D. Smiley

发表

M. Tschöp, D. Smiley, M. Heiman, 2000, Nature.

Erratum: Does gut hormone PVY3-36 decrease food intake in rodents? (Nature (2004) 430 (165) DOI:10.1038/nature03019)

D. Allison, R. Seeley, M. Tschöp, 2004 .

Characterization of growth hormone-releasing hormone (GHRH) binding to cloned porcine GHRH receptor

H. Hsiung, D. Smiley, M. Heiman, 1995, Peptides.

Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic β-cells.

R. DiMarchi, S. Maddika, D. Smiley, 2013, American journal of physiology. Endocrinology and metabolism.

Optimization of co‐agonism at GLP‐1 and glucagon receptors to safely maximize weight reduction in DIO‐rodents

M. Erion, M. Tschöp, J. Gidda, 2012, Biopolymers.

A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1.

P. Pfluger, M. Tschöp, R. DiMarchi, 2011, ACS chemical biology.

Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2.

L. Slieker, B. Zhong, J. Morin, 2004, Analytical biochemistry.

Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold.

David L Smiley, Patrick Edwards, P. Emmerson, 2005, Bioorganic & medicinal chemistry letters.

Discovery of a β-MSH-derived MC-4R selective agonist

P. Emmerson, H. Hsiung, Saba Husain, 2005 .

A new quorum‐sensing system (TprA/PhrA) for Streptococcus pneumoniae D39 that regulates a lantibiotic biosynthesis gene cluster

M. Winkler, R. DiMarchi, B. Lazazzera, 2015, Molecular microbiology.

Physiology: Does gut hormone PYY3–36 decrease food intake in rodents?

D. Allison, R. Seeley, M. Tschöp, 2004, Nature.

Characterization of the peptide binding requirements for the cloned human pancreatic polypeptide-preferring receptor.

D. Larhammar, R. Chance, D. Smiley, 1996, Molecular pharmacology.

The Neuropeptide Y Y1 Antagonist, 1229U91, A Potent Agonist for the Human Pancreatic Polypeptide-Preferring (NPY Y4) Receptor

D. Smiley, D. Gehlert, D. Schober, 1998, Peptides.

Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala

D. Smiley, D. Gehlert, D. Schober, 2002, Pharmacology Biochemistry and Behavior.

Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence.

J. Mayer, R. DiMarchi, Fa Liu, 2020, Journal of medicinal chemistry.

Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice

R. DiMarchi, D. Smiley, D. Perez-Tilve, 2015, Diabetologia.

Discovery of a beta-MSH-derived MC-4R selective agonist.

P. Emmerson, H. Hsiung, Saba Husain, 2005, Journal of Medicinal Chemistry.

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

S. Woods, R. Seeley, P. Pfluger, 2013, Diabetes.

Structure-activity relationships of beta-MSH derived melanocortin-4 receptor peptide agonists.

P. Emmerson, H. Hsiung, Saba Husain, 2007, Current topics in medicinal chemistry.

Ghrelin‐induced adiposity is independent of orexigenic effects

S. Woods, P. Pfluger, M. Tschöp, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Disulfide as a Constraint to Build Super Potent and Selective Melanocortin-4 Receptor (MC4R) Agonists

P. Emmerson, H. Hsiung, Saba Husain, 2006 .

Intrinsic Size Parameters for Palmitoylated and Carboxyamidomethylated Peptides.

Jonathan M. Dilger, P. Radivojac, S. Mooney, 2014, International journal of mass spectrometry.

Acylation type determines ghrelin's effects on energy homeostasis in rodents.

S. Woods, B. Holst, P. Pfluger, 2012, Endocrinology.

Synthesis and activity of proteolysis-resistant GLP-1 analogs

R. DiMarchi, D. Flora, D. Smiley, 2002 .

The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms

S. Woods, P. Pfluger, M. Tschöp, 2013, Nature Communications.

Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors

P. Pfluger, M. Tschöp, H. Biebermann, 2013, Diabetes.

Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via CNS ghrelin receptors. Short Title: CNS ghrelin receptor regulation of metabolism

P. Pfluger, M. Tschöp, R. DiMarchi, 2013 .

Synthesis and biological evaluation of an orally active ghrelin agonist that stimulates food consumption and adiposity in rats.

M. Clay, T. Lindstrom, J. Dodge, 2004, Bioorganic & medicinal chemistry letters.

Design, synthesis and crystallization of a novel glucagon analog as a therapeutic agent.

R. DiMarchi, Faming Zhang, D. Smiley, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Development of an internally quenched fluorescent substrate and a continuous fluorimetric assay for Streptococcus pneumoniae signal peptidase I.

D. Smiley, J. Scott, E. Angleton, 2001, Analytical biochemistry.

A glucagon analog chemically stabilized for immediate treatment of life-threatening hypoglycemia☆

R. DiMarchi, V. Gelfanov, D. Smiley, 2014, Molecular metabolism.

A novel and selective beta-melanocyte-stimulating hormone-derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats.

H. Mo, H. Hsiung, Saba Husain, 2005, Endocrinology.

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

Bin Yang, Brian Finan, Tao Ma, 2013, Science Translational Medicine.

1 ! 1 ! A new quorum sensing system ( TprA / PhrA ) for Streptococcus pneumoniae D 39 that 2 ! regulates a lantibiotic biosynthesis gene cluster 3 ! 4 ! 5 !

M. Winkler, R. DiMarchi, B. Lazazzera, 2015 .

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.

S. Woods, D. Drucker, P. Pfluger, 2009, Nature chemical biology.

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

R. Seeley, D. Drucker, P. Pfluger, 2014, Nature Medicine.

Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution.

N. Chirgadze, S. Briggs, D. Clawson, 2000, The Journal of biological chemistry.

Potent peptide agonists for human melanocortin 3 and 4 receptors derived from enzymatic cleavages of human β-MSH(5–22) by dipeptidyl peptidase I and dipeptidyl peptidase IV

H. Hsiung, D. Smiley, M. Heiman, 2005, Peptides.

Design and synthesis of statine-containing BACE inhibitors.

D. Timm, P. May, D. Smiley, 2003, Bioorganic & medicinal chemistry letters.

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

D. Drucker, P. Pfluger, M. Tschöp, 2013, Science Translational Medicine.

A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1.

P. Pfluger, M. Tschöp, R. DiMarchi, 2011, ACS Chemical Biology.

Optimization of co‐agonism at GLP‐1 and glucagon receptors to safely maximize weight reduction in DIO‐rodents

M. Erion, M. Tschöp, J. Gidda, 2012, Biopolymers.

ntrinsic size parameters for palmitoylated and arboxyamidomethylated peptides

Jonathan M. Dilger, P. Radivojac, S. Mooney, 2014 .