M. Sakaguchi

发表

Structural requirements for interruption of protein translocation across rough endoplasmic reticulum membrane.

K. Mihara, T. Kuroiwa, M. Sakaguchi, 1990, Journal of biochemistry.

Molecular Dissection of the Contribution of Negatively and Positively Charged Residues in S2, S3, and S4 to the Final Membrane Topology of the Voltage Sensor in the K+ Channel, KAT1*

Yoko Sato, N. Uozumi, M. Sakaguchi, 2003, The Journal of Biological Chemistry.

A mitochondrial import factor purified from rat liver cytosol is an ATP‐dependent conformational modulator for precursor proteins.

K. Mihara, M. Sakaguchi, T. Omura, 1993, The EMBO journal.

Vestibular Hair Bundles Control pH with (Na+, K+)/H+ Exchangers NHE6 and NHE9

R. Rao, P. Gillespie, M. Sakaguchi, 2006, The Journal of Neuroscience.

Protein synthesis inhibitors and ethanol selectively enhance heterologous expression of P450s and related proteins in Escherichia coli.

M. Waterman, N. Kagawa, M. Sakaguchi, 1999, Archives of biochemistry and biophysics.

Requirement of Negative Residues, Asp 95 and Asp 105, in S2 on Membrane Integration of a Voltage-dependent K+ Channel, KAT1

Yoko Sato, N. Uozumi, M. Sakaguchi, 2003, Bioscience, biotechnology, and biochemistry.

Targeting and Assembly of Mitochondrial Tail-anchored Protein Tom5 to the TOM Complex Depend on a Signal Distinct from That of Tail-anchored Proteins Dispersed in the Membrane*

K. Mihara, M. Sakaguchi, Chika Horie, 2003, Journal of Biological Chemistry.

Identification of Mammalian TOM22 as a Subunit of the Preprotein Translocase of the Mitochondrial Outer Membrane*

E. Mekada, Maki Maeda, M. Tsuneoka, 2000, The Journal of Biological Chemistry.

A new concept in polytopic membrane proteins following from the study of band 3 protein.

N. Hamasaki, K. Mihara, M. Sakaguchi, 1998, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Direct targeting of cis-Golgi matrix proteins to the Golgi apparatus.

Y. Misumi, Y. Ikehara, F. Barr, 2001, Journal of cell science.

Assessment of Topogenic Functions of Anticipated Transmembrane Segments of Human Band 3*

K. Ota, K. Mihara, M. Sakaguchi, 1998, The Journal of Biological Chemistry.

Reinitiation of Protein Translocation across the Endoplasmic Reticulum Membrane for the Topogenesis of Multispanning Membrane Proteins (*)

K. Mihara, T. Kuroiwa, M. Sakaguchi, 1996, The Journal of Biological Chemistry.

The highly conserved DAD1 protein involved in apoptosis is required for N‐linked glycosylation

T. Makishima, S. Komiyama, Y. Ikehara, 1997, Genes to cells : devoted to molecular & cellular mechanisms.

Translocation of a long amino‐terminal domain through ER membrane by following signal‐anchor sequence

K. Mihara, M. Sakaguchi, Y. Kida, 2005, The EMBO journal.

Malfolded cytochrome P-450(M1) localized in unusual membrane structures of the endoplasmic reticulum in cultured animal cells.

K. Mihara, M. Sakaguchi, T. Omura, 1995, Journal of biochemistry.

Importance of the proline-rich region following signal-anchor sequence in the formation of correct conformation of microsomal cytochrome P-450s.

S. Yamazaki, K. Mihara, M. Sakaguchi, 1993, Journal of biochemistry.

The amino‐terminal structures that determine topological orientation of cytochrome P‐450 in microsomal membrane.

K. Mihara, M. Sakaguchi, T. Omura, 1990, The EMBO journal.

Amino acid residues before the hydrophobic region which are critical for membrane translocation of the N‐terminal domain of synaptotagmin II

K. Mikoshiba, M. Fukuda, K. Mihara, 2001, FEBS letters.

Capsid protease domain as a tool for assessing protein-domain folding during organelle import of nascent polypeptides in living cells.

M. Sakaguchi, Haruka Sakaue, Michiyo Takahara, 2016, Journal of biochemistry.

70-kDa peroxisomal membrane protein related protein (P70R/ABCD4) localizes to endoplasmic reticulum not peroxisomes, and NH2-terminal hydrophobic property determines the subcellular localization of ABC subfamily D proteins.

M. Morita, M. Sakaguchi, Yoshitaka Tanaka, 2009, Experimental cell research.

Functions of signal and signal-anchor sequences are determined by the balance between the hydrophobic segment and the N-terminal charge.

K. Mihara, T. Kuroiwa, M. Sakaguchi, 1992, Proceedings of the National Academy of Sciences of the United States of America.

The topogenic function of S4 promotes membrane insertion of the voltage-sensor domain in the KvAP channel.

G. von Heijne, Yoko Sato, N. Uozumi, 2016, The Biochemical journal.

Identification of potential regulatory elements for the transport of Emp24p.

A. Nakano, S. Yamazaki, K. Mihara, 1998, Molecular biology of the cell.

Core glycosylation of cytochrome P-450(arom). Evidence for localization of N terminus of microsomal cytochrome P-450 in the lumen.

N. Harada, K. Mihara, M. Sakaguchi, 1993, The Journal of biological chemistry.

The tenth membrane region of band 3 is initially exposed to the luminal side of the endoplasmic reticulum and then integrated into a partially folded band 3 intermediate.

N. Hamasaki, K. Mihara, M. Sakaguchi, 2002, Biochemistry.

Manipulation of membrane protein topology on the endoplasmic reticulum by a specific ligand in living cells.

S. Ikushiro, M. Sakaguchi, Y. Kida, 2005, Journal of biochemistry.

Human interferon‐γ lacking 23 COOH‐terminal amino acids is biologically active

O. Nishimura, M. Sakaguchi, S. Honda, 1988 .

Signal recognition particle is required for co-translational insertion of cytochrome P-450 into microsomal membranes.

K. Mihara, M. Sakaguchi, R. Sato, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Tail-extension following the termination codon is critical for release of the nascent chain from membrane-bound ribosomes in a reticulocyte lysate cell-free system.

M. Sakaguchi, Haruka Sakaue, Michiyo Takahara, 2013, Biochemical and biophysical research communications.

Membrane topogenesis of the three amino-terminal transmembrane segments of glucose-6-phosphatase on endoplasmic reticulum.

N. Hamasaki, K. Mihara, M. Sakaguchi, 2002, Biochemical and biophysical research communications.

Membrane perturbing factor in reticulocyte lysate, which is transiently activated by proteases

K. Mihara, M. Sakaguchi, K. Ota, 1999, FEBS letters.

Membrane topology of NADPH-cytochrome P450 reductase on the endoplasmic reticulum.

K. Mihara, M. Sakaguchi, S. Ohgiya, 1998, Archives of biochemistry and biophysics.

Microsomal p450s use specific proline-rich sequences for efficient folding, but not for maintenance of the folded structure.

M. Waterman, N. Kagawa, M. Sakaguchi, 2001, Journal of biochemistry.

Importance of a proline-rich sequence in the amino-terminal region for correct folding of mitochondrial and soluble microbial p450s.

M. Waterman, N. Kagawa, M. Sakaguchi, 2001, Journal of biochemistry.

Both amino- and carboxy-terminal portions are required for insertion of yeast porin into the outer mitochondrial membrane.

K. Mihara, M. Sakaguchi, R. Sato, 1988, Journal of biochemistry.

Cytoplasmic chaperones determine the targeting pathway of precursor proteins to mitochondria.

K. Mihara, M. Sakaguchi, T. Komiya, 1996, The EMBO journal.

Role of Pex19p in the targeting of PMP70 to peroxisome.

H. Kato, R. Wanders, N. Shimozawa, 2005, Biochimica et biophysica acta.

MSF, a novel cytoplasmic chaperone which functions in precursor targeting to mitochondria.

K. Mihara, M. Sakaguchi, T. Omura, 1994, The EMBO journal.

Human ABC transporter isoform B6 (ABCB6) localizes primarily in the Golgi apparatus.

M. Sakaguchi, Y. Emi, Y. Kida, 2008, Biochemical and biophysical research communications.

Membrane Topology of Alzheimer’s Disease-related Presenilin 1

Toshiki Nakai, Masao Sakaguchi, Kenji Kosaka, 1999, The Journal of Biological Chemistry.

Membrane Topogenesis of a Type I Signal-Anchor Protein, Mouse Synaptotagmin Ii, on the Endoplasmic Reticulum

K. Mikoshiba, M. Fukuda, K. Mihara, 2000, The Journal of cell biology.

Eukaryotic protein secretion.

M. Sakaguchi, M Sakaguchi, 1997, Current opinion in biotechnology.

The N-terminal motif of PMP70 suppresses cotranslational targeting to the endoplasmic reticulum.

M. Sakaguchi, Haruka Sakaue, Y. Kida, 2016, Journal of biochemistry.

Multiple organelle-targeting signals in the N-terminal portion of peroxisomal membrane protein PMP70.

M. Sakaguchi, M. Komori, Y. Kashiwayama, 2010, Journal of biochemistry.

Role of Pex 19 p in the targeting of PMP 70 to peroxisome

H. Kato, R. Wanders, N. Shimozawa, 2005 .

Topological Rules for Membrane Protein Assembly in Eukaryotic Cells*

G von Heijne, G. von Heijne, H. Andersson, 1997, The Journal of Biological Chemistry.

Involvement of a di-leucine motif in targeting of ABCC1 to the basolateral plasma membrane of polarized epithelial cells.

M. Sakaguchi, Y. Emi, Y. Harada, 2013, Biochemical and biophysical research communications.

Phosphatidylserine-binding protein lactadherin inhibits protein translocation across the ER membrane.

Hitoshi Yamamoto, M. Sakaguchi, Y. Kida, 2013, Biochemical and biophysical research communications.

Pleiotropic effects of membrane cholesterol upon translocation of protein across the endoplasmic reticulum membrane.

Hitoshi Yamamoto, M. Sakaguchi, Hidenobu Fujita, 2012, Biochemistry.

Two translocating hydrophilic segments of a nascent chain span the ER membrane during multispanning protein topogenesis

M. Sakaguchi, Y. Kida, Fumiko Morimoto, 2007, The Journal of cell biology.

Function of Positive Charges Following Signal-Anchor Sequences during Translocation of the N-terminal Domain*

Masao Sakaguchi, Yuichiro Kida, K. Mihara, 2006, Journal of Biological Chemistry.

Switching the sorting mode of membrane proteins from cotranslational endoplasmic reticulum targeting to posttranslational mitochondrial import.

K. Mihara, M. Sakaguchi, Y. Kida, 2005, Molecular biology of the cell.

Autonomous and heteronomous positioning of transmembrane segments in multispanning membrane protein.

M. Sakaguchi, 2002, Biochemical and biophysical research communications.

NHE6 Protein Possesses a Signal Peptide Destined for Endoplasmic Reticulum Membrane and Localizes in Secretory Organelles of the Cell*

K. Mihara, M. Sakaguchi, M. Shigekawa, 2001, The Journal of Biological Chemistry.

Characterization of the Signal That Directs Tom20 to the Mitochondrial Outer Membrane

K. Mihara, M. Sakaguchi, S. Kanaji, 2000, The Journal of cell biology.

A cis-acting five-amino-acid motif controls targeting of ABCC2 to the apical plasma membrane domain

M. Sakaguchi, Y. Emi, Y. Yasuda, 2012, Journal of Cell Science.

ATP-binding cassette transporter isoform C2 localizes to the apical plasma membrane via interactions with scaffolding protein.

S. Nomura, M. Sakaguchi, H. Yokota, 2011, Journal of biochemistry.

Topogenesis of NHE1: direct insertion of the membrane loop and sequestration of cryptic glycosylation and processing sites just after TM9.

Yoko Sato, K. Mihara, M. Sakaguchi, 2004, Biochemical and biophysical research communications.

Topogenesis of Two Transmembrane Type K+ Channels, Kir 2.1 and KcsA*

Yoko Sato, T. Utsumi, N. Uozumi, 2003, Journal of Biological Chemistry.

Forced transmembrane orientation of hydrophilic polypeptide segments in multispanning membrane proteins.

G von Heijne, G. von Heijne, G. Heijne, 1998, Molecular cell.

The N-terminal Region of the Transmembrane Domain of Human Erythrocyte Band 3

M. Tanner, N. Hamasaki, M. Sakaguchi, 2003, The Journal of Biological Chemistry.

Membrane Integration of the Second Transmembrane Segment of Band 3 Requires a Closely Apposed Preceding Signal-anchor Sequence*

K. Ota, K. Mihara, M. Sakaguchi, 2000, The Journal of Biological Chemistry.

Evidence in support of a four transmembrane-pore-transmembrane topology model for the Arabidopsis thaliana Na+/K+ translocating AtHKT1 protein, a member of the superfamily of K+ transporters

Yoko Sato, N. Uozumi, M. Sakaguchi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Ontogenic isoform switching of UDP-glucuronosyltransferase family 1 in rat liver.

T. Iyanagi, S. Ikushiro, M. Sakaguchi, 2008, Biochemical and biophysical research communications.

Systematic analysis of stop-transfer sequence for microsomal membrane.

K. Mihara, T. Kuroiwa, M. Sakaguchi, 1991, The Journal of biological chemistry.

Characterization of signal that directs C-tail-anchored proteins to mammalian mitochondrial outer membrane.

K. Mihara, M. Sakaguchi, Chika Horie, 2002, Molecular biology of the cell.

Membrane-embedded C-terminal Segment of Rat Mitochondrial TOM40 Constitutes Protein-conducting Pore with Enriched β-Structure*

Masao Sakaguchi, Tomoko Kadowaki, Maki Maeda, 2004, Journal of Biological Chemistry.

Targeting and Assembly of Rat Mitochondrial Translocase of Outer Membrane 22 (TOM22) into the TOM Complex*

K. Mihara, M. Sakaguchi, Yasuhiko Nakamura, 2004, Journal of Biological Chemistry.

A few positively charged residues slow movement of a polypeptide chain across the endoplasmic reticulum membrane.

M. Sakaguchi, Kenta Imai, Hidenobu Fujita, 2014, Biochemistry.

Interaction mapping of the Sec61 translocon identifies two Sec61α regions interacting with hydrophobic segments in translocating chains

M. Sakaguchi, Y. Kida, 2018, The Journal of Biological Chemistry.

Stability and flexibility of marginally hydrophobic–segment stalling at the endoplasmic reticulum translocon

M. Sakaguchi, Hidenobu Fujita, Y. Kida, 2016, Molecular biology of the cell.

Membrane translocation of lumenal domains of membrane proteins powered by downstream transmembrane sequences

M. Sakaguchi, Y. Kida, Fumiko Morimoto, 2013, Molecular biology of the cell.

Stop-and-move of a marginally hydrophobic segment translocating across the endoplasmic reticulum membrane.

M. Sakaguchi, Kenta Imai, Hidenobu Fujita, 2013, Journal of molecular biology.

cDNA cloning and characterization of mitochondrial import stimulation factor (MSF) purified from rat liver cytosol.

S. Kawabata, K. Mihara, M. Sakaguchi, 1994, Journal of biochemistry.

Recognition of mitochondria-targeting signals by a cytosolic import stimulation factor, MSF.

K. Mihara, M. Sakaguchi, T. Omura, 1994, The Journal of biological chemistry.

A short amino‐terminal segment of microsomal cytochrome P‐450 functions both as an insertion signal and as a stop‐transfer sequence.

K. Mihara, M. Sakaguchi, R. Sato, 1987, The EMBO journal.

Characterization of the initial steps of precursor import into rat liver mitoplasts.

A. Ito, K. Mihara, M. Sakaguchi, 1998, Journal of Biochemistry (Tokyo).

Integration of Shaker-type K+ channel, KAT1, into the endoplasmic reticulum membrane: Synergistic insertion of voltage-sensing segments, S3–S4, and independent insertion of pore-forming segments, S5–P–S6

Yoko Sato, N. Uozumi, M. Sakaguchi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Mitochondrial porin can be translocated across both endoplasmic reticulum and mitochondrial membranes.

K. Mihara, M. Sakaguchi, T. Omura, 1992, Journal of biochemistry.

Environmental Transition of Signal-Anchor Sequences during Membrane Insertion via the Endoplasmic Reticulum Translocon

M. Sakaguchi, Y. Kida, M. Hirano, 2010, Molecular biology of the cell.

Contribution of hydrophobic and electrostatic interactions to the membrane integration of the Shaker K+ channel voltage sensor domain

G. von Heijne, T. Hessa, Yoko Sato, 2007, Proceedings of the National Academy of Sciences.

Positive charges on the translocating polypeptide chain arrest movement through the translocon

M. Sakaguchi, Hidenobu Fujita, Y. Kida, 2011, Journal of Cell Science.

A sugar chain at a specific position in the nascent polypeptide chain induces forward movement during translocation through the translocon.

M. Sakaguchi, Hidenobu Fujita, Y. Kida, 2011, Journal of biochemistry.

Positive Charges of Translocating Polypeptide Chain Retrieve an Upstream Marginal Hydrophobic Segment from the Endoplasmic Reticulum Lumen to the Translocon

M. Hagiwara, M. Sakaguchi, Hidenobu Fujita, 2010, Molecular biology of the cell.

Signal Anchor Sequence Provides Motive Force for Polypeptide Chain Translocation through the Endoplasmic Reticulum Membrane*

M. Sakaguchi, Y. Kida, Fumiko Morimoto, 2009, Journal of Biological Chemistry.

Sendai virus-based production of HIV type 1 subtype B and subtype E envelope glycoprotein 120 antigens and their use for highly sensitive detection of subtype-specific serum antibodies.

H. Sato, S. Oka, Y. Takebe, 1999, AIDS research and human retroviruses.

Topogenic properties of transmembrane segments of Arabidopsis thaliana NHX1 reveal a common topology model of the Na+/H+ exchanger family.

Yoko Sato, M. Sakaguchi, 2005, Journal of biochemistry.