P. Delhanty

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Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity.

E. Ghigo, F. Broglio, C. Gauna, 2004, The Journal of clinical endocrinology and metabolism.

Melanocortin 2 receptor-associated protein (MRAP) and MRAP2 in human adrenocortical tissues: regulation of expression and association with ACTH responsiveness.

F. de Jong, P. Delhanty, P. V. van Koetsveld, 2012, The Journal of clinical endocrinology and metabolism.

Overweight and obesity in type 1 diabetes is not associated with higher ghrelin concentrations

J. Visser, A. J. van der Lely, P. Delhanty, 2021, Diabetology & Metabolic Syndrome.

Obesity Is Underestimated Using Body Mass Index and Waist-Hip Ratio in Long-Term Adult Survivors of Childhood Cancer

R. Pieters, A. J. van der Lely, P. Delhanty, 2012, PloS one.

Ghrelin deficiency sex-dependently affects food intake, locomotor activity, and adipose and hepatic gene expression in a binge-eating mouse model.

J. Visser, B. Karels, P. Delhanty, 2022, American journal of physiology. Endocrinology and metabolism.

Regulation of insulin-like growth factor binding protein-1 during protracted critical illness.

G. Van den Berghe, R. Baxter, P. Delhanty, 2002, The Journal of clinical endocrinology and metabolism.

Does des-acyl ghrelin improve glycemic control in obese diabetic subjects by decreasing acylated ghrelin levels?

A. R. Miller, E. Sijbrands, Hsiu-Chiung Yang, 2014, European journal of endocrinology.

Unacylated Ghrelin Rapidly Modulates Lipogenic and Insulin Signaling Pathway Gene Expression in Metabolically Active Tissues of GHSR Deleted Mice

W. V. van IJcken, Yuxiang Sun, Roy G. Smith, 2010, PloS one.

Unacylated ghrelin modulates circulating angiogenic cell number in insulin-resistant states

A. J. van der Lely, P. Delhanty, P. Leenen, 2017, Diabetology & Metabolic Syndrome.

Ghrelin Levels in Children With Intestinal Failure Receiving Long-Term Parenteral Nutrition

E. Neelis, M. Tabbers, J. Visser, 2022, Frontiers in Nutrition.

Plasma acylated and plasma unacylated ghrelin: useful new biomarkers in patients with neuroendocrine tumors?

P. Kramer, A. J. van der Lely, P. Delhanty, 2016, Endocrine connections.

Obesity and Hyperphagia With Increased Defective ACTH: A Novel POMC Variant.

K. Wakamatsu, S. Ito, B. van der Voorn, 2022, The Journal of clinical endocrinology and metabolism.

Transcriptional repression of the RET proto-oncogene by a mitogen activated protein kinase-dependent signalling pathway.

L. Mulligan, D. Marsh, P. Delhanty, 2002, Gene.

Regulation of the growth hormone receptor/binding protein, insulin-like growth factor ternary complex system in human cirrhosis.

Roger Williams, R. Baxter, K. Ho, 2002, Journal of hepatology.

Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1999 by The Endocrine Society Acute and Short-Term Effects of Growth Hormone on Insulin-Like Growth Factors and Their Binding Proteins: Serum Levels and Hepatic Messenger Ribon

T. Ekström, H. Barle, B. Nyberg, 2022 .

Bariatric Surgery for Hypothalamic Obesity in Craniopharyngioma Patients: A Retrospective, Matched Case–Control Study

M. Buchfelder, M. Krebs, C. Boguszewski, 2021, The Journal of clinical endocrinology and metabolism.

Efficacy and Safety of Switching to Pasireotide in Patients With Acromegaly Controlled With Pegvisomant and First-Generation Somatostatin Analogues (PAPE Study)

A. J. van der Lely, P. Delhanty, I. Haitsma, 2017, The Journal of clinical endocrinology and metabolism.

High unacylated ghrelin levels support the concept of anorexia in infants with prader-willi syndrome

M. Tauber, P. Delhanty, A. Hokken-Koelega, 2016, Orphanet Journal of Rare Diseases.

Elevated ratio of acylated to unacylated ghrelin in children and young adults with Prader–Willi syndrome

M. Tauber, A. J. van der Lely, P. Delhanty, 2015, Endocrine.

Ghrelin and glucose homeostasis

P. Delhanty, A. J. Lely, P.J.D. Delhanty, 2011, Peptides.

Des‐acyl ghrelin analogs prevent high‐fat‐diet‐induced dysregulation of glucose homeostasis

A. Grefhorst, A. Themmen, T. Abribat, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

IGF-binding protein mRNAs in the human fetus: tissue and cellular distribution of developmental expression.

V. Han, D. Hill, P. Delhanty, 1996, Hormone research.

Acid-labile subunit regulation during the early stages of liver regeneration: implications for glucoregulation.

R. Baxter, P. Delhanty, C. Scott, 2001, American journal of physiology. Endocrinology and metabolism.

Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats.

R. Baxter, P. Delhanty, D. Mesotten, 2002, Endocrinology.

Expression of insulin-like growth factor and binding protein genes during nephrogenesis.

V. Han, P. Delhanty, C. Goodyer, 1994, Kidney international.

Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a.

H. Pols, H. Jahr, H. Chiba, 2006, The Journal of endocrinology.

Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions.

E. Ghigo, A. Themmen, C. Gauna, 2007, American journal of physiology. Endocrinology and metabolism.

Intravenous glucose administration in fasting rats has differential effects on acylated and unacylated ghrelin in the portal and systemic circulation: a comparison between portal and peripheral concentrations in anesthetized rats.

E. Ghigo, P. Kramer, A. Themmen, 2007, Endocrinology.

Insulin-like growth factor-II (IGF-II) messenger ribonucleic acid is expressed in steroidogenic cells of the developing ovine adrenal gland: evidence of an autocrine/paracrine role for IGF-II.

V. Han, P. Delhanty, J. Challis, 1992, Endocrinology.

Preoperative fasting induced protection against renal ischemia/reperfusion injury is independent of ghrelin in mice.

J. Ijzermans, J. Ijzermans, J. van den Berg, 2010, Nutrition research.

0021-972X/05/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 90(2):1055–1060 Printed in U.S.A. Copyright © 2005 by The Endocrine Society doi: 10.1210/jc.2004-1069 Ghrelin Stimulates, Whereas Des-Octanoyl Ghrelin Inhibits, Glucose Output by Pri

E. Ghigo, F. Broglio, R. Ross, 2022 .

The expression of insulin-like growth factor (IGF)-binding protein-2 and IGF-II genes in the tissues of the developing ovine fetus.

V. Han, P. Delhanty, 1993, Endocrinology.

N-Linked Glycosylation and Sialylation of the Acid-labile Subunit

R. Baxter, P. Delhanty, S. Firth, 1999, The Journal of Biological Chemistry.

Interleukin-1 beta suppresses growth hormone-induced acid-labile subunit mRNA levels and secretion in primary hepatocytes.

P. Delhanty, 1998, Biochemical and biophysical research communications.

Efficacy and Safety of switching to Pasireotide in Acromegaly Patients controlled with Pegvisomant and Somatostatin Analogues: PAPE extension study.

A. J. van der Lely, P. Delhanty, I. Haitsma, 2018, European journal of endocrinology.

Acylated and unacylated ghrelin during OGTT in Prader‐Willi syndrome: support for normal response to food intake

P. Delhanty, A. Hokken-Koelega, A. Lely, 2016, Clinical endocrinology.

Oxytocin in young children with Prader‐Willi syndrome: Results of a randomized, double‐blind, placebo‐controlled, crossover trial investigating 3 months of oxytocin

J. Visser, P. Delhanty, A. Hokken-Koelega, 2020, Clinical endocrinology.

Insulin-like growth factor binding protein-4, -5 and -6 mRNAs in the human fetus: localization to sites of growth and differentiation?

V. Han, D. Hill, P. Delhanty, 1993, Growth regulation.

Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor

E. Ghigo, M. O. Aken, M. Culler, 2006, Molecular and Cellular Endocrinology.

The Acylated/Unacylated Ghrelin Ratio Is Similar in Patients With Acromegaly During Different Treatment Regimens

J. Visser, P. Delhanty, S. Neggers, 2017, The Journal of clinical endocrinology and metabolism.

The regulation of acid-labile subunit gene expression and secretion by cyclic adenosine 3',5'-monophosphate.

R. Baxter, P. Delhanty, 1998, Endocrinology.

Regulation of the acid-labile subunit in sustained endotoxemia.

R. Baxter, P. Delhanty, S. Kong, 2002, American journal of physiology. Endocrinology and metabolism.

Efficacy and safety of bariatric surgery for craniopharyngioma-related hypothalamic obesity: a matched case–control study with 2 years of follow-up

V. Wallenius, G. Johannsson, P. Delhanty, 2017, International Journal of Obesity.

Development of potent selective competitive-antagonists of the melanocortin type 2 receptor

A. Themmen, P. Delhanty, S. Neggers, 2014, Molecular and Cellular Endocrinology.

What is the efficacy of switching to weekly pegvisomant in acromegaly patients well controlled on combination therapy?

J. Jørgensen, J. Dal, A. J. van der Lely, 2016, European journal of endocrinology.

The acylated (AG) to unacylated (UAG) ghrelin ratio in esterase inhibitor‐treated blood is higher than previously described

A. Themmen, T. Abribat, P. Delhanty, 2015, Clinical endocrinology.

Desacyl ghrelin is influenced by changes in insulin concentration during an insulin tolerance test.

A. Themmen, A. J. van der Lely, P. Delhanty, 2013, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Des-acyl ghrelin: a metabolically active peptide.

A. J. van der Lely, P. Delhanty, S. Neggers, 2013, Endocrine development.

In vitro and in vivo stability and pharmacokinetic profile of unacylated ghrelin (UAG) analogues.

E. Ghigo, R. Granata, T. Abribat, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

An age-dependent interaction with leptin unmasks ghrelin's bone-protective effects.

Yuxiang Sun, Roy G. Smith, A. J. van der Lely, 2012, Endocrinology.

Cloning and characterization of the rat gene for the acid-labile subunit of the insulin-like growth factor binding protein complex.

R. Baxter, P. Delhanty, P. Delhanty, 1997, Journal of molecular endocrinology.

Characterisation of the rat acid-labile subunit gene.

R. Baxter, P. Delhanty, 1995, Progress in growth factor research.

Age-dependent regulation of the acid-labile subunit in response to fasting-refeeding in rats.

R. Baxter, P. Delhanty, S. Kong, 2002, Endocrinology.

Glucocorticoids, stress and eating: The mediating role of appetite‐regulating hormones

B. van der Voorn, J. Visser, P. Delhanty, 2022, Obesity reviews : an official journal of the International Association for the Study of Obesity.

The Use of Oxytocin to Improve Feeding and Social Skills in Infants With Prader–Willi Syndrome

K. Boulanouar, D. Cohen, P. Payoux, 2017, Pediatrics.

Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization.

A. Themmen, C. Gauna, A. J. van der Lely, 2010, American journal of physiology. Endocrinology and metabolism.

The Acid-labile Subunit of the Serum Insulin-like Growth Factor-binding Protein Complexes

R. Baxter, P. Delhanty, M. R. Mott, 1999, Journal of Biological Chemistry.

Functional characterization of a new human melanocortin-4 receptor homozygous mutation (N72K) that is associated with early-onset obesity

A. Themmen, P. Delhanty, A. J. Lely, 2014, Molecular Biology Reports.

Mechanisms in endocrinology: Ghrelin: the differences between acyl- and des-acyl ghrelin.

A. J. van der Lely, P. Delhanty, S. Neggers, 2012, European journal of endocrinology.

Direct activating effects of adrenocorticotropic hormone (ACTH) on brown adipose tissue are attenuated by corticosterone

U. Pagotto, M. Lombès, A. Grefhorst, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Prolonged hypoxia induced by the reduction of maternal uterine blood flow alters insulin-like growth factor-binding protein-1 (IGFBP-1) and IGFBP-2 gene expression in the ovine fetus.

S. Hooper, V. Han, D. Hill, 1992, Endocrinology.

Growth hormone modulation of the rat hepatic bile transporter system in endotoxin-induced cholestasis.

G. Van den Berghe, R. Baxter, P. Delhanty, 2003, Endocrinology.

Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2.

R. Baxter, Shin-ichiro Takahashi, P. Delhanty, 2003, The Journal of clinical endocrinology and metabolism.

The Effect of the Exon-3-Deleted Growth Hormone Receptor on Pegvisomant-Treated Acromegaly: A Systematic Review and Meta-Analysis

F. Rivadeneira, L. Broer, A. J. van der Lely, 2016, Neuroendocrinology.

Pegvisomant in combination with long-acting somatostatin analogues in acromegaly: the role of the GH receptor deletion of exon 3.

J. Jørgensen, A. J. van der Lely, P. Delhanty, 2015, European journal of endocrinology.

Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes.

E. Ghigo, A. Themmen, T. Abribat, 2009, European journal of endocrinology.

Ghrelin and bone

P. Delhanty, J. Leeuwen, Bram C. J. Eerden, 2014, BioFactors.

Ghrelin and bone.

A. J. van der Lely, P. Delhanty, J. V. van Leeuwen, 2007, Vitamins and hormones.

Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R)

A. Themmen, C. Gauna, P. Delhanty, 2007, Molecular and Cellular Endocrinology.

Should we consider des-acyl ghrelin as a separate hormone and if so, what does it do?

A. J. van der Lely, P. Delhanty, S. Neggers, 2014, Frontiers of hormone research.

Genetic manipulation of the ghrelin signaling system in male mice reveals bone compartment specificity of acylated and unacylated ghrelin in the regulation of bone remodeling.

Yuxiang Sun, Roy G. Smith, A. J. van der Lely, 2014, Endocrinology.

Correction: Unacylated Ghrelin Suppresses Ghrelin-Induced Neuronal Activity in the Hypothalamus and Brainstem of Male Rats

J. Holstege, A. Grefhorst, A. Themmen, 2014, PloS one.

Unacylated Ghrelin Suppresses Ghrelin-Induced Neuronal Activity in the Hypothalamus and Brainstem of Male Rats

J. Holstege, A. Grefhorst, A. Themmen, 2014, PLoS ONE.

Changes in the circulating IGF system during short-term fasting and refeeding in rats.

R. Baxter, J. Frystyk, P. Delhanty, 1999, The American journal of physiology.

The characterization and expression of ovine insulin-like growth factor-binding protein-2.

V. Han, P. Delhanty, 1992, Journal of molecular endocrinology.

Metabolic syndrome detection with biomarkers in childhood cancer survivors

F. Mattace-Raso, P. Delhanty, M. D. de Maat, 2020, Endocrine connections.

The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options

P. Delhanty, E. Rossum, L. Fani, 2014, International Journal of Obesity.

Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway.

G. Vitale, C. Gauna, A. J. van der Lely, 2007, American journal of physiology. Endocrinology and metabolism.