P. de Neef

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Ghrelin is produced by the human erythroleukemic HEL cell line and involved in an autocrine pathway leading to cell proliferation.

C. Delporte, C. De Vriese, F. Grégoire, 2005, Endocrinology.

Hydrolysis of the cyclic 3':5'-monophosphates of adenosine and guanosine by rat pancreas.

P. de Neef, P. Robberecht, J. Christophe, 1974, European journal of biochemistry.

VPAC(1) receptors have different agonist efficacy profiles on membrane and intact cells.

F. Grégoire, P. de Neef, P. Robberecht, 2002, Cellular signalling.

Molecular cloning and functional characterization of a human VIP receptor from SUP-T1 lymphoblasts.

J. Goossens, P. de Neef, P. Robberecht, 1994, Biochemical and biophysical research communications.

Vasoactive intestinal polypeptide VPAC1 and VPAC2 receptor chimeras identify domains responsible for the specificity of ligand binding and activation.

P. de Neef, P. Robberecht, M. Waelbroeck, 1999, European journal of biochemistry.

Low responsiveness of cardiac adenylate cyclase activity to peptide hormones in spontaneously hypertensive rats

P. de Neef, P. Robberecht, J. Christophe, 1979, FEBS letters.

Molecular characteristics and evidence for internalization of vasoactive-intestinal-peptide (VIP) receptors in the tumoral rat-pancreatic acinar cell line AR 4-2 J.

P. de Neef, J. Christophe, M. Svoboda, 1988, European journal of biochemistry.

Early decrease in secretin-, glucagon-, and isoproterenol-stimulated cardiac adenylate cyclase activity in rats treated with isoproterenol.

P. de Neef, P. Robberecht, J. Christophe, 1982, Biochemical pharmacology.

The human heart beta-adrenergic receptors. I. Heterogeneity of the binding sites: presence of 50% beta 1- and 50% beta 2-adrenergic receptors.

P. de Neef, P. Robberecht, M. Delhaye, 1983, Molecular pharmacology.

Pituitary adenylate cyclase-activating polypeptide receptors of types I and II and glucagon-like peptide-I receptors are expressed in the rat medullary carcinoma of the thyroid cell line 6/23.

P. de Neef, P. Robberecht, P. Vertongen, 1994, Endocrinology.

Specific binding of vasoactive intestinal peptide to brain membranes from the guinea pig.

P. de Neef, P. Robberecht, J. Christophe, 1978, European journal of biochemistry.

In vivo effects of pancreozymin, secretin, vasoactive intestinal polypeptide and pilocarpine on the levels of cyclic AMP and cyclic GMP in the rat pancreas

P. de Neef, P. Robberecht, J. Christophe, 1974, FEBS letters.

The two forms of the pituitary adenylate cyclase activating polypeptide (PACAP (1–27) and PACAP (1–38)) interact with distinct receptors on rat pancreatic AR 4‐2J cell membranes

L. Buscail, P. de Neef, P. Robberecht, 1991, FEBS letters.

The activation of adenylate cyclase by pituitary adenylate cyclase activating polypeptide (PACAP) via helodermin-preferring VIP receptors in human SUP-T1 lymphoblastic membranes.

P. de Neef, P. Robberecht, A. Vandermeers, 1991, Biochimica et biophysica acta.

Decreased secretin and glucagon responsiveness of adenylate cyclase in cardiac membranes from hypothyroid rats

P. de Neef, P. Robberecht, J. Christophe, 1981, FEBS letters.

Presence of helodermin‐like peptides of the VIP‐secretin family in mammalian salivary glands and saliva

P. de Neef, P. Robberecht, N. Yanaihara, 1985, FEBS letters.

Purification and amino acid sequence of vasoactive intestinal peptide, peptide histidine isoleucinamide (1-27) and secretin from the small intestine of guinea pig.

L. Buscail, P. de Neef, P. Robberecht, 1990, Biochimica et biophysica acta.

Presence of vasoactive intestinal peptide receptors coupled to adenylate cyclase in rat lung membranes.

P. de Neef, P. Robberecht, J. Christophe, 1981, Biochimica et biophysica acta.

Structural requirements for the activation of rat anterior pituitary adenylate cyclase by growth hormone-releasing factor (GRF): discovery of (N-Ac-Tyr1, D-Arg2)-GRF(1-29)-NH2 as a GRF antagonist on membranes.

D. Coy, M. Heiman, P. de Neef, 1985, Endocrinology.

Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist.

D. Coy, P. de Neef, P. Robberecht, 1985, Endocrinology.

Different vasoactive intestinal polypeptide receptor domains are involved in the selective recognition of two VPAC(2)-selective ligands.

P. de Neef, P. Robberecht, M. Waelbroeck, 1999, Molecular pharmacology.

Properties of the pituitary adenylate cyclase-activating polypeptide I and II receptors, vasoactive intestinal peptide1, and chimeric amino-terminal pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal peptide1 receptors: evidence for multiple receptor states.

P. de Neef, P. Robberecht, M. Waelbroeck, 1996, Molecular pharmacology.

Increased number of high-affinity muscarinic receptors in rat heart after phenylhydrazine treatment.

P. de Neef, P. Robberecht, J. Christophe, 1983, European journal of pharmacology.

In vitro action of bombesin and bombesin-like peptides on amylase secretion, calcium efflux, and adenylate cyclase activity in the rat pancreas: a comparison with other secretagogues.

P. de Neef, P. Robberecht, J. Christophe, 1976, The Journal of clinical investigation.

Pharmacological properties of two recombinant splice variants of the PACAP type I receptor, transfected and stably expressed in CHO cells.

J. Vilardaga, P. de Neef, P. Robberecht, 1995, European journal of pharmacology.

Effects of somatostatin on pancreatic exocrine function. Interaction with secretin.

P. de Neef, P. Robberecht, J. Christophe, 1975, Biochemical and biophysical research communications.

Mutations of aromatic residues in the first transmembrane helix impair signalling by the secretin receptor.

P. de Neef, P. Robberecht, E. Di Paolo, 1999, Receptors & channels.

Interaction of amino acid residues at positions 8-15 of secretin with the N-terminal domain of the secretin receptor.

J. Vilardaga, P. de Neef, P. Robberecht, 1996, European journal of biochemistry.

Chemical, immunological and biological properties of peptides like vasoactive-intestinal-peptide and peptide-histidine-isoleucinamide extracted from the venom of two lizards (Heloderma horridum and Heloderma suspectum).

P. de Neef, P. Robberecht, A. Vandermeers, 1987, European journal of biochemistry.

Secretin Receptors in Human Pancreatic Membranes

L. Pradayrol, N. Vaysse, P. de Neef, 1988, Pancreas.

VIP activation of rat anterior pituitary adenylate cyclase

P. de Neef, P. Robberecht, J. Christophe, 1979, FEBS letters.

Receptors for pituitary adenylate cyclase activating peptides in human pituitary adenomas.

C. Raftopoulos, J. Brotchi, E. Hooghe-Peters, 1993, The Journal of clinical endocrinology and metabolism.

Characterization of secretin and vasoactive intestinal peptide receptors in rat pancreatic plasma membranes using the native peptides, secretin-(7-27) and five secretin analogues.

W. König, P. de Neef, P. Robberecht, 1982, Digestion.

The adenylate cyclase activity in heart membranes from normotensive and spontaneously hypertensive rats, after chemical sympathectomy, suggests the presence of presynaptic secretin receptors.

P. de Neef, P. Robberecht, J. Christophe, 1983, European journal of pharmacology.

Mutational analysis of extracellular cysteine residues of rat secretin receptor shows that disulfide bridges are essential for receptor function.

J. Vilardaga, P. de Neef, P. Robberecht, 1997, European journal of biochemistry.

Characterization of a novel VPAC1 selective agonist and identification of the receptor domains implicated in the carboxyl‐terminal peptide recognition

C. Delporte, P. de Neef, P. Robberecht, 2000, British journal of pharmacology.

Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin.

J. Vilardaga, P. de Neef, P. Robberecht, 1996, Biochemical and biophysical research communications.

Properties and regulation of the coupling to adenylate cyclase of secretin receptors stably transfected in Chinese hamster ovary cells.

J. Vilardaga, P. de Neef, P. Robberecht, 1994, Molecular pharmacology.

A new type of functional VIP receptor has an affinity for helodermin in human SUP‐T1 lymphoblasts

P. de Neef, P. Robberecht, J. Christophe, 1988, FEBS letters.

Properties of vasoactive-intestinal-peptide receptors and beta-adrenoceptors in the murine radiation leukemia-virus-induced lymphoma cell line BL/VL3.

P. de Neef, P. Robberecht, J. Christophe, 1989, European journal of biochemistry.

Pancreatic secretion of total protein and of three hydrolases collected in healthy subjects via duodenoscopic cannulation. Effects of secretin, pancreozymin, and caerulein.

P. de Neef, P. Robberecht, A. Vandermeers, 1975, Gastroenterology.

Effects of temperature and ethanol on agonist and antagonist binding to rat heart muscarinic receptors in the absence and presence of GTP.

P. de Neef, P. Robberecht, J. Christophe, 1985, The Biochemical journal.

Multiple effects of short-chain alcohols on binding to rat heart muscarinic receptors.

P. de Neef, P. Robberecht, J. Christophe, 1984, The Biochemical journal.

Importance of disulfide bonds in receptors for vasoactive intestinal peptide and secretin in rat pancreatic plasma membranes.

P. de Neef, P. Robberecht, J. Christophe, 1984, Biochimica et biophysica acta.

In vitro interactions of gastrointestinal hormones on cyclic adenosine 3':5'-monophosphate levels and amylase output in the rat pancreas.

P. de Neef, P. Robberecht, J. Christophe, 1975, Gastroenterology.

The interaction of caerulein with the rat pancreas. 2. Specific binding of [3H]caerulein on dispersed acinar cells.

P. de Neef, P. Robberecht, J. Christophe, 1978, European journal of biochemistry.

Decreased stimulation of adenylate cyclase by growth hormone-releasing factor in the anterior pituitary of old rats.

P. de Neef, P. Robberecht, J. Christophe, 1986, Neuroendocrinology.

Effects of d-tubocurarine on rat cardiac muscarinic receptors: a comparison with gallamine.

P. de Neef, P. Robberecht, J. Christophe, 1988, Journal of receptor research.

Inhibitory effects of quinidine on rat heart muscarinic receptors.

P. de Neef, P. Robberecht, J. Christophe, 1984, Life sciences.

Effects of verapamil on the binding properties of rat heart muscarinic receptors: evidence for an allosteric site.

P. de Neef, P. Robberecht, J. Christophe, 1984, Biochemical and biophysical research communications.

Receptor occupancy and adenylate cyclase activation in AR 4-2J rat pancreatic acinar cell membranes by analogs of pituitary adenylate cyclase-activating peptides amino-terminally shortened or modified at position 1, 2, 3, 20, or 21.

P. de Neef, P. Robberecht, A. Vandermeers, 1992, Molecular pharmacology.

Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist.

P. de Neef, P. Robberecht, A. Vandermeers, 1992, European journal of biochemistry.

Variable stimulation of adenylate cyclase activity by vasoactive intestinal-like peptides and beta-adrenergic agonists in murine T cell lymphomas of immature, helper, and cytotoxic types.

P. de Neef, P. Robberecht, J. Christophe, 1989, Immunobiology.

Immunoreactive helodermin-like peptides in rat: a new class of mammalian neuropeptides related to secretin and VIP.

P. de Neef, P. Robberecht, N. Yanaihara, 1985, Biochemical and biophysical research communications.

Butyryl derivatives of cyclic GMP interfere with the biological and the immunological properties of the pancreozymin-gastrin family of peptides.

P. de Neef, P. Robberecht, J. Christophe, 1980, Molecular pharmacology.

Thermodependence of basal and stimulated cardiac adenylate cyclase activity in normotensive and spontaneously hypertensive rats.

P. de Neef, P. Robberecht, J. Christophe, 1983, Journal of molecular and cellular cardiology.

Stimulation of rat pancreatic tumoral AR4-2J cell proliferation by pituitary adenylate cyclase-activating peptide.

N. Vaysse, C. Seva, L. Buscail, 1992, Gastroenterology.

PACAP and VIP receptors in rat liver membranes.

L. Buscail, A. Arimura, P. de Neef, 1991, The American journal of physiology.

Presence of highly selective receptors for PACAP (pituitary adenylate cyclase activating peptide) in membranes from the rat pancreatic acinar cell line AR 4‐2J

L. Buscail, D. Coy, A. Arimura, 1990, FEBS letters.

CCK and gastrin inhibit adenylate cyclase activity through a pertussis toxin‐sensitive mechanism in the tumoral rat pancreatic acinar cell line AR 4‐2J

L. Pradayrol, N. Vaysse, P. de Neef, 1988, FEBS letters.

Interaction of vasoactive intestinal peptide (VIP) and N-terminally modified VIP analogs with rat pancreatic, hepatic and pituitary membranes.

D. Coy, P. de Neef, P. Robberecht, 1986, European journal of biochemistry.

[D-Phe4]peptide histidine-isoleucinamide ([D-Phe4]PHI), a highly selective vasoactive-intestinal-peptide (VIP) agonist, discriminates VIP-preferring from secretin-preferring receptors in rat pancreatic membranes.

D. Coy, P. de Neef, P. Robberecht, 1987, European journal of biochemistry.

Specific labelling of high-affinity vasoactive intestinal peptide receptors in rat liver membranes by a growth hormone-releasing factor analog.

D. Coy, P. de Neef, P. Robberecht, 1986, Neuroendocrinology.

Binding of vasoactive intestinal peptide and its stimulation of adenylate cyclase through two classes of receptors in rat liver membranes. Effects of 12 secretin analogues and 2 secretin fragments.

P. de Neef, P. Robberecht, J. Christophe, 1981, Biochimica et biophysica acta.

Properties of chimeric secretin and VIP receptor proteins indicate the importance of the N-terminal domain for ligand discrimination.

J. Vilardaga, P. de Neef, P. Robberecht, 1995, Biochemical and biophysical research communications.

Vasoactive intestinal polypeptide receptor VPAC1 subtype is predominant in rat prostate membranes

P. de Neef, P. Robberecht, M. Juarranz, 1999, The Prostate.

Fragments of pituitary adenylate cyclase activating polypeptide discriminate between type I and II recombinant receptors.

P. de Neef, P. Robberecht, A. Vandermeers, 1995, European journal of pharmacology.

Vasoactive intestinal peptide modification at position 22 allows discrimination between receptor subtypes.

P. de Neef, P. Robberecht, M. Vandermeers-piret, 1998, European journal of pharmacology.

Structural requirements for the binding of the pituitary adenylate-cyclase-activating peptide to receptors and adenylate-cyclase activation in pancreatic and neuronal membranes.

P. de Neef, P. Robberecht, A. Vandermeers, 1991, European journal of biochemistry.

Influence of selective VIP receptor agonists in the rat gastric fundus.

P. de Neef, P. Robberecht, R. Lefebvre, 1998, European journal of pharmacology.

Interaction of lipophilic VIP derivatives with recombinant VIP1/PACAP and VIP2/PACAP receptors.

P. de Neef, P. Robberecht, M. Vandermeers-piret, 1998, European journal of pharmacology.

Characterization of ocular receptors for pituitary adenylate cyclase activating polypeptide (PACAP) and their coupling to adenylate cyclase.

S. Nilsson, P. de Neef, P. Robberecht, 1994, Experimental eye research.

Antagonistic properties are shifted back to agonistic properties by further N-terminal shortening of pituitary adenylate-cyclase-activating peptides in human neuroblastoma NB-OK-1 cell membranes.

P. de Neef, P. Robberecht, A. Vandermeers, 1992, European journal of biochemistry.

Addition of the (28-38) peptide sequence of PACAP to the VIP sequence modifies peptide selectivity and efficacy.

P. de Neef, P. Robberecht, A. Vandermeers, 2009, International journal of peptide and protein research.

Alterations of rat cardiac adenylate cyclase activity with age.

P. de Neef, P. Robberecht, J. Christophe, 1986, European journal of pharmacology.

In vivo effects of five secretin analogs on fluid and potassium secretion from the rat pancreas.

W. König, P. de Neef, P. Robberecht, 1980, Life sciences.

Contribution of the second transmembrane helix of the secretin receptor to the positioning of secretin

P. de Neef, P. Robberecht, A. Bollen, 1998, FEBS letters.

Effect of introduction of an arginine16 in VIP, PACAP and secretin on ligand affinity for the receptors.

P. de Neef, P. Robberecht, A. Vandermeers, 1996, Biochimica et biophysica acta.

Vasoactive intestinal peptide: levels and functional receptors in rat brain before and after weaning.

P. de Neef, P. Robberecht, M. Deschodt-Lanckman, 1979, Life sciences.