J. Imler

发表

J. Hoffmann, S. Tauszig, E. Jouanguy, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Toll and Toll-like receptors in Drosophila.

J. Imler, H. Bilak, S. Tauszig-Delamasure, 2003, Biochemical Society transactions.

The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila

J. Hoffmann, E. Jouanguy, J. Imler, 2005, Nature Immunology.

RNA Interference to Treat Virus Infections

J. Imler, Karim Majzoub, K. Majzoub, 2015 .

Antiviral immunity in drosophila.

J. Imler, C. Kemp, 2009, Current opinion in immunology.

Sequence-independent characterization of viruses based on the pattern of viral small RNAs produced by the host

D. Gatherer, E. Kroon, J. Marques, 2015, Nucleic acids research.

Genetic analysis of resistance to viral infection

Osamu Takeuchi, Shizuo Akira, S. Akira, 2007, Nature Reviews Immunology.

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

N. Gay, S. Tauszig-Delamasure, H. Gascan, 2003, Nature Immunology.

Immune pathways and defence mechanisms in honey bees Apis mellifera

Y. P. Chen, D. Hultmark, J. Imler, 2006, Insect molecular biology.

Toll signaling in flies and mammals: two sorts of MyD88.

J. Imler, A. Goto, 2012, Immunity.

Biology of Toll receptors: lessons from insects and mammals

J. Imler, Liangbiao Zheng, 2004, Journal of leukocyte biology.

Insights into social insects from the genome of the honeybee Apis mellifera

Ying Wang, Michal Linial, Andrew G. Clark, 2006, Nature.

LPS-induced immune response in Drosophila

S. Tauszig, E. Jouanguy, J. Imler, 2000, Journal of endotoxin research.

Dicing with viruses: microRNAs as antiviral factors.

J. Imler, S. Müller, 2007, Immunity.

Toll-like receptors and innate antiviral immunity.

J. Imler, D. Galiana-Arnoux, Delphine Galiana-Arnoux, 2006, Tissue antigens.

ATP-sensitive potassium channel (KATP)–dependent regulation of cardiotropic viral infections

K. Ocorr, R. Bodmer, B. Beutler, 2011, Proceedings of the National Academy of Sciences.

Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia.

B. Lemaître, M. Capovilla, J. Hoffmann, 2000, Immunity.

Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer

B. Wasylyk, J. Imler, C. Lemaire, 1987, Molecular and cellular biology.

Cytoplasmic Granule Formation and Translational Inhibition of Nodaviral RNAs in the Absence of the Double-Stranded RNA Binding Protein B2

A. Schneemann, J. Imler, Safia Deddouche, 2013, Journal of Virology.

Microbial sensing by Toll receptors: a historical perspective.

J. Imler, Stanislava Chtarbanova, 2011, Arteriosclerosis, thrombosis, and vascular biology.

A Harvey-ras responsive transcription element is also responsive to a tumour-promoter and to serum

B. Wasylyk, J. Imler, C. Wasylyk, 1988, Nature.

Toll and Toll-like proteins: an ancient family of receptors signaling infection.

J. Hoffmann, J. Imler, J. Hoffmann, 2000, Reviews in immunogenetics.

Induced antiviral innate immunity in Drosophila.

J. Imler, O. Lamiable, 2014, Current opinion in microbiology.

[Antiviral immunity in drosophila].

J. Imler, D. Galiana-Arnoux, Safia Deddouche, 2007, Journal de la Societe de biologie.

Insect Immunity: From Systemic to Chemosensory Organs Protection

J. Imler, Evelyne Einhorn, 2019, Olfactory Concepts of Insect Control - Alternative to insecticides.

The diversity of insect antiviral immunity: insights from viruses.

J. Marques, J. Imler, 2016, Current opinion in microbiology.

Repression by Jun of the Polyoma-virus enhancer overrides activation in a cell specific manner.

B. Wasylyk, J. Imler, J. Schneikert, 1991, Nucleic acids research.

Sensing viral RNAs by Dicer/RIG-I like ATPases across species.

J. Imler, Simona Paro, C. Meignin, 2015, Current opinion in immunology.

cGAS-STING: insight on the evolution of a primordial antiviral signaling cassette

J. Imler, Hua Cai, 2021, Faculty reviews.

2′3′-cGAMP triggers a STING- and NF-κB–dependent broad antiviral response in Drosophila

J. Marques, J. Imler, Di Chen, 2020, Science Signaling.

2′3′-cGAMP triggers a STING- and NF-κB–dependent broad antiviral response in Drosophila

J. Marques, J. Imler, Di Chen, 2019, Science Signaling.

Toll signaling: the TIReless quest for specificity

J. Hoffmann, J. Imler, 2003, Nature Immunology.

Faculty Opinions recommendation of HORMA Domain Proteins and a Trip13-like ATPase Regulate Bacterial cGAS-like Enzymes to Mediate Bacteriophage Immunity.

J. Imler, 2021, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

Genomic Analysis of Two Phlebotomine Sand Fly Vectors of Leishmania from the New and Old World

Gloria I. Giraldo-Calderón, J. C. Miranda, S. Scherer, 2022, bioRxiv.

Toll-dependent and Toll-independent immune responses in Drosophila

J. Hoffmann, J. Imler, C. Hétru, 2004, Journal of endotoxin research.

v-jun is a transcriptional activator, but not in all cell-lines.

B. Wasylyk, J. Imler, C. Wasylyk, 1988, Nucleic acids research.

RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila

S. Pfeffer, N. Vodovar, J. Hoffmann, 2010, Proceedings of the National Academy of Sciences.

Immune response of Drosophila melanogaster to infection with the flagellate parasite Crithidia spp.

D. Zachary, P. Bulet, J. Imler, 2001, Insect biochemistry and molecular biology.

Use of a membrane potential-sensitive probe to assess biological expression of the cystic fibrosis transmembrane conductance regulator.

A. Pavirani, A. Tamanini, E. Nicolis, 1995, Human gene therapy.

cGAS-like receptor-mediated immunity: the insect perspective.

J. Imler, C. Meignin, Hua Cai, 2022, Current opinion in immunology.

An efficient procedure to select and recover recombinant adenovirus vectors.

M. Mehtali, A. Pavirani, J. Imler, 1995, Gene therapy.

Two cGAS-like receptors induce antiviral immunity in Drosophila

A. Pichlmair, J. Imler, K. Kleigrewe, 2021, Nature.

Genomic analysis of two phlebotomine sand fly vectors of Leishmania from the New and Old World

Robert M. Waterhouse, Gloria I. Giraldo-Calderón, J. C. Miranda, 2023, bioRxiv.

Mosquito vector competence for dengue is modulated by insect-specific viruses

E. Marois, E. Kroon, J. Marques, 2023, Nature Microbiology.

Viral Suppressors of RNA Silencing Hinder Exogenous and Endogenous Small RNA Pathways in Drosophila

C. Antoniewski, J. Imler, Safia Deddouche, 2009, PloS one.

Insect-specific viruses regulate vector competence in Aedes aegypti mosquitoes via expression of histone H4

E. Marois, E. Kroon, J. Marques, 2021, bioRxiv.

Sensing and signalling viral infection in drosophila.

J. Imler, Juliette Schneider, 2020, Developmental and comparative immunology.

The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections

J. Hoffmann, J. Imler, C. Hétru, 2007, Nature Reviews Immunology.

Broad RNA Interference–Mediated Antiviral Immunity and Virus-Specific Inducible Responses in Drosophila

S. Pfeffer, J. Hoffmann, J. Imler, 2013, The Journal of Immunology.

Drosophila as a model for studying antiviral defences

J. Imler, I. Eleftherianos, 2009 .

Innate and intrinsic antiviral immunity in Drosophila

J. Imler, L. Daeffler, A. Mussabekova, 2017, Cellular and Molecular Life Sciences.

Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila

A. Schneemann, J. Hoffmann, J. Imler, 2006, Nature Immunology.

Antimicrobial peptides in Drosophila: structures, activities and gene regulation.

P. Bulet, J. Imler, 2005, Chemical immunology and allergy.

Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin.

B. Lemaître, E. Levashina, J. Imler, 1998, Journal of molecular biology.

Overview of Drosophila immunity: a historical perspective.

J. Imler, 2014, Developmental and comparative immunology.

WITHDRAWN: Overview of Drosophila immunity: A historical perspective.

J. Imler, 2013, Developmental and comparative immunology.

Definition of a RACK1 Interaction Network in Drosophila melanogaster Using SWATH-MS

Johana Chicher, L. Kuhn, P. Hammann, 2017, G3: Genes, Genomes, Genetics.

Sensing infection in Drosophila: Toll and beyond.

J. Hoffmann, J. Imler, D. Ferrandon, 2004, Seminars in immunology.

cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila

P. J. Kranzusch, R. Seifert, J. Imler, 2021, Nature.

Adenovirus vectors as recombinant viral vaccines.

J. Imler, 1995, Vaccine.

The 5′ flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c‐Ha‐ras oncoprotein and the c‐jun protein.

P Chambon, P. Chambon, J. Imler, 1989, The EMBO journal.

Regenerating cells in human airway surface epithelium represent preferential targets for recombinant adenovirus.

J. Zahm, D. Pierrot, A. Pavirani, 1995, Human gene therapy.

Insect Immunity: From Systemic to Chemosensory Organs Protection

J. Imler, Evelyne Einhorn, 2019, Olfactory Concepts of Insect Control - Alternative to insecticides.

A Transgenic Flock House Virus Replicon Reveals an RNAi Independent Antiviral Mechanism Acting in Drosophila Follicular Somatic Cells

J. Imler, Simona Paro, C. Meignin, 2018, G3: Genes, Genomes, Genetics.

The Kinase IKK&bgr; Regulates a STING‐ and NF‐&kgr;B‐Dependent Antiviral Response Pathway in Drosophila

L. Kuhn, J. Hoffmann, J. Imler, 2018, Immunity.

Analysis of the Contribution of Hemocytes and Autophagy to Drosophila Antiviral Immunity

J. Marques, J. Hoffmann, J. Imler, 2016, Journal of Virology.

Sequence-independent characterization of viruses based on the pattern of viral small RNAs produced by the host

D. Gatherer, E. Kroon, J. Marques, 2016, Nucleic acids research.

Cross-species comparative analysis of Dicer proteins during Sindbis virus infection

S. Pfeffer, J. Imler, E. Girardi, 2015, Scientific Reports.

Drosophila C Virus Systemic Infection Leads to Intestinal Obstruction

J. Hoffmann, J. Imler, L. Troxler, 2014, Journal of Virology.

Drosophila C virus systemic infection leads to intestinal 2 obstruction 3 4 5

J. Hoffmann, J. Imler, L. Troxler, 2014 .

The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila

A. Budd, C. Antoniewski, J. Hoffmann, 2008, Nature Immunology.

Drosophila viruses and the study of antiviral host-defense.

J. Imler, T. Huszar, 2008, Advances in virus research.

ATP-sensitive potassium channels mediate survival during infection in mammals and insects

B. Beutler, B. Croker, J. Imler, 2007, Nature Genetics.

Pherokine-2 and -3.

D. Zachary, P. Bulet, E. Jouanguy, 2003, European journal of biochemistry.

Splice‐activated UAS hairpin vector gives complete RNAi knockout of single or double target transcripts in drosophila melanogaster

D. Gubb, S. Naitza, J. Imler, 2002, Genesis.

Distinct Roles of Hemocytes at Different Stages of Infection by Dengue and Zika Viruses in Aedes aegypti Mosquitoes

J. Marques, J. Imler, Álvaro G A Ferreira, 2021, Frontiers in Immunology.

WntD and Diedel: Two immunomodulatory cytokines in Drosophila immunity

J. Imler, C. Meignin, O. Lamiable, 2016, Fly.

Immunity in Insects

J. Imler, Simona Paro, 2016 .

The Chromatin Regulator DMAP1 Modulates Activity of the Nuclear Factor κB (NF-κB) Transcription Factor Relish in the Drosophila Innate Immune Response*

J. Hoffmann, J. Imler, H. Fukuyama, 2014, The Journal of Biological Chemistry.

Crystal Structure of Diedel, a Marker of the Immune Response of Drosophila melanogaster

A. Roussel, J. Imler, C. Hétru, 2012, PloS one.

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections

S. Tauszig-Delamasure, M. Capovilla, J. Hoffmann, 2002, Nature Immunology.

The Kinase IKKβ Regulates a STING-and NF-κB-Dependent Antiviral Response Pathway in Drosophila.

L. Kuhn, J. Hoffmann, J. Imler, 2020, Immunity.

Invading viral DNA triggers dsRNA synthesis by RNA polymerase II to activate antiviral RNA interference in Drosophila.

R. Carthew, J. Marques, J. Imler, 2022, Cell reports.

Ligand-Receptor and Receptor-Receptor Interactions Act in Concert to Activate Signaling in the Drosophila Toll Pathway*♦

N. Gay, J. Imler, A. Weber, 2005, Journal of Biological Chemistry.

Signaling mechanisms in the antimicrobial host defense of Drosophila.

J. Hoffmann, J. Imler, 2000, Current opinion in microbiology.

Treatment of l(2)mbn Drosophila tumorous blood cells with the steroid hormone ecdysone amplifies the inducibility of antimicrobial peptide gene expression.

C. Janeway, R. Lanot, M. Lagueux, 1997, Insect biochemistry and molecular biology.

A single unidirectional piRNA cluster similar to the flamenco locus is the major source of EVE-derived transcription and small RNAs in Aedes aegypti mosquitoes

B. Matthews, A. Gruber, L. S. Oliveira, 2020, RNA.

Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators

Rasha E. Boulos, G. Superti-Furga, A. Stukalov, 2021, Nature Communications.

Control of dengue virus in the midgut of Aedes aegypti by ectopic expression of the dsRNA-binding protein Loqs2

E. Marois, L. Kuhn, P. Hammann, 2018, Nature Microbiology.

Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila

M. Boutros, A. Roussel, J. Marques, 2016, Proceedings of the National Academy of Sciences.

The small non-coding RNA response to virus infection in the Leishmania vector Lutzomyia longipalpis

E. Kroon, J. Marques, J. Imler, 2018, PLoS neglected tropical diseases.

The c-Ha-ras oncogene and a tumor promoter activate the polyoma virus enhancer

B. Wasylyk, J. Imler, C. Wasylyk, 1987, Cell.

RACK1 Controls IRES-Mediated Translation of Viruses

S. Marzi, C. Schuster, T. Baumert, 2014, Cell.

The IRES5′UTR of the dicistrovirus cricket paralysis virus is a type III IRES containing an essential pseudoknot structure

G. Eriani, F. Martin, Q. Vicens, 2017, Nucleic acids research.

Toll receptors in innate immunity.

J. Hoffmann, J. Imler, J L Imler, 2001, Trends in cell biology.

Discovery of novel targets for antivirals: learning from flies.

J. Imler, C. Meignin, N. Martins, 2016, Current opinion in virology.

Toll Family Receptors

J. Imler, Yann Hyvert, 2010 .

CHAPTER 179 – Toll Family Receptors

J. Imler, H. Bilak, S. Tauszig-Delamasure, 2003 .

Insect decline: immediate action is needed.

H. Jactel, P. Cossart, J. Duplessy, 2021, Comptes rendus biologies.

Transforming but not immortalizing oncogenes activate the transcription factor PEA1.

B. Wasylyk, J. Imler, C. Wasylyk, 1988, The EMBO journal.

Targeting cell-specific gene expression with an adenovirus vector containing the lacZ gene under the control of the CFTR promoter.

A. Pavirani, N. Accart, J. Imler, 1996, Gene therapy.

Molecular determinants of adenovirus serotype 5 fibre binding to its cellular receptor CAR.

J. Bergelson, M. Mehtali, R. Finberg, 1999, The Journal of general virology.

Lung gene therapy: in vivo adenovirus-mediated gene transfer to rhesus monkey airway epithelium.

M. Perricaudet, B. Scholte, A. Bout, 1994, Human gene therapy.

Aerosol-mediated delivery of recombinant adenovirus to the airways of nonhuman primates.

A. Bout, A. Pavirani, J. Imler, 1995, Human gene therapy.

In vivo adenovirus-mediated transfer of human CFTR cDNA to rhesus monkey airway epithelium: efficacy, toxicity and safety.

M. Perricaudet, A. Bout, A. Pavirani, 1994, Gene therapy.

Toll receptors in Drosophila: a family of molecules regulating development and immunity.

J. Hoffmann, J. Imler, Jules A. Hoffmann, 2002, Current topics in microbiology and immunology.

DmMyD88 controls dorsoventral patterning of the Drosophila embryo.

M. Belvin, M. Capovilla, J. Imler, 2003 .

Trans-complementation of E1-deleted adenovirus: a new vector to reduce the possibility of codissemination of wild-type and recombinant adenoviruses.

M. Mehtali, A. Bout, A. Pavirani, 1995, Human gene therapy.

AP1, a composite transcription factor implicated in abnormal growth control.

B. Wasylyk, J. Imler, 1989, Progress in growth factor research.

A change in gating mode leading to increased intrinsic Cl‐ channel activity compensates for defective processing in a cystic fibrosis mutant corresponding to a mild form of the disease.

V. Gribkoff, M. Lazdunski, P. Barbry, 1995, The EMBO journal.

Partial agonist/antagonist mouse interleukin‐2 proteins indicate that a third component of the receptor complex functions in signal transduction.

J. Imler, G. Zurawski, S. Zurawski, 1990, The EMBO journal.

[Insects: An exceptional reservoir for viruses and antiviral genes].

J. Marques, J. Imler, R. P. Olmo, 2018, Biologie aujourd'hui.

A novel virus-induced cyclic dinucleotide, 2′3′-c-di-GMP, mediates STING-dependent antiviral immunity in Drosophila

R. Jiao, J. Imler, Di Chen, 2023, bioRxiv.

Control of dengue virus in the midgut of Aedes aegypti by ectopic expression of the dsRNA-binding protein Loqs2

E. Marois, L. Kuhn, P. Hammann, 2018, Nature Microbiology.

The insect reservoir of biodiversity for viruses and for antiviral mechanisms.

J. Marques, J. Imler, R. P. Olmo, 2019, Anais da Academia Brasileira de Ciencias.

Tissue and stage-specific expression of the Tolls in Drosophila embryos.

M. Capovilla, J. Hoffmann, J. Imler, 2002, Gene expression patterns : GEP.

Role of the Spätzle Pro-domain in the Generation of an Active Toll Receptor Ligand*

N. Gay, J. Imler, A. Weber, 2007, Journal of Biological Chemistry.

Novel complementation cell lines derived from human lung carcinoma A549 cells support the growth of E1-deleted adenovirus vectors.

T. Faure, M. Mehtali, A. Pavirani, 1996, Gene therapy.

Negative and positive factors determine the activity of the polyoma virus enhancer alpha domain in undifferentiated and differentiated cell types.

B. Wasylyk, J. Imler, C. Wasylyk, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of three Toll‐like genes from mosquito Aedes aegypti

J. Zhang, J. Imler, S. E. Brown, 2003, Insect molecular biology.

Receptor binding and internalization of mouse interleukin-2 derivatives that are partial agonists.

J. Imler, G. Zurawski, 1992, The Journal of biological chemistry.

Weckle Is a Zinc Finger Adaptor of the Toll Pathway in Dorsoventral Patterning of the Drosophila Embryo

N. Perrimon, J. Imler, Li-Ying Chen, 2006, Current Biology.

Identification of three adjacent amino acids of interleukin‐2 receptor beta chain which control the affinity and the specificity of the interaction with interleukin‐2.

A. Miyajima, J. Imler, G. Zurawski, 1992, The EMBO journal.

Faculty Opinions recommendation of Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.

J. Imler, 2021, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

Induced antiviral innate immunity in Drosophila.

J. Imler, O. Lamiable, 2014, Current opinion in microbiology.

The virus-induced cyclic dinucleotide 2'3'-c-di-GMP mediates STING-dependent antiviral immunity in Drosophila.

J. Imler, Di Chen, K. Slavik, 2023, Immunity.

Microbial sensing by Toll receptors: a historical perspective.

J. Imler, Stanislava Chtarbanova, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Faculty Opinions recommendation of STING cyclic dinucleotide sensing originated in bacteria.

J. Imler, 2021, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

Broad RNA Interference–Mediated Antiviral Immunity and Virus-Specific Inducible Responses in Drosophila

S. Pfeffer, J. Hoffmann, J. Imler, 2013, The Journal of Immunology.

Drosophila C Virus Systemic Infection Leads to Intestinal Obstruction

J. Hoffmann, J. Imler, L. Troxler, 2014, Journal of Virology.

Investigating the Evolution of Drosophila STING-Dependent Antiviral Innate Immunity by Multispecies Comparison of 2′3′-cGAMP Responses

Robert M. Waterhouse, R. Waterhouse, J. Imler, 2024, Molecular biology and evolution.

Evolutionary immunology to explore original antiviral strategies

J. Imler, C. Meignin, Nelson Martins, 2024, Philosophical Transactions of the Royal Society B.

An evolutionary perspective to innate antiviral immunity in animals.

J. Imler, C. Meignin, João T. Marques, 2024, Cell reports.