P. Modrich

发表

Christian Raetz: scientist and friend extraordinaire.

H. Nikaido, J. Stubbe, W. Wickner, 2013, Annual review of biochemistry.

Endonucleolytic Function of MutLα in Human Mismatch Repair

P. Modrich, F. Kadyrov, L. Dzantiev, 2006, Cell.

Endonucleolytic function of MutLalpha in human mismatch repair.

P. Modrich, F. Kadyrov, L. Dzantiev, 2006, Cell.

Effects of high levels of DNA adenine methylation on methyl-directed mismatch repair in Escherichia coli.

M. Meselson, P. Modrich, P. Pukkila, 1983, Genetics.

Genomic mismatch scanning: a new approach to genetic linkage mapping

S. Nelson, P. Brown, J. Mccusker, 1993, Nature Genetics.

Mechanisms in Eukaryotic Mismatch Repair*

P. Modrich, 2006, Journal of Biological Chemistry.

Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

Paul Modrich, S. Kowalczykowski, P. Modrich, 2008, Proceedings of the National Academy of Sciences.

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.

Paul Modrich, S. Kowalczykowski, C. Wyman, 2011, Genes & development.

In vitro maturation of circular bacteriophage P2 DNA. Purification of ter components and characterization of the reaction.

P. Modrich, D. Bowden, 1985, The Journal of biological chemistry.

Direct atomic force microscope imaging of EcoRI endonuclease site specifically bound to plasmid DNA molecules.

T. Thundat, F. Larimer, M. Doktycz, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Mapping individual cosmid DNAs by direct AFM imaging.

M J Doktycz, T. Thundat, F. Larimer, 1997, Genomics.

Investigation of the complexes of EcoRI endonuclease with decanucleotides containing canonical and modified recognition sequences using fluorescence and optical detection of magnetic resonance spectroscopy.

J. Casas-Finet, P. Modrich, N. Jhon, 1988, Biochimica et biophysica acta.

DNA determinants important in sequence recognition by Eco RI endonuclease.

P. Modrich, A. Lu, W. Jack, 1981, The Journal of biological chemistry.

Thermodynamic parameters governing interaction of EcoRI endonuclease with specific and nonspecific DNA sequences.

P. Modrich, R. A. Rubin, W. Jack, 1983, The Journal of biological chemistry.

'Interactive' recognition in EcoRI restriction enzyme-DNA complex.

S. Kim, R. Kim, P. Modrich, 1984, Nucleic acids research.

Hypermutability and mismatch repair deficiency in RER+ tumor cells

Bert Vogelstein, Kenneth W. Kinzler, Paul Modrich, 1993, Cell.

Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.

P. Modrich, Guo-Min Li, P Modrich, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Engineering life: building a fab for biology.

Ron Weiss, Drew Endy, Christina Smolke, 2006, Scientific American.

MutL traps MutS at a DNA mismatch

D. Erie, M. Hingorani, K. Weninger, 2015, Proceedings of the National Academy of Sciences.

Isolation and characterization of the Escherichia coli mutH gene product.

P. Modrich, A. Lu, K. Welsh, 1987, The Journal of biological chemistry.

Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.

D. Lilley, A. Murchie, D. R. Duckett, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of phospholipid biosynthesis in Escherichia coli. Cloning of the structural gene for the biosynthetic sn-glycerol-3-phosphate dehydrogenase.

J. Cronan, R. Bell, P. Modrich, 1980, The Journal of biological chemistry.

Facilitated diffusion during catalysis by EcoRI endonuclease. Nonspecific interactions in EcoRI catalysis.

P. Modrich, W. Jack, B. Terry, 1985, The Journal of biological chemistry.

Mechanisms and biological effects of mismatch repair.

P. Modrich, P Modrich, 1991, Annual review of genetics.

Redundant Exonuclease Involvement in Escherichia coli Methyl-directed Mismatch Repair*

S. Lovett, M. Viswanathan, P. Modrich, 2001, The Journal of Biological Chemistry.

MutS and MutL Activate DNA Helicase II in a Mismatch-dependent Manner*

M. Yamaguchi, P. Modrich, M. Yamaguchi, 1998, The Journal of Biological Chemistry.

MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2

J. Jiricny, J. Hsuan, I. Iaccarino, 1996, Current Biology.

Repair of DNA base-pair mismatches in extracts of Escherichia coli.

P. Modrich, A. Lu, K. Welsh, 1984, Cold Spring Harbor symposia on quantitative biology.

Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLα activation and function in mismatch repair

P. Modrich, F. Kadyrov, J. Genschel, 2017, Proceedings of the National Academy of Sciences.

Structure of the endonuclease domain of MutL: unlicensed to cut.

P. Friedhoff, M. Pillon, A. Guarné, 2010, Molecular cell.

The MutSα-Proliferating Cell Nuclear Antigen Interaction in Human DNA Mismatch Repair*♦

Greg L. Hura, L. Beese, P. Modrich, 2008, Journal of Biological Chemistry.

Saccharomyces cerevisiae MutLα Is a Mismatch Repair Endonuclease*

T. Kunkel, M. O’Donnell, P. Modrich, 2007, Journal of Biological Chemistry.

The β Sliding Clamp Binds to Multiple Sites within MutL and MutS*

M. O’Donnell, M. Marinus, P. Modrich, 2006, Journal of Biological Chemistry.

Mutation detection with MutH, MutL, and MutS mismatch repair proteins.

P. Modrich, J. Smith, 1996, Proceedings of the National Academy of Sciences of the United States of America.

HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

A. Harris, K. Kumamoto, L. Huang, 2005, Molecular cell.

Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability.

J. Eshleman, J. Lutterbaugh, S. Markowitz, 1996, Oncogene.

Involvement of outside DNA sequences in the major kinetic path by which EcoRI endonuclease locates and leaves its recognition sequence.

P. Modrich, W. Jack, B. Terry, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Recognition sequence of the dam methylase of Escherichia coli K12 and mode of cleavage of Dpn I endonuclease.

P. Modrich, P Modrich, G E Geier, 1979, The Journal of biological chemistry.

Escherichia coli K-12 clones that overproduce dam methylase are hypermutable

P. Modrich, G. Herman, Gail E. Herman, 1981, Journal of bacteriology.

A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair

W. Edelmann, P. Modrich, F. Kadyrov, 2009, Proceedings of the National Academy of Sciences.

Mechanism of 5'-directed excision in human mismatch repair.

P. Modrich, J. Genschel, 2003, Molecular cell.

DNA polymerase delta is required for human mismatch repair in vitro.

P. Modrich, A. Pierce, M. Longley, 1997, The Journal of biological chemistry.

The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease

P. Modrich, E. Penland, S. Sherrer, 2018, Proceedings of the National Academy of Sciences.

Type-II Restriction and Modification Enzymes

R. Roberts, P. Modrich, 1982 .

Human MutScv recognizes damaged DNA base pairs containing 06-methylguanine, 04-methylthymine, or the cisplatin-d(GpG) adduct

D. Lilley, A. Murchie, D. R. Duckett, 2005 .

Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family.

R. Bertina, J. Ware, P. Modrich, 1987, Gene.

hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage.

D. R. Duckett, Y. Taya, P. Modrich, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System*

A. Sancar, L. Lindsey-Boltz, P. Modrich, 2014, The Journal of Biological Chemistry.

Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma.

D. Bigner, H. Friedman, F. Ali-Osman, 2002, Molecular cancer therapeutics.

Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability

L. Kasturi, J. Lutterbaugh, S. Markowitz, 2000, Oncogene.

PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance

W. Edelmann, R. Sellers, P. Modrich, 2010, Proceedings of the National Academy of Sciences.

Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems

D. R. Duckett, A. Sancar, A. Sancar, 1997, Molecular and cellular biology.

Modulation of cyclophosphamide activity by O 6-alkylguanine-DNA alkyltransferase

M. Dolan, S. Keir, D. Bigner, 1999, Cancer Chemotherapy and Pharmacology.

The negative charge of Glu-111 is required to activate the cleavage center of EcoRI endonuclease.

P. Modrich, D. Wright, K. King, 1989, The Journal of biological chemistry.

Mismatch-containing oligonucleotide duplexes bound by the E. coli mutS-encoded protein.

J. Jiricny, P. Modrich, S. G. Wood, 1988, Nucleic acids research.

Isolation of gram quantities of EcoRI restriction and modification enzymes from an overproducing strain.

S. Kim, R. Kim, P. Modrich, 1984, The Journal of biological chemistry.

Mechanism of specific site location and DNA cleavage by EcoR I endonuclease.

P. Modrich, W. Jack, B. Terry, 1987, Gene amplification and analysis.

Methyl-directed mismatch repair is bidirectional.

P. Modrich, D. Cooper, R. Lahue, 1993, The Journal of biological chemistry.

Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors

S. Keir, D. Bigner, H. Friedman, 1998, Cancer Chemotherapy and Pharmacology.

Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway*

A. Sancar, L. Lindsey-Boltz, P. Modrich, 2009, The Journal of Biological Chemistry.

Hydrolytically Deficient MutS E694A Is Defective in the MutL-dependent Activation of MutH and in the Mismatch-dependent Assembly of the MutS · MutL · Heteroduplex Complex*

P. Modrich, V. Burdett, C. Baitinger, 2003, Journal of Biological Chemistry.

Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair–deficient malignant glioma xenograft

S. Keir, D. Bigner, H. Friedman, 2005, Molecular Cancer Therapeutics.

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

N. Rosen, D. Solit, G. Chiosis, 2004, Chemistry & biology.

Increased transversions in a novel mutator colon cancer cell line

J. Eshleman, J. Lutterbaugh, J. Willson, 1998, Oncogene.

PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro.

P. Modrich, Yiyong Liu, F. Kadyrov, 2011, DNA repair.

Preliminary x-ray diffraction studies of EcoRI restriction endonuclease-DNA complex.

P. Modrich, S. Kim, E. Jay, 1981, Journal of molecular biology.

[12] Purification and properties of EcoRI endonuclease

P. Modrich, R. A. Rubin, 1980 .

Mismatch repair and genetic stability in human cells.

W. Thilly, P. Modrich, M. Longley, 1993, Cold Spring Harbor symposia on quantitative biology.

The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase

X. Wang, C. Harris, I. Stagljar, 2004, Oncogene.

Mismatch Repair-dependent Iterative Excision at Irreparable O6-Methylguanine Lesions in Human Nuclear Extracts*

P. Modrich, S. York, 2006, Journal of Biological Chemistry.

DNA Polymerase (cid:100) Is Required for Human Mismatch Repair in Vitro *

Paul Modrich, Andrew J. Pierce, P. Modrich, 2022 .

Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks

K. Vasquez, Aklank Jain, P. Modrich, 2009, Nucleic acids research.

Misincorporation and mispaired primer extension by human immunodeficiency virus reverse transcriptase.

S. Zinnen, P. Modrich, J. Hsieh, 1994, The Journal of biological chemistry.

Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase.

J. Hsieh, S. Zinnen, P. Modrich, 1993, The Journal of biological chemistry.

Stereochemical course of nucleotidyl transfer catalyzed by bacteriophage T7 induced DNA polymerase.

P. Frey, W. Stec, P. Modrich, 1982, Biochemistry.

Strand-specific Mismatch Repair in Mammalian Cells*

P. Modrich, 1997, The Journal of Biological Chemistry.

Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.

M. Dolan, D. Bigner, H. Friedman, 2004, Molecular cancer therapeutics.

Methyl-directed DNA mismatch correction.

P. Modrich, Paul Modrich, 1989, The Journal of biological chemistry.

Mismatch Repair Deficiency Does Not Mediate Clinical Resistance to Temozolomide in Malignant Glioma

R. McLendon, A. Friedman, D. Bigner, 2008, Clinical Cancer Research.

Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR)

D. Bigner, R. Nahta, H. Friedman, 1999, Cancer Chemotherapy and Pharmacology.

T7-induced DNA polymerase. Characterization of associated exonuclease activities and resolution into biologically active subunits.

P. Modrich, S. Adler, 1979, The Journal of biological chemistry.

Bacteriophage T7 deoxyribonucleic acid replication invitro. Bacteriophage T7 DNA polymerase: an an emzyme composed of phage- and host-specific subunits.

P. Modrich, C. Richardson, 1975, The Journal of biological chemistry.

Studies on sequence recognition by type II restriction and modification enzymes.

P. Modrich, 1982, CRC critical reviews in biochemistry.

Mechanisms of DNA-mismatch correction.

P. Modrich, M. Grilley, J. Holmes, 1990, Mutation research.

Removal of polymerase-produced mutant sequences from PCR products.

P. Modrich, P Modrich, J Smith, 1997, Proceedings of the National Academy of Sciences of the United States of America.

DNA mismatch correction.

P. Modrich, 1987, Annual review of biochemistry.

Structures and mechanisms of DNA restriction and modification enzymes

P. Modrich, 1979, Quarterly Reviews of Biophysics.

Human MutLγ, the MLH1–MLH3 heterodimer, is an endonuclease that promotes DNA expansion

P. Modrich, F. Kadyrov, V. Burdett, 2020, Proceedings of the National Academy of Sciences.

PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair

P. Modrich, F. Kadyrov, L. Dzantiev, 2010, Proceedings of the National Academy of Sciences.

Structure of the Human MutSα DNA Lesion Recognition Complex

L. Beese, P. Modrich, J. J. Warren, 2007 .

Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease.

Mike O'Donnell, Paul Modrich, T. Kunkel, 2007, The Journal of biological chemistry.

Structure of the human MutSalpha DNA lesion recognition complex.

L. Beese, P. Modrich, J. J. Warren, 2007, Molecular cell.

DNA mismatch repair: functions and mechanisms.

P. Modrich, V. Burdett, R. Iyer, 2006, Chemical reviews.

A defined human system that supports bidirectional mismatch-provoked excision.

P. Modrich, P. Burgers, L. Dzantiev, 2004, Molecular cell.

Human Exonuclease I Is Required for 5′ and 3′ Mismatch Repair*

Paul Modrich, P. Modrich, J. Genschel, 2002, The Journal of Biological Chemistry.

Nucleotide-promoted Release of hMutSα from Heteroduplex DNA Is Consistent with an ATP-dependent Translocation Mechanism*

K. Bjornson, P. Modrich, L. Blackwell, 1998, The Journal of Biological Chemistry.

Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines.

P. Modrich, P Modrich, S Clark, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.

L. Kasturi, J. Lutterbaugh, S. Markowitz, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Mispair specificity of methyl-directed DNA mismatch correction in vitro.

P. Modrich, P Modrich, K G Au, 1988, The Journal of biological chemistry.

MutLα and Proliferating Cell Nuclear Antigen Share Binding Sites on MutSβ*

L. Beese, M. Tsai, P. Modrich, 2010, The Journal of Biological Chemistry.

DNA Mismatch Repair: Functions and Mechanisms

P. Modrich, V. Burdett, R. Iyer, 2006 .

EcoRI methylase. Physical and catalytic properties of the homogeneous enzyme.

P. Modrich, R. A. Rubin, P Modrich, 1977, The Journal of biological chemistry.

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

W. Thilly, W. Fang, P. Modrich, 1993, Proceedings of the National Academy of Sciences of the United States of America.

hMutS a - and hMutL a -dependent phosphorylation of p53 in response to DNA methylator damage

D. R. Duckett, Y. Taya, P. Modrich, 1999 .

Cisplatin and Adriamycin Resistance Are Associated with MutLα and Mismatch Repair Deficiency in an Ovarian Tumor Cell Line*

P. Modrich, P Modrich, A. Anthoney, 1996, The Journal of Biological Chemistry.

DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSα/hMutSβ ratio and reduces the efficiency of base–base mismatch repair

P. Modrich, J. Genschel, J. Drummond, 1997 .

DHFR y MSH 3 amplification in methotrexate-resistant cells alters the hMutS a y hMutS b ratio and reduces the efficiency of base – base mismatch repair ( drug resistance y genetic instability )

P. Modrich, J. Genschel, J. Drummond, 1997 .

Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells.

P. Modrich, Guo-Min Li, P Modrich, 1995, Science.

Initiation of methyl-directed mismatch repair.

P. Modrich, P Modrich, K G Au, 1992, The Journal of biological chemistry.

Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.

P. Modrich, S. Su, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Mismatch repair in replication fidelity, genetic recombination, and cancer biology.

P. Modrich, P Modrich, R Lahue, 1996, Annual review of biochemistry.

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

R. McLendon, A. Friedman, D. Bigner, 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Distinct MutS DNA-binding Modes That Are Differentially Modulated by ATP Binding and Hydrolysis*

K. Bjornson, P. Modrich, D. Allen, 2001, The Journal of Biological Chemistry.

Mismatch repair, genetic stability and tumour avoidance.

P. Modrich, 1995, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture).

P. Modrich, 2016, Angewandte Chemie.

Mismatch repair deficiency in phenotypically normal human cells

K. Kinzler, B. Vogelstein, R. Parsons, 1995, Science.

HIF-1α Induces Genetic Instability by Transcriptionally Downregulating MutSα Expression

A. Harris, K. Kumamoto, L. Huang, 2005 .

Assembly and Molecular Activities of the MutS Tetramer*

Paul Modrich, K. Bjornson, P. Modrich, 2003, Journal of Biological Chemistry.

Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha.

T. Kunkel, D. Erie, P. Modrich, 2008, Molecular cell.

In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair

S. Lovett, M. Viswanathan, P. Modrich, 2001, Proceedings of the National Academy of Sciences of the United States of America.

The MutL ATPase Is Required for Mismatch Repair*

P. Modrich, C. Spampinato, 2000, The Journal of Biological Chemistry.

DNA mismatch correction in a defined system.

P. Modrich, P Modrich, K G Au, 1989, Science.

DNA end resection machineries for human DNA break repair MRN constitute two − RPA − BLM − MRN and EXO 1 − RPA − DNA 2 − BLM Material

S. Kowalczykowski, C. Wyman, P. Modrich, 2011 .

Deoxyribonucleic acid ligase. Isolation and physical characterization of the homogeneous enzyme from Escherichia coli.

I. Lehman, Y. Anraku, P. Modrich, 1973, The Journal of biological chemistry.

Enzymatic joining of polynucleotides. IX. A simple and rapid assay of polynucleotide joining (ligase) activity by measurement of circle formation from linear deoxyadenylate-deoxythymidylate copolymer.

I. Lehman, P. Modrich, 1970, The Journal of biological chemistry.

Genetic and enzymatic characterization of a conditional lethal mutant of Escherichia coli K12 with a temperature-sensitive DNA ligase.

I. Lehman, P. Modrich, E. Konrad, 1973, Journal of molecular biology.

Human Mismatch Repair

P. Modrich, F. Kadyrov, L. Dzantiev, 2005, Journal of Biological Chemistry.

Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs.

J. Miller, P. Modrich, S. Clark, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Escherichia coli mutY gene product is required for specific A-G----C.G mismatch correction.

J. Miller, P. Modrich, K. Au, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Isolation and characterization of the Escherichia coli mutL gene product.

P. Modrich, M. Grilley, K. Welsh, 1989, The Journal of biological chemistry.

Early thinking on the nature of mismatch repair

P. Modrich, 2005 .

EcoRI endonuclease. Physical and catalytic properties of the homogenous enzyme.

P. Modrich, D. Zabel, 1976, The Journal of biological chemistry.

The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation*

P. Modrich, Jianhong Wu, T. Hsieh, 2016, The Journal of Biological Chemistry.

Functions of MutLα, Replication Protein A (RPA), and HMGB1 in 5′-Directed Mismatch Repair*

P. Modrich, J. Genschel, 2009, The Journal of Biological Chemistry.

Methyl-directed repair of DNA base-pair mismatches in vitro.

P. Modrich, A. Lu, P Modrich, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair

P. Modrich, A. Pluciennik, 2007, Proceedings of the National Academy of Sciences.

Mismatch-, MutS-, MutL-, and Helicase II-dependent Unwinding from the Single-strand Break of an Incised Heteroduplex*

P. Modrich, V. Dao, 1998, The Journal of Biological Chemistry.

MutS mediates heteroduplex loop formation by a translocation mechanism

J. Griffith, A. Makhov, P. Modrich, 1997, The EMBO journal.

Bidirectional excision in methyl-directed mismatch repair.

J. Griffith, J. Griffith, P. Modrich, 1993, The Journal of biological chemistry.

Requirement for d(GATC) sequences in Escherichia coli mutHLS mismatch correction.

P. Modrich, S. Su, R. Lahue, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Mismatch repair, genetic stability, and cancer.

P. Modrich, Paul Modrich, 1994, Science.

Isolation of MutSβ from Human Cells and Comparison of the Mismatch Repair Specificities of MutSβ and MutSα*

Paul Modrich, P. Modrich, J. Genschel, 1998, The Journal of Biological Chemistry.

DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair.

P. Modrich, J. Genschel, J. Drummond, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction.

W. Fang, P. Modrich, P Modrich, 1993, The Journal of biological chemistry.

Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs.

M. Radman, P. Modrich, S. Clark, 1994, Proceedings of the National Academy of Sciences of the United States of America.

The DNA sequences encoding plsB and dgk loci of Escherichia coli.

R. Bell, P. Modrich, V. Lightner, 1983, The Journal of biological chemistry.

Membrane phospholipid synthesis in Escherichia coli. Cloning of a structural gene (plsB) of the sn-glycerol-3-phosphate acyl/transferase.

R. Bell, C. Raetz, P. Modrich, 1980, The Journal of biological chemistry.

A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children’s oncology group

R. McLendon, P. Burger, J. Michalski, 2006, Journal of Neuro-Oncology.

Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft.

S. Keir, P. Houghton, S. Bigner, 1997, Cancer research.

Enzymatic joining of polynucleotides. XI. Reversal of Escherichia coli deoxyribonucleic acid ligase reaction.

I. Lehman, J. Wang, P. Modrich, 1972, The Journal of biological chemistry.

Extent of equilibrium perturbation of the DNA helix upon enzymatic methylation of adenine residues.

P. Modrich, S. Cheng, G. Herman, 1985, The Journal of biological chemistry.

High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6

S. Bigner, P. Modrich, P Modrich, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation

P. Modrich, Kevin Shi, V. Burdett, 2013, Proceedings of the National Academy of Sciences.

Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR‐Chk1 pathway

A. Sancar, L. Lindsey-Boltz, P. Modrich, 2010 .

Differential Specificities and Simultaneous Occupancy of Human MutSα Nucleotide Binding Sites*

Paul Modrich, P. Modrich, Diana Martik, 2004, Journal of Biological Chemistry.

Differential and Simultaneous Adenosine Di- and Triphosphate Binding by MutS*

K. Bjornson, P. Modrich, 2003, The Journal of Biological Chemistry.

DNA Chain Length Dependence of Formation and Dynamics of hMutSα·hMutLα·Heteroduplex Complexes*

Paul Modrich, P. Modrich, Shuntai Wang, 2001, The Journal of Biological Chemistry.

DNA-dependent Activation of the hMutSα ATPase*

K. Bjornson, P. Modrich, L. Blackwell, 1998, The Journal of Biological Chemistry.

A Naturally Occurring hPMS2 Mutation Can Confer a Dominant Negative Mutator Phenotype

K. Kinzler, B. Vogelstein, P. Modrich, 1998, Molecular and Cellular Biology.

Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

H. Hellinga, L. Beese, P. Modrich, 2011, Cell.

Involvement of the β Clamp in Methyl-directed Mismatch Repair in Vitro*

M. O’Donnell, P. Modrich, V. Burdett, 2009, The Journal of Biological Chemistry.

Role of the 2-amino group of deoxyguanosine in sequence recognition by EcoRI restriction and modification enzymes.

P. Modrich, R. A. Rubin, 1977, The Journal of biological chemistry.

The DNA helicase activities of Rad3 protein of Saccharomyces cerevisiae and helicase II of Escherichia coli are differentially inhibited by covalent and noncovalent DNA modifications.

H. Naegeli, E. Friedberg, P. Modrich, 1993, The Journal of biological chemistry.

Gap formation is associated with methyl-directed mismatch correction under conditions of restricted DNA synthesis.

J. Griffith, P. Modrich, R. Thresher, 1989, Genome.

DNA synthesis in strains of Escherichia coli K12 with temperature-sensitive DNA ligase and DNA polymerase I.

I. Lehman, P. Modrich, E. Konrad, 1974, Journal of molecular biology.

Analysis of the excision step in human DNA mismatch repair.

P. Modrich, J. Genschel, 2006, Methods in enzymology.

Modification of Escherichia coli DNA ligase by cleavage with trypsin.

I. Lehman, P. Modrich, S. Panasenko, 1976, The Journal of biological chemistry.

Analysis of DNA mismatch repair proteins in human medulloblastoma.

R. McLendon, A. Friedman, D. Bigner, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Enzymatic characterization of a mutant of Escherichia coli with an altered DNA ligase.

I. Lehman, P. Modrich, 1971, Proceedings of the National Academy of Sciences of the United States of America.

Hydrolytic function of Exo1 in mammalian mismatch repair

E. Soderblom, P. Modrich, V. Burdett, 2014, Nucleic acids research.

T7-induced DNA polymerase. Requirement for thioredoxin sulfhydryl groups.

P. Modrich, S. Adler, 1983, The Journal of biological chemistry.

Glu-111 is required for activation of the DNA cleavage center of EcoRI endonuclease.

S. Benkovic, P. Modrich, P Modrich, 1989, The Journal of biological chemistry.

Bacteriophage T7 Deoxyribonucleic acid replication in vitro. A protein of Escherichia coli required for bacteriophage T7 DNA polymerase activity.

P. Modrich, C. Richardson, 1975, The Journal of biological chemistry.

Modulation of MutS ATP hydrolysis by DNA cofactors.

K. Bjornson, P. Modrich, D. Allen, 2000, Biochemistry.

The beta sliding clamp binds to multiple sites within MutL and MutS.

M. O’Donnell, M. Marinus, F. J. López de Saro, 2006, The Journal of biological chemistry.

Substrate dependence of the mechanism of EcoRI endonuclease.

P. Modrich, R. A. Rubin, 1978, Nucleic acids research.

Methyl-directed DNA mismatch repair in Escherichia coli.

P. Modrich, R. Lahue, 1988, Mutation research.

Escherichia coli dam methylase. Physical and catalytic properties of the homogeneous enzyme.

P. Modrich, G. Herman, 1982, The Journal of biological chemistry.

Positive-selection cloning vehicle useful for overproduction of hybrid proteins

P. Modrich, S. Cheng, 1983, Journal of bacteriology.

Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ.

L. Beese, P. Modrich, J. Orans, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Membrane phospholipid synthesis in Escherichia coli. Identification of the sn-glycerol-3-phosphate acyltransferase polypeptide as the plsB gene product.

R. Bell, P. Modrich, T. Larson, 1980, The Journal of biological chemistry.