P. Wedegaertner

发表

Assembly and trafficking of heterotrimeric G proteins.

Yannick Marrari, Marykate Crouthamel, R. Irannejad, 2007, Biochemistry.

Reversible Palmitoylation in G Protein Signaling

P. Wedegaertner, 2010 .

CHAPTER 228 – Reversible Palmitoylation in G-Protein Signaling

P. Wedegaertner, 2003 .

Prognostic Values of G-Protein Mutations in Metastatic Uveal Melanoma

J. Swensen, A. Aplin, J. Benovic, 2021, Cancers.

Activation and depalmitoylation of Gs alpha.

H. Bourne, P. Wedegaertner, 1994, Cell.

Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma

A. Aplin, J. Benovic, P. Wedegaertner, 2017, Molecular Cancer Research.

Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma

A. Aplin, T. Charpentier, J. Benovic, 2018, Molecular Cancer Research.

Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq.

D. Evanko, D. Siderovski, P. Wedegaertner, 2001, The Journal of biological chemistry.

G protein trafficking.

P. Wedegaertner, 2012, Sub-cellular biochemistry.

FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts

J. Parsons, M. Iwanicki, T. Vomastek, 2008, Journal of Cell Science.

Differential interaction of GRK2 with members of the Gαqfamily

C. Carman, J. Benovic, P. Wedegaertner, 2003 .

G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits.

J. Benovic, A. Pronin, P. Wedegaertner, 2003, The Journal of biological chemistry.

Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth.

C. Billington, T. Chan, R. Panettieri, 2005, Biochemistry.

An N-Terminal Polybasic Motif of Gαq Is Required for Signaling and Influences Membrane Nanodomain Distribution

J. Hancock, D. Abankwa, Marykate Crouthamel, 2010, Molecular Pharmacology.

Inducible Inhibition of Gβγ Reveals Localization-dependent Functions at the Plasma Membrane and Golgi*

P. Wedegaertner, Lauren M. Klayman, 2016, The Journal of Biological Chemistry.

Selectivity of phospholipase C phosphorylatiion by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains

G. Carpenter, S. Rhee, J. W. Kim, 1990, Proceedings of the National Academy of Sciences of the United States of America.

G protein‐coupled receptor kinase 4‐induced cellular senescence and its senescence‐associated gene expression profiling

P. Wedegaertner, Xiaoshan Jiang, Ang Li, 2017, Experimental cell research.

Activation-induced subcellular redistribution of G alpha(s) is dependent upon its unique N-terminus.

D. Evanko, H. V. Van Tol, T. Hébert, 2002, Biochemistry.

Palmitoylation Is Required for Signaling Functions and Membrane Attachment of G,a and G,a*

M. Levis, P. Wedegaertner, Henry, 2001 .

Analysis of G-protein-coupled receptor kinase RGS homology domains.

J. Benovic, P. Wedegaertner, P. Day, 2004, Methods in enzymology.

Identification of a Specific Domain Responsible for JNK2α2 Autophosphorylation*

H. Tsuiki, P. Wedegaertner, J. Cui, 2005, Journal of Biological Chemistry.

The regulator of G protein signaling (RGS) domain of G protein–coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function

P. Wedegaertner, Hua Xu, Ke Shen, 2014, Molecular biology of the cell.

Palmitoylation and Plasma Membrane Targeting of RGS7 Are Promoted by αo

P. Wedegaertner, S. Takida, Christopher C. Fischer, 2005, Molecular Pharmacology.

Exocytic pathway‐independent plasma membrane targeting of heterotrimeric G proteins

P. Wedegaertner, S. Takida, 2004, FEBS letters.

Loss of association between activated Gαq and Gβγ disrupts receptor-dependent and receptor-independent signaling

D. Evanko, P. Wedegaertner, M. Thiyagarajan, 2005 .

Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A.

J. Benovic, P. Wedegaertner, Xiaoshan Jiang, 2007, Molecular biology of the cell.

Functional consequences of Gα13 mutations that disrupt interaction with p115RhoGEF

P. Wedegaertner, Elda Grabocka, 2005, Oncogene.

Selective Regulation of Gαq/11 by an RGS Domain in the G Protein-coupled Receptor Kinase, GRK2*

C. Carman, A. Gilman, J. Benovic, 1999, The Journal of Biological Chemistry.

Lipid-protein interactions in GPCR-associated signaling.

P. Escribá, F. Goñi, P. Wedegaertner, 2007, Biochimica et biophysica acta.

Activation of the purified protein tyrosine kinase domain of the epidermal growth factor receptor.

P. Wedegaertner, G. Gill, 1989, The Journal of biological chemistry.

Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission

P. Wedegaertner, T. Yen, Elda Grabocka, 2013, Molecular biology of the cell.

Disruption of Oligomerization Induces Nucleocytoplasmic Shuttling of Leukemia-Associated Rho Guanine-Nucleotide Exchange Factor

P. Wedegaertner, Elda Grabocka, 2007, Molecular Pharmacology.

G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway

R. Irannejad, P. Wedegaertner, A. Smrcka, 2015, Molecular biology of the cell.

PAQR3 regulates Golgi vesicle fission and transport via the Gβγ-PKD signaling pathway.

P. Wedegaertner, T. Hewavitharana, 2015, Cellular signalling.

Gα13 Requires Palmitoylation for Plasma Membrane Localization, Rho-dependent Signaling, and Promotion of p115-RhoGEF Membrane Binding*

P. Wedegaertner, R. Bhattacharyya, 2000, The Journal of Biological Chemistry.

Effect of carboxyl terminal truncation on the tyrosine kinase activity of the epidermal growth factor receptor.

P. Wedegaertner, G. Gill, 1992, Archives of biochemistry and biophysics.

The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF.

P. Wedegaertner, Jayashree Banerjee, Christopher C. Fischer, 2009, Biochemistry.

Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton.

P. Wedegaertner, Jayashree Banerjee, 2004, Molecular biology of the cell.

Mutation of an N‐terminal acidic‐rich region of p115‐RhoGEF dissociates α13 binding and α13‐promoted plasma membrane recruitment

P. Wedegaertner, R. Bhattacharyya, 2003 .

Activation and depalmitoylation of Gsα

H. Bourne, P. Wedegaertner, 1994, Cell.

Lipid Modifications of Trimeric G Proteins (*)

Henry R. Bourne, H. Bourne, P. Wedegaertner, 1995, The Journal of Biological Chemistry.

Reciprocal regulation of Gsα by palmitate and the βγ subunit

H. Bourne, P. Backlund, P. Wedegaertner, 1996 .

N-terminal polybasic motifs are required for plasma membrane localization of Galpha(s) and Galpha(q).

D. Evanko, Marykate Crouthamel, P. Wedegaertner, 2008, Cellular signalling.

Interaction with Gβγ Is Required for Membrane Targeting and Palmitoylation of Gαs and Gαq *

D. Evanko, P. Wedegaertner, M. Thiyagarajan, 2000, The Journal of Biological Chemistry.

Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1.

P. Wedegaertner, Elda Grabocka, Nobuchika Suzuki, 2016, Cellular signalling.

Disruption of the interaction between mutationally activated Gαq and Gβγ attenuates aberrant signaling

P. Wedegaertner, Jenna Aumiller, Jenna L. Aumiller, 2023, The Journal of biological chemistry.

Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890

A. Inoue, P. Wedegaertner, P. Osei-Owusu, 2022, The Journal of biological chemistry.

Functional selectivity of GPCR-directed drug action through location bias

M. von Zastrow, M. Conti, R. Irannejad, 2017, Nature chemical biology.

Non-canonical signaling and localizations of heterotrimeric G proteins.

P. Wedegaertner, T. Hewavitharana, 2012, Cellular signalling.

G Protein-coupled Receptor Kinase 2/Gαq/11Interaction: A NOVEL SURFACE ON A REGULATOR OF G PROTEIN SIGNALING HOMOLOGY DOMAIN FOR BINDING Gα SUBUNITS

J. Benovic, A. Pronin, P. Wedegaertner, 2003 .

Interaction with Gbetagamma is required for membrane targeting and palmitoylation of Galpha(s) and Galpha(q).

D. Evanko, P. Wedegaertner, M. Thiyagarajan, 2000, The Journal of biological chemistry.

Characterization of subcellular localization and stability of a splice variant of G alphai2

P. Wedegaertner, 2002, BMC Cell Biology.

Gβγ Isoforms Selectively Rescue Plasma Membrane Localization and Palmitoylation of Mutant Gαs and Gαq *

David P. Siderovski, D. Evanko, D. Siderovski, 2001, The Journal of Biological Chemistry.

Gβγ signaling regulates microtubule-dependent control of Golgi integrity.

P. Wedegaertner, Kalpana Rajanala, 2023, Cellular signalling.

Regulation of Constitutive Cargo Transport from the trans-Golgi Network to Plasma Membrane by Golgi-localized G Protein βγ Subunits*

R. Irannejad, P. Wedegaertner, Roshanak Irannejad, 2010, The Journal of Biological Chemistry.

Gβγ regulates mitotic Golgi fragmentation and G2/M cell cycle progression.

P. Wedegaertner, Kalpana Rajanala, Lauren M. Klayman, 2021, Molecular biology of the cell.

A Predicted Amphipathic Helix Mediates Plasma Membrane Localization of GRK5*

D. Evanko, J. Benovic, A. Pronin, 2004, Journal of Biological Chemistry.

Coexpression of both alpha and beta subunits is required for assembly of regulated casein kinase II.

E. Chambaz, P. Wedegaertner, O. Filhol, 1991, Biochemistry.

Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha.

H. Bourne, M. Levis, P. Wedegaertner, 1993, The Journal of biological chemistry.

Characterization of the GRK2 Binding Site of Gαq*

J. Benovic, P. Wedegaertner, J. Tesmer, 2004, Journal of Biological Chemistry.

Lipid Modifications and Membrane Targeting of Gα

P. Wedegaertner, 1998, Neurosignals.

Reciprocal regulation of Gs alpha by palmitate and the beta gamma subunit.

H. Bourne, P. Backlund, P. Wedegaertner, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Heterotrimer Formation, Together with Isoprenylation, Is Required for Plasma Membrane Targeting of Gβγ*

P. Wedegaertner, S. Takida, 2003, The Journal of Biological Chemistry.

Characterization of the GRK2 binding site of Galphaq.

J. Benovic, P. Wedegaertner, J. Tesmer, 2004, The Journal of biological chemistry.

Differences in Galpha12- and Galpha13-mediated plasma membrane recruitment of p115-RhoGEF.

K. Khalili, P. Wedegaertner, Jayashree Banerjee, 2009, Cellular signalling.

Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF.

P. Wedegaertner, R. Bhattacharyya, 2003, The Biochemical journal.

Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth

A. Aplin, J. Harbour, Dzmitry Mukha, 2023, Cancers.

Differential interaction of GRK2 with members of the G alpha q family.

C. Carman, J. Benovic, P. Wedegaertner, 2003, Biochemistry.

Palmitoylation and plasma membrane targeting of RGS7 are promoted by alpha o.

P. Wedegaertner, S. Takida, Christopher C. Fischer, 2005, Molecular pharmacology.

Activation-induced subcellular redistribution of Gs alpha.

H. Bourne, M. von Zastrow, P. Wedegaertner, 1996, Molecular biology of the cell.

Palmitoylation and Plasma Membrane Targeting of RGS7 Are Promoted by (cid:1) o

P. Wedegaertner, S. Takida, Christopher C. Fischer, 2004 .

Identification of a Specific Domain Responsible for JNK2α2 Autophosphorylation*

P. Wedegaertner, J. Cui, A. Wong, 2005, Journal of Biological Chemistry.

Identification of a specific domain responsible for JNK2alpha2 autophosphorylation.

P. Wedegaertner, J. Cui, A. Wong, 2005, The Journal of biological chemistry.