P. Hariharan

发表

Complete cysteine-scanning mutagenesis of the Salmonella typhimurium melibiose permease

L. Guan, Kelsey J Markham, E. Tikhonova, 2021, The Journal of biological chemistry.

X-ray crystallography reveals molecular recognition mechanism for sugar binding in a melibiose transporter MelB

L. Guan, P. Hariharan, 2021, Communications Biology.

Molecular recognition of sugar binding in a melibiose transporter MelB by X-ray crystallography

L. Guan, P. Hariharan, 2020, bioRxiv.

Cooperative binding ensures the obligatory melibiose/Na+ cotransport in MelB

L. Guan, P. Hariharan, 2021, The Journal of general physiology.

Insights into the Inhibitory Mechanisms of the Regulatory Protein IIAGlc on Melibiose Permease Activity*

L. Guan, P. Hariharan, 2014, The Journal of Biological Chemistry.

Diastereomeric Cyclopentane-Based Maltosides (CPMs) as Tools for Membrane Protein Study.

P. S. Chae, B. Kobilka, B. Byrne, 2020, Journal of the American Chemical Society.

Lipid bilayer-assisted release of an enediyne antibiotic from neocarzinostatin chromoprotein.

S. Chou, P. Hariharan, D. Chin, 2010, Biochemistry.

Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAGlc

H. Kaback, L. Guan, P. Hariharan, 2015, Proceedings of the National Academy of Sciences.

Effect of Detergents on Galactoside Binding by Melibiose Permeases.

P. S. Chae, L. Guan, P. Hariharan, 2015, Biochemistry.

Self-assembly behaviors and application of terphenyl-cored trimaltosides for membrane protein study: Impact of detergent hydrophobic group geometry on protein stability.

P. S. Chae, G. Skiniotis, B. Kobilka, 2019, Chemistry.

Maltose-bis(hydroxymethyl)phenol (MBPs) and Maltose-tris(hydroxymethyl)phenol (MTPs) Amphiphiles for Membrane Protein Stability.

P. S. Chae, B. Kobilka, B. Byrne, 2021, ACS chemical biology.

Conformationally restricted monosaccharide-cored glycoside amphiphiles: the effect of detergent head group variation on membrane protein stability.

P. S. Chae, B. Kobilka, Aiman Sadaf, 2019, ACS chemical biology.

Asymmetric maltose neopentyl glycol amphiphiles for a membrane protein study: effect of detergent asymmetricity on protein stability† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02560f

P. S. Chae, B. Kobilka, K. K. Kumar, 2018, Chemical science.

Steroid‐Based Amphiphiles for Membrane Protein Study: The Importance of Alkyl Spacers for Protein Stability

P. S. Chae, B. Kobilka, B. Byrne, 2018, Chembiochem : a European journal of chemical biology.

Vitamin E-based glycoside amphiphiles for membrane protein structural studies.

P. S. Chae, G. Skiniotis, B. Kobilka, 2018, Organic & biomolecular chemistry.

Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc03700g

P. S. Chae, G. Skiniotis, B. Kobilka, 2017, Chemical science.

New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies.

P. S. Chae, G. Skiniotis, B. Kobilka, 2017, The Analyst.

A transcription blocker isolated from a designed repeat protein combinatorial library by in vivo functional screen

A. S. Ethayathulla, L. Guan, E. Tikhonova, 2015, Scientific Reports.

Thermodynamic cooperativity of cosubstrate binding and cation selectivity of Salmonella typhimurium MelB

L. Guan, P. Hariharan, 2017, The Journal of general physiology.

3,4-Bis(hydroxymethyl)hexane-1,6-diol-based maltosides (HDMs) for membrane-protein study: Importance of detergent rigidity-flexibility balance in protein stability.

P. S. Chae, B. Byrne, C. Loland, 2022, Chemistry, an Asian journal.

FEATHER - A POTENTIAL SOURCE FOR REENTRY OF ENROFLOXACIN AND ITS METABOLITE CIPROFLOXACIN RESIDUES IN FOOD CHAIN

P. Hariharan, S. Vairamuthu, P. Thejomoorthy, 2014 .

Structural and functional characterization of protein–lipid interactions of the Salmonella typhimurium melibiose transporter MelB

J. Brouwers, M. Bogdanov, W. Dowhan, 2018, BMC Biology.

Molecular basis for the cation selectivity of Salmonella typhimurium melibiose permease.

L. Guan, P. Hariharan, Satoshi Katsube, 2022, Journal of molecular biology.

Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study.

P. S. Chae, B. Kobilka, B. Byrne, 2019, Chemistry, an Asian journal.

Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy

P. S. Chae, B. Kobilka, B. Byrne, 2018, Chembiochem : a European journal of chemical biology.

A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability.

P. S. Chae, B. Kobilka, B. Byrne, 2018, The Analyst.

Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties.

P. S. Chae, G. Skiniotis, B. Kobilka, 2017, Journal of the American Chemical Society.

Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc02981g Click here for additional data file.

P. S. Chae, B. Kobilka, B. Byrne, 2016, Chemical science.

Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation.

P. S. Chae, B. Kobilka, Kyung Ho Cho, 2015, Chemistry.

A class of rigid linker-bearing glucosides for membrane protein structural study

P. S. Chae, Aiman Sadaf, B. Byrne, 2015, Chemical science.

permease activity on melibiose Glc the regulatory protein IIA Insights into the inhibitory mechanisms of

L. Guan, P. Hariharan, 2014 .

In vivo and in vitro characterizations of melibiose permease (MelB) conformation-dependent nanobodies reveal sugar-binding mechanisms

E. Pardon, J. Steyaert, H. Kaback, 2023, The Journal of biological chemistry.

Thermodynamics of Nanobody Binding to Lactose Permease.

E. Pardon, J. Steyaert, H. Kaback, 2016, Biochemistry.

A New Model for Ligand Release

S. Chou, P. Hariharan, D. Chin, 2006, Journal of Biological Chemistry.

Substrate-binding guides individual melibiose permeases MelB to structurally soften and to destabilize cytoplasmic middle-loop C3.

D. Müller, L. Guan, P. Hariharan, 2022, Structure.

Potential modulation on P-glycoprotein and CYP3A by soymilk and miso: in vivo and ex-vivo studies.

P. Hariharan, Y. Hsieh, Y. Hou, 2014, Food chemistry.

Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy.

P. S. Chae, B. Kobilka, Kyung Ho Cho, 2016, Chemistry.

Mimicking the regulatory state of a major facilitator superfamily sugar transporter

E. Pardon, J. Steyaert, H. Kaback, 2023 .

Insights into the Inhibitory Mechanisms of the Regulatory Protein IIAGlc on Melibiose Permease Activity*

L. Guan, P. Hariharan, 2014, The Journal of Biological Chemistry.

Thermodynamics of Nanobody Binding to Lactose Permease.

E. Pardon, J. Steyaert, H. Kaback, 2016, Biochemistry.

Tandem malonate-based glucosides (TMGs) for membrane protein structural studies

P. S. Chae, B. Kobilka, B. Byrne, 2017, Scientific Reports.

Tris(hydroxymethyl)aminomethane Linker-Bearing Triazine-Based Triglucosides for Solubilization and Stabilization of Membrane Proteins

P. S. Chae, B. Byrne, C. Loland, 2023, Bioconjugate chemistry.

P. S. Chae, B. Kobilka, K. K. Kumar, 2018, Chemical science.

Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter‐Alkyl‐Chain Distance and Alkyl Chain Length

P. S. Chae, B. Kobilka, Kyung Ho Cho, 2016, Chembiochem : a European journal of chemical biology.

Structure, function, and ion-binding properties of a K+ channel stabilized in the 2,4-ion–bound configuration

L. Guan, P. Hariharan, L. G. Cuello, 2019, Proceedings of the National Academy of Sciences.