R. Castillo

发表

Activity landscape modeling of PPAR ligands with dual-activity difference maps.

Jaime Pérez-Villanueva, José L Medina-Franco, Rafael Castillo, 2012, Bioorganic & medicinal chemistry.

Towards a systematic characterization of the antiprotozoal activity landscape of benzimidazole derivatives.

Jaime Pérez-Villanueva, Rafael Castillo, Radleigh Santos, 2010, Bioorganic & medicinal chemistry.

Antiprotozoal activity of proton-pump inhibitors.

Jaime Pérez-Villanueva, Rafael Castillo, Alicia Hernández-Campos, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and antiprotozoal activity of novel 2-{[2-(1H-imidazol-1-yl)ethyl]sulfanyl}-1H-benzimidazole derivatives.

O. Méndez-Lucio, J. Pérez-Villanueva, R. Castillo, 2013, Bioorganic & medicinal chemistry letters.

Exploring the interplay of physicochemical properties, membrane permeability and giardicidal activity of some benzimidazole derivatives.

R. Castillo, A. Hernández-Campos, F. Hernández‐Luis, 2012, European journal of medicinal chemistry.

Effectiveness of the Experimental Fosfatriclaben in Comparison with Two Commercial Fasciolicides in Cattle

F. Ibarra-Velarde, R. Castillo, A. Hernández-Campos, 2019, Pharmacology & Pharmacy.

Diversity in the supramolecular interactions of 5,6-dichloro-2-(trifluoromethyl)-1H-benzimidazole with modified cyclodextrins: Implications for physicochemical properties and antiparasitic activity.

R. Castillo, F. Hernández‐Luis, Y. Rojas-Aguirre, 2012, Carbohydrate polymers.

In silico hit optimization toward AKT inhibition: fragment-based approach, molecular docking and molecular dynamics study

R. Castillo, A. Hernández-Campos, A. Téllez-Valencia, 2019, Journal of biomolecular structure & dynamics.

Insights into the structure and inhibition of Giardia intestinalis arginine deiminase: homology modeling, docking, and molecular dynamics studies

J. Medina-Franco, R. Castillo, A. Hernández-Campos, 2016, Journal of biomolecular structure & dynamics.

Synthesis, antiprotozoal activity, and chemoinformatic analysis of 2-(methylthio)-1H-benzimidazole-5-carboxamide derivatives: Identification of new selective giardicidal and trichomonicidal compounds.

R. Castillo, A. Hernández-Campos, L. Yépez-Mulia, 2017, European journal of medicinal chemistry.

Assessment of the effective dose of an experimental intramuscular formulation against immature and adult Fasciola hepatica in sheep.

F. Ibarra-Velarde, R. Castillo, A. Hernández-Campos, 2018, Veterinary parasitology.

In vitro and in vivo trypanocidal activity of some benzimidazole derivatives against two strains of Trypanosoma cruzi.

J. Pérez-Villanueva, R. Castillo, A. Hernández-Campos, 2012, Acta tropica.

Effects of the Protonation State of Titratable Residues and the Presence of Water Molecules on Nocodazole Binding to β‐Tubulin

R. Castillo, A. Hernández-Campos, L. Domínguez, 2018, ChemMedChem.

Computational Methods in Cooperation with Experimental Approaches to Design Protein Tyrosine Phosphatase 1B Inhibitors in Type 2 Diabetes Drug Design: A Review of the Achievements of This Century

R. Castillo, A. Hernández-Campos, M. Valdez-Solana, 2022, Pharmaceuticals.

Leishmania mexicana Trypanothione Reductase Inhibitors: Computational and Biological Studies

R. Castillo, A. Hernández-Campos, L. Yépez-Mulia, 2019, Molecules.

Cardiovascular effects of milk enriched with omega-3 polyunsaturated fatty acids, oleic acid, folic acid, and vitamins E and B6 in volunteers with mild hyperlipidemia.

J. Carrero, J. Fonollá, J. Boza, 2004, Nutrition.

Homology modeling, docking and molecular dynamics of the Leishmania mexicana arginase: a description of the catalytic site useful for drug design.

O. Méndez-Lucio, R. Castillo, C. Méndez-Cuesta, 2012, Journal of molecular graphics & modelling.

Angiogenic properties of adult human thymus fat

E. Jiménez, M. Montiel, R. Castillo, 2009, Cell and Tissue Research.

Pyridin‐2(1H)‐ones: A Promising Class of HIV‐1 Non‐nucleoside Reverse Transcriptase Inhibitors

J. Medina-Franco, K. Martínez-Mayorga, R. Castillo, 2007, ChemMedChem.

An evaluation of the efficacy of compound alpha and triclabendazole against two isolates of Fasciola hepatica.

I. Fairweather, G. Brennan, R. Castillo, 2009, Veterinary parasitology.

Synthesis and antiparasitic activity of 1H-benzimidazole derivatives.

R. Castillo, A. Hernández-Campos, F. Hernández‐Luis, 2002, Bioorganic & medicinal chemistry letters.

AN IMPROVED METHOD FOR THE SYNTHESIS OF 3-AMINO-1H-QUINOLIN-2-ONE

R. Castillo, A. Hernández-Campos, Cecilia Juárez-Gordiano, 2002 .

Synthesis and antiprotozoal activity of nitazoxanide-N-methylbenzimidazole hybrids.

R. Castillo, A. Hernández-Campos, F. Hernández‐Luis, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of 2-(trifluoromethyl)-1H-benzimidazole derivatives against some protozoa and Trichinella spiralis.

Gabriel Navarrete-Vázquez, Rafael Castillo, Alicia Hernández-Campos, 2010, European journal of medicinal chemistry.

Synthesis and antiprotozoal activity of novel 1-methylbenzimidazole derivatives.

R. Castillo, A. Hernández-Campos, F. Hernández‐Luis, 2009, Bioorganic & medicinal chemistry.

Synthesis and antiprotozoal activity of some 2-(trifluoromethyl)-1H-benzimidazole bioisosteres.

Gabriel Navarrete-Vázquez, Rafael Castillo, Alicia Hernández-Campos, 2006, European journal of medicinal chemistry.

Molecular modeling of tricyclic compounds with anilino substituents and their intercalation complexes with DNA sequences.

R. Castillo, A. Lira-Rocha, Marco A. Loza-Mejía, 2009, Journal of molecular graphics & modelling.

In search of AKT kinase inhibitors as anticancer agents: structure-based design, docking, and molecular dynamics studies of 2,4,6-trisubstituted pyridines

José L Medina-Franco, Rafael Castillo, Alicia Hernández-Campos, 2018, Journal of biomolecular structure & dynamics.

Synthesis and antiparasitic activity of albendazole and mebendazole analogues.

A. Martínez-Fernández, R. Castillo, A. Hernández-Campos, 2003, Bioorganic & medicinal chemistry.

Synthesis and in vitro cysticidal activity of new benzimidazole derivatives.

R. Castillo, A. Hernández-Campos, F. Hernández‐Luis, 2009, European journal of medicinal chemistry.

Molecular docking of the highly hypolipidemic agent alpha-asarone with the catalytic portion of HMG-CoA reductase.

J. Medina-Franco, J. Tamariz, Fabian López-Vallejo, 2005, Bioorganic & medicinal chemistry letters.

Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of some benzimidazole derivatives with trichomonicidal activity.

Jaime Pérez-Villanueva, José L Medina-Franco, Rafael Castillo, 2011, European journal of medicinal chemistry.

Pyridin-2(1H)-ones: A Promising Class of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

J. Medina-Franco, K. Martínez-Mayorga, R. Castillo, 2007 .

Chemoinformatic characterization of activity and selectivity switches of antiprotozoal compounds.

Jaime Pérez-Villanueva, José L Medina-Franco, Rodrigo Aguayo-Ortiz, 2014, Future medicinal chemistry.

Determination of the effective dose of an experimental fasciolicide in naturally and experimentally infected cattle.

R. Castillo, F. Ibarra, J. Cantó, 2004, Veterinary parasitology.

Efficiency comparison of experimental fosfatriclaben with three commercial fasciolicides in experimentally infected sheep

F. Ibarra-Velarde, R. Castillo, A. Hernández-Campos, 2020, Parasitology Research.

Partial inhibition of the tricarboxylic acid cycle in Taenia crassiceps cysticerci after the in vitro exposure to a benzimidazole derivative (RCB15).

R. Castillo, A. Hernández-Campos, T. Costa, 2020, Acta tropica.

Partial inhibition of the main energetic pathways and its metabolic consequences after in vivo treatment with benzimidazole derivatives in experimental neurocysticercosis

R. Castillo, R. Lino-Júnior, M. C. Vinaud, 2019, Parasitology.

A benzimidazole derivative (RCB15) in vitro induces the alternative energetic metabolism and glycolysis in Taenia crassiceps cysticerci.

R. Castillo, M. C. Vinaud, T. L. da Costa, 2017, Acta tropica.

Molecular basis for benzimidazole resistance from a novel β-tubulin binding site model.

J. Medina-Franco, O. Méndez-Lucio, R. Castillo, 2013, Journal of molecular graphics & modelling.

Pharmacokinetic behavior in sheep and cattle of 5-chloro-2-(methylthio)-6-(1-naphthyloxy)-1H-benzimidazole, a new fasciolicide agent.

F. Ibarra-Velarde, R. Castillo, A. Hernández-Campos, 2009, Journal of veterinary pharmacology and therapeutics.

Towards the identification of the binding site of benzimidazoles to β-tubulin of Trichinella spiralis: insights from computational and experimental data.

J. Medina-Franco, O. Méndez-Lucio, R. Castillo, 2013, Journal of molecular graphics & modelling.

Ultrastructural changes to the tegumental system and the gastrodermal cells in adult Fasciola hepatica following in vivo treatment with the experimental fasciolicide, compound alpha

I. Fairweather, G. Brennan, R. Castillo, 2009, Parasitology.

Adult triclabendazole-resistant Fasciola hepatica: surface and subsurface tegumental responses to in vitro treatment with the sulphoxide metabolite of the experimental fasciolicide compound alpha

I. Fairweather, G. Brennan, R. Castillo, 2006, Parasitology.

Tegumental surface changes in adult Fasciola hepatica following treatment in vitro and in vivo with an experimental fasciolicide

Norma Rivera, R. Castillo, T. Fortoul, 2004, Parasitology Research.

A Germination Bioassay as a Toxicological Screening System for Studying the Effects of Potential Prodrugs of Naproxen

R. Castillo, R. Enríquez, M. Jiménez-Estrada, 1998, Alternatives to laboratory animals : ATLA.

High-performance liquid chromatographic assay for a new fasciolicide agent, αBIOF10, in biological fluids

R. Castillo, A. Hernández-Campos, Helgi Jung, 1998 .

Impact of compound alpha treatment in vivo on egg production by the liver fluke, Fasciola hepatica.

I. Fairweather, G. Brennan, R. Castillo, 2012, Veterinary parasitology.

The effect of the 5-chloro-2-methylthio-6-(1-naphtyloxy)-1H-benzimidazole on the tegument of immature Fasciola hepatica in their natural host

Norma Rivera, R. Castillo, T. Fortoul, 2005, Parasitology Research.

Synthesis and fasciolicidal activity of 5-chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole.

F. Ibarra-Velarde, R. Castillo, A. Hernández-Campos, 2002, Chemical & pharmaceutical bulletin.

3D-QSAR studies on purine-carbonitriles as cruzain inhibitors: comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA)

O. Méndez-Lucio, R. Castillo, Antonio Romo-Mancillas, 2011 .

New fragmentation processes of pyridin-2(1H)-ones upon electron impact ionization.

J. Medina-Franco, R. Castillo, A. Hernández-Campos, 2005, Rapid communications in mass spectrometry : RCM.

Studies on the Selective S-oxidation of Albendazole, Fenbendazole, Triclabendazole, and Other Benzimidazole Sulfides

J. Medina-Franco, R. Castillo, A. Hernández-Campos, 2005 .

Anthelmintic activity of benzimidazole derivatives against Toxocara canis second-stage larvae and Hymenolepis nana adults.

R. Castillo, A. Hernández-Campos, F. Hernández‐Luis, 2009, Acta tropica.

RCB20, an experimental benzimidazole derivative, affects tubulin expression and induces gross anatomical changes in Taenia crassiceps cysticerci

R. Castillo, A. Hernández-Campos, F. Hernández‐Luis, 2013, Parasitology Research.

Biopharmaceutic evaluation of novel anthelmintic (1H-benzimidazol-5(6)-yl)carboxamide derivatives.

R. Castillo, A. Hernández-Campos, H. Jung-Cook, 2007, International journal of pharmaceutics.

Preparation of N-methoxycarbonyl-N′-[2-nitro-4(5)-propylthiophenyl]thiourea as prodrugs of albendazole

R. Castillo, A. Hernández-Campos, F. Hernández‐Luis, 1996 .

Field study on the determination of the effective dose of injectable fosfatriclaben prodrug in sheep naturally infected with Fasciola hepatica

F. Ibarra-Velarde, R. Castillo, Y. Vera-Montenegro, 2021, Parasitology Research.

Structural characterization, biochemical, inhibition and computational studies of Entamoeba histolytica phosphoglycerate mutase: finding hits for a new antiamoebic drug

R. Castillo, A. Hernández-Campos, L. Yépez-Mulia, 2018, Medicinal Chemistry Research.

Analysis of the effect of a 2-(trifluoromethyl)-1H-benzimidazole derivative on Trichinella spiralis muscle larvae.

R. Castillo, A. Hernández-Campos, F. Hernández‐Luis, 2013, Veterinary parasitology.

A benzimidazole derivative (RCB20) in vitro induces an activation of energetic pathways on Taenia crassiceps (ORF strain) cysticerci.

R. Castillo, A. Hernández-Campos, M. C. Vinaud, 2017, Experimental parasitology.

Surface changes in adult Fasciola hepatica following treatment in vivo with the experimental fasciolicide, compound alpha

I. Fairweather, G. Brennan, R. Castillo, 2009, Parasitology Research.

Surface and internal tegumental changes in juvenile Fasciola hepatica following treatment in vivo with the experimental fasciolicide, compound alpha.

I. Fairweather, G. Brennan, R. Castillo, 2008, Veterinary parasitology.

Fasciola hepatica: disruption of spermatogenesis by the fasciolicide compound alpha

I. Fairweather, G. Brennan, R. Castillo, 2009, Parasitology Research.

Novel triclabendazole prodrug: A highly water soluble alternative for the treatment of fasciolosis.

F. Ibarra-Velarde, R. Castillo, A. Hernández-Campos, 2017, Bioorganic & medicinal chemistry letters.

Immature triclabendazole-resistant Fasciola hepatica: tegumental responses to in vitro treatment with the sulphoxide metabolite of the experimental fasciolicide compound alpha

I. Fairweather, G. Brennan, R. Castillo, 2006, Parasitology Research.

Field trial on the efficacy of an experimental fasciolicide compared with some commercial compounds in naturally infected cattle

R. Castillo, H. Quiroz Romero, Y. Vera Montenegro, 2003, Parasitology Research.

Efficiency comparison of experimental fosfatriclaben with three commercial fasciolicides in experimentally infected sheep

F. Ibarra-Velarde, R. Castillo, A. Hernández-Campos, 2020, Parasitology Research.

Alternative energy production pathways in Taenia crassiceps cysticerci in vitro exposed to a benzimidazole derivative (RCB20)

R. Castillo, A. Hernández-Campos, M. C. Vinaud, 2015, Parasitology.

JVG9, a benzimidazole derivative, alters the surface and cytoskeleton of Trypanosoma cruzi bloodstream trypomastigotes

R. Castillo, A. Hernández-Campos, F. Hernández‐Luis, 2014, Memorias do Instituto Oswaldo Cruz.

JVG9, a benzimidazole derivative, alters the surface and cytoskeleton of Trypanosoma cruzi bloodstream trypomastigotes.

R. Castillo, A. Hernández-Campos, F. Hernández‐Luis, 2014, Memorias do Instituto Oswaldo Cruz.

Studies on 6-chloro-5-(1-naphthyloxy)-2-(trifluoromethyl)-1H-benzimidazole/2-hydroxypropyl-β-cyclodextrin association: Characterization, molecular modeling studies, and in vivo anthelminthic activity.

Fabian López-Vallejo, R. Castillo, A. Hernández-Campos, 2011, Bioorganic & medicinal chemistry.

Liquid chromatography determination of residue levels on apples treated with cetylpyridinium chloride.

R. Castillo, C. Compadre, H. Salari, 2005, Journal of chromatography. A.

Benzotriazoles and Indazoles Are Scaffolds with Biological Activity against Entamoeba histolytica

José L. Medina-Franco, Fabian López-Vallejo, Rafael Castillo, 2011, Journal of biomolecular screening.

The design and inhibitory profile of new benzimidazole derivatives against triosephosphate isomerase from Trypanosoma cruzi: a problem of residue motility.

R. Castillo, A. Hernández-Campos, F. Hernández‐Luis, 2011, Journal of molecular graphics & modelling.

Structure–activity relationships of benzimidazole derivatives as antiparasitic agents: Dual activity-difference (DAD) maps

José L. Medina-Franco, Jaime Pérez-Villanueva, Rafael Castillo, 2011 .

In vitro activity of new N-benzyl-1H-benzimidazol-2-amine derivatives against cutaneous, mucocutaneous and visceral Leishmania species.

M. Dea-Ayuela, R. Castillo, A. Hernández-Campos, 2017, Experimental parasitology.

Novel Mixed-Type Inhibitors of Protein Tyrosine Phosphatase 1B. Kinetic and Computational Studies

R. Castillo, A. Hernández-Campos, J. Salas-Pacheco, 2017, Molecules.

Proteomic and ultrastructural analysis of the effect of a new nitazoxanide-N-methyl-1H-benzimidazole hybrid against Giardia intestinalis.

W. de Souza, R. Castillo, A. Hernández-Campos, 2016, Research in veterinary science.

Docking of Protein Kinase B Inhibitors: Implications in the Structure‐Based Optimization of a Novel Scaffold

J. Medina-Franco, M. Giulianotti, R. Castillo, 2010, Chemical biology & drug design.

Flexible docking of pyridinone derivatives into the non-nucleoside inhibitor binding site of HIV-1 reverse transcriptase.

Jesús Jiménez-Barbero, Rafael Castillo, Cecilia Juárez-Gordiano, 2004, Bioorganic & medicinal chemistry.

Quantitative Structure–activity Relationship Analysis of Pyridinone HIV-1 Reverse Transcriptase Inhibitors using the k Nearest Neighbor Method and QSAR-based Database Mining

Alexander Golbraikh, Alexander Tropsha, José L. Medina-Franco, 2005, J. Comput. Aided Mol. Des..

Synthesis and trypanocidal activity of novel benzimidazole derivatives.

R. Castillo, A. Hernández-Campos, L. Yépez-Mulia, 2016, Bioorganic & medicinal chemistry letters.

Benzimidazole Derivatives as New and Selective Inhibitors of Arginase from Leishmania mexicana with Biological Activity against Promastigotes and Amastigotes

J. Hermoso, R. Castillo, A. Hernández-Campos, 2021, International journal of molecular sciences.

Design, synthesis, kinetic, molecular dynamics, and hypoglycemic effect characterization of new and potential selective benzimidazole derivatives as Protein Tyrosine Phosphatase 1B inhibitors.

W. Peti, R. Castillo, A. Hernández-Campos, 2021, Bioorganic & medicinal chemistry.

Identifying Activity Cliff Generators of PPAR Ligands Using SAS Maps

Oscar Méndez-Lucio, Jaime Pérez-Villanueva, Rafael Castillo, 2012, Molecular informatics.

Characterisation of the in vitro activity of a Nitazoxanide-N-methyl-1H-benzimidazole hybrid molecule against albendazole and nitazoxanide susceptible and resistant strains of Giardia intestinalis and its in vivo giardicidal activity

R. Castillo, A. Hernández-Campos, L. Yépez-Mulia, 2020, Memorias do Instituto Oswaldo Cruz.

Molecular modeling of some 1H-benzimidazole derivatives with biological activity against Entamoeba histolytica: a comparative molecular field analysis study.

J. Medina-Franco, Fabian López-Vallejo, R. Castillo, 2007, Bioorganic & medicinal chemistry.

3D-QSAR, synthesis, and antimicrobial activity of 1-alkylpyridinium compounds as potential agents to improve food safety.

R. Castillo, C. Compadre, P. Breen, 2005, European journal of medicinal chemistry.

Structure‐based approaches for the design of benzimidazole‐2‐carbamate derivatives as tubulin polymerization inhibitors

R. Castillo, A. Hernández-Campos, L. Domínguez, 2017, Chemical biology & drug design.

Species-Specific Inactivation of Triosephosphate Isomerase from Trypanosoma brucei: Kinetic and Molecular Dynamics Studies

R. Castillo, A. Hernández-Campos, F. Hernández‐Luis, 2017, Molecules.

Computational study on the inhibition mechanism of cruzain by nitrile-containing molecules.

J. Medina-Franco, O. Méndez-Lucio, R. Castillo, 2012, Journal of molecular graphics & modelling.

Structural characterization, biochemical, inhibition and computational studies of Entamoeba histolytica phosphoglycerate mutase: finding hits for a new antiamoebic drug

R. Castillo, A. Hernández-Campos, A. Cruz, 2018, Medicinal Chemistry Research.

CASE Plots for the Chemotype‐Based Activity and Selectivity Analysis: A CASE Study of Cyclooxygenase Inhibitors

Jaime Pérez-Villanueva, José L Medina-Franco, Rafael Castillo, 2012, Chemical biology & drug design.

Synthesis and antiparasitic activity of 2-(trifluoromethyl)-benzimidazole derivatives.

R. Castillo, A. Hernández-Campos, F. Hernández‐Luis, 2001, Bioorganic & medicinal chemistry letters.

Development and Pharmacokinetic Evaluation of Two Parenteral Formulations of Albendazole Using Prodrug and Cosolvent Approaches

R. Castillo, A. Hernández-Campos, H. Jung-Cook, 2023, AAPS PharmSciTech.

A highly water soluble benzimidazole derivative useful for the treatment of fasciolosis.

F. Ibarra-Velarde, R. Castillo, A. Hernández-Campos, 2014, Bioorganic & medicinal chemistry letters.

Curcumin alters the cytoskeleton and microtubule organization on trophozoites of Giardia lamblia.

Araceli Castillo-Romero, R. Castillo, A. Hernández-Campos, 2017, Acta tropica.

special Focus: computational chemist R y

Jaime Pérez-Villanueva, Nathalie Meurice, Rodrigo Aguayo-Ortiz, 2014 .

RCB20, an experimental benzimidazole derivative, affects tubulin expression and induces gross anatomical changes in Taenia crassiceps cysticerci

R. Castillo, A. Hernández-Campos, F. Hernández‐Luis, 2013, Parasitology Research.

Computational study on the inhibition mechanism of cruzain by nitrile-containing molecules.

O. Méndez-Lucio, R. Castillo, Antonio Romo-Mancillas, 2012, Journal of molecular graphics & modelling.

Garbage in, garbage out: how reliable training data improved a virtual screening approach against SARS-CoV-2 MPro

Lucas N. Alberca, A. Talevi, C. Kunick, 2023, Frontiers in Pharmacology.

Identifying Activity Cliff Generators of PPAR Ligands Using SAS Maps

J. Medina-Franco, O. Méndez-Lucio, R. Castillo, 2012, Molecular informatics.

Cardiovascular effects of milk enriched with omega-3 polyunsaturated fatty acids, oleic acid, folic acid, and vitamins E and B6 in volunteers with mild hyperlipidemia.

J. Carrero, J. Fonollá, J. Boza, 2004, Nutrition.