M. D. de Jonge

发表

Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants.

H. M. Vinkers, A. D. Clark, R. Pauwels, 2004, Journal of medicinal chemistry.

A computational model of the inhibition of Mycobacterium tuberculosis ATPase by a new drug candidate R207910

L. Koymans, M. D. de Jonge, K. Andries, 2007, Proteins.

Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues.

R. Pauwels, E. Arnold, F. Daeyaert, 2001, Bioorganic & medicinal chemistry letters.

In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).

Stephen H Hughes, Peter Williams, Paul J Lewi, 2005, Journal of medicinal chemistry.

SYNOPSIS: SYNthesize and OPtimize System in Silico.

H. M. Vinkers, J. H. van Lenthe, F. Daeyaert, 2003, Journal of medicinal chemistry.

Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity.

R. Pauwels, E. Arnold, F. Daeyaert, 2005, Journal of medicinal chemistry.

Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.

R. Pauwels, E. Arnold, F. Daeyaert, 2001, Bioorganic & medicinal chemistry letters.

Studies on synthetic approaches to 1H- and 2H-indazolyl derivatives.

M. D. de Jonge, N. Castagnoli, E. Isin, 2001, The Journal of organic chemistry.

Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1.

K. Hertogs, R. Pauwels, E. Arnold, 2005, Journal of medicinal chemistry.

Improving QSAR models for the biological activity of HIV Reverse Transcriptase inhibitors: Aspects of outlier detection and uninformative variable elimination.

H. M. Vinkers, D. Massart, M. Daszykowski, 2005, Talanta.

A pharmacophore docking algorithm and its application to the cross‐docking of 18 HIV‐NNRTI's in their binding pockets

Frits Daeyaert, F. Daeyaert, J. Heeres, 2004, Proteins.

Structure based activity prediction of HIV-1 reverse transcriptase inhibitors.

Paul J Lewi, H. M. Vinkers, F. Daeyaert, 2005, Journal of medicinal chemistry.