for characterization of monoclonal antibodies and antibody drug conjugates in the period 2016-2018.

Yannis-Nicolas François, A. Beck, E. Leize‐Wagner, 2019, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Intact monoclonal antibodies separation and analysis by sheathless capillary electrophoresis-mass spectrometry

Yannis-Nicolas François, A. Beck, E. Leize‐Wagner, 2018, European journal of mass spectrometry.

Development of a fast workflow to screen the charge variants of therapeutic antibodies.

D. Guillarme, S. Cianférani, A. Beck, 2017, Journal of chromatography. A.

Characterization of the N-terminal heterogeneities of monoclonal antibodies using in-gel charge derivatization of α-amines and LC-MS/MS.

S. Cianférani, A. van Dorsselaer, A. Beck, 2015, Analytical chemistry.

Streptococcus pneumoniae polysaccharides conjugated to the outer membrane protein A from Klebsiella pneumoniae elicit protective antibodies.

J. Bonnefoy, A. Beck, N. Corvaïa, 2002, Vaccine.

Direct identification of rituximab main isoforms and subunit analysis by online selective comprehensive two-dimensional liquid chromatography-mass spectrometry.

D. Guillarme, D. Harmes, D. Stoll, 2015, Analytical chemistry.

Coupling non-denaturing chromatography to mass spectrometry for the characterization of monoclonal antibodies and related products.

J. Veuthey, D. Guillarme, A. Beck, 2020, Journal of pharmaceutical and biomedical analysis.

Impact of the column on effluent pH in cation exchange pH gradient chromatography, a practical study.

D. Guillarme, A. Beck, S. Fekete, 2020, Journal of chromatography. A.

Tuning selectivity in cation‐exchange chromatography applied for monoclonal antibody separations, part 1: Alternative mobile phases and fine tuning of the separation

D. Guillarme, A. Beck, S. Fekete, 2019, Journal of pharmaceutical and biomedical analysis.

A proof of concept to achieve infinite selectivity for the chromatographic separation of therapeutic proteins.

J. Veuthey, D. Guillarme, A. Beck, 2019, Analytical chemistry.

Absolute and multiplex quantification of antibodies in serum using PSAQ™ standards and LC-MS/MS.

M. Jaquinod, A. Beck, V. Brun, 2015, Bioanalysis.

Antibody Glycans Characterization

A. Beck, A. Dorsselaer, Elsa Wagner-Rousset, 2010 .

European Medicines Agency workshop on biosimilar monoclonal antibodies

J. Reichert, A. Beck, H. Iyer, 2009, mAbs.

Trends in glycosylation, glycoanalysis and glycoengineering of therapeutic antibodies and Fc-fusion proteins.

T. Wurch, A. van Dorsselaer, A. Beck, 2008, Current pharmaceutical biotechnology.

th Annual European Antibody Congress 2011

J. Reichert, A. Lugovskoy, A. Beck, 2012 .

Orthogonal Middle-up Approaches for Characterization of the Glycan Heterogeneity of Etanercept by Hydrophilic Interaction Chromatography Coupled to High-Resolution Mass Spectrometry.

D. Guillarme, D. Stoll, V. D’Atri, 2018, Analytical chemistry.

A Case Study to Identify the Drug Conjugation Site of a Site-Specific Antibody-Drug-Conjugate Using Middle-Down Mass Spectrometry

S. Cianférani, A. Beck, R. Huguet, 2019, Journal of The American Society for Mass Spectrometry.

Advantages of extended bottom-up proteomics using Sap9 for analysis of monoclonal antibodies.

A. Beck, K. Srzentić, L. Fornelli, 2014, Analytical chemistry.

Unraveling the mysteries of modern size exclusion chromatography - the way to achieve confident characterization of therapeutic proteins.

J. Veuthey, D. Guillarme, A. Beck, 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Evaluation of size exclusion chromatography columns packed with sub-3μm particles for the analysis of biopharmaceutical proteins.

D. Guillarme, K. Sandra, A. Beck, 2017, Journal of chromatography. A.

Independent highly sensitive characterization of asparagine deamidation and aspartic acid isomerization by sheathless CZE-ESI-MS/MS.

Yannis-Nicolas François, A. Beck, E. Leize‐Wagner, 2016, Journal of mass spectrometry : JMS.

Therapeutic Fc-fusion proteins: Current analytical strategies.

D. Guillarme, V. D’Atri, A. Beck, 2020, Journal of separation science.

A sensitive multidimensional method for the detection, characterization, and quantification of trace free drug species in antibody-drug conjugate samples using mass spectral detection

Weibin Chen, A. Beck, R. Birdsall, 2015, mAbs.

NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods*

Erdmann Rapp, David J. Harvey, Stephen E. Stein, 2019, Molecular & Cellular Proteomics.

Protocols for the analytical characterization of therapeutic monoclonal antibodies. II - Enzymatic and chemical sample preparation.

D. Guillarme, Balázs Bobály, V. D’Atri, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Middle-down analysis of monoclonal antibodies with electron transfer dissociation orbitrap fourier transform mass spectrometry.

A. Beck, L. Fornelli, Daniel Ayoub, 2014, Analytical chemistry.

Top-down and middle-down approach by fraction collection enrichment using Off-line CE-UV/MALDI-MS: application to monoclonal antibody Fc/2 charge variants

François, A. Beck, E. Leize‐Wagner, 2019 .

Characterization of cation exchanger stationary phases applied for the separations of therapeutic monoclonal antibodies.

D. Guillarme, A. Beck, S. Fekete, 2015, Journal of pharmaceutical and biomedical analysis.

Time resolved native ion-mobility mass spectrometry to monitor dynamics of IgG4 Fab arm exchange and "bispecific" monoclonal antibody formation.

François Debaene, S. Cianférani, A. van Dorsselaer, 2013, Analytical chemistry.

Hydrophilic Interaction Chromatography Hyphenated with Mass Spectrometry: A Powerful Analytical Tool for the Comparison of Originator and Biosimilar Therapeutic Monoclonal Antibodies at the Middle-up Level of Analysis.

D. Guillarme, V. D’Atri, A. Beck, 2017, Analytical chemistry.

Analysis of Monoclonal Antibody Glycopeptides by Capillary Electrophoresis-Mass Spectrometry Coupling (CE-MS).

Yannis-Nicolas François, A. Beck, E. Leize‐Wagner, 2021, Methods in molecular biology.

1 Monoclonal Antibody N-Glycosylation Profiling using 1 Capillary Electrophoresis – Mass Spectrometry : 2 Assessment and Method Validation . 3

D. Guillarme, V. D’Atri, A. Beck, 2019 .

Editorial [Hot Topic: Therapeutic Antibodies and Derivatives: From the Bench to the Clinic(Guest Editor: Alain Beck)]

T. Wurch, A. Beck, N. Corvaia, 2008 .

Therapeutic antibodies and derivatives: from the bench to the clinic.

T. Wurch, A. Beck, N. Corvaïa, 2008, Current pharmaceutical biotechnology.

Glycosylation Engineering of Biopharmaceuticals

A. Beck, 2013, Methods in Molecular Biology.

Full antibody primary structure and microvariant characterization in a single injection using transient isotachophoresis and sheathless capillary electrophoresis-tandem mass spectrometry.

Yannis-Nicolas François, A. Beck, Jean-Marc Busnel, 2014, Analytical chemistry.

CESI-MS Comparison of Tryptic Digests from Different Monoclonal Antibodies in an Assessment of Biosimilarity

Yannis-Nicolas François, A. Beck, R. Gahoual, 2020 .

Characterization of the Primary Structure of Cysteine-Linked Antibody-Drug Conjugates Using Capillary Electrophoresis with Mass Spectrometry.

Yannis-Nicolas François, A. Beck, E. Leize‐Wagner, 2020, Methods in molecular biology.

Structural Characterization of Antibody Drug Conjugates (ADCs) by a Combination of Intact, Middle-up and Bottom-up Approaches using CESI-MS

Yannis-Nicolas François, A. Beck, E. Leize‐Wagner, 2020 .

Characterization of Cetuximab F c/2 aggregates by Offline CZE-MS

Yannis-Nicolas François, A. Beck, E. Leize‐Wagner, 2019 .

BIOPHARMACEUTICALAPPLICATIONS OF CAPILLARY ELECTROMIGRATION METHODS 19

Yannis-Nicolas François, A. Beck, E. Leize‐Wagner, 2018 .

Characterization of therapeutic antibodies and related products by two-dimensional liquid chromatography coupled with UV absorbance and mass spectrometric detection.

D. Stoll, A. Beck, Kelly Zhang, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Impact of organic modifier and temperature on protein denaturation in hydrophobic interaction chromatography.

J. Veuthey, D. Guillarme, Balázs Bobály, 2016, Journal of pharmaceutical and biomedical analysis.

Characterization of 30 therapeutic antibodies and related products by size exclusion chromatography: Feasibility assessment for future mass spectrometry hyphenation.

D. Guillarme, V. D’Atri, A. Beck, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Protocols for the analytical characterization of therapeutic monoclonal antibodies. III - Denaturing chromatographic techniques hyphenated to mass spectrometry.

D. Guillarme, Balázs Bobály, V. D’Atri, 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Analysis of antibody-drug conjugates by comprehensive on-line two-dimensional hydrophobic interaction chromatography x reversed phase liquid chromatography hyphenated to high resolution mass spectrometry. II- Identification of sub-units for the characterization of even and odd load drug species.

D. Guillarme, A. Beck, S. Fekete, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A new anti-human Fc method to capture and analyze ADCs for characterization of drug distribution and the drug-to-antibody ratio in serum from pre-clinical species.

A. Beck, L. Troncy, Marie-Claire Janin-Bussat, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Fourth World Antibody-Drug Conjugate Summit

A. Beck, Michael M C Sun, J. Lambert, 2012, mAbs.

Ultra-short ion-exchange columns for fast charge variants analysis of therapeutic proteins.

D. Guillarme, A. Beck, S. Fekete, 2021, Journal of chromatography. A.

D. Guillarme, A. Beck, S. Fekete, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Practical method development for the separation of monoclonal antibodies and antibody-drug-conjugate species in hydrophobic interaction chromatography, part 1: optimization of the mobile phase.

D. Guillarme, A. Beck, S. Fekete, 2016, Journal of pharmaceutical and biomedical analysis.

Practical method development for the separation of monoclonal antibodies and antibody-drug-conjugate species in hydrophobic interaction chromatoraphy, part 2: Optimization of the phase system.

D. Guillarme, A. Beck, S. Fekete, 2016, Journal of pharmaceutical and biomedical analysis.

Glycan-mediated technology for obtaining homogeneous site-specific conjugated antibody-drug conjugates: synthesis and analytical characterization by using complementary middle-up LC/HRMS analysis.

D. Guillarme, S. Cianférani, V. D’Atri, 2020, Analytical chemistry.

Drug Loading and Distribution of ADCs After Reduction or IdeS Digestion and Reduction.

D. Guillarme, Yannis-Nicolas François, S. Cianférani, 2020, Methods in molecular biology.

[Antibody-drug conjugates in oncology. Recent success of an ancient concept].

C. Dumontet, A. Beck, Nicolas Joubert, 2019, Medecine sciences : M/S.

[Immunotoxins and immunocytokines].

A. Beck, V. Caussanel, Alicia Contet, 2019, Medecine sciences : M/S.

A Novel Online Four-Dimensional SEC×SEC-IM×MS Methodology for Characterization of Monoclonal Antibody Size Variants.

D. Guillarme, C. Dreyfus, S. Cianférani, 2018, Analytical chemistry.

Characterizing various monoclonal antibodies with milder reversed phase chromatography conditions.

D. Guillarme, Balázs Bobály, V. D’Atri, 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Characterization of an antibody-drug conjugate by hydrophilic interaction chromatography coupled to mass spectrometry.

D. Guillarme, D. Stoll, V. D’Atri, 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine‐linked antibody drug conjugate

S. Cianférani, A. van Dorsselaer, J. Marcoux, 2015, Protein science : a publication of the Protein Society.

A triumph for glyco-engineering

J. Reichert, A. Beck, 2012 .

Alternative mobile phase additives for the characterization of protein biopharmaceuticals in liquid chromatography - Mass spectrometry.

D. Guillarme, V. D’Atri, A. Beck, 2021, Analytica chimica acta.

Systematic evaluation of mobile phase additives for the LC-MS characterization of therapeutic proteins.

D. Guillarme, J. Fekete, Balázs Bobály, 2015, Talanta.

9th Annual European Antibody Congress, November 11–13, 2013, Geneva, Switzerland

T. Wurch, J. Reichert, A. Lugovskoy, 2014, mAbs.

Optimization of MS-Compatible Mobile Phases for IEX Separation of Monoclonal Antibodies

D. Guillarme, A. Beck, S. Fekete, 2019 .

Hyphenation of size exclusion chromatography to native ion mobility mass spectrometry for the analytical characterization of therapeutic antibodies and related products.

D. Guillarme, S. Cianférani, A. Beck, 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Method development for the separation of monoclonal antibody charge variants in cation exchange chromatography, Part II: pH gradient approach.

D. Guillarme, J. Fekete, A. Beck, 2015, Journal of pharmaceutical and biomedical analysis.

An Online Four-Dimensional HIC×SEC-IM×MS Methodology for Proof-of-Concept Characterization of Antibody Drug Conjugates.

D. Guillarme, S. Cianférani, V. D’Atri, 2018, Analytical chemistry.

Comparison of originator and biosimilar therapeutic monoclonal antibodies using comprehensive two-dimensional liquid chromatography coupled with time-of-flight mass spectrometry

D. Guillarme, D. Harmes, D. Stoll, 2016, mAbs.

Characterization of antibody drug conjugate positional isomers at cysteine residues by peptide mapping LC-MS analysis.

A. Beck, Marie-Claire Janin-Bussat, C. Klinguer-Hamour, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Adsorption and recovery issues of recombinant monoclonal antibodies in reversed-phase liquid chromatography.

D. Guillarme, Karine Vuignier, A. Beck, 2015, Journal of separation science.

Safety and immunogenicity of a novel recombinant subunit respiratory syncytial virus vaccine (BBG2Na) in healthy young adults.

A. Osterhaus, T. Nguyen, J. Bonnefoy, 2001, The Journal of infectious diseases.

Identification of Multiple Protective Epitopes (Protectopes) in the Central Conserved Domain of a Prototype Human Respiratory Syncytial Virus G Protein

J. Bonnefoy, A. Beck, T. Nguyen, 1999, Journal of Virology.

5th European Antibody Congress 2009

T. Wurch, J. Reichert, A. Beck, 2010, mAbs.

Stability and CTL-activity of P40/ELA melanoma vaccine candidate.

J. Bonnefoy, A. Beck, L. Goetsch, 2001, Biologicals : journal of the International Association of Biological Standardization.

Use of a type zwittergent detergent for the preparation of a pharmaceutical composition to be administered nasally

A. Beck, L. Goestch, N. Corvaia, 2000 .

7th Cancer Scientific Forum of the Cancéropôle Lyon Auvergne Rhône-Alpes

B. Coiffier, P. Pauwels, B. Teicher, 2012, mAbs.

Targeting of Nasal Mucosa-Associated Antigen-Presenting Cells In Vivo with an Outer Membrane Protein A Derived from Klebsiellapneumoniae

J. Bonnefoy, A. Beck, L. Goetsch, 2001, Infection and Immunity.

A New Anti-CXCR4 Antibody That Blocks the CXCR4/SDF-1 Axis and Mobilizes Effector Cells

C. Bailly, C. Dumontet, A. Robert, 2016, Molecular Cancer Therapeutics.

Identification and characterisation of multiple linear B cell protectopes in the respiratory syncytial virus G protein.

T. Nguyen, J. Bonnefoy, A. Beck, 2001, Vaccine.

Bispecific antibody characterization by a combination of intact and site-specific/chain-specific LC/MS techniques.

D. Guillarme, V. D’Atri, A. Beck, 2022, Talanta.

High‐resolution separation of monoclonal antibodies mixtures and their charge variants by an alternative and generic CZE method

J. Veuthey, D. Guillarme, Yannis-Nicolas François, 2018, Electrophoresis.

Hydrophobic interaction chromatography for the characterization of monoclonal antibodies and related products.

Davy Guillarme, Jean-Luc Veuthey, Szabolcs Fekete, 2016, Journal of pharmaceutical and biomedical analysis.

Priming by Microbial Antigens from the Intestinal Flora Determines the Ability of CD4+ T Cells to Rapidly Secrete IL-4 in BALB/c Mice Infected with Leishmania major1

N. Glaichenhaus, V. Julia, A. Beck, 2000, The Journal of Immunology.

BALB / c Mice Infected with T Cells to Rapidly Secrete IL-4 in + CD 4 Intestinal Flora Determines

N. Glaichenhaus, V. Julia, A. Beck, 2000 .

Marketing approval of mogamulizumab

J. Reichert, A. Beck, 2012, mAbs.

Elsa Bodier-Montagutelli, Renaud Respaud, Davy Guillarme, 2019, Medecine sciences : M/S.

Ion-exchange chromatography for the characterization of biopharmaceuticals.

Davy Guillarme, Jean-Luc Veuthey, Szabolcs Fekete, 2015, Journal of pharmaceutical and biomedical analysis.

Theory and practice of size exclusion chromatography for the analysis of protein aggregates.

Davy Guillarme, Jean-Luc Veuthey, Szabolcs Fekete, 2014, Journal of pharmaceutical and biomedical analysis.

Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry.

Lloyd M. Smith, Norelle C. Wildburger, Anton N. Kozhinov, 2020, Journal of the American Society for Mass Spectrometry.

Multiplexed Middle-Down Mass Spectrometry as a Method for Revealing Light and Heavy Chain Connectivity in a Monoclonal Antibody.

Anton N. Kozhinov, A. Lobas, M. Gorshkov, 2018, Analytical chemistry.

A recombinant humanized anti‐insulin‐like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti‐epidermal growth factor receptor therapy against human cancer xenografts

P. Pauwels, A. Beck, L. Goetsch, 2005, International journal of cancer.

A novel antagonist anti‐cMet antibody with antitumor activities targeting both ligand‐dependent and ligand‐independent c‐Met receptors

C. Bailly, A. Robert, A. Beck, 2016, International journal of cancer.

UV and X‐ray structural studies of a 101‐residue long Tat protein from a HIV‐1 primary isolate and of its mutated, detoxified, vaccine candidate

Patrice Gouet, Alain Beck, Bernard Verrier, 2010, Proteins.

GlycoFi's technology to control the glycosylation of recombinant therapeutic proteins

Alain Beck, Olivier Cochet, O. Cochet, 2010, Expert opinion on drug discovery.

Strategies and challenges for the next generation of therapeutic antibodies

Christian Bailly, Alain Beck, C. Bailly, 2010, Nature Reviews Immunology.

7th Annual European Antibody Congress 2011

J. Reichert, A. Lugovskoy, A. Beck, 2012, mAbs.

Efficacy of the Antibody–Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors

C. Dreyfus, A. Robert, A. Beck, 2019, Molecular Cancer Therapeutics.

The immunodominant influenza matrix T cell epitope recognized in human induces influenza protection in HLA-A2/K(b) transgenic mice.

A Beck, J. Bonnefoy, A. Beck, 2003, Virology.

Therapeutic Fc-fusion proteins and peptides as successful alternatives to antibodies

Janice M Reichert, Alain Beck, J. Reichert, 2011, mAbs.

Structure, heterogeneity and developability assessment of therapeutic antibodies

Ning Li, Wei Xu, Dongdong Wang, 2019, mAbs.

High-Resolution IMS-MS to Assign Additional Disulfide Bridge Pairing in Complementarity-Determining Regions of an IgG4 Monoclonal Antibody.

S. Cianférani, A. Beck, K. Giles, 2021, Journal of the American Society for Mass Spectrometry.

Structural Analysis of Monoclonal Antibodies by Ultrahigh Resolution MALDI In-Source Decay FT-ICR Mass Spectrometry

S. Nicolardi, Y. V. D. van der Burgt, A. Beck, 2018, Analytical chemistry.

Alain Van Dorsselaer, Alain Beck, A. van Dorsselaer, 2012, Analytical chemistry.

Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies.

Alain Van Dorsselaer, Alain Beck, François Debaene, 2015, Journal of mass spectrometry : JMS.

Characterization of therapeutic antibodies and related products.

Alain Van Dorsselaer, Alain Beck, A. van Dorsselaer, 2013, Analytical chemistry.

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody.

Alain Beck, R. Ionescu, A. Beck, 2009, Analytical biochemistry.

Comparison of Host Immune Responses to Homologous and Heterologous Type II Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Challenge in Vaccinated and Unvaccinated Pigs

F. Blecha, R. Rowland, A. Beck, 2014, BioMed research international.

Expression of recombinant proteins in a lipid A mutant of Escherichia coli BL21 with a strongly reduced capacity to induce dendritic cell activation and maturation.

S. Chevalier, A. Beck, G. Caron, 2003, JIM - Journal of Immunological Methods.

Analytical comparability study of recombinant monoclonal antibody therapeutics

Dongdong Wang, Ning Li, Bruce Mason, 2018, mAbs.

Epitope characterization of anti-JAM-A antibodies using orthogonal mass spectrometry and surface plasmon resonance approaches

François Debaene, S. Cianférani, A. Beck, 2017, mAbs.

Use of PASEF for Accelerated Protein Sequence Confirmation and De Novo Sequencing with High Data Quality.

Wilfred H. Tang, E. Belau, D. Suckau, 2022, Methods in molecular biology.

Design and characterization of an HIV-1 Tat mutant: inactivation of viral and cellular functions but not antigenicity.

B. Verrier, S. Munier, A. Beck, 2007, Vaccine.

The recombinant Klebsiella pneumoniae outer membrane protein OmpA has carrier properties for conjugated antigenic peptides.

T. Nguyen, T. Baussant, J. Bonnefoy, 1998, European journal of biochemistry.

Characterization by liquid chromatography combined with mass spectrometry of monoclonal anti-IGF-1 receptor antibodies produced in CHO and NS0 cells.

Alain Van Dorsselaer, Alain Beck, A. van Dorsselaer, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Absence of lung immunopathology following respiratory syncytial virus (RSV) challenge in mice immunized with a recombinant RSV G protein fragment.

T. Nguyen, J. Bonnefoy, A. Beck, 1999, Virology.

CD4+ T-Cell-Mediated Antiviral Protection of the Upper Respiratory Tract in BALB/c Mice following Parenteral Immunization with a Recombinant Respiratory Syncytial Virus G Protein Fragment

J. Bonnefoy, A. Robert, A. Beck, 2000, Journal of Virology.

Approval of the first biosimilar antibodies in Europe

J. Reichert, A. Beck, 2013, mAbs.

Monoclonal antibody N-glycosylation profiling using capillary electrophoresis - Mass spectrometry: Assessment and method validation.

Davy Guillarme, Alain Beck, Yannis-Nicolas François, 2018, Talanta.

8(th) Annual European Antibody Congress 2012: November 27-28, 2012, Geneva, Switzerland.

P. Carter, T. Wurch, R. Kontermann, 2013, mAbs.

November 27, 2012: Day 1 Opening Plenary Session Annual European Antibody Congress 2012

P. Carter, T. Wurch, R. Kontermann, 2022 .

Cell Cultivation Process Transfer and Scale-Up in Support of Production of Early Clinical Supplies of an Anti IGF-1 R Antibody , Part 1

M. Chartrain, A. Kejariwal, T. Wurch, 2008 .

Insulin-like growth factor receptor type I as a target for cancer therapy.

Alain Beck, A. Beck, L. Goetsch, 2013, Frontiers in bioscience.

Determination of isoelectric points and relative charge variants of 23 therapeutic monoclonal antibodies.

D. Guillarme, Balázs Bobály, A. Beck, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Advanced assessment of the physicochemical characteristics of Remicade® and Inflectra® by sensitive LC/MS techniques

W. Alley, Weibin Chen, Y. Yu, 2016, mAbs.

On-Chip Mesoporous Functionalized Magnetic Microspheres for Protein Sequencing by Extended Bottom-up Mass Spectrometry.

H. Girault, A. Beck, K. Srzentić, 2016, Analytical chemistry.

Development of Comprehensive Online Two-Dimensional Liquid Chromatography/Mass Spectrometry Using Hydrophilic Interaction and Reversed-Phase Separations for Rapid and Deep Profiling of Therapeutic Antibodies.

Davy Guillarme, Dwight R Stoll, Alain Beck, 2018, Analytical chemistry.

Current possibilities of liquid chromatography for the characterization of antibody‐drug conjugates

J. Veuthey, D. Guillarme, Balázs Bobály, 2018, Journal of pharmaceutical and biomedical analysis.

Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion

Alain Beck, A. Beck, Daniel Ayoub, 2013, mAbs.

Full validation of therapeutic antibody sequences by middle-up mass measurements and middle-down protein sequencing

E. Belau, D. Suckau, A. Wiechmann, 2016, mAbs.

Monitoring therapeutic monoclonal antibodies in brain tumor

O. Chinot, D. Figarella-Branger, L. Ouafik, 2014, mAbs.

Macro- and Micro-Heterogeneity of Natural and Recombinant IgG Antibodies

Hongcheng Liu, A. Beck, 2019, Antibodies.

Protocols for the analytical characterization of therapeutic monoclonal antibodies. I - Non-denaturing chromatographic techniques.

D. Guillarme, Balázs Bobály, V. D’Atri, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Cutting-edge capillary electrophoresis characterization of monoclonal antibodies and related products.

Yannis-Nicolas François, A. Beck, E. Leize‐Wagner, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Characterization of cetuximab Fc/2 dimers by off-line CZE-MS.

Yannis-Nicolas François, A. Beck, E. Leize‐Wagner, 2016, Analytica chimica acta.

Method development for the separation of monoclonal antibody charge variants in cation exchange chromatography, Part I: salt gradient approach.

D. Guillarme, J. Fekete, A. Beck, 2015, Journal of pharmaceutical and biomedical analysis.

Cutting-edge multi-level analytical and structural characterization of antibody-drug conjugates: present and future

D. Guillarme, Yannis-Nicolas François, S. Cianférani, 2019, Expert review of proteomics.

Comprehensive study on the effects of sodium and potassium additives in size exclusion chromatographic separations of protein biopharmaceuticals

J. Veuthey, D. Guillarme, A. Beck, 2017, Journal of pharmaceutical and biomedical analysis.

Risk-Based Control Strategies of Recombinant Monoclonal Antibody Charge Variants

Hongcheng Liu, C. Nowak, A. Beck, 2022, Antibodies.

Utility of a high coverage phenyl-bonding and wide-pore superficially porous particle for the analysis of monoclonal antibodies and related products.

D. Guillarme, Balázs Bobály, A. Beck, 2018, Journal of chromatography. A.

New wide-pore superficially porous stationary phases with low hydrophobicity applied for the analysis of monoclonal antibodies.

D. Guillarme, A. Beck, S. Fekete, 2021, Journal of chromatography. A.

Analytical characterization of biosimilar antibodies and Fc-fusion proteins

François Debaene, C. Carapito, A. Beck, 2013 .

Rapid and multi-level characterization of trastuzumab using sheathless capillary electrophoresis-tandem mass spectrometry

Alain Beck, Rabah Gahoual, Yannis-Nicolas François, 2013, mAbs.

Determination of size variants by CE-SDS for approved therapeutic antibodies: Key implications of subclasses and light chain specificities.

D. Guillarme, Yannis-Nicolas François, S. Cianférani, 2020, Journal of pharmaceutical and biomedical analysis.

Optimized Sample Preparation and Data Processing of Data-Independent Acquisition Methods for the Robust Quantification of Trace-Level Host Cell Protein Impurities in Antibody Drug Products.

S. Cianférani, C. Carapito, A. Beck, 2020, Journal of proteome research.

Use of Ultra-short Columns for Therapeutic Protein Separations, Part 2: Designing the Optimal Column Dimension for Reversed-Phase Liquid Chromatography.

J. Veuthey, D. Guillarme, A. Beck, 2020, Analytical chemistry.

Analysis of monoclonal antibody by a novel CE‐UV/MALDI‐MS interface

Alain Beck, Ricky Bhajun, Yannis-Nicolas François, 2014, Electrophoresis.

Structure-antigenicity relationship studies of the central conserved region of human respiratory syncytial virus protein G.

T. Nguyen, J. Czaplicki, A. Beck, 2002, The journal of peptide research : official journal of the American Peptide Society.

The next generation of antibody-drug conjugates comes of age.

Christian Bailly, Alain Beck, C. Bailly, 2010, Discovery medicine.

Potential of hydrophilic interaction chromatography for the analytical characterization of protein biopharmaceuticals.

J. Veuthey, A. Periat, D. Guillarme, 2016, Journal of chromatography. A.

Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer.

Pavel A Pevzner, Alexander Makarov, Yury O Tsybin, 2017, Journal of proteomics.

Intact Antibody Characterization Using Orbitrap Mass Spectrometry

Yue Xuan, A. Makarov, D. Horn, 2015 .

Use of Ultrashort Columns for Therapeutic Protein Separations. Part 1: Theoretical Considerations and Proof of Concept.

J. Veuthey, D. Guillarme, Balázs Bobály, 2020, Analytical chemistry.

Glycoform Separation and Characterization of Cetuximab Variants by Middle-up Off-Line Capillary Zone Electrophoresis-UV/Electrospray Ionization-MS.

Yannis-Nicolas François, A. Beck, E. Leize‐Wagner, 2015, Analytical chemistry.

Cetuximab Fab and Fc N-glycan fast characterization using IdeS digestion and liquid chromatography coupled to electrospray ionization mass spectrometry.

A. Beck, N. Corvaïa, Olivier Colas, 2013, Methods in molecular biology.

Native Mass Spectrometry, Ion Mobility, and Collision-Induced Unfolding for Conformational Characterization of IgG4 Monoclonal Antibodies.

S. Cianférani, A. Beck, O. Hernandez-Alba, 2018, Analytical chemistry.

Effects of the COVID-19 pandemic: new approaches for accelerated delivery of gene to first-in-human CMC data for recombinant proteins

H. Broly, A. Beck, J. Souquet, 2023, mAbs.

Forced degradation of recombinant monoclonal antibodies: A practical guide

Hongcheng Liu, Amit Katiyar, Christine Nowak, 2017, mAbs.

Interlaboratory Evaluation of a User-Friendly Benchtop Mass Spectrometer for Multiple-Attribute Monitoring Studies of a Monoclonal Antibody

D. Guillarme, S. Cianférani, V. D’Atri, 2023, Molecules.

Insights from native mass spectrometry and ion mobility-mass spectrometry for antibody and antibody-based product characterization.

S. Cianférani, A. Beck, Guillaume Terral, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Peptides as tools and drugs for immunotherapies

Alain Van Dorsselaer, Alain Beck, Alain Milon, 2007, Journal of peptide science : an official publication of the European Peptide Society.

Proteomics for Development of Immunotherapies

A. Beck, Jean-Françis Haeuw, 2004 .

Synthesis, refolding and protective immune responses of a potential antigen for human Respiratory Syncytial Virus vaccine.

A. Beck, N. Corvaïa, C. Klinguer-Hamour, 2003, The journal of peptide research : official journal of the American Peptide Society.

Innovative native MS methodologies for antibody drug conjugate characterization: High resolution native MS and IM-MS for average DAR and DAR distribution assessment.

Alain Van Dorsselaer, Alain Beck, François Debaene, 2014, Analytical chemistry.

Measurement of nuclear factor-kappa B translocation on lipopolysaccharide-activated human dendritic cells by confocal microscopy and flow cytometry.

Pascale Jeannin, Alain Beck, J. Bonnefoy, 2002, Cytometry.

Mass Spectrometry‐Based Strategies for Therapeutic Antibodies Extensive Characterization and Optimization (OptimAbs)

François Debaene, S. Cianférani, A. Beck, 2020 .

Structural characterization of antibody drug conjugate by a combination of intact, middle-up and bottom-up techniques using sheathless capillary electrophoresis - Tandem mass spectrometry as nanoESI infusion platform and separation method.

Yannis-Nicolas François, L. Kuhn, A. Beck, 2016, Analytica chimica acta.

Benefits and Limitations of High-Resolution Cyclic IM-MS for Conformational Characterization of Native Therapeutic Monoclonal Antibodies.

H. Rogniaux, S. Cianférani, A. Beck, 2023, Analytical chemistry.

Middle level IM-MS and CIU experiments for improved therapeutic immunoglobulin subclass fingerprinting.

S. Cianférani, A. Beck, Thomas Botzanowski, 2020, Analytical chemistry.

Antibody–drug conjugates come of age in oncology

J. Reichert, C. Dumontet, A. Beck, 2023, Nature Reviews Drug Discovery.

Middle-level IM-MS and CIU experiments for improved therapeutic immunoglobulin isotype fingerprinting

S. Cianférani, A. Beck, Thomas Botzanowski, 2020, bioRxiv.

Top-down and middle-down approach by fraction collection enrichment using off-line capillary electrophoresis - mass spectrometry coupling: Application to monoclonal antibody Fc/2 charge variants.

Yannis-Nicolas François, A. Beck, E. Leize‐Wagner, 2017, Journal of chromatography. A.

Orthogonal liquid chromatography-mass spectrometry methods for the comprehensive characterization of therapeutic glycoproteins, from released glycans to intact protein level.

Alain Beck, A. Beck, Eric Largy, 2017, Journal of chromatography. A.

DDA adjuvant induces a mixed Th1/Th2 immune response when associated with BBG2Na, a respiratory syncytial virus potential vaccine.

J. Bonnefoy, A. Beck, T. Nguyen, 2002, Vaccine.

Quantitative N-Glycan Profiling of Therapeutic Monoclonal Antibodies Performed by Middle-Up Level HILIC-HRMS Analysis

D. Guillarme, K. Sandra, V. D’Atri, 2021, Pharmaceutics.

Fast Afucosylation Profiling of Glycoengineered Antibody Subunits by Middle-Up Mass Spectrometry.

D. Guillarme, Yannis-Nicolas François, S. Cianférani, 2021, Methods in molecular biology.

Monoclonal antibodies biosimilarity assessment using transient isotachophoresis capillary zone electrophoresis-tandem mass spectrometry

Yannis-Nicolas François, Johana Chicher, L. Kuhn, 2014, mAbs.

Review of Antibody-Drug Conjugates, Methods in Molecular Biology series

A. Beck, 2013, mAbs.

World Antibody Drug Conjugate Summit Europe

A. Beck, P. Senter, R. Chari, 2011, mAbs.

Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion.

A. Beck, Daniel Ayoub, N. Corvaïa, 2014, mAbs.

Structural Characterization of Antibodies by Mass Spectrometry

J. Strub, A. Beck, A. Dorsselaer, 2010 .

Stability and CTL activity of N-terminal glutamic acid containing peptides.

E. Julien, J. Bonnefoy, A. Beck, 2001, Journal of Peptide Research.

Why is there no biosimilar of Erbitux®?

D. Guillarme, V. D’Atri, A. Beck, 2023, Journal of pharmaceutical and biomedical analysis.

Residual DNA quantification in clinical batches of BBG2Na, a recombinant subunit vaccine against human respiratory syncytial virus.

E. Julien, J. Bonnefoy, A. Beck, 2001, Biologicals : journal of the International Association of Biological Standardization.

The way forward, enhanced characterization of therapeutic antibody glycosylation: comparison of three level mass spectrometry-based strategies.

Alain Van Dorsselaer, Alain Beck, Christine Schaeffer, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[Protein scaffolds as alternatives to whole antibodies: from discovery research to clinical development].

T. Wurch, A. Beck, N. Corvaia, 2009, Medecine sciences : M/S.

Towards a simple on-line coupling of ion exchange chromatography and native mass spectrometry for the detailed characterization of monoclonal antibodies.

D. Guillarme, J. Bourquin, V. D’Atri, 2021, Journal of chromatography. A.

Advanced mass spectrometry workflows for accurate quantification of trace‐level host cell proteins in drug products: Benefits of FAIMS separation and gas‐phase fractionation DIA

A. Beck, O. Hernandez-Alba, Corentin Beaumal, 2023, Proteomics.

10th antibody industrial symposium: new developments in antibody and adoptive cell therapies

P. Martineau, T. Wurch, L. Álvarez-Vallina, 2023, mAbs.

Physico-chemical characterization and immunogenicity studies of peptide and polysaccharide conjugate vaccines based on a promising new carrier protein, the recombinant Klebsiella pneumoniae OmpA.

J. Bonnefoy, A. Beck, L. Zanna, 2000, Developments in biologicals.

Insights from native mass spectrometry and ion mobility-mass spectrometry for antibody and antibody-based product characterization.

S. Cianférani, A. Beck, Guillaume Terral, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.