S. Farr

S. Farr, M. Bardgett, G. Taylor, 1996, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Adropin expression correlates with age-related neuropathologies in the human brain and improves neuroinflammation and cognitive function in aging mice

W. Banks, E. Candelario-Jalil, Subhashish Banerjee, 2021 .

Shortened estrous cycle length, increased FSH levels, FSH variance, oocyte spindle aberrations, and early declining fertility in aging senescence-accelerated mouse prone-8 (SAMP8) mice: concomitant characteristics of human midlife female reproductive aging.

C. Chaffin, J. Morley, S. Farr, 2014, Endocrinology.

Permeability of the Blood-Brain Barrier to Albumin and Insulin in the Young and Aged SAMP 8 Mouse

W. Banks, J. Morley, S. Farr, 2000 .

Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease.

S. M. Robinson, W. Banks, N. Nonaka, 2002, Peptides.

Effects of orexin-A on memory processing

W. Banks, J. Morley, S. Farr, 2002, Peptides.

Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice

W. Banks, J. Morley, A. Schally, 2010, Proceedings of the National Academy of Sciences.

Extra virgin olive oil improves learning and memory in SAMP8 mice.

M. Barbagallo, W. Banks, J. Morley, 2012, Journal of Alzheimer's disease : JAD.

Permeability of the blood-brain barrier to albumin and insulin in the young and aged SAMP8 mouse.

J. Morley, S. Farr, W. A. Banks, 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

SAMP8 mice have altered hippocampal gene expression in LTP, phosphatidylinositol signaling, and endocytosis pathways

A. Siddiqui, J. Morley, H. Armbrecht, 2013 .

Adropin expression correlates with age-related neuropathologies in the human brain and improves neuroinflammation and cognitive function in aging mice

W. Banks, E. Candelario-Jalil, Subhashish Banerjee, 2021 .

Risk of incident dementia following metformin initiation compared with noninitiation or delay of antidiabetic medication therapy

J. Morley, S. Dublin, S. Farr, 2020, Pharmacoepidemiology and drug safety.

Cachexia and neuropeptide Y.

J. Morley, S. Farr, 2008, Nutrition.

Inhibition of feeding by a nitric oxide synthase inhibitor: effects of aging.

J. Morley, S. Farr, Vijaya B. Kumar, 1996, European journal of pharmacology.

Sphingosine-1-phosphate receptor 1 activation in the central nervous system drives cisplatin-induced cognitive impairment

S. Cuzzocrea, S. Spiegel, E. Esposito, 2022, The Journal of clinical investigation.

Isolation of Peptide Transport System-6 from Brain Endothelial Cells: Therapeutic Effects with Antisense Inhibition in Alzheimer and Stroke Models

W. Banks, N. Nonaka, J. Morley, 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

What is the Physiological Function of Amyloid-Beta Protein?

J. Morley, S. Farr, F. Xu, 2019, The journal of nutrition, health & aging.

Effect of alpha-lipoic acid on memory, oxidation, and lifespan in SAMP8 mice.

W. Banks, J. Morley, S. Farr, 2012, Journal of Alzheimer's disease : JAD.

Lipid peroxidation in brain during aging in the senescence-accelerated mouse (SAM)

J. Morley, S. Farr, G. Skuladottir, 2007, Neurobiology of Aging.

J. Morley, S. Farr, J. Flood, 1995, Pharmacology Biochemistry and Behavior.

Peripheral administration of antisense oligonucleotides targeting the amyloid-β protein precursor reverses AβPP and LRP-1 overexpression in the aged SAMP8 mouse brain.

W. Banks, J. Morley, S. Farr, 2012, Journal of Alzheimer's disease : JAD.

Inhibition of Glycogen Synthase Kinase 3β as a Treatment for the Prevention of Cognitive Deficits after a Traumatic Brain Injury.

J. Morley, S. Farr, Vijaya B. Kumar, 2019, Journal of neurotrauma.

Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation

Ian Mitchelle S. de Vera, B. Leavitt, J. Morley, 2022, bioRxiv.

Effects of amylin on appetite regulation and memory.

J. Morley, S. Farr, J. Flood, 1995, Canadian journal of physiology and pharmacology.

Corrigendum to "Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity" [Journal of Controlled Release 191 (2014) 34-46].

W. Banks, A. Kabanov, S. Farr, 2021, Journal of controlled release : official journal of the Controlled Release Society.

Chronic fluoxetine suppresses circulating estrogen and the enhanced spatial learning of estrogen-treated ovariectomized rats

S. Farr, G. Taylor, K. Klinga, 2004, Psychoneuroendocrinology.

Peripheral administration of CRF and urocortin: effects on food intake and the HPA axis in the marsupial Sminthopsis crassicaudata

G. Chrousos, J. Morley, D. Torpy, 2000, Peptides.

Regional procarbazine delivery reduces testicular toxicity.

S. Farr, F. Johnson, R. Susman, 1993, Surgical oncology.

Somatostatin receptor subtype-4 agonist NNC 26-9100 decreases extracellular and intracellular Aβ₁₋₄₂ trimers.

W. Banks, J. Morley, S. Farr, 2012, European journal of pharmacology.

Delivery of Galanin-Like Peptide to the Brain: Targeting with Intranasal Delivery and Cyclodextrins

W. Banks, N. Nonaka, S. Shioda, 2008, Journal of Pharmacology and Experimental Therapeutics.

Intranasal administration of PACAP: Uptake by brain and regional brain targeting with cyclodextrins

W. Banks, N. Nonaka, J. Morley, 2012, Peptides.

Sociosexual behaviour and paternity in procarbazine-exposed rats with or without regional testicular circulatory isolation.

S. Farr, F. Johnson, G. Taylor, 1997, Journal of reproduction and fertility.

Entry of Blood-Borne Cytokines into the Central Nervous System: Effects on Cognitive Processes

W. Banks, J. Morley, S. Farr, 2003, Neuroimmunomodulation.

Peripherally administered calcitonin gene-related peptide decreases food intake in mice

J. Morley, S. Farr, J. Flood, 1996, Peptides.

Antisense directed at the Aβ region of APP decreases brain oxidative markers in aged senescence accelerated mice

D. Butterfield, W. Banks, R. Sultana, 2004, Brain Research.

Antiaging methods and medicines for the memory.

W. Banks, S. Farr, 2004, Clinics in geriatric medicine.

Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Abeta region of amyloid precursor protein.

D. Butterfield, W. Banks, H. Poon, 2005, Brain research. Molecular brain research.

Quantitative proteomics analysis of specific protein expression and oxidative modification in aged senescence-accelerated-prone 8 mice brain

D. Butterfield, W. Banks, H. Poon, 2004, Neuroscience.

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer’s Disease

J. Jelsing, N. Vrang, J. Morley, 2015, Journal of Alzheimer's disease : JAD.

Research report Antisense directed at the Ah region of APP decreases brain oxidative markers in aged senescence accelerated mice

D. Butterfield, W. Banks, R. Sultana, 2004 .

Antisense Directed at the Ah Region of App Decreases Brain Oxidative Markers in Aged Senescence Accelerated Mice

D. Butterfield, W. Banks, R. Sultana, 2022 .

Antibody to beta-amyloid protein increases acetylcholine in the hippocampus of 12 month SAMP8 male mice.

W. Banks, J. Morley, A. Sano, 2003, Life sciences.

Alzheimer’s disease through the eye of a mouse Acceptance lecture for the 2001 Gayle A. Olson and Richard D. Olson prize

W. Banks, J. Morley, S. Farr, 2002, Peptides.

The pharmacology of post-trial memory processing in septum.

J. Morley, S. Farr, J. Flood, 1998, European journal of pharmacology.

Modulation of Memory Processing in the Cingulate Cortex of Mice

J. Morley, S. Farr, J. Flood, 2000, Pharmacology Biochemistry and Behavior.

Increase in Presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing

W. Banks, J. Morley, S. Farr, 2009, Journal of Experimental Biology.

Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders

D. Butterfield, W. Banks, H. Poon, 2005, Neurochemistry International.

The effects of high fat diets on the blood–brain barrier transport of leptin: Failure or adaptation?

W. Banks, J. Morley, S. Farr, 2006, Physiology & Behavior.

Adropin correlates with aging-related neuropathology in humans and improves cognitive function in aging mice

W. Banks, E. Candelario-Jalil, Subhashish Banerjee, 2021, NPJ aging and mechanisms of disease.

A physiological role for amyloid-beta protein:enhancement of learning and memory.

W. Banks, J. Morley, S. Farr, 2010, Journal of Alzheimer's disease : JAD.

A DUAL MTOR/NAD+ ACTING GEROTHERAPY

Timothy A. Miller, Shi-Yan Ng, J. Colca, 2023, bioRxiv.

Intravenous human interleukin-1alpha impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum.

W. Banks, J. Morley, S. Farr, 2001, The Journal of pharmacology and experimental therapeutics.

Sphingosine 1-Phosphate Receptor Subtype 1 as a Therapeutic Target for Brain Trauma.

S. Cuzzocrea, E. Esposito, S. Farr, 2018, Journal of neurotrauma.

Adenosine A3 receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injury

S. Cuzzocrea, E. Esposito, S. Farr, 2020, Journal of neuroinflammation.

Molecular Mechanisms of Intranasal Insulin in SAMP8 Mice.

W. Banks, R. Beyer, J. Morley, 2019, Journal of Alzheimer's disease : JAD.

Effects of leptin on memory processing

W. Banks, J. Morley, S. Farr, 2006, Peptides.

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease.

D. Butterfield, R. Sultana, M. Murphy, 2014, Free radical biology & medicine.

Peripheral Administration of GSK-3β Antisense Oligonucleotide Improves Learning and Memory in SAMP8 and Tg2576 Mouse Models of Alzheimer's Disease.

J. Morley, S. Farr, Vijaya B. Kumar, 2016, Journal of Alzheimer's disease : JAD.

Effect of dietary n-3 polyunsaturated fatty acids on brain lipid fatty acid composition, learning ability, and memory of senescence-accelerated mouse.

W. Banks, J. Morley, S. Farr, 2008, The journals of gerontology. Series A, Biological sciences and medical sciences.

Identification of age-dependent changes in expression of senescence-accelerated mouse (SAMP8) hippocampal proteins by expression array analysis.

J. Morley, S. Farr, Vijaya B. Kumar, 2000, Biochemical and biophysical research communications.

Nitric oxide is a central component in neuropeptide regulation of appetite

W. Banks, J. Morley, S. Farr, 2011, Peptides.

Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration.

S. M. Robinson, W. Banks, C. Mattern, 2010, European journal of pharmacology.

Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ42 oligomers via a metalloproteinase-dependent mechanism

W. Banks, J. Morley, S. Farr, 2013, Brain Research.

Nitric oxide activity and isoenzyme expression in the senescence-accelerated mouse p8 model of Alzheimer's disease: effects of anti-amyloid antibody and antisense treatments.

W. Banks, J. Morley, G. Shah, 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

Alzheimer Mythology: A Time to Think Out of the Box.

J. Morley, S. Farr, 2016, Journal of the American Medical Directors Association.

Synthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment.

S. Farr, A. Crider, Karin E. Sandoval, 2021, RSC medicinal chemistry.

Passage of amyloid β protein antibody across the blood–brain barrier in a mouse model of Alzheimer’s disease

S. M. Robinson, W. Banks, N. Nonaka, 2002, Peptides.

Association Between Metformin Initiation and Incident Dementia Among African American and White Veterans Health Administration Patients

J. Morley, S. Dublin, S. Farr, 2019, The Annals of Family Medicine.

Alzheimer Disease.

J. Morley, S. Farr, A. Nguyen, 2018, Clinics in geriatric medicine.

The role of amyloid-beta in the regulation of memory.

J. Morley, S. Farr, 2014, Biochemical pharmacology.

Neurovascular protection by adropin in experimental ischemic stroke through an endothelial nitric oxide synthase-dependent mechanism

M. Febo, C. Kuan, Lei Liu, 2021, Redox biology.

Nitric oxide synthase inhibition and food intake: Effects on motivation to eat and in female mice

J. Morley, S. Farr, J. Flood, 1995, Pharmacology Biochemistry and Behavior.

Blind mice are not impaired in T-maze footshock avoidance acquisition and retention

W. Banks, J. Morley, S. Farr, 2002, Physiology & Behavior.

Permanent and temporary inactivation of the hippocampus impairs T-maze footshock avoidance acquisition and retention

J. Morley, S. Farr, J. Flood, 2000, Brain Research.

Adult ontogeny of rat working memory of social interactions.

S. Farr, G. Taylor, M. Griffin, 1999, The journals of gerontology. Series A, Biological sciences and medical sciences.

Orexin-A-induced feeding is dependent on nitric oxide

W. Banks, J. Morley, S. Farr, 2003, Peptides.

Effect of ovarian steroids on footshock avoidance learning and retention in female mice

J. Morley, S. Farr, Jeffrey F. Scherrer, 1995, Physiology & Behavior.

Adropin correlates with aging-related neuropathology in humans and improves cognitive function in aging mice

W. Banks, E. Candelario-Jalil, A. Butler, 2021, npj Aging and Mechanisms of Disease.

Hormesis and amyloid-β protein: physiology or pathology?

J. Morley, S. Farr, 2012, Journal of Alzheimer's disease : JAD.

Ghrelin-induced feeding is dependent on nitric oxide

W. Banks, J. Morley, F. Gaskin, 2003, Peptides.

Obesity and hypertriglyceridemia produce cognitive impairment.

N. E. Miller, D. Butterfield, W. Banks, 2008, Endocrinology.

Antisense against Amyloid-β Protein Precursor Reverses Memory Deficits and Alters Gene Expression in Neurotropic and Insulin-Signaling Pathways in SAMP8 Mice.

W. Banks, A. Siddiqui, J. Morley, 2015, Journal of Alzheimer's disease : JAD.

SAMP8 mice have altered hippocampal gene expression in long term potentiation, phosphatidylinositol signaling, and endocytosis pathways

W. Banks, A. Siddiqui, G. Shah, 2014, Neurobiology of Aging.

Effect of metformin on nitric oxide synthase in genetically obese (ob/ob) mice.

J. Morley, S. Farr, V. B. Kumar, 2001, Life sciences.

Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding

J. Morley, S. Farr, Vijaya B. Kumar, 1999, Peptides.

Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer’s disease

E. Musiek, J. Morley, S. Farr, 2019, PloS one.

Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer’s disease

W. Banks, J. Morley, Jessica L Smith, 2023, Brain, Behavior, and Immunity.

Chronic ethanol consumption impairs learning and memory after cessation of ethanol.

W. Banks, J. Morley, S. Farr, 2005, Alcoholism, clinical and experimental research.

Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: a proteomics study.

D. Butterfield, R. Sultana, Jian Cai, 2013, Free radical biology & medicine.

Targeting nonsense-mediated RNA decay does not increase progranulin levels in the Grn R493X mouse model of frontotemporal dementia

F. Rigo, M. Wilkinson, S. Farr, 2023, PloS one.

Antisense oligonucleotide strategies to increase progranulin levels for frontotemporal dementia

Ian Mitchelle S. de Vera, B. Leavitt, J. Morley, 2022 .

Central and peripheral administration of antisense oligonucleotide targeting amyloid-β protein precursor improves learning and memory and reduces neuroinflammatory cytokines in Tg2576 (AβPPswe) mice.

W. Banks, J. Morley, S. Farr, 2014, Journal of Alzheimer's disease : JAD.

Intranasal delivery of N‐terminal modified leptin‐pluronic conjugate for treatment of obesity

W. Banks, A. Kabanov, S. Farr, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition.

S. M. Robinson, W. Banks, M. Murphy, 2009, Journal of Alzheimer's disease : JAD.

Steroidal interactions in the ageing endocrine system: absence of suppression and pathology in reproductive systems of old males from a mixed-sex socially stressful rat colony.

S. Farr, D. Komitowski, M. Bardgett, 1993, The Journal of endocrinology.

Gonadal hormones and conspecific marking in male rats

S. Farr, G. Taylor, G. Bartko, 1987, Hormones and Behavior.

Effect of botanical extracts containing carnosic acid or rosmarinic acid on learning and memory in SAMP8 mice

D. Butterfield, J. Morley, S. Farr, 2016, Physiology & Behavior.

Effects of chronic ethanol administration on brain interstitial fluid levels of Methionine-enkephalin as measured by microdialysis in vivo

W. Banks, F. Gaskin, S. Farr, 2006, Peptides.

Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice

K. Jacobson, A. Kavelaars, S. Farr, 2022, Acta neuropathologica communications.

Estradiol potentiates acetylcholine and glutamate-mediated post-trial memory processing in the hippocampus

W. Banks, J. Morley, S. Farr, 2000, Brain Research.

Methods to identify dementia in the electronic health record: Comparing cognitive test scores with dementia algorithms.

J. Morley, S. Dublin, S. Farr, 2020, Healthcare.

Aging, Plasminogen Activator Inhibitor 1, Brain Cell Senescence, and Alzheimer’s Disease

Gang Liu, J. Morley, S. Farr, 2023, Aging and disease.

Mechanisms of HIV type 1-induced cognitive impairment: evidence for hippocampal cholinergic involvement with overstimulation of the VIPergic system by the viral coat protein core.

W. Banks, E. Freed, J. Morley, 2002, AIDS research and human retroviruses.

Testicular cytotoxicity of intravenous methotrexate in rats

S. Farr, Maurice Mawad, F. Johnson, 1994, Journal of surgical oncology.

Isatin inhibits food intake in mice.

J. Morley, S. Farr, J. Flood, 1996, European journal of pharmacology.

A Life without Hunger: The Ups (and Downs) to Modulating Melanocortin-3 Receptor Signaling

D. Marks, A. Butler, S. Farr, 2017, Front. Neurosci..

Biochemical, biomarker, and behavioral characterization of the GrnR493X mouse model of frontotemporal dementia

S. Farr, Geetika Aggarwal, M. Niehoff, 2023, bioRxiv.

Effects of wheatgerm agglutinin and aging on the regional brain uptake of HIV-1GP120.

J. Morley, S. Farr, J. Flood, 1999, Life sciences.

The Effect of Cholinergic, GABAergic, Serotonergic, and Glutamatergic Receptor Modulation on Posttrial Memory Processing in the Hippocampus

J. Morley, S. Farr, J. Flood, 2000, Neurobiology of Learning and Memory.

J. Morley, S. Farr, J. Flood, 1998, Mechanisms of Ageing and Development.

Adropin confers neuroprotection and promotes functional recovery from ischemic stroke

M. Febo, C. Kuan, M. Mohamadzadeh, 2021, bioRxiv.

A Physiological Role for Amyloid Beta Protein: Enhancement of Learning and Memory

W. Banks, J. Morley, S. Farr, 2008 .

Septo-hippocampal drug interactions in post-trial memory processing

J. Morley, S. Farr, J. Flood, 1999, Brain Research.

Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation

Ian Mitchelle S. de Vera, B. Leavitt, J. Morley, 2022, bioRxiv.

H. Sei, A. Sano, Y. Morita, 2004 .

Alzheimer Mythology: A Time to Think Out of the Box.

J. Morley, S. Farr, 2016, Journal of the American Medical Directors Association.

Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice.

R. Sultana, H. Poon, S. Farr, 2004, Brain research.

Biochemical, Biomarker, and Behavioral Characterization of the GrnR493X Mouse Model of Frontotemporal Dementia.

S. Farr, M. Niehoff, Sp Jones, 2024, Molecular neurobiology.