Christian C. Lee

发表

An approach to rapid protein crystallization using nanodroplets

Earl W. Cornell, Peter G. Schultz, D. Scheibe, 2002 .

A general strategy for creating "inactive-conformation" abl inhibitors.

Taebo Sim, Yi Liu, Yongping Xie, 2006, Chemistry & biology.

A general strategy for creating

M. Warmuth, N. Gray, G. Spraggon, 2006 .

The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer.

Makoto Nishio, Peter McNamara, Ryohei Katayama, 2014, Cancer discovery.

Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology.

Laura J. Kingsley, S. Bender, M. Vaillancourt, 2021, Journal of medicinal chemistry.

Synthetic, structural mimetics of the β-hairpin flap of HIV-1 protease inhibit enzyme function.

J. DeStefano, E. Freire, S. Fletcher, 2015, Bioorganic & medicinal chemistry.

Cationic Metallatricarbadecaboranyl Analogues of Metallocene Antitumor Agents: Synthesis, Structure, and Antineoplastic Activity of [1‐(η5‐C5H5)Fe‐2‐Me‐2,3,4‐C3B7H9]+[X]− Salts (X− = AsF 6−, SbF 6−)

L. Sneddon, Christian C. Lee, P. Carroll, 1997 .

Cytotoxicity of Metallic Complexes of Furan Oximes in Murine and Human Tissue Cultured Cell Lines

Christian C. Lee, G. Ibrahim, I. Hall, 1999 .

A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function.

M. Warmuth, T. Wiltshire, M. Cooke, 2009, Molecular cell.

How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase?

Tatyana G. Karabencheva, R. Donev, Christian C. Lee, 2014, Molecular bioSystems.

Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.

Glen Spraggon, Scott A Lesley, Nanxin Li, 2010, The Biochemical journal.

Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2.

J. Caldwell, N. Gray, T. Honda, 2006, Bioorganic & medicinal chemistry letters.

Efficacy and Tolerability of Pyrazolo[1,5-a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma.

Nanxin Li, J. Shaffer, S. Kasibhatla, 2020, ACS medicinal chemistry letters.

Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors.

Sungjoon Kim, Nanxin Li, Christian C. Lee, 2016, Bioorganic & Medicinal Chemistry Letters.

Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2

Sungjoon Kim, Nanxin Li, M. Warmuth, 2013, Journal of medicinal chemistry.

Discovery of selective aminothiazole aurora kinase inhibitors.

N. Gray, J. Chang, A. Musacchio, 2008, ACS chemical biology.

Crystal structure of the human neuropilin-1 b1 domain.

G. Spraggon, A. Kreusch, D. Mcmullan, 2003, Structure.

Crystal structure of the type III effector AvrB from Pseudomonas syringae.

F. Katagiri, P. Luginbühl, G. Spraggon, 2004, Structure.

Discovery and profiling of a selective and efficacious Syk inhibitor.

Eric Vangrevelinghe, E. Vangrevelinghe, Christian C. Lee, 2015, Journal of medicinal chemistry.

Crystal structure of an Udp‐n‐acetylmuramate‐alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 Å resolution

Mitchell D. Miller, A. Godzik, A. Deacon, 2004, Proteins.

Divalent cations slow activation of EAG family K+ channels through direct binding to S4.

T. Jegla, Christian C. Lee, B. Bursulaya, 2009, Biophysical journal.

Syk inhibitors with high potency in presence of blood.

Jianwei Che, E. Vangrevelinghe, Christian C. Lee, 2014, Bioorganic & medicinal chemistry letters.

Structure analysis of peptide deformylases from Streptococcus pneumoniae, Staphylococcus aureus, Thermotoga maritima and Pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase.

G. Spraggon, S. Lesley, A. Kreusch, 2003, Journal of molecular biology.

Orally bioavailable Syk inhibitors with activity in a rat PK/PD model.

E. Vangrevelinghe, Christian C. Lee, G. Thoma, 2015, Bioorganic & medicinal chemistry letters.

Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.

Sungjoon Kim, Nanxin Li, Jennifer L. Harris, 2010, The Biochemical journal.

A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function.

M. Warmuth, T. Wiltshire, M. Cooke, 2009, Molecular cell.

Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3-d]pyrimidine RET Inhibitors.

Nanxin Li, J. Shaffer, S. Kasibhatla, 2021, ACS medicinal chemistry letters.