A. Oakley

发表

Structure and function of a spectrin-like regulator of bacterial cytokinesis

N. Dixon, R. Lewis, A. Solovyova, 2014, Nature Communications.

A Molecular Mousetrap Determines Polarity of Termination of DNA Replication in E. coli

C. Neylon, N. Dixon, P. Schaeffer, 2006, Cell.

S-(4-Nitrophenacyl)glutathione is a specific substrate for glutathione transferase omega 1-1.

A. Oakley, M. W. Anders, P. Board, 2008, Analytical biochemistry.

Dynamics of Open DNA Sliding Clamps

A. Oakley, 2016, PloS one.

Structural and biophysical analyses of the skeletal dihydropyridine receptor β subunit β1a reveal critical roles of domain interactions for stability

N. Norris, A. Oakley, M. Casarotto, 2017, The Journal of Biological Chemistry.

Mechanism and Putative Structure of B0-like Neutral Amino Acid Transporters

S. Bröer, A. Oakley, M. O’Mara, 2006, The Journal of Membrane Biology.

Sodium translocation by the iminoglycinuria associated imino transporter (SLC6A20)

A. Bröer, S. Bröer, A. Oakley, 2009, Molecular membrane biology.

Mechanism of transcription modulation by the transcription-repair coupling factor

S. Jergic, N. Dixon, A. V. van Oijen, 2021, bioRxiv.

Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase.

J. Rossjohn, M. Parker, W. McKinstry, 1998, Acta crystallographica. Section D, Biological crystallography.

Haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26: X-ray crystallographic studies of dehalogenation of brominated substrates.

Yuji Nagata, Jirí Damborský, Zbynek Prokop, 2003, Biochemistry.

Purification, crystallization and preliminary crystallographic analysis of DehIVa, a dehalogenase from Burkholderia cepacia MBA4.

M. Wilce, A. Oakley, J. Schmidberger, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structural and thermodynamic dissection of linear motif recognition by the E. coli sliding clamp.

Z. Yin, A. Oakley, M. Kelso, 2013, Journal of medicinal chemistry.

Crystal and Solution Structures of the Helicase-binding Domain of Escherichia coli Primase*

Guido Pintacuda, Gottfried Otting, Edvards Liepinsh, 2005, Journal of Biological Chemistry.

Comparison of anisotropic atomic motions in biological macromolecules

Conrad J. Burden, L. Formont, Aaron J. Oakley, 2007 .

Molecular interactions of STAC proteins with skeletal muscle dihydropyridine receptor and excitation‐contraction coupling

A. Oakley, M. Casarotto, A. Dulhunty, 2022, Protein science : a publication of the Protein Society.

Proposed Mechanism for Monomethylarsonate Reductase Activity of Human Omega-class Glutathione Transferase GSTO1-1

A. Oakley, 2021 .

Proposed mechanism for monomethylarsonate reductase activity of human omega-class glutathione transferase GSTO1-1.

A. Oakley, 2021, Biochemical and biophysical research communications.

Structural biology and its applications to the health sciences.

M. Wilce, A. Oakley, A. Ketterman, 2001, Croatian medical journal.

Structural Insights into Omega-Class Glutathione Transferases: A Snapshot of Enzyme Reduction and Identification of a Non-Catalytic Ligandin Site

A. Oakley, J. Brock, P. Board, 2013, PloS one.

Time to Face the Fats: What Can Mass Spectrometry Reveal about the Structure of Lipids and Their Interactions with Proteins?

H. Pham, S. Blanksby, T. Mitchell, 2012, Journal of The American Society for Mass Spectrometry.

Molecular basis for RNA polymerase-dependent transcription complex recycling by the helicase-like motor protein HelD

J. Bouwer, S. Brown, P. Lewis, 2020, Nature Communications.

Structural basis for cofactor-independent dioxygenation of N-heteroaromatic compounds at the α/β-hydrolase fold

P. Roversi, R. Steiner, S. Fetzner, 2009, Proceedings of the National Academy of Sciences.

Comparison of negative and positive ion electrospray ionization mass spectra of calmodulin and its complex with trifluoperazine.

A. Oakley, M. Sheil, J. Beck, 2005, Rapid communications in mass spectrometry : RCM.

Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach.

S. Jergic, N. Dixon, Z. Yin, 2014, Journal of medicinal chemistry.

Glutathione transferases: new functions.

A. Oakley, 2005, Current opinion in structural biology.

Mutations of Gly to Ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione.

A. Tramontano, M. Parker, A. Caccuri, 1998, Journal of molecular biology.

Binding inhibitors of the bacterial sliding clamp by design.

B. Dalrymple, D. Winkler, N. Dixon, 2011, Journal of medicinal chemistry.

Macromolecular Crystallography As A Tool For Investigating Drug, Enzyme And Receptor Interactions

M. Wilce, A. Oakley, 2000, Clinical and experimental pharmacology & physiology.

Polymorphism of glutathione transferase Omega 1 in a population exposed to a high environmental arsenic burden

R. Marcos, A. Creus, A. Oakley, 2008, Pharmacogenetics and genomics.

Efficient synthesis and antioxidant activity of coelenterazine analogues

A. Oakley, P. Keller, R. Hendra, 2014 .

Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal-ion preference.

D. Ollis, C. Jackson, P. Carr, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Characterization of a family 11 xylanase from Bacillus subtillis B230 used for paper bleaching.

M. Wilce, A. Oakley, T. Heinrich, 2003, Acta crystallographica. Section D, Biological crystallography.

The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants.

Sarah Ciccone, Michael W Parker, Alessandra Primavera, 2008, Journal of molecular biology.

Structural Flexibility Modulates the Activity of Human Glutathione Transferase P1-1

M. Parker, P. Ascenzi, A. Caccuri, 1996, The Journal of Biological Chemistry.

The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.

H. Villar, J. Rossjohn, M. Parker, 1997, Journal of molecular biology.

DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs.

S. Jergic, N. Dixon, Z. Yin, 2014, Chemistry & biology.

Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses†

Thomas S. Peat, Janet Newman, Takehiko Saito, 2010, Journal of medicinal chemistry.

T Cell Determinants Incorporating β-Amino Acid Residues Are Protease Resistant and Remain Immunogenic In Vivo1

J. McCluskey, J. Rossjohn, A. Purcell, 2005, The Journal of Immunology.

Glutathione transferases: a structural perspective

A. Oakley, 2011, Drug metabolism reviews.

Identification, characterization and structure of a new Delta class glutathione transferase isoenzyme.

M. Wilce, A. Oakley, A. Ketterman, 2005, The Biochemical journal.

Hotspots of age-related protein degradation: the importance of neighboring residues for the formation of non-disulfide crosslinks derived from cysteine.

K. Schey, R. Truscott, M. Friedrich, 2017, The Biochemical journal.

Bacterial Sliding Clamp Inhibitors that Mimic the Sequential Binding Mechanism of Endogenous Linear Motifs.

S. Jergic, N. Dixon, Z. Yin, 2015, Journal of medicinal chemistry.

Magneto-optic spectroscopy of a protein tetramer binding two exciton-coupled chlorophylls.

A. Oakley, R. Razeghifard, E. Krausz, 2006, Journal of the American Chemical Society.

Multiple classes and isoforms of the RNA polymerase recycling motor protein HelD

N. Dixon, P. Lewis, A. Oakley, 2021, bioRxiv.

The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate.

J Rossjohn, M W Parker, J. Rossjohn, 1997, Biochemistry.

Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases.

A. Oakley, Dan Liu, J. Brock, 2012, Journal of molecular biology.

Emplacement, growth, and gravitational deformation of serpentinite seamounts on the Mariana forearc

Brian Taylor, Gregory F. Moore, Julia K. Morgan, 2007 .

Mechanism of transcription modulation by the transcription-repair coupling factor

Antoine M. van Oijen, S. Jergic, N. Dixon, 2022, bioRxiv.

Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site.

G Chelvanayagam, J Rossjohn, M W Parker, 1998, Structure.

Expression, purification, crystallization, and NMR studies of the helicase interaction domain of Escherichia coli DnaG primase.

N. Dixon, G. Otting, M. Wilce, 2004, Protein expression and purification.

The structure of Aspergillus niger phytase PhyA in complex with a phytate mimetic.

A. Oakley, 2010, Biochemical and biophysical research communications.

Identification of a novel tetrameric structure for human apolipoprotein-D

B. Garner, A. Oakley, A. Whitten, 2018, bioRxiv.

Identification of a novel tetrameric structure for human apolipoprotein-D

B. Garner, A. Oakley, A. Whitten, 2018, bioRxiv.

RNA polymerases from low G+C gram-positive bacteria

P. Lewis, A. Oakley, Michael Miller, 2021, Transcription.

RNA polymerases from Low G+C Gram Positive Bacteria

P. Lewis, A. Oakley, Michael Miller, 2021, bioRxiv.

The crystal structures of glutathione S‐transferases isozymes 1–3 and 1–4 from Anopheles dirus species B

M. Wilce, A. Oakley, A. Ketterman, 2001, Protein science : a publication of the Protein Society.

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity

Jayme L. Dahlin, J. Baell, P. Tummala, 2017, Scientific Reports.

Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors.

Jayme L. Dahlin, J. Baell, P. Tummala, 2020, Journal of medicinal chemistry.

Novel Folding and Stability Defects Cause a Deficiency of Human Glutathione Transferase Omega 1*

A. Oakley, M. Casarotto, J. Brock, 2010, The Journal of Biological Chemistry.

Atomistic Insights into Photoprotein Formation: Computational Prediction of the Properties of Coelenterazine and Oxygen Binding in Obelin

Haibo Yu, Thomas M Griffiths, Aaron J Oakley, 2019, J. Comput. Chem..

Molecular Dynamics Analysis of Apolipoprotein-D - Lipid Hydroperoxide Interactions: Mechanism for Selective Oxidation of Met-93

B. Garner, A. Oakley, H. Ecroyd, 2012, PloS one.

The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site).

M W Parker, M. Parker, A. Oakley, 1999, Journal of molecular biology.

Anisotropic atomic motions in high-resolution protein crystallography molecular dynamics simulations

Conrad J Burden, C. Burden, A. Oakley, 2007, Physical biology.

Anisotropic atomic motions in molecular dynamics simulations

C. Burden, A. Oakley, 2007 .

Evidence for an induced-fit mechanism operating in pi class glutathione transferases.

M W Parker, M. Parker, G. Federici, 1998, Biochemistry.

Structure and function of the bacterial mechanosensitive channel of large conductance

M. Wilce, B. Martinac, A. Oakley, 1999, Protein science : a publication of the Protein Society.

Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: implications for lipid antioxidant activity and Alzheimer's disease.

W. Kim, B. Garner, A. Oakley, 2012, The Biochemical journal.

A structural view of bacterial DNA replication

A. Oakley, 2019, Protein science : a publication of the Protein Society.

Intramolecular binding mode of the C-terminus of Escherichia coli single-stranded DNA binding protein determined by nuclear magnetic resonance spectroscopy

N. Dixon, G. Otting, T. Huber, 2013, Nucleic acids research.

Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens.

N. Dixon, A. Oakley, M. Kelso, 2018, Journal of structural biology.

Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits α, ε, θ and β reveals a highly flexible arrangement of the proofreading domain

Thomas Huber, Nan Li, Nicholas E. Dixon, 2013, Nucleic acids research.

Flexibility revealed by the 1.85 A crystal structure of the beta sliding-clamp subunit of Escherichia coli DNA polymerase III.

N. Dixon, M. Wilce, A. Oakley, 2003, Acta crystallographica. Section D, Biological crystallography.

Replisome speed determines the efficiency of the Tus−Ter replication termination barrier

S. Hamdan, S. Jergic, N. Dixon, 2015, Nature.

Three‐dimensional structure of (1,4)‐β‐d‐mannan mannanohydrolase from tomato fruit

Aaron J. Oakley, M. Wilce, J. Bewley, 2005 .

Three-dimensional structure of (1,4)-beta-D-mannan mannanohydrolase from tomato fruit.

M. Wilce, J. Bewley, A. Oakley, 2005, Protein science : a publication of the Protein Society.

Fragment-Based Screening by Protein Crystallography: Successes and Pitfalls

Aaron J. Oakley, Z. Yin, A. Oakley, 2012, International journal of molecular sciences.

Structures of thermolabile mutants of human glutathione transferase P1-1.

J. Rossjohn, M. Parker, B. Mannervik, 2000, Journal of molecular biology.

The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle.

Tetsuo Yamada, A. Oakley, Dan Liu, 2008, The Journal of biological chemistry.

Proprietary Claims and Their Priority in Insolvency

A. Oakley, 1995, The Cambridge Law Journal.

The 2.0-Å Crystal Structure of eqFP611, a Far Red Fluorescent Protein from the Sea Anemone Entacmaea quadricolor*

Mark Prescott, Jamie Rossjohn, Jan Petersen, 2003, Journal of Biological Chemistry.

The 2.2 A crystal structure of a pocilloporin pigment reveals a nonplanar chromophore conformation.

O. Hoegh‐Guldberg, T. Beddoe, J. Rossjohn, 2003, Structure.

Rational Design of a 310 -Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp.

N. Dixon, J. Bruning, A. Abell, 2018, Chemistry.

Exploring the structure and activity of haloalkane dehalogenase from Sphingomonas paucimobilis UT26: evidence for product- and water-mediated inhibition.

Yuji Nagata, Jirí Damborský, Zbynek Prokop, 2002, Biochemistry.

Crystal structure of haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26 at 0.95 A resolution: dynamics of catalytic residues.

Yuji Nagata, Michal Otyepka, Jirí Damborský, 2004, Biochemistry.

Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction

N. Dixon, G. Otting, Zhi-Qiang Xu, 2018, Antibiotics.

The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1‐1 in two different modes

M. Parker, G. Federici, A. Oakley, 1997, FEBS letters.

Thermodynamic Description of the Effect of the Mutation Y49F on Human Glutathione Transferase P1-1 in Binding with Glutathione and the Inhibitor S-Hexylglutathione*

M. Parker, A. Oakley, M. Bello, 2003, Journal of Biological Chemistry.

Crystallization and diffraction data of 1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase: a cofactor-free oxygenase of the α/β-hydrolase family

S. Fetzner, A. Oakley, Ruhu Qi, 2007 .

Identification and Characterization of γ-Glutamylamine Cyclotransferase, an Enzyme Responsible for γ-Glutamyl-ϵ-lysine Catabolism*

A. Oakley, P. Board, M. Coggan, 2010, The Journal of Biological Chemistry.

Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase.

D. Hume, Angelika N. Christ, J. Hayes, 2010, European journal of medicinal chemistry.

Multifunctional role of Tyr 108 in the catalytic mechanism of human glutathione transferase P1-1. Crystallographic and kinetic studies on the Y108F mutant enzyme.

J. Rossjohn, M. Parker, A. Oakley, 1997, Biochemistry.

Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli

N. Dixon, J. Bouwer, P. Lewis, 2023, bioRxiv.

Hidden Glutathione Transferases in the Human Genome

A. Oakley, 2023, Biomolecules.