Jing-kang Shen

发表

ScafBank: a public comprehensive Scaffold database to support molecular hopping

Bing Xiong, Ke Liu, B. Yan, 2009, Acta Pharmacologica Sinica.

Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain.

Yechun Xu, Lele Zhao, Z. Miao, 2013, Journal of medicinal chemistry.

CCLab--a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design.

Mengzhu Xue, B. Xiong, Jing-kang Shen, 2012, Bioorganic & medicinal chemistry letters.

A facile one-pot synthesis of 3-unsubstituted-2,4-oxazolidinediones via in situ generation of carbamates from α-hydroxyesters using trichloroacetyl isocyanate

Jing-kang Shen, Yue H. Li, Li Zhang, 2009 .

Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A

Cheng Luo, Jingkang Shen, Suxin Zheng, 2004, Biochemical and Biophysical Research Communications - BBRC.

Palladium‐Catalyzed Route to Three‐Component, One‐Pot Sequential Synthesis of Functionalized Cyclazines: 2,2a1,4‐Triazacyclopenta[cd]indenes

Jing-kang Shen, Lan-ping Ma, T. Meng, 2013 .

Three-component, one-pot sequential synthesis of functionalized cyclazines: 3H-1,2a1,3-triazaacenaphthylenes.

Jing-kang Shen, Xin Wang, T. Meng, 2012, The Journal of organic chemistry.

Three‐Component, One‐Pot Sequential Synthesis of Tetracyclic Pyrido[2′,1′:2,3]imidazo[5,1‐a]isoquinolinium Compounds as Potent Anticancer Agents

Weiqi Wang, Z. Miao, Jing-kang Shen, 2012 .

Design and Synthesis of 4‐(2,4,5‐Trifluorophenyl)butane‐1,3‐diamines as Dipeptidyl Peptidase IV Inhibitors

B. Xiong, Jing-kang Shen, Xin Wang, 2013, ChemMedChem.

Discovery of novel PTP1B inhibitors with antihyperglycemic activity

Jia Li, Jing-kang Shen, Q. Chai, 2010, Acta Pharmacologica Sinica.

Fragment-Based Drug Discovery for Developing Inhibitors of Protein-Protein Interactions

B. Xiong, Jing-kang Shen, Qi Wang, 2018 .

Designing of novel ERRγ inverse agonists by molecular modeling studies of docking and 3D-QSAR on hydroxytamoxifen derivatives

Jing-kang Shen, Yongli Du, Rui Li, 2019, Medicinal Chemistry Research.

Correction to "Discovery and Optimization of 4,5-Diarylisoxazoles as Potent Dual Inhibitors of Pyruvate Dehydrogenase Kinase and Heat Shock Protein 90".

Min Huang, M. Geng, M. Huang, 2014, Journal of medicinal chemistry.

Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90.

Min Huang, M. Geng, Jing-kang Shen, 2014, Journal of medicinal chemistry.

Dual Mechanisms of Novel CD73-Targeted Antibody and Antibody–Drug Conjugate in Inhibiting Lung Tumor Growth and Promoting Antitumor Immune-Effector Function

Jing-kang Shen, Yun Xing, Xin Wang, 2020, Molecular Cancer Therapeutics.

(N,N-Diisopropylcarbamoyloxy)-methyl p-tolyl sulfone: preparation and application for the syntheses of 1,2-diols

Jing-kang Shen, Lin Chen, Xin Wang, 2012 .

Design and synthesis of benzylpiperidine inhibitors targeting the menin-MLL1 interface.

Yu-bo Zhou, Yi Zang, W. Xu, 2016, Bioorganic & medicinal chemistry letters.

Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers

Z. Miao, B. Xiong, Jing-kang Shen, 2021, Investigational New Drugs.

Potent and novel 11β-HSD1 inhibitors identified from shape and docking based virtual screening.

Bing Xiong, Jingkang Shen, Guangxin Xia, 2011, Bioorganic & medicinal chemistry letters.

Design and Synthesis of (R)‐1‐Arylsulfonylpiperidine‐2‐carboxamides as 11β‐Hydroxysteroid Dehydrogenase Type 1 Inhibitors

B. Xiong, Jing-kang Shen, Haiyan Liu, 2013, ChemMedChem.

Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors.

B. Xiong, Jing-kang Shen, Jianxin Yu, 2012, ACS medicinal chemistry letters.

Efficient Synthesis of a (Z)-3-Methyleneisoindolin-1-one Library Using Cu(OAc)2•H2O/DBU under Microwave Irradiation

Xin Wang, Li Zhang, Jingkang Shen, 2013, Molecules.

FS-93, an Hsp90 inhibitor, induces G2/M arrest and apoptosis via the degradation of client proteins in oncogene addicted and derived resistant cancer cells

M. Geng, B. Xiong, Jing-kang Shen, 2015, Oncoscience.

FS-93 , an Hsp 90 inhibitor , induces G 2 / M arrest and apoptosis via the degradation of client proteins in oncogene addicted and derived resistant cancer cells

M. Geng, B. Xiong, Jing-kang Shen, 2015 .

Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienaymé reaction and their Hsp90 inhibitory activity.

J. Li, Min Yang, M. Geng, 2015, Organic & biomolecular chemistry.

Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.

Yechun Xu, Min Huang, M. Geng, 2014, European journal of medicinal chemistry.

Design, synthesis and SAR of piperidyl-oxadiazoles as 11β-hydroxysteroid dehydrogenase 1 inhibitors.

B. Xiong, Jing-kang Shen, Haiyan Liu, 2013, European journal of medicinal chemistry.

Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents.

Z. Miao, Jing-kang Shen, T. Meng, 2016, European journal of medicinal chemistry.

Condensed Fukui function predicts innate C–H radical functionalization sites on multi-nitrogen containing fused arenes

B. Xiong, Jing-kang Shen, Dongmei Zhao, 2014 .

Formation of 1,3-diazocine by palladium catalyzed C–H arylation

B. Xiong, Jing-kang Shen, Jingge Ren, 2016 .

MCL-1 Degradation Mediated by JNK Activation via MEKK1/TAK1-MKK4 Contributes to Anticancer Activity of New Tubulin Inhibitor MT189

Yi Chen, Z. Miao, Jian Ding, 2014, Molecular Cancer Therapeutics.

A Facile One-Pot Synthesis of 3-Unsubstituted-2,4-oxazolidinediones via in situ Generation of Carbamates from α-Hydroxyesters Using Trichloroacetyl Isocyanate.

Jing-kang Shen, Yue H. Li, Li Zhang, 2009 .

A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction

Z. Miao, B. Xiong, Jing-kang Shen, 2019, Investigational New Drugs.

Novel liver-specific cholic acid-cytarabine conjugates with potent antitumor activities: Synthesis and biological characterization

Z. Miao, Jing-kang Shen, Dan-qi Chen, 2011, Acta Pharmacologica Sinica.

Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction.

M. Huang, Min Huang, M. Geng, 2019, European journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting EGFR.

Wenteng Chen, Jing-kang Shen, Qinjie Weng, 2013, ACS medicinal chemistry letters.

Phage-Display Based Discovery and Characterization of Peptide Ligands against WDR5

B. Xiong, Jing-kang Shen, D. Cao, 2021, Molecules.

Asymmetric synthesis and biological evaluation of N-cyclohexyl-4-[1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl]piperazine-1-carboxamide as hCB1 receptor antagonists.

Jing-kang Shen, Xin Wang, T. Meng, 2011, European journal of medicinal chemistry.

Quinoxalinylurea Derivatives as a Novel Class of JSP‐1 Inhibitors.

B. Xiong, Jing-kang Shen, Xin Wang, 2007 .

Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution.

Jing-kang Shen, Xin Wang, Jingya Li, 2006, Molecules.

Convenient preparation of pinometostat and related 5′-deoxy-5′-amino adenosine derivatives as well as their activity against DOT1L

Tongchao Liu, Jia Li, Yu-bo Zhou, 2018 .

Preparation of 5'-deoxy-5'-amino-5'-C-methyl adenosine derivatives and their activity against DOT1L.

Tongchao Liu, Yu-bo Zhou, B. Xiong, 2017, Bioorganic & medicinal chemistry letters.

Inhibition of the BET family reduces its new target gene IDO1 expression and the production of l-kynurenine

Z. Miao, B. Xiong, Jing-kang Shen, 2019, Cell Death & Disease.

Efficient syntheses of alpha- and beta-C-nucleosides and the origin of anomeric selectivity

Tongchao Liu, B. Xiong, Jing-kang Shen, 2018 .

Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors.

B. Xiong, Jing-kang Shen, Xin Wang, 2007, Bioorganic & medicinal chemistry letters.

An efficient synthesis of novel dibenzoxdiazepine-fused heterocycles through a multicomponent reaction

Jing-kang Shen, Xin Wang, T. Meng, 2014 .

Highly Stereoselective Nucleophilic Addition of Difluoromethyl‐2‐pyridyl Sulfone to Sugar Lactones and Efficient Synthesis of Fluorinated 2‐Ketoses

B. Xiong, Jing-kang Shen, Jian Yin, 2014 .

Facile synthesis of new functionalized 3,4-dihydro-2H-pyrroles using 2-isocyanoacetates

Jing-kang Shen, Lin Chen, Xin Wang, 2020 .

Ga(OTf)3-promoted synthesis of functionalized 2-carbonyl-imidazo[1,2-a]pyridines derived from ethyl α-benzotriazolyl-α-morpholinoacetate

Jing-kang Shen, Xin Wang, Lan-ping Ma, 2015 .

Simple and Efficient Copper(I)-Catalyzed Access to Three Versatile Aminocoumarin-Based Scaffolds using Isocyanoacetate

Jing-kang Shen, Xin Wang, D. Hu, 2011 .

Synthesis of 3-substituted isocoumarins via a cascade intramolecular Ullmann-type coupling-rearrangement process.

Jing-kang Shen, T. Tang, Xiang-Dong Fei, 2012, The Journal of organic chemistry.

Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor.

Z. Miao, B. Xiong, Jing-kang Shen, 2017, European journal of medicinal chemistry.

Buchwald–Hartwig Coupling/Michael Addition Reactions: One‐Pot Synthesis of 1,2‐Disubstituted 4‐Quinolones from Chalcones and Primary Amines

Jing-kang Shen, Xiang-Dong Fei, W. Li, 2012 .

Direct glycosylation of bioactive small molecules with glycosyl iodide and strained olefin as acid scavenger.

B. Xiong, Jing-kang Shen, Xin Wang, 2014, The Journal of organic chemistry.

Strained olefin enables triflic anhydride mediated direct dehydrative glycosylation.

B. Xiong, Jing-kang Shen, Jian Yin, 2014, Organic & biomolecular chemistry.

Palladium-Catalyzed Synthesis of α-Iminonitriles from Aryl Halides via Isocyanide Double Insertion Reaction.

Jing-kang Shen, Fangjun Zhang, Q. Yuan, 2016, The Journal of organic chemistry.

Palladium-catalyzed synthesis of 4H-benzo[d][1,3]oxazin-4-ones and N-(2-cyanophenyl)benzamides via tert-butyl isocyanide insertion

Jing-kang Shen, Yong‐Ming Zhu, Xiao Jiang, 2015 .

Synthesis of 3-substituted isocoumarins via a cascade intramolecular Ullmann-type coupling-rearrangement process.

Jing-kang Shen, T. Tang, Xiang-Dong Fei, 2012, The Journal of organic chemistry.

Discovery of pyrazole as C-terminus of selective BACE1 inhibitors.

Yechun Xu, Li Li, Jian Li, 2013, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase.

Wei Wang, Jingkang Shen, Xin Wang, 2009, Bioorganic & medicinal chemistry.

Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action.

B. Xiong, Jing-kang Shen, Xin Wang, 2008, Bioorganic & medicinal chemistry.

NICKEL-CATALYZED LIGAND-FREE SYNTHESIS OF BENZOXAZOLES AND OXAZOLINES VIA ISOCYANIDE INSERTION

Jing-kang Shen, T. Tang, Yong‐Ming Zhu, 2014 .

Microwave-assisted rapid and straightforward synthesis of 2-aryl-4-quinolones from acylated 2′-aminoacetophenones

Jing-kang Shen, Xin Wang, Yongli Du, 2006 .

Soluble polymer-supported synthesis of 5-arylidene thiazolidinones and pyrimidinones using a novel traceless linker strategy.

Wei Zhang, Jing-kang Shen, Xin Wang, 2008, Journal of combinatorial chemistry.

Design and optimization of a series of 1-sulfonylpyrazolo[4,3-b]pyridines as selective c-Met inhibitors.

Jian Ding, M. Geng, B. Xiong, 2015, Journal of medicinal chemistry.

Stereoselective addition of Grignard reagents to (2-methyl-5-tert-butyl)phenyl 1-thio-β-D-ribopentodialdo-1,4-furanoside derivative

B. Xiong, Jing-kang Shen, Guohua Chen, 2017 .

Synthesis of pyrrolidine analogues of solamin

L. Lou, Jing-kang Shen, Xin Wang, 2005 .

One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation

Li Zhang, Yu Qin, Jingkang Shen, 2006, Bioorganic & Medicinal Chemistry.

Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors.

Jian Ding, Jing-kang Shen, Zhen Wang, 2013, Bioorganic & medicinal chemistry.

Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.

Zhuqing Zhang, Jian Ding, M. Geng, 2019, Journal of medicinal chemistry.

Stereoselective and Regioselective Preparation of C-Pentopyranosides and Formal Synthesis of Omarigliptin

Tongchao Liu, B. Xiong, Jing-kang Shen, 2016 .

Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach.

Xin Eric Wang, B. Xiong, Jing-kang Shen, 2010, European journal of medicinal chemistry.

Stereoselective N-glycosylation with N4-acyl cytosines and efficient synthesis of gemcitabine

Tongchao Liu, B. Xiong, Jing-kang Shen, 2019, Tetrahedron.

A one-pot synthesis of omarigliptin and its analogues through stabilized beta-amino ketone intermediate

Tongchao Liu, B. Xiong, Jing-kang Shen, 2017 .

1,2-Tans-1-dihydroxyboryl benzyl S-glycoside as glycosyl donor.

B. Xiong, Jing-kang Shen, Xin Wang, 2014, Carbohydrate research.

Discovery of a new series of imidazo[1,2-a]pyridine compounds as selective c-Met inhibitors

Dong-mei Zhao, M. Geng, B. Xiong, 2016, Acta Pharmacologica Sinica.

Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer

Jing-kang Shen, Xin Wang, Lan-ping Ma, 2016, Oncotarget.

Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells

Jian Ding, M. Geng, B. Xiong, 2016, Acta Pharmacologica Sinica.

Synthesis and LAR inhibition of 7-alkoxy analogues of illudalic acid.

B. Xiong, Jing-kang Shen, Xin Wang, 2010, Yao xue xue bao = Acta pharmaceutica Sinica.

Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study

M. Geng, B. Xiong, Jing-kang Shen, 2018, Acta pharmaceutica Sinica. B.

A chemical tuned strategy to develop novel irreversible EGFR-TK inhibitors with improved safety and pharmacokinetic profiles.

Wei Huang, Wenteng Chen, Jing-kang Shen, 2014, Journal of medicinal chemistry.

Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives

Jing-kang Shen, Xin Wang, T. Meng, 2012, Molecules.

Pathological expression of tissue factor confers promising antitumor response to a novel therapeutic antibody SC1 in triple negative breast cancer and pancreatic adenocarcinoma

Hui Zhao, Jing-kang Shen, Lan-ping Ma, 2017, Oncotarget.

Discovery of novel sulfonamides as potent and selective inhibitors against human and mouse 11β-hydroxysteroid dehydrogenase type 1

Mengzhu Xue, B. Xiong, Jing-kang Shen, 2012, Molecular and Cellular Endocrinology.

Author Correction: Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells

M. Geng, B. Xiong, Jing-kang Shen, 2020, Acta Pharmacologica Sinica.

Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists.

B. Xiong, Jing-kang Shen, Qunyi Li, 2010, Bioorganic & medicinal chemistry.

Molecular Modeling Studies on Carbazole Carboxamide Based BTK Inhibitors Using Docking and Structure-Based 3D-QSAR

Jing-kang Shen, Yongli Du, Rui Li, 2018, International journal of molecular sciences.

Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups.

Z. Miao, Jian Li, B. Xiong, 2018, European journal of medicinal chemistry.

Design and discovery of new pyrimidine coupled nitrogen aromatic rings as chelating groups of JMJD3 inhibitors.

Min Huang, Jian-Ping Zuo, Rongfeng Liu, 2016, Bioorganic & medicinal chemistry letters.

Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design.

Jing-kang Shen, Qunyi Li, Yongli Du, 2015, Bioorganic & medicinal chemistry.

MT119, a new planar‐structured compound, targets the colchicine site of tubulin arresting mitosis and inhibiting tumor cell proliferation

Yi Chen, Z. Miao, Jian Ding, 2011, International journal of cancer.

Design, synthesis and biological evaluation of bivalent ligands against A1–D1 receptor heteromers

Ye-chun Xu, Jing-kang Shen, Xin Wang, 2013, Acta Pharmacologica Sinica.