C. Dempsey

发表

Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices.

D. Engelman, B. Bormann, J. Hunt, 1992, The Journal of biological chemistry.

Structure, location, and lipid perturbations of melittin at the membrane interface.

S. White, K. Hristova, C. Dempsey, 2001, Biophysical journal.

The interaction of guanidinium ions with a model peptide.

J. Brady, C. Dempsey, John W Brady, 2007, Biophysical journal.

Erythromycin block of the HERG K+ channel: accessibility to F656 and Y652.

J. Hancox, H. Witchel, C. Dempsey, 2006, Biochemical and biophysical research communications.

Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant

C. Du, J. Hancox, C. Dempsey, 2021, Cellular and molecular life sciences : CMLS.

Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker

C. Du, J. Hancox, C. Dempsey, 2018, The Journal of Biological Chemistry.

An exploration of interactions between the antiarrhythmic drug dronedarone and hERG potassium channel pore

Charlotte K. Colenso, J. Hancox, C. Dempsey, 2018, Journal of Integrative Cardiology Open Access.

The Basis for Low-affinity hERG Potassium Channel Block by Sotalol

Yi H. Zhang, J. Hancox, C. Dempsey, 2017, Journal of pharmacology & pharmacotherapeutics.

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

Charlotte K. Colenso, J. Hancox, H. Witchel, 2016, Biochemical pharmacology.

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

J. Hancox, C. Dempsey, A. El Harchi, 2015, Journal of molecular and cellular cardiology.

Ranolazine inhibition of hERG potassium channels: Drug–pore interactions and reduced potency against inactivation mutants

C. Du, J. Hancox, C. Dempsey, 2014, Journal of molecular and cellular cardiology.

Molecular determinants of hERG potassium channel inhibition by disopyramide.

Yi H. Zhang, J. Hancox, C. Dempsey, 2012, Journal of molecular and cellular cardiology.

The Low-Potency, Voltage-Dependent HERG Blocker Propafenone—Molecular Determinants and Drug Trapping

Jules C Hancox, Richard B Sessions, Harry J Witchel, 2004, Molecular Pharmacology.

An Update on the Structure of hERG

J. Hancox, C. Dempsey, Yihong Zhang, 2020, Frontiers in Pharmacology.

Origin of Low Mammalian Cell Toxicity in a Class of Highly Active Antimicrobial Amphipathic Helical Peptides*

C. Dempsey, R. Howe, T. Walsh, 2008, Journal of Biological Chemistry.

Evidence from deuterium nuclear magnetic resonance for the temperature-dependent reversible self-association of erythrocyte band 3 in dimyristoylphosphatidylcholine bilayers.

N. Ryba, A. Watts, C. Dempsey, 1986, Biochemistry.

Nanometer-scale ion aggregates in aqueous electrolyte solutions: guanidinium carbonate.

J. Brady, C. Dempsey, G. W. Neilson, 2006, The journal of physical chemistry. B.

Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome

C. Du, J. Hancox, Hongwei Cheng, 2019, Journal of molecular and cellular cardiology.

Anti‐inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) and compound 48/80 results from mast cell degranulation in vivo

J. Warner, C. Dempsey, C. A. Vernon, 1990, British journal of pharmacology.

hERG1a/1b heteromeric currents exhibit amplified attenuation of inactivation in variant 1 short QT syndrome

J. Hancox, J. Cordeiro, H. Witchel, 2009, Biochemical and biophysical research communications.

Serine mutation of a conserved threonine in the hERG K+ channel S6-pore region leads to loss-of-function through trafficking impairment

J. Hancox, Henggui Zhang, C. Dempsey, 2020, Biochemical and biophysical research communications.

Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome

J. Hancox, C. Dempsey, Yihong Zhang, 2018, Physiological reports.

hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes

J. Hancox, C. Dempsey, J. Mitcheson, 2015, Therapeutic advances in drug safety.

Characterization of recombinant hERG K(+) channel inhibition by the active metabolite of amiodarone desethyl-amiodarone.

Jules C Hancox, Yi H. Zhang, J. Hancox, 2010, Journal of electrocardiology.

pH dependence of hydrogen exchange from backbone peptide amides in apamin.

C. Dempsey, 1986, Biochemistry.

Enhanced membrane permeabilization and antibacterial activity of a disulfide-dimerized magainin analogue.

C. Dempsey, M. Avison, S. Ueno, 2003, Biochemistry.

The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption

N. Buurma, K. Beck, R. Schweins, 2017, Scientific Reports.

Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant

C. Du, J. Hancox, C. Dempsey, 2021, Cellular and Molecular Life Sciences.

hERG Potassium Channel Blockade by the HCN Channel Inhibitor Bradycardic Agent Ivabradine

Jules C. Hancox, Christopher E. Dempsey, John S. Mitcheson, 2015, Journal of the American Heart Association.

Hancox, J. C. (2020). Serine mutation of a conserved threonine in the hERG K+ channel S6-pore region leads to loss-of-function through trafcking

J. Hancox, Henggui Zhang, C. Dempsey, 2020 .

(2020). Serine mutation of a conserved threonine in the hERG K+ channel S6-pore region leads to loss-of-function through trafﬁcking impairment.

J. Hancox, Henggui Zhang, C. Dempsey, 2022 .

Interaction of melittin with mixed phospholipid membranes composed of dimyristoylphosphatidylcholine and dimyristoylphosphatidylserine studied by deuterium NMR

A. Watts, C. Dempsey, M. Bitbol, 1989 .

A deuterium and phosphorus-31 nuclear magnetic resonance study of the interaction of melittin with dimyristoylphosphatidylcholine bilayers and the effects of contaminating phospholipase A2.

A. Watts, C. Dempsey, 1987, Biochemistry.

The interaction of amino‐deuteromethylated melittin with phospholipid membranes studied by deuterium NMR

A. Watts, C. Dempsey, G. Cryer, 1987, FEBS letters.

Inhibition of prostaglandin biosynthesis by the mast-cell-degranulating agent compound 48/80 but not by the mast-cell-degranulating peptide (peptide-401) from bee venom.

C. Dempsey, N. Roberts, C. A. Vernon, 1985, Biochemical pharmacology.

New methods of isolating been venom peptides.

C. Dempsey, C. A. Vernon, B. Banks, 1981, Analytical biochemistry.

Structure-activity studies on bee venom polypeptides.

A. Garman, C. Dempsey, B. Banks, 1980 .

Identification of a fatty acyl responsive regulator (FarR) in Escherichia coli

M. Quail, C. Dempsey, J. Guest, 1994, FEBS letters.

Generalised bilayer perturbation from peptide helix dimerisation at membrane surfaces: vesicle lysis induced by disulphide‐dimerised melittin analogues

A. Reményi, J. Takei, C. Dempsey, 1999, FEBS letters.

Evolutionary coupling analysis guides identification of mistrafficking-sensitive variants in cardiac K+ channels: Validation with hERG

J. Hancox, C. Dempsey, S. Harmer, 2022, Frontiers in Pharmacology.

The accumulation of triacylglycerols within the endoplasmic reticulum of developing seeds of Helianthus annuus

P. Shewry, J. Napier, F. Beaudoin, 1999 .

Effect of Protein Kinase A-mediated Phosphorylation on the Structure and Association Properties of the Enteropathogenic Escherichia coli Tir Virulence Protein*

A. Clarke, D. Scott, M. Banfield, 2003, Journal of Biological Chemistry.

Preferential interactions of guanidinum ions with aromatic groups over aliphatic groups.

J. Brady, C. Dempsey, P. Mason, 2009, Journal of the American Chemical Society.

The structure of aqueous guanidinium chloride solutions.

Alexander D. MacKerell, Alexander D MacKerell, J. Brady, 2004, Journal of the American Chemical Society.

The actions of melittin on membranes.

C. Dempsey, 1990, Biochimica et biophysica acta.

Weak interaction of spectrin with phosphatidylcholine‐phosphatidylserine multilayers: A 2H and 31P NMR study

A. Watts, C. Dempsey, M. Bitbol, 1989, FEBS letters.

Protein-lipid interactions at membrane surfaces: a deuterium and phosphorus nuclear magnetic resonance study of the interaction between bovine rhodopsin and the bilayer head groups of dimyristoylphosphatidylcholine.

N. Ryba, A. Watts, C. Dempsey, 1986, Biochemistry.

The hydration structure of guanidinium and thiocyanate ions: Implications for protein stability in aqueous solution

J. Cruickshank, C. Dempsey, A. Barnes, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Reversible disc-micellization of dimyristoylphosphatidylcholine bilayers induced by melittin and [Ala-14]melittin.

B. Sternberg, C. Dempsey, 1991, Biochimica et biophysica acta.

Direct 1H NMR evidence for conversion of β‐d‐cellobiose to cellobionolactone by cellobiose dehydrogenase from Phanerochaete chrysosporium

C. Dempsey, P. Wood, D. Gordon-Smith, 1994, FEBS letters.

Regenerated and denatured peroxidase as potential lipid oxidation catalysts

C. Dempsey, A. Harvey, Jb Adams, 1996 .

Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2).

C. Dempsey, D. Hopwood, T. J. Simpson, 1997, Biochemistry.

Hydrogen exchange in peptides and proteins using NMR spectroscopy

C. Dempsey, 2001 .

A combined X-ray and neutron diffraction study of selectively deuterated melittin in phospholipid bilayers: effect of pH.

A. Watts, C. Dempsey, J. Bradshaw, 1994, Molecular membrane biology.

Arginine side chain interactions and the role of arginine as a gating charge carrier in voltage sensitive ion channels

Craig T. Armstrong, John G. Anderson, C. Dempsey, 2016, Scientific Reports.

Specificity of ion-protein interactions: complementary and competitive effects of tetrapropylammonium, guanidinium, sulfate, and chloride ions.

Pavel Jungwirth, J. Heyda, J. Brady, 2009, The journal of physical chemistry. B.

Glucose interactions with a model peptide

J. Brady, M. Saboungi, C. Dempsey, 2011, Proteins.

Interactions between Voltage Sensor and Pore Domains in a hERG K+ Channel Model from Molecular Simulations and the Effects of a Voltage Sensor Mutation

Jules C. Hancox, Christopher E. Dempsey, Charlotte K. Colenso, 2013, J. Chem. Inf. Model..

Contribution of proline‐14 to the structure and actions of melittin

I. Campbell, R. Bazzo, T. Harvey, 1991, FEBS letters.

Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting

P. J. Cullen, P. Cullen, B. Potter, 1997, Current Biology.

Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm‐1 scorpion toxin

J. Hancox, O. Crociani, A. Arcangeli, 2003, FEBS letters.

Identification of a proton sensor that regulates conductance and open time of single hERG channels

J. Hancox, N. Marrion, C. Dempsey, 2019, Scientific Reports.

Biological membranes: A molecular perspective from computation and experiment

Christopher E. Dempsey, C. Dempsey, 1997 .

Analysis of α-Dystroglycan/LG Domain Binding Modes: Investigating Protein Motifs That Regulate the Affinity of Isolated LG Domains

Josephine C. Adams, C. Dempsey, A. Brancaccio, 2019, Front. Mol. Biosci..

Structural characterization of a methionine‐rich, emulsifying protein from sunflower seed

P. Shewry, A. Clarke, A. Tatham, 2000, Proteins.

pH Dependence of hydrogen exchange from backbone peptide amides of melittin in methanol

C. Dempsey, 1988 .

Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome

J. Hancox, C. Dempsey, Yihong Zhang, 2019, Heliyon.

The hERG K+ channel S4 domain L532P mutation: Characterization at 37 °C

Charlotte K. Colenso, Yi H. Zhang, J. Hancox, 2011, Biochimica et biophysica acta.

Topology, sequence evolution and folding dynamics of an immunoglobulin domain

M. J. Parker, A. Clarke, J. Waltho, 1998, Nature Structural Biology.

Hydrogen bond stabilities in the isolated alamethicin helix pH-dependent amide exchange measurements in Methanol

C. Dempsey, 1995 .

Helical structure and orientation of melittin in dispersed phospholipid membranes from amide exchange analysis in situ.

C. Dempsey, G. Butler, Christopher E. Dempsey, 1992, Biochemistry.

Hydrogen bonding in helical polypeptides from molecular dynamics simulations and amide hydrogen exchange analysis: alamethicin and melittin in methanol.

N Gibbs, C. Dempsey, R B Sessions, 1998, Biophysical journal.

Helix bending in alamethicin: molecular dynamics simulations and amide hydrogen exchange in methanol.

C. Dempsey, N. Gibbs, R. Sessions, 1997, Biophysical journal.

Quantitation of the effects of an internal proline residue on individual hydrogen bond stabilities in an alpha-helix: pH-dependent amide exchange in melittin and [Ala-14]melittin.

C. Dempsey, 1992, Biochemistry.

Hydrogen bond stabilities in membrane-reconstituted alamethicin from amide-resolved hydrogen-exchange measurements.

C. Dempsey, L. J. Handcock, 1996, Biophysical journal.

A general method for relieving substrate inhibition in lactate dehydrogenases.

J. Holbrook, R. Sessions, J. Takei, 1999, Protein engineering.

Amphipathic antimicrobial peptides--from biophysics to therapeutics?

C. Dempsey, R. Howe, T. Walsh, 2010, Protein and peptide letters.

High potency inhibition of hERG potassium channels by the sodium–calcium exchange inhibitor KB‐R7943

C. Du, J. Hancox, Hongwei Cheng, 2012, British journal of pharmacology.

Complex ion effects on polypeptide conformational stability: chloride and sulfate salts of guanidinium and tetrapropylammonium.

Christopher E. Dempsey, Pavel Jungwirth, P. Jungwirth, 2011, Journal of the American Chemical Society.

The reversal by sulfate of the denaturant activity of guanidinium.

J. Brady, C. Dempsey, P. Mason, 2007, Journal of the American Chemical Society.

Voltage Sensor Gating Charge Transfer in a hERG Potassium Channel Model

Charlotte K. Colenso, J. Hancox, R. Sessions, 2014, Biophysical journal.

hERG potassium channel inhibition by ivabradine requires channel gating.

J. Hancox, C. Dempsey, A. El Harchi, 2015, Journal of molecular and cellular cardiology.

Assessing hERG Pore Models As Templates for Drug Docking Using Published Experimental Constraints: The Inactivated State in the Context of Drug Block

Jules C. Hancox, Christopher E. Dempsey, Dominic Wright, 2014, J. Chem. Inf. Model..

Thermodynamics of RTA3 peptide binding to membranes and consequences for antimicrobial activity☆

C. Dempsey, R. Howe, T. Walsh, 2010, Biochimica et biophysica acta.

Intrinsic helical propensities and stable secondary structure in a membrane-bound fragment (S4) of the shaker potassium channel.

C. Dempsey, A. Halsall, 1999, Journal of molecular biology.

Direct Kinetic Evidence for Folding via a Highly Compact, Misfolded State*

P. Shewry, A. Clarke, M. Pandya, 1999, The Journal of Biological Chemistry.

Dissecting contributions to the denaturant sensitivities of proteins.

T. Piggot, C. Dempsey, P. Mason, 2005, Biochemistry.

The asparagine-stabilized beta-turn of apamin: contribution to structural stability from dynamics simulation and amide hydrogen exchange analysis.

S. J. Campbell, C. Dempsey, R. Sessions, 2000, Biochemistry.

The partitioning of delta 1-tetrahydrocannabinol into erythrocyte membranes in vivo and its effect on membrane fluidity.

W. Paton, G. Brent, A. Watts, 1984, Experientia.

The tyrosine-containing internalization motif in the cytoplasmic domain of TGN38/41 lies within a nascent helix.

G. Banting, A. Wilde, C. Dempsey, 1994, The Journal of biological chemistry.

Helical structure and dynamics in membrane polypeptides.

J. Takei, C. Dempsey, A. Halsall, 1998, Biochemical Society Transactions.

The solution structures of the first and second transmembrane-spanning segments of band 3.

M. Tanner, C. Dempsey, A. Gargaro, 1994, European journal of biochemistry.

The short QT syndrome

Jules C Hancox, Harry J Witchel, J. Hancox, 2011, Journal of Interventional Cardiac Electrophysiology.

Identification of a proton sensor that regulates conductance and open time of single hERG channels

J. Hancox, N. Marrion, C. Dempsey, 2019, Scientific Reports.

Electrophysiological characterization of the modified hERGT potassium channel used to obtain the first cryo‐EM hERG structure

J. Hancox, C. Dempsey, Yihong Zhang, 2020, Physiological reports.

Conserved secondary structure in the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2) and the fatty acid synthase acyl carrier protein from Escherichia coli

C. Dempsey, D. Hopwood, T. J. Simpson, 1996, FEBS letters.

The short QT syndrome

M. Link, J. Hancox, Henggui Zhang, 2011, Journal of Interventional Cardiac Electrophysiology.

The dynamic properties of melittin in solution

I. Campbell, A. Pastore, T. Harvey, 2004, European Biophysics Journal.

Molecular determinants of hERG potassium channel inhibition by disopyramide.

Yi H. Zhang, J. Hancox, C. Dempsey, 2012, Journal of molecular and cellular cardiology.

Melittin-Induced Reversible Micelle ↔ Bilayer Transition

B. Sternberg, C. Dempsey, 1992 .

Acquisition of native beta-strand topology during the rapid collapse phase of protein folding.

M. J. Parker, A. Clarke, M. Lorch, 1997, Biochemistry.

Amide-resolved hydrogen—deuterium exchange measurements from membrane-reconstituted polypeptides using exchange trapping and semiselective two-dimensional NMR

C. Dempsey, 1994, Journal of biomolecular NMR.