D. Gordon

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Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men.

D. Witcher, H. M. Geysen, M. Thorner, 2008, The Journal of clinical endocrinology and metabolism.

Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability.

H. Jamil, R. Gregg, D. Gordon, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311).

David S. Taylor, Hong Shen, M. Poss, 2015, Journal of medicinal chemistry.

Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure

D. Rader, B. French, D. Mann, 2020, Circulation.

Clinical and Proteomic Correlates of Plasma ACE2 (Angiotensin-Converting Enzyme 2) in Human Heart Failure

D. Seiffert, M. Morley, Jeffrey Brandimarto, 2020, Hypertension.

Triazolopyrimidines identified as reversible myeloperoxidase inhibitors.

P. Sleph, L. Abell, D. Gordon, 2017 .

Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) which Demonstrate HDL-C Increase In Vivo.

David S. Taylor, K. Behnia, E. Liu, 2020, Journal of medicinal chemistry.

Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1).

M. Kirby, R. Seethala, A. Nayeem, 2011, Bioorganic & medicinal chemistry letters.

Cofactor-specific modulation of 11beta-hydroxysteroid dehydrogenase 1 inhibitor potency.

L. Hamann, R. Seethala, A. Nayeem, 2007, Biochimica et biophysica acta.

Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding

J. Guay, D. Seiffert, M. Bouvier, 2017, Science Translational Medicine.

PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor.

David S. Taylor, P. Sleph, L. Abell, 2018, ACS medicinal chemistry letters.

Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis.

L. Aronne, S. Caprio, C. Bruno, 1999, Diabetes.

Effect of Serum Albumin Levels in Patients With Heart Failure With Preserved Ejection Fraction (from the TOPCAT Trial).

Zhuyin Li, D. Seiffert, D. Gordon, 2019, American Journal of Cardiology.

Cloning and regulation of hamster microsomal triglyceride transfer protein. The regulation is independent from that of other hepatic and intestinal proteins which participate in the transport of fatty acids and triglycerides.

B. Kienzle, D. Gordon, M. Lin, 1994, The Journal of biological chemistry.

Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia

D. Rader, C. Turck, R. Gregg, 1993, Nature.

Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression.

Marie C. M. Lin, D. Gordon, M. Lin, 1995, Journal of lipid research.

An inhibitor of the microsomal triglyceride transfer protein inhibits apoB secretion from HepG2 cells.

H. Jamil, C. Chu, R. Gregg, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Molecular cloning, expression, and hormonal regulation of the chicken microsomal triglyceride transfer protein.

B. Kienzle, W. Schneider, D. Gordon, 2013, Gene.

Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction

Rongan Zhang, M. Bouvier, D. Gordon, 2021, JACC. Basic to translational science.

Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure.

Y. Saito, D. Gordon, R. Wexler, 2020, Journal of medicinal chemistry.

Evidence that microsomal triglyceride transfer protein is limiting in the production of apolipoprotein B-containing lipoproteins in hepatic cells.

H. Jamil, C. Chu, R. Gregg, 1998, Journal of lipid research.

Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly.

H. Jamil, D. Gordon, 2000, Biochimica et biophysica acta.

The Microsomal Triglyceride Transfer Protein Facilitates Assembly and Secretion of Apolipoprotein B-containing Lipoproteins and Decreases Cotranslational Degradation of Apolipoprotein B in Transfected COS-7 Cells*

R. McLeod, D. Gordon, Z. Yao, 1996, The Journal of Biological Chemistry.

A Novel Abetalipoproteinemia Genotype

H. Jamil, B. Kienzle, D. Gordon, 1996, The Journal of Biological Chemistry.

25 – Sequence and Structural Elements Associated with the Degradation of Apolipoprotein II Messenger RNA

Sheng-Ping L. Hwang, G. S. Shelness, D. Gordon, 1987 .

Multiple Plasma Biomarkers for Risk Stratification in Patients With Heart Failure and Preserved Ejection Fraction.

Zhuyin Li, K. Margulies, D. Seiffert, 2020, Journal of the American College of Cardiology.

Enhanced Gastrointestinal Motility with Orally Active Ghrelin Receptor Agonists

P. Distefano, J. Hixon, K. Longo, 2009, Journal of Pharmacology and Experimental Therapeutics.

A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.

H. Jamil, D. Gordon, T. Harrity, 2001, Journal of medicinal chemistry.

Microsomal triglyceride transfer protein: a protein complex required for the assembly of lipoprotein particles.

R. Gregg, D. Gordon, J. Wetterau, 1995, Trends in cell biology.

Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development.

Robert V Farese, H. Jamil, L. Packer, 1999, Journal of lipid research.

Endotrophin, a Collagen VI Formation-Derived Peptide, in Heart Failure.

M. Karsdal, R. Doughty, D. Seiffert, 2022, NEJM evidence.

The Microsomal Triglyceride Transfer Protein Catalyzes the Post-translational Assembly of Apolipoprotein B-100 Very Low Density Lipoprotein in McA-RH7777 Cells*

S. Olofsson, D. Gordon, P. Stillemark, 1998, The Journal of Biological Chemistry.

Discovery of a potent and novel motilin agonist.

R. Stoffel, Huabin Sun, R. Seethala, 2004, Journal of medicinal chemistry.

P2Y6 Receptor Potentiates Pro-Inflammatory Responses in Macrophages and Exhibits Differential Roles in Atherosclerotic Lesion Development

Rongan Zhang, P. Gargalovic, D. Gordon, 2014, PloS one.

Proteomic Analysis of Effects of Spironolactone in Heart Failure With Preserved Ejection Fraction

R. Doughty, D. Mann, E. Rietzschel, 2022, Circulation. Heart failure.

The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

R. Leibel, D. Allison, S. Caprio, 1999, International Journal of Obesity.

Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors for the treatment of metabolic disorders.

L. Hamann, R. Seethala, A. Nayeem, 2014, Bioorganic & medicinal chemistry letters.

11b-Hydroxysteroid Dehydrogenase Type 1 Gene Knockout Attenuates Atherosclerosis and In Vivo Foam Cell Formation in Hyperlipidemic apoE Mice

Wen-pin Yang, Rongan Zhang, P. Gargalovic, 2013 .

Self-Assembling Cyclic d,l-α-Peptides as Modulators of Plasma HDL Function. A Supramolecular Approach toward Antiatherosclerotic Agents

M. Ghadiri, D. Gordon, L. Leman, 2017, ACS central science.

Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases.

C. Chu, S. Jusuf, Yanou Yang, 2021, Journal of medicinal chemistry.

Discovery and optimization of (R)-prolinol-derived agonists of the Growth Hormone Secretagogue receptor (GHSR).

R. Stoffel, S. Gerritz, D. Gordon, 2008, Bioorganic & medicinal chemistry letters.

(D)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: synthesis and incorporation into the growth hormone secretagogues.

W. Humphreys, R. Seethala, P. Sleph, 2008, Bioorganic & medicinal chemistry letters.

Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11β-hydroxydehydrogenase 1 (11β-HSD1).

S. Sheriff, R. Seethala, A. Nayeem, 2011, Bioorganic & medicinal chemistry letters.

MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.

C. Chu, E. A. Brown, D. Gordon, 2022, Cell metabolism.

Triazolopyrimidines identified as reversible myeloperoxidase inhibitors.

P. Sleph, L. Abell, D. Gordon, 2017, MedChemComm.

Tetrazole based amides as growth hormone secretagogues.

R. Seethala, G. Grover, P. Sleph, 2008, Bioorganic & medicinal chemistry letters.

Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues.

R. Stoffel, K. Dickinson, R. Seethala, 2005, Bioorganic & medicinal chemistry letters.

Recent advances in elucidating the role of the microsomal triglyceride transfer protein in apolipoprotein B lipoprotein assembly.

D. Gordon, 1997, Current opinion in lipidology.

Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues.

K. Dickinson, R. Seethala, G. Grover, 2007, Bioorganic & medicinal chemistry letters.

Biphenyl Acid Derivatives as APJ Receptor Agonists.

Michael A. Galella, P. Gargalovic, D. Gordon, 2019, Journal of medicinal chemistry.

Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain.

W. Humphreys, K. Dickinson, R. Seethala, 2008, Bioorganic & medicinal chemistry letters.

Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180).

W. Humphreys, K. Dickinson, R. Seethala, 2007, Journal of medicinal chemistry.

Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.

Shana L. Posy, A. Mathur, J. Guay, 2022, Journal of medicinal chemistry.

Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment

M. Bouvier, D. Gordon, F. Villarreal, 2019, JACC. Basic to translational science.

Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

R. Parker, D. Gordon, B. Pearce, 1993, The Journal of biological chemistry.

Inhibition of the Microsomal Triglyceride Transfer Protein Blocks the First Step of Apolipoprotein B Lipoprotein Assembly but Not the Addition of Bulk Core Lipids in the Second Step*

J. Borén, H. Jamil, R. Gregg, 1996, The Journal of Biological Chemistry.

Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction

E. Rietzschel, A. Javaheri, D. Seiffert, 2021, JACC. Basic to translational science.

Milvexian, an orally bioavailable, small‐molecule, reversible, direct inhibitor of factor XIa: In vitro studies and in vivo evaluation in experimental thrombosis in rabbits

D. Gordon, W. R. Ewing, J. Bozarth, 2021, Journal of thrombosis and haemostasis : JTH.

Estrogen-induced destabilization of yolk precursor protein mRNAs in avian liver.

G. S. Shelness, D. Gordon, D. Williams, 1988, The Journal of biological chemistry.

Estrogen-induced destabilization and associated degradation intermediates of apolipoprotein II mRNA.

D. Gordon, D. Williams, R. Binder, 1990, Progress in clinical and biological research.

Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase.

David S. Taylor, Brandon L. Parkhurst, E. Liu, 2019, Bioorganic & medicinal chemistry letters.

Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors.

David S. Taylor, Michael A. Galella, Hong Shen, 2018, Bioorganic & medicinal chemistry letters.

Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase.

David S. Taylor, Michael A. Galella, L. Abell, 2018, ACS medicinal chemistry letters.

Clinical Phenogroups in Heart Failure With Preserved Ejection Fraction: Detailed Phenotypes, Prognosis, and Response to Spironolactone.

Zhuyin Li, K. Margulies, D. Chirinos, 2020, JACC. Heart failure.

Characterization of Agonist-Induced Motilin Receptor Trafficking and Its Implications for Tachyphylaxis

R. Seethala, D. Gordon, Zhengping Ma, 2006, Molecular Pharmacology.

Design and preparation of N-linked hydroxypyridine-based APJ agonists.

P. Gargalovic, D. Gordon, R. Wexler, 2022, Bioorganic & medicinal chemistry letters.

Body Composition, Natriuretic Peptides, and Adverse Outcomes in Heart Failure With Preserved and Reduced Ejection Fraction.

S. Selvaraj, D. Seiffert, B. Car, 2020, JACC Cardiovascular Imaging.

Favorable therapeutic index of an orally-active small-molecule antagonist of the platelet protease-activated receptor-4, BMS-986141, compared with the P2Y12 antagonist ticagrelor in cynomolgus monkeys

M. Bouvier, D. Gordon, A. Marinier, 2020 .

In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure

P. Gargalovic, M. Bouvier, D. Gordon, 2021, Circulation. Heart failure.

Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues.

W. Humphreys, K. Dickinson, R. Seethala, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1).

M. Kirby, R. Seethala, A. Nayeem, 2014, Bioorganic & medicinal chemistry letters.

Identification of 6-Hydroxypyrimidin-4(1H)-one-3-carboxamides as Potent and Orally Active APJ Receptor Agonists.

P. Gargalovic, D. Gordon, R. Wexler, 2021, ACS medicinal chemistry letters.

Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.

David K. Leahy, J. Barrish, M. Kirby, 2017, Journal of medicinal chemistry.

Regulation of microsomal triglyceride transfer protein mRNA expression by endotoxin and cytokines.

W. Fiers, H. Jamil, K. Feingold, 1998, Journal of lipid research.

Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1).

S. Sheriff, R. Seethala, A. Nayeem, 2014, ACS Medicinal Chemistry Letters.

Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1).

L. Hamann, R. Seethala, D. Gordon, 2011, Bioorganic & medicinal chemistry letters.

Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1).

S. Sheriff, R. Seethala, A. Nayeem, 2018, ACS medicinal chemistry letters.

Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.

Akbar Nayeem, Haixia Wang, Steven Sheriff, 2008, Bioorganic & medicinal chemistry letters.

A 30-Amino Acid Truncation of the Microsomal Triglyceride Transfer Protein Large Subunit Disrupts Its Interaction with Protein Disulfide-isomerase and Causes Abetalipoproteinemia (*)

D. Rader, R. Gregg, B. Kienzle, 1995, The Journal of Biological Chemistry.

An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits.

H. Jamil, C. Chu, R. Gregg, 1998, Science.

Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate.

Michael A. Galella, P. Gargalovic, Soong-Hoon Kim, 2021, Journal of medicinal chemistry.

Endotrophin, a fibroblast matrikine, may be a driver of fibroblast activation in fibro-inflammatory diseases

M. Karsdal, D. Gordon, F. Genovese, 2023, Frontiers in molecular biosciences.

Systemic distribution of apolipoprotein E secreted by grafts of epidermal keratinocytes: implications for epidermal function and gene therapy.

D. Gordon, L. Pershing, D. Williams, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1).

L. Hamann, R. Seethala, D. Gordon, 2011, Bioorganic & medicinal chemistry letters.

Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men.

D. Witcher, M. Thorner, B. Gaylinn, 2008, The Journal of clinical endocrinology and metabolism.

Enhanced Gastrointestinal Motility with Orally Active Ghrelin Receptor Agonists

P. Distefano, J. Hixon, K. Longo, 2009, Journal of Pharmacology and Experimental Therapeutics.

Regulation of chicken apolipoprotein B: cloning, tissue distribution, and estrogen induction of mRNA.

K. Svenson, T. Kirchgessner, D. Gordon, 1987, Gene.