E. Hohenester

发表

Domain structure and organisation in extracellular matrix proteins.

J. Engel, E. Hohenester, Jürgen Engel, 2002, Matrix biology : journal of the International Society for Matrix Biology.

Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1

E. Hohenester, N. Aghajari, E. Bettler, 2018, Structure.

Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1

R. Timpl, W. Göhring, E. Hohenester, 2001, Nature Structural Biology.

Crystal structure of the collagen alpha1(VIII) NC1 trimer.

O. Bogin, A. Yayon, E. Hohenester, 2003, Matrix biology : journal of the International Society for Matrix Biology.

Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan

S. Winder, M. Peckham, K. Ayscough, 2010, Journal of Cell Science.

Structure of a novel extracellular Ca2+-binding module in BM-40

R. Timpl, J. Engel, J. Jansonius, 1996, Nature Structural Biology.

Laminin Network Formation Studied by Reconstitution of Ternary Nodes in Solution*

E. Hohenester, A. Purvis, 2012, The Journal of Biological Chemistry.

Alan Purvis and Erhard Hohenester Solution Reconstitution of Ternary Nodes in Laminin Network Formation Studied by Glycobiology and Extracellular

E. Hohenester, A. Purvis, 2012 .

Structural basis of sequence-specific collagen recognition by SPARC

Takako Sasaki, E. Hohenester, H. Bächinger, 2008, Proceedings of the National Academy of Sciences.

Crystal Structure of a C-terminal Fragment of Growth Arrest-specific Protein Gas6

R. Timpl, Takako Sasaki, A. Ullrich, 2002, The Journal of Biological Chemistry.

Crystallographic analysis of the laminin β2 short arm reveals how the LF domain is inserted into a regular array of LE domains

E. Hohenester, D. Pulido, D. C. Briggs, 2017, Matrix biology : journal of the International Society for Matrix Biology.

Laminin G-like domains: dystroglycan-specific lectins.

E. Hohenester, 2019, Current opinion in structural biology.

Novel fold revealed by the structure of a FAS1 domain pair from the insect cell adhesion molecule fasciclin I.

E. Hohenester, D. Tisi, N. J. Clout, 2003, Structure.

Structural basis for Gas6–Axl signalling

R. Timpl, Takako Sasaki, A. Ullrich, 2006, The EMBO journal.

Human Serum Amyloid P Component is a Single Uncomplexed Pentamer in Whole Serum

M. Pepys, E. Hohenester, W. Hutchinson, 2000, Molecular medicine.

Amyloid P component. A critical review

D. Booth, M. Pepys, J. Gallimore, 1997 .

Structural biology of laminins

E. Hohenester, 2019, Essays in biochemistry.

Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1

J. Enghild, S. W. Manka, E. Hohenester, 2012, Proceedings of the National Academy of Sciences.

Measurement of prostaglandins, thromboxanes and hydroxy fatty acids by stable isotope dilution gas chromatography/mass spectrometry.

E. Hohenester, H. Leis, H. Gleispach, 1987, Biomedical & environmental mass spectrometry.

The C-terminal portion of BM-40 (SPARC/osteonectin) is an autonomously folding and crystallisable domain that binds calcium and collagen IV.

R. Timpl, J. Engel, W. Göhring, 1995, Journal of molecular biology.

Laminin: the crux of basement membrane assembly.

Takako Sasaki, R. Fässler, E. Hohenester, 2004, The Journal of cell biology.

Structure and Function of Collagen‐Derived Endostatin Inhibitors of Angiogenesis

R. Timpl, Takako Sasaki, E. Hohenester, 2002, IUBMB life.

Signalling complexes at the cell-matrix interface.

E. Hohenester, 2014, Current opinion in structural biology.

Rollingby Allosteric Antibodies Affects Leukocyte Heterotropic Modulation of Selectin Affinity

C. Kuehne, T. Tedder, E. Hohenester, 2014 .

A Transmembrane Leucine Zipper Is Required for Activation of the Dimeric Receptor Tyrosine Kinase DDR1*

M. Horton, E. Hohenester, B. Leitinger, 2006, Journal of Biological Chemistry.

Normal Activation of Discoidin Domain Receptor 1 Mutants with Disulfide Cross-links, Insertions, or Deletions in the Extracellular Juxtamembrane Region

E. Hohenester, I. Zalivina, Justin K H Liu, 2014, The Journal of Biological Chemistry.

220th ENMC workshop: Dystroglycan and the dystroglycanopathies Naarden, The Netherlands, 27–29 May 2016

Susan C. Brown, S. Winder, H. Bokhoven, 2017, Neuromuscular Disorders.

Crystallographic studies on the vitamin B6-assisted enzymic transamination reaction

B. Shen, V. Malashkevich, M. Hennig, 1994 .

Two-step release of kinase autoinhibition in discoidin domain receptor 1

E. Hohenester, B. Leitinger, D. Sammon, 2020, Proceedings of the National Academy of Sciences.

Characterization of High Affinity Binding Motifs for the Discoidin Domain Receptor DDR2 in Collagen*♦

E. Hohenester, D. Bihan, R. Farndale, 2008, Journal of Biological Chemistry.

Exploration of human xylosyltransferase for chemoenzymatic synthesis of proteoglycan linkage region.

Kefei Yu, E. Hohenester, Xuefei Huang, 2021, Organic & biomolecular chemistry.

Zinc-dependent dimers observed in crystals of human endostatin.

R. Timpl, D. Wiley, J. Folkman, 1998, Proceedings of the National Academy of Sciences of the United States of America.

A model of FAS1 domain 4 of the corneal protein beta(ig)-h3 gives a clearer view on corneal dystrophies.

E. Hohenester, N. J. Clout, 2003, Molecular vision.

A model of FAS 1 domain 4 of the corneal protein β igh 3 gives a clearer view on corneal dystrophies

E. Hohenester, N. J. Clout, 2003 .

Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium.

P. Burkhard, Paul Cook, J. Jansonius, 1998, Journal of molecular biology.

Structure of 1-aminocyclopropane-1-carboxylate synthase, a key enzyme in the biosynthesis of the plant hormone ethylene.

G Capitani, J. Kirsch, G. Capitani, 1999, Journal of molecular biology.

Dialkylglycine decarboxylase structure: bifunctional active site and alkali metal sites.

S. Cowan, J. Jansonius, E. Hohenester, 1994, Science.

Structural and mechanistic analysis of two refined crystal structures of the pyridoxal phosphate-dependent enzyme dialkylglycine decarboxylase.

J. Jansonius, E. Hohenester, M. Toney, 1995, Journal of molecular biology.

Crystal structure of a decameric complex of human serum amyloid P component with bound dAMP.

S. Wood, M. Pepys, E. Hohenester, 1997, Journal of molecular biology.

Low-temperature crystal structure of superoxocobalamin obtained by solid-state oxygenation of the B12 derivative cob(II)alamin

E. Hohenester, C. Kratky, B. Kraeutler, 1991 .

A simplified laminin nomenclature.

J. Sanes, Takako Sasaki, K. Sekiguchi, 2005, Matrix biology : journal of the International Society for Matrix Biology.

Structural and functional aspects of calcium binding in extracellular matrix proteins.

E. Hohenester, P. Maurer, Patrik Maurer, 1997, Matrix biology : journal of the International Society for Matrix Biology.

Extracellular calcium-binding proteins.

J. Engel, E. Hohenester, P. Maurer, 1996, Current opinion in cell biology.

Crystal structure of a pair of follistatin‐like and EF‐hand calcium‐binding domains in BM‐40

R. Timpl, E. Hohenester, P. Maurer, 1997, The EMBO journal.

LG/LNS domains: multiple functions -- one business end?

Y. Muller, G. Rudenko, E. Hohenester, 2001, Trends in biochemical sciences.

An alkali metal ion size-dependent switch in the active site structure of dialkylglycine decarboxylase.

J. Jansonius, E. Hohenester, J. Keller, 1994, Biochemistry.

Insight into Schmid metaphyseal chondrodysplasia from the crystal structure of the collagen X NC1 domain trimer.

O. Bogin, J. Singer, A. Yayon, 2002, Structure.

A peptide from the first fibronectin domain of NCAM acts as an inverse agonist and stimulates FGF receptor activation, neurite outgrowth and survival

E. Hohenester, Erhard Hohenester, Alexandra A. Anderson, 2005, Journal of neurochemistry.

Structure of a thrombospondin C‐terminal fragment reveals a novel calcium core in the type 3 repeats

Josephine C. Adams, Marc Kvansakul, E. Hohenester, 2004, The EMBO journal.

Laminins in basement membrane assembly

E. Hohenester, P. Yurchenco, 2013, Cell adhesion & migration.

Collagen recognition and transmembrane signalling by discoidin domain receptors☆

E. Hohenester, F. Carafoli, 2013, Biochimica et biophysica acta.

Structure of the Discoidin Domain Receptor 1 Extracellular Region Bound to an Inhibitory Fab Fragment Reveals Features Important for Signaling

E. Hohenester, B. Leitinger, R. Nan, 2012, Structure.

Crystallographic Insight into Collagen Recognition by Discoidin Domain Receptor 2

E. Hohenester, D. Bihan, R. Farndale, 2009, Structure.

Structural basis for Gas 6 – Axl signalling

R. Timpl, Takako Sasaki, A. Ullrich, 2005 .

Mammalian collagen receptors.

E. Hohenester, Erhard Hohenester, B. Leitinger, 2007, Matrix biology : journal of the International Society for Matrix Biology.

Limited Cleavage of Extracellular Matrix Protein BM-40 by Matrix Metalloproteinases Increases Its Affinity for Collagens*

R. Timpl, Takako Sasaki, W. Göhring, 1997, The Journal of Biological Chemistry.

Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity.

T. Sasaki, R. Timpl, Takako Sasaki, 2000, Journal of molecular biology.

A propofol binding site on mammalian GABAA receptors identified by photolabeling

Edward H. Smith, R. Dickinson, N. Franks, 2013, Nature chemical biology.

Crystal structure of the angiogenesis inhibitor endostatin at 1.5 Å resolution

R. Timpl, Takako Sasaki, E. Hohenester, 1998, The EMBO journal.

Biologically-active laminin-111 fragment that modulates the epithelial-to-mesenchymal transition in embryonic stem cells

Molly M Stevens, Christine-Maria Horejs, Sergio Bertazzo, 2014, Proceedings of the National Academy of Sciences.

Aberrant splicing as potential modifier of the phenotype of junctional epidermolysis bullosa

H. Schneider, E. Hohenester, C. Has, 2020, Journal of the European Academy of Dermatology and Venereology : JEADV.

Extracellular matrix retention of thrombospondin 1 is controlled by its conserved C-terminal region

Josephine C. Adams, E. Hohenester, M. Kvansakul, 2008, Journal of Cell Science.

Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1–4

E. Hohenester, D. C. Briggs, P. Paracuellos, 2015, Structure.

Crystal structure of human recombinant ornithine aminotransferase.

B. Shen, M. Hennig, J. Jansonius, 1998, Journal of molecular biology.

Signaling Switch of the Axon Guidance Receptor Robo3 during Vertebrate Evolution

H. R. Crollius, Zhuhao Wu, M. Tessier-Lavigne, 2014, Neuron.

Structural insight into Slit-Robo signalling.

E. Hohenester, 2008, Biochemical Society transactions.

Heterotropic Modulation of Selectin Affinity by Allosteric Antibodies Affects Leukocyte Rolling

C. Kuehne, T. Tedder, E. Hohenester, 2014, The Journal of Immunology.

The crystal structure of a laminin G-like module reveals the molecular basis of alpha-dystroglycan binding to laminins, perlecan, and agrin.

R. Timpl, E. Hohenester, D. Tisi, 1999, Molecular cell.

Crystal structure of the collagen a1(VIII) NC1 trimer

O. Bogin, A. Yayon, E. Hohenester, 2003 .

Structural basis of laminin binding to the LARGE glycans on dystroglycan

Liping Yu, K. Campbell, M. Moracci, 2016, Nature chemical biology.

Structure and function of laminin LG modules.

T. Sasaki, R. Timpl, E. Hohenester, 2000, Matrix biology : journal of the International Society for Matrix Biology.

Crystal Structure and Cell Surface Anchorage Sites of Laminin α1LG4-5*

J. Ervasti, E. Hohenester, S. Hussain, 2007, Journal of Biological Chemistry.

Crystal Structure of the LG1-3 Region of the Laminin α2 Chain

E. Hohenester, N. J. Clout, F. Carafoli, 2009, The Journal of Biological Chemistry.

Distinct requirements for heparin and α-dystroglycan binding revealed by structure-based mutagenesis of the laminin α2 LG4-LG5 domain pair

R. Timpl, Takako Sasaki, E. Hohenester, 2003 .

Structure of the C‐terminal laminin G‐like domain pair of the laminin α2 chain harbouring binding sites for α‐dystroglycan and heparin

R. Timpl, E. Hohenester, D. Tisi, 2000 .

A Bethlem myopathy Gly to Glu mutation in the von Willebrand factor A domain N2 of the collagen α3(VI) chain interferes with protein folding

R. Timpl, Takako Sasaki, E. Hohenester, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Concave Face of Decorin Mediates Reversible Dimerization and Collagen Binding

Y. Ishikawa, S. Perkins, E. Hohenester, 2013, The Journal of Biological Chemistry.

Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin

E. Hohenester, S. Kalamajski, D. Bihan, 2017, Matrix biology : journal of the International Society for Matrix Biology.

Structural basis and potential role of heparin/heparan sulfate binding to the angiogenesis inhibitor endostatin

R. Timpl, Takako Sasaki, M. Salmivirta, 1999, The EMBO journal.

Crystal structure and mapping by site‐directed mutagenesis of the collagen‐binding epitope of an activated form of BM‐40/SPARC/osteonectin

R. Timpl, Takako Sasaki, W. Göhring, 1998, The EMBO journal.

Structural basis for the high‐affinity interaction of nidogen‐1 with immunoglobulin‐like domain 3 of perlecan

R. Timpl, E. Hohenester, M. Kvansakul, 2001, The EMBO journal.

Basement Membrane Protein BM‐40

R. Timpl, E. Hohenester, 2006 .

Calcium Affinity, Cooperativity, and Domain Interactions of Extracellular EF-hands Present in BM-40*

R. Timpl, M. Paulsson, E. Hohenester, 2000, The Journal of Biological Chemistry.

An Activating Mutation Reveals a Second Binding Mode of the Integrin α2 I Domain to the GFOGER Motif in Collagens

E. Hohenester, D. Bihan, R. Farndale, 2013, PloS one.

Structure of the Tandem Fibronectin Type 3 Domains of Neural Cell Adhesion Molecule

E. Hohenester, J. Saffell, F. Carafoli, 2008, Journal of molecular biology.

Crystalline mitochondrial aspartate aminotransferase exists in only two conformations.

J. Jansonius, E. Hohenester, 1994, Journal of molecular biology.

Interaction of the guidance molecule Slit with cellular receptors.

E. Hohenester, S. Hussain, J. Howitt, 2006, Biochemical Society transactions.

Binding site for Robo receptors revealed by dissection of the leucine‐rich repeat region of Slit

E. Hohenester, J. Howitt, N. J. Clout, 2004, The EMBO journal.

Amyloid and amyloidosis

D. Booth, S. Wood, M. Pepys, 1998 .

Novel Mechanisms of Fibroblast Growth Factor Receptor 1 Regulation by Extracellular Matrix Protein Anosmin-1*

P. Travers, J. Turnbull, S. Guimond, 2009, The Journal of Biological Chemistry.

Crystal structure of a scavenger receptor cysteine-rich domain sheds light on an ancient superfamily

R. Timpl, Takako Sasaki, E. Hohenester, 1999, Nature Structural Biology.

Organization of the Laminin Polymer Node: Laminin Polymer Node.

E. Hohenester, P. Yurchenco, Maya Aleksandrova, 2021, Matrix biology : journal of the International Society for Matrix Biology.

Crystal Structures of the Network-Forming Short-Arm Tips of the Laminin β1 and γ1 Chains

E. Hohenester, S. Hussain, F. Carafoli, 2012, PloS one.

Determinants of Laminin Polymerisation Revealed by the Crystal Structure of the Alpha5 Chain Amino-Terminal Region

E. Hohenester, S. Hussain, F. Carafoli, 2011 .

Determinants of laminin polymerization revealed by the structure of the α5 chain amino-terminal region

E. Hohenester, S. Hussain, F. Carafoli, 2011, EMBO reports.

Variable zinc coordination in endostatin.

T. Sasaki, R. Timpl, E. Hohenester, 2000, Journal of molecular biology.

Distinct requirements for heparin and alpha-dystroglycan binding revealed by structure-based mutagenesis of the laminin alpha2 LG4-LG5 domain pair.

R. Timpl, Takako Sasaki, E. Hohenester, 2003, Journal of molecular biology.

Crystal Structure of the Heterotrimeric Integrin-Binding Region of Laminin-111

E. Hohenester, D. Pulido, S. Hussain, 2017, Structure.

Crystal structures and solution studies of oxime adducts of mitochondrial aspartate aminotransferase.

P. Christen, J. Jansonius, E. Hohenester, 1996, European journal of biochemistry.

Crystal structure and cell surface anchorage sites of laminin alpha1LG4-5.

J. Ervasti, E. Hohenester, S. Hussain, 2007, The Journal of biological chemistry.

A Molecular Mechanism for the Heparan Sulfate Dependence of Slit-Robo Signaling*

Yassir A. Ahmed, C. Holt, J. Turnbull, 2006, Journal of Biological Chemistry.

Structural and Functional Analysis of Slit and Heparin Binding to Immunoglobulin-like Domains 1 and 2 of Drosophila Robo*

N. Fukuhara, E. Hohenester, S. Hussain, 2008, Journal of Biological Chemistry.

Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1

E. Hohenester, D. C. Briggs, 2018, Structure.

Laminin

Takako Sasaki, R. Fässler, E. Hohenester, 2004, The Journal of Cell Biology.

Crystallization and preliminary X-ray diffraction studies of the spinach-chloroplast thioredoxin f.

P. Schürmann, J. Jansonius, E. Hohenester, 1991, Journal of molecular biology.

Structure of the C-terminal laminin G-like domain pair of the laminin alpha2 chain harbouring binding sites for alpha-dystroglycan and heparin.

R. Timpl, E. Hohenester, D. Tisi, 2000, The EMBO journal.

Structure of the transmembrane protein 2 (TMEM2) ectodomain and its lack of hyaluronidase activity

R. Morgan, E. Hohenester, D. Bubeck, 2023, Wellcome Open Research.

Crystallization and preliminary X-ray analysis of recombinant 1-aminocyclopropane-1-carboxylate synthase from apple. A key enzyme in the biosynthesis of the plant hormone ethylene.

M. F. White, J. Kirsch, J. Jansonius, 1994, Journal of molecular biology.

Structural insight into Slit-Robo signalling.

E. Hohenester, 2008, Biochemical Society transactions.

Molecular mechanism of decision-making in glycosaminoglycan biosynthesis

S. Haslam, E. Hohenester, B. Schumann, 2023, Nature communications.

Xylosyltransferase Bump-and-hole Engineering to Chemically Manipulate Proteoglycans in Mammalian Cells

Yoshiki Narimatsu, E. Hohenester, Stacy A. Malaker, 2024, bioRxiv.