D. Zechel

发表

Glycosidase Mechanisms: Anatomy of a Finely Tuned Catalyst

S. Withers, D. Zechel, 2000 .

An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products

Michael A. Skinnider, Lian Yang, Chad W. Johnston, 2015, Nature Communications.

Characterization of covalently bonded proteins on poly(methyl methacrylate) by X-ray photoelectron spectroscopy.

Shu-mei He, J. Horton, Geoffrey W. Nelson, 2010, Colloids and surfaces. B, Biointerfaces.

A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene.

D. Zechel, Gerard D. Wright, M. Thaker, 2013, Chemistry & biology.

C-H Bond Cleavage Is Rate-Limiting for Oxidative C-P Bond Cleavage by the Mixed Valence Diiron-Dependent Oxygenase PhnZ.

D. Zechel, F. Hammerschmidt, Simanga R. Gama, 2019, Biochemistry.

Enzymatic Strategies for the Catabolism of Organophosphonates

D. Zechel, Siddhesh S. Kamat, Abinaya Rajendran, 2020 .

An Oxidative Pathway for Microbial Utilization of Methylphosphonic Acid as a Phosphate Source.

D. Zechel, F. Hammerschmidt, M. Vogt, 2019, ACS chemical biology.

Understanding how diverse beta-mannanases recognize heterogeneous substrates.

Keith S Wilson, David L Zechel, T. Borchert, 2009, Biochemistry.

Crystal Structure of PhnH: an Essential Component of Carbon-Phosphorus Lyase in Escherichia coli

Shu-mei He, Z. Jia, D. Zechel, 2007, Journal of bacteriology.

Structure and mechanism of PhnP, a phosphodiesterase of the carbon-phosphorus lyase pathway.

Shu-mei He, Z. Jia, D. Zechel, 2011, Biochemistry.

Antitumor compounds from Streptomyces sp. KML-2, isolated from Khewra salt mines, Pakistan

D. Zechel, Usman Aftab, I. Sajid, 2015, Biological Research.

Five phosphonate operon gene products as components of a multi-subunit complex of the carbon-phosphorus lyase pathway

J. Stougaard, D. Zechel, B. Hove-Jensen, 2011, Proceedings of the National Academy of Sciences.

The E358S mutant of Agrobacterium sp. β‐glucosidase is a greatly improved glycosynthase

S. Withers, D. Zechel, R. Warren, 2000, FEBS letters.

Substrate distortion by a beta-mannanase: snapshots of the Michaelis and covalent-intermediate complexes suggest a B(2,5) conformation for the transition state.

S. Withers, D. Stoll, G. Murshudov, 2002, Angewandte Chemie.

Crystal structure of PhnZ in complex with substrate reveals a di-iron oxygenase mechanism for catabolism of organophosphonates

P. B. Wyatt, Z. Jia, D. Zechel, 2014, Proceedings of the National Academy of Sciences.

A fluorescent substrate for carbon-phosphorus lyase: towards the pathway for organophosphonate metabolism in bacteria.

Shu-mei He, D. Zechel, B. Hove-Jensen, 2009, Bioorganic & medicinal chemistry letters.

Accumulation of Intermediates of the Carbon-Phosphorus Lyase Pathway for Phosphonate Degradation in phn Mutants of Escherichia coli

M. Willemoës, D. Zechel, B. Hove-Jensen, 2009, Journal of bacteriology.

PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond.

P. B. Wyatt, E. Delong, D. Zechel, 2012, Journal of the American Chemical Society.

Expression, purification and preliminary diffraction studies of PhnP.

Shu-mei He, Z. Jia, D. Zechel, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

New WS9326A Derivatives and One New Annimycin Derivative with Antimalarial Activity are Produced by Streptomyces asterosporus DSM 41452 and Its Mutant

D. Zechel, A. Bechthold, R. Eastman, 2018, Chembiochem : a European journal of chemical biology.

Phosphonate Biochemistry.

D. Zechel, Geoff P. Horsman, 2017, Chemical reviews.

Expression, purification and preliminary X-ray diffraction studies of RebC.

Z. Jia, D. Zechel, L. V. van Staalduinen, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Changing Biosynthetic Profiles by Expressing bldA in Streptomyces Strains

R. Murillo, D. Zechel, A. Bechthold, 2015, Chembiochem : a European journal of chemical biology.

β-Mannosynthase: Synthesis ofβ-Mannosides with a Mutantβ-Mannosidase

S. Withers, D. Stoll, D. Zechel, 2001 .

-Mannosynthase: Synthesis of -Mannosides with a Mutant -Mannosidase

S. Withers, D. Stoll, D. Zechel, 2001 .

β-Mannosynthase: Synthesis of β-Mannosides with a Mutant β-Mannosidase.

S. Withers, D. Stoll, D. Zechel, 2001, Angewandte Chemie.

Identification of Glu-120 as the catalytic nucleophile in Streptomyces lividans endoglucanase celB.

S. Withers, D. Zechel, S. He, 1998, The Biochemical journal.

Catabolism and Detoxification of 1-Aminoalkylphosphonic Acids: N-Acetylation by the phnO Gene Product

D. Zechel, B. Hove-Jensen, Fern R. McSorley, 2012, PloS one.

PhnK: Another Piece of the Carbon-Phosphorus Lyase Puzzle.

D. Zechel, 2016, Structure.

Physiological role of phnP-specified phosphoribosyl cyclic phosphodiesterase in catabolism of organophosphonic acids by the carbon-phosphorus lyase pathway.

D. Zechel, B. Hove-Jensen, Fern R. McSorley, 2011, Journal of the American Chemical Society.

Enzymatic synthesis of carbon-fluorine bonds.

S. Withers, D. Stoll, C. Mayer, 2001, Journal of the American Chemical Society.

Glycosidase mechanisms: anatomy of a finely tuned catalyst.

S. Withers, D. Zechel, David L. Zechel and, 1999, Accounts of chemical research.

Antitumor compounds from Streptomyces sp. KML-2, isolated from Khewra salt mines, Pakistan

D. Zechel, Usman Aftab, I. Sajid, 2015, Biological Research.

A concise synthesis of α-D-ribofuranosyl alkylphosphonates Putative substrate intermediates for the carbonphosphorous lyase system

D. Zechel, Yan Luo, 2006 .

Synthesis, structural characterization, electrochemical properties and polymerization behaviour of the first silicon-bridged [1.1]ferrocenophane [{Fe(η-C5H4)2SiMe2}2]

I. Manners, D. Zechel, A. Rheingold, 1995 .

Thermal and Transition-Metal-Catalyzed Ring-Opening Polymerization (ROP) of [1]Silaferrocenophanes with Chlorine Substituents at Silicon: A Route to Tunable Poly(ferrocenylsilanes)

I. Manners, D. Zechel, K. Hultzsch, 1996 .

Rational design of hybrid natural products by utilizing the promiscuity of an amide synthetase.

D. Zechel, A. Bechthold, T. Paululat, 2019, ACS chemical biology.

Methylphosphonic Acid Biosynthesis and Catabolism in Pelagic Archaea and Bacteria.

D. Zechel, B. Hove-Jensen, Siddhesh S. Kamat, 2018, Methods in enzymology.

Biosynthesis of the Fungal Organophosphonate Fosfonochlorin Involves an Iron(II) and 2‐(Oxo)glutarate Dependent Oxacyclase

D. Zechel, D. Beauchemin, F. Hammerschmidt, 2021, Chembiochem : a European journal of chemical biology.

Oxidative carbon backbone rearrangement in rishirilide biosynthesis.

D. Zechel, A. Bechthold, O. Tsypik, 2020, Journal of the American Chemical Society.

Rebeccamycin and Staurosporine Biosynthesis: Insight into the Mechanisms of the Flavin‐Dependent Monooxygenases RebC and StaC

D. Zechel, K. Groom, Anupam Bhattacharya , 2011, Chembiochem : a European journal of chemical biology.

Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA‐Specified Leu‐tRNAUUA Molecule

J. Feldmann, D. Zechel, Gerard D. Wright, 2015, Chembiochem : a European journal of chemical biology.

Direct observation of the protonation state of an imino sugar glycosidase inhibitor upon binding.

David L Zechel, Annabelle Varrot, S. Withers, 2003, Journal of the American Chemical Society.

Iminosugar glycosidase inhibitors: structural and thermodynamic dissection of the binding of isofagomine and 1-deoxynojirimycin to beta-glucosidases.

David L Zechel, G. Davies, A. Boraston, 2003, Journal of the American Chemical Society.

Glycosidase inhibition: an assessment of the binding of 18 putative transition-state mimics.

David Zechel, A. Vasella, G. Davies, 2007, Journal of the American Chemical Society.

Role of Two Exceptional trans Adenylation Domains and MbtH‐like Proteins in the Biosynthesis of the Nonribosomal Peptide WS9324A from Streptomyces calvus ATCC 13382

D. Zechel, A. Bechthold, S. Berman, 2020, Chembiochem : a European journal of chemical biology.

5.12 – Glycosyl Transferase Mechanisms

S. Withers, D. Zechel, 1999 .

Mapping the conformational itinerary of β-glycosidases by X-ray crystallography

G. Davies, A. Varrot, D. Zechel, 2003 .

Secondary nucleotide messenger c-di-GMP exerts a global control on natural product biosynthesis in streptomycetes

D. Zechel, A. Bechthold, O. Tsypik, 2020, Nucleic acids research.

Understanding How Diverse -Mannanases Recognise Heterogeneous Substrates.

Keith S. Wilson, Torben Vedel Borchert, Harry J. Gilbert, 2009 .

Chloramphenicol biosynthesis: the structure of CmlS, a flavin-dependent halogenase showing a covalent flavin-aspartate bond.

Z. Jia, D. Zechel, L. Vining, 2010, Journal of molecular biology.

Anatomy of glycosynthesis: structure and kinetics of the Humicola insolens Cel7B E197A and E197S glycosynthase mutants.

S. Withers, A. Brzozowski, G. Davies, 2004, Chemistry & biology.

Mechanism, mutagenesis, and chemical rescue of a beta-mannosidase from cellulomonas fimi.

S. Withers, D. Stoll, D. Zechel, 2003, Biochemistry.

Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis.

S. Withers, H. Gilbert, G. Davies, 2009, Chemical communications.

Utilization of Glyphosate as Phosphate Source: Biochemistry and Genetics of Bacterial Carbon-Phosphorus Lyase

D. Zechel, B. Hove-Jensen, B. Jochimsen, 2014, Microbiology and Molecular Reviews.

Biological Control of Potato Common Scab With Rare Isatropolone C Compound Produced by Plant Growth Promoting Streptomyces A1RT

D. Zechel, A. Bechthold, Z. Latif, 2018, Front. Microbiol..

Pre-steady state kinetic analysis of an enzymatic reaction monitored by time-resolved electrospray ionization mass spectrometry.

D J Douglas, D. J. Douglas, S. Withers, 1998, Biochemistry.

The functional importance of bacterial oxidative phosphonate pathways.

D. Zechel, K. Pallitsch, 2023, Biochemical Society transactions.

Mapping the conformational itinerary of beta-glycosidases by X-ray crystallography.

G. Davies, A. Varrot, D. Zechel, 2003, Biochemical Society transactions.

Dissection of nucleophilic and acid-base catalysis in glycosidases.

S. Withers, D. Zechel, S G Withers, 2001, Current opinion in chemical biology.

Rational design of an aryl-C-glycoside catalyst from a natural product O-glycosyltransferase.

S. Günther, D. Zechel, A. Bechthold, 2011, Chemistry & biology.

Structure and Kinetic Investigation of Streptococcus pyogenes Family GH38 α-Mannosidase

H. Gilbert, G. Davies, D. Zechel, 2010, PloS one.

Discovery of 3'-O-β-Glucosyltubercidin and the Nucleoside Specific Glycosyltransferase AvpGT through Genome Mining.

Marcy J. Balunas, D. Zechel, A. Pasternak, 2022, ACS chemical biology.

Identification of Genes Essential for Sulfamate and Fluorine Incorporation During Nucleocidin Biosynthesis

D. Zechel, A. Bechthold, A. Pasternak, 2022, Chembiochem : a European journal of chemical biology.

Genome mining reveals the origin of a bald phenotype and a cryptic nucleocidin gene cluster in Streptomyces asterosporus DSM 41452.

S. Günther, D. Zechel, A. Bechthold, 2019, Journal of biotechnology.

Combinatorial Approaches To Novel Proteins

Andreas Plückthun, Tomoaki Matsuura, Andreas Ernst, 2004, Chembiochem : a European journal of chemical biology.

Structure of PhnP, a Phosphodiesterase of the Carbon-Phosphorus Lyase Pathway for Phosphonate Degradation*

Shu-mei He, Z. Jia, A. Yakunin, 2009, The Journal of Biological Chemistry.