H. Hashimoto

H. Onoe, Yasuyoshi Watanabe, S. Chaki, 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy

B. Ujvári, D. Reglodi, B. Gaszner, 2022, Frontiers in Endocrinology.

Differential Regulatory Role of Pituitary Adenylate Cyclase–Activating Polypeptide in the Serum-Transfer Arthritis Model

A. Mócsai, D. Reglodi, T. Németh, 2014, Arthritis & rheumatology.

Endothelins Stimulate Expression of Cyclooxygenase 2 in Rat Cultured Astrocytes

H. Hashimoto, A. Baba, Y. Koyama, 1999, Journal of neurochemistry.

Critical involvement of the orbitofrontal cortex in hyperlocomotion induced by NMDA receptor blockade in mice.

S. Yamaguchi, H. Hashimoto, T. Nakazawa, 2016, Biochemical and biophysical research communications.

Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency

H. Hashimoto, T. Matsuda, Y. Ago, 2016, Psychopharmacology.

Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice

H. Onoe, S. Chaki, A. Nakazato, 2013, Neuropharmacology.

Cloning and characterization of the mouse pituitary adenylate cyclase-activating polypeptide (PACAP) gene.

H. Hashimoto, A. Baba, T. Matsuda, 1998, Gene.

A Mouse Model of Human Primitive Neuroectodermal Tumors Resulting from Microenvironmentally-Driven Malignant Transformation of Orthotopically Transplanted Radial Glial Cells

M. Hendrix, M. Soares, H. Meltzer, 2015, PloS one.

Altered Notch Signaling in Developing Molar Teeth of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)-Deficient Mice

A. Tamas, D. Reglodi, B. Gaszner, 2018, Journal of Molecular Neuroscience.

Neuroprotective Effect of Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide on Spinal Cord Injury

T. Atsumi, Akira Yoshikawa, S. Shioda, 2012, Journal of Molecular Neuroscience.

PACAP is an Endogenous Protective Factor—Insights from PACAP-Deficient Mice

A. Lakatos, A. Tamas, D. Reglodi, 2012, Journal of Molecular Neuroscience.

Mice Deficient in Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) are More Susceptible to Retinal Ischemic Injury In Vivo

A. Tamas, G. Toth, D. Reglodi, 2011, Neurotoxicity Research.

Regulation of Oxidative Stress by Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Mediated by PACAP Receptor

S. Shioda, H. Hashimoto, N. Shintani, 2010, Journal of Molecular Neuroscience.

Increased Stathmin1 Expression in the Dentate Gyrus of Mice Causes Abnormal Axonal Arborizations

M. Tohyama, Kazuo Yamada, T. Yoshikawa, 2010, Neuroscience Research.

Neuroprotective Effect of PACAP Against NMDA-Induced Retinal Damage in the Mouse

S. Shioda, H. Hashimoto, A. Baba, 2010, Journal of Molecular Neuroscience.

Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6.

S. Shioda, Y. Iwakura, A. Takaki, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Distribution of the mRNA for a pituitary adenylate cyclase‐activating polypeptide receptor in the rat brain: An in situ hybridization study

R. Shigemoto, N. Mizuno, K. Mori, 1996, The Journal of comparative neurology.

PACAP–PAC1 Signaling Regulates Serotonin 2A Receptor Internalization

H. Hashimoto, T. Nakazawa, A. Hayata-Takano, 2021, Frontiers in Endocrinology.

Functional roles of the neuropeptide PACAP in brain and pancreas.

H. Hashimoto, N. Shintani, A. Baba, 2003, Life sciences.

Overexpression of PACAP in transgenic mouse pancreatic beta-cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes.

H. Aihara, J. Miyazaki, Y. Matsuzawa, 2003, Diabetes.

Vasoactive intestinal peptide–VIPR2 signaling regulates tumor cell migration

J. Waschek, Kotaro Sakamoto, H. Hashimoto, 2022, Frontiers in Oncology.

Central PACAP mediates the sympathetic effects of leptin in a tissue-specific manner

D. Morgan, K. Rahmouni, N. Yamamoto, 2013, Neuroscience.

Roles of the monoaminergic system in the antidepressant effects of ketamine and its metabolites

H. Hashimoto, Y. Ago, Satoshi Asano, 2022, Neuropharmacology.

Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders

Masahiko Watanabe, M. Kano, T. Manabe, 2016, Nature Communications.

15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells.

H. Hashimoto, N. Shintani, A. Baba, 2010, Journal of pharmacological sciences.

PACAP centrally mediates emotional stress-induced corticosterone responses in mice

M. Tanida, K. Ogata, H. Hashimoto, 2011, Stress.

Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test.

H. Hashimoto, A. Baba, Keiko Takahashi, 2007, Journal of pharmacological sciences.

Markedly reduced white adipose tissue and increased insulin sensitivity in adcyap1-deficient mice.

Takeshi Shimada, M. Nakata, T. Yada, 2008, Journal of pharmacological sciences.

Na+–Ca2+ exchanger isoforms in rat neuronal preparations: different changes in their expression during postnatal development

H. Hashimoto, A. Baba, Y. Koyama, 2000, Brain Research.

Vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide receptor chimeras reveal domains that determine specificity of vasoactive intestinal polypeptide binding and activation.

H. Hashimoto, A. Baba, T. Matsuda, 1997, Molecular pharmacology.

PACAP is Implicated in the Stress Axes

R. Hashimoto, M. Tanida, H. Hashimoto, 2011, Current pharmaceutical design.

Altered Functional Connectivity of the Orbital Cortex and Striatum Associated with Catalepsy Induced by Dopamine D1 and D2 Antagonists.

H. Hashimoto, A. Kasai, K. Seiriki, 2021, Biological & pharmaceutical bulletin.

The Pivotal Role of Neuropeptide Crosstalk from Ventromedial-PACAP to Dorsomedial-Galanin in the Appetite Regulation in the Mouse Hypothalamus

H. Hashimoto, N. Shintani, A. Miyata, 2022, Molecular neurobiology.

Expression of glutamate transporters in cultured glial cells

T. Marunouchi, H. Hashimoto, A. Baba, 1995, Neuroscience Letters.

Rivastigmine improves isolation rearing-induced prepulse inhibition deficits via muscarinic acetylcholine receptors in mice

H. Hashimoto, T. Matsuda, Y. Ago, 2016, Psychopharmacology.

Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice

Soken Tsuchiya, Y. Sugimoto, A. Ichikawa, 2015, Biochemistry and biophysics reports.

Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied by their association with cytoskeletal components

Y. Yoshioka, H. Hashimoto, A. Baba, 2000, Neuroscience.

Retardation of Retinal Vascular Development in Apelin-Deficient Mice

Y. Tano, S. Matsuda, H. Hashimoto, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP)

J. Miyazaki, F. Tashiro, H. Niwa, 2001, Proceedings of the National Academy of Sciences of the United States of America.

The Protective Effects of Endogenous PACAP in Oxygen-Induced Retinopathy

D. Reglodi, H. Hashimoto, T. Ertl, 2021, Journal of Molecular Neuroscience.

Comparison of intestinal cold preservation injury on pituitary adenylate cyclase-activating polypeptide in knockout and wild-type mice.

B. Rácz, H. Hashimoto, A. Baba, 2010, Transplantation proceedings.

Mice deficient in pituitary adenylate cyclase activating polypeptide display increased sensitivity to renal oxidative stress in vitro

A. Tamas, D. Reglodi, B. Rácz, 2010, Neuroscience Letters.

PACAP- and PHI-mediated sustained relaxation in circular muscle of gastric fundus: Findings obtained in PACAP knockout mice

H. Hashimoto, N. Shintani, A. Baba, 2006, Regulatory Peptides.

Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons.

M. Kubo, H. Hashimoto, N. Shintani, 2009, Biological & pharmaceutical bulletin.

Disturbed spermatogenic signaling in pituitary adenylate cyclase activating polypeptide-deficient mice.

A. Tamas, D. Reglodi, T. Juhász, 2018, Reproduction.

Effects of Pituitary Adenylate Cyclase Activating Polypeptide on Human Sperm Motility

A. Tamas, G. Toth, D. Reglodi, 2012, Journal of Molecular Neuroscience.

Implications of PACAP Signaling in Psychiatric Disorders

R. Hashimoto, M. Tohyama, H. Hashimoto, 2016 .

The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide

H. Onoe, S. Chaki, A. Nakazato, 2013, Behavioural pharmacology.

Serotonin 5-HT7 Receptor Blockade Reverses Behavioral Abnormalities in PACAP-Deficient Mice and Receptor Activation Promotes Neurite Extension in Primary Embryonic Hippocampal Neurons

K. Ogata, H. Hashimoto, N. Shintani, 2012, Journal of Molecular Neuroscience.

Behavioral characterization of mice overexpressing human dysbindin-1

T. Nabeshima, R. Hashimoto, M. Takeda, 2014, Molecular Brain.

Epigenetic and Neuronal Activity Markers Suggest the Recruitment of the Prefrontal Cortex and Hippocampus in the Three-Hit Model of Depression in Male PACAP Heterozygous Mice

B. Ujvári, D. Reglodi, B. Gaszner, 2022, International journal of molecular sciences.

Possible involvement of a cyclic AMP-dependent mechanism in PACAP-induced proliferation and ERK activation in astrocytes.

T. Fujita, H. Hashimoto, N. Shintani, 2003, Biochemical and biophysical research communications.

Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1 (VPAC1) receptor.

N. Copeland, N. Jenkins, H. Hashimoto, 1999, Genomics.

Cerulein-Induced Acute Pancreatitis in PACAP Knockout Mice

H. Hashimoto, N. Shintani, A. Baba, 2010, Journal of Molecular Neuroscience.

Cultured rat astrocytes possess Na+‐Ca2+ exchanger

H. Hashimoto, A. Baba, T. Matsuda, 1994, Glia.

Tunicamycin inhibits prostaglandin F2α receptor-mediated phosphoinositide hydrolysis in cultured rat astrocytes

H. Hashimoto, A. Baba, J. Kitanaka, 1994, Neurochemical Research.

Isoform‐Specific Up‐Regulation by Ouabain of Na+,K+‐ATPase in Cultured Rat Astrocytes

H. Hashimoto, A. Baba, T. Matsuda, 1997, Journal of neurochemistry.

Structural and Morphometric Comparison of Lower Incisors in PACAP-Deficient and Wild-Type Mice

A. Tamas, D. Reglodi, H. Hashimoto, 2016, Journal of Molecular Neuroscience.

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

H. Vaudry, L. Galas, B. Chow, 2009, Pharmacological Reviews.

Synergistic Induction of Pituitary Adenylate Cyclase‐Activating Polypeptide (PACAP) Gene Expression by Nerve Growth Factor and PACAP in PC12 Cells

H. Hashimoto, N. Shintani, A. Baba, 2000, Journal of neurochemistry.

PACAP suppresses dry eye signs by stimulating tear secretion

Ingela Lanekoff, D. Reglodi, S. Shioda, 2016, Nature Communications.

Pituitary adenylate cyclase‐activating polypeptide promotes eccrine gland sweat secretion

J. Hannibal, J. Fahrenkrug, H. Hashimoto, 2017, The British journal of dermatology.

Role of Na+‐Ca2+ Exchanger in Agonist‐Induced Ca2+ Signaling in Cultured Rat Astrocytes

H. Hashimoto, A. Baba, T. Matsuda, 1996, Journal of neurochemistry.

Effects of herbal medicine “Sai-rei-to” (TJ-114) on in vitro interleukin-1 receptor antagonist production in peripheral blood mononuclear cells

H. Hashimoto, M. Kimura, Y. Kosaka, 1993 .

Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist

C. Colwell, M. Fanselow, Michael C. Condro, 2015, Psychopharmacology.

Autism-associated protein kinase D2 regulates embryonic cortical neuron development.

Makoto Sato, R. Hashimoto, H. Hashimoto, 2019, Biochemical and biophysical research communications.

Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia

R. Hashimoto, I. Imoto, M. Kikuchi, 2017, International journal of molecular sciences.

Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice

T. Miyakawa, K. Takao, H. Hashimoto, 2012, Front. Behav. Neurosci..

Differential expression of mRNAs for PACAP and its receptors during neural differentiation of embryonic stem cells

J. Miyazaki, H. Niwa, H. Hashimoto, 2005, Regulatory Peptides.

The pituitary adenylate cyclase-activating polypeptide is a physiological inhibitor of platelet activation.

J. Vermylen, Y. Tomiyama, M. Hoylaerts, 2004, The Journal of clinical investigation.

Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome

S. Yamaguchi, R. Hashimoto, N. Ozaki, 2019, Neuropsychopharmacology.

De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ

R. Hashimoto, H. Yamamori, Y. Yasuda, 2016, Journal of molecular psychiatry.

Lipopolysaccharide affects exploratory behaviors toward novel objects by impairing cognition and/or motivation in mice: Possible role of activation of the central amygdala

H. Hashimoto, N. Shintani, A. Baba, 2012, Behavioural Brain Research.

Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism

S. Nakagawa, J. Waschek, H. Hashimoto, 2020, Frontiers in Neuroscience.

Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice

A. Tamas, D. Reglodi, B. Gaszner, 2019, Scientific Reports.

Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice

M. Fanselow, J. Waschek, H. Hashimoto, 2017, Neurobiology of Learning and Memory.

Characterization of the Thermoregulatory Response to Pituitary Adenylate Cyclase-Activating Polypeptide in Rodents

A. Tamas, G. Toth, D. Reglodi, 2014, Journal of Molecular Neuroscience.

Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide

R. Shigemoto, K. Mori, H. Hashimoto, 1993, Neuron.

Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia

D. Weinberger, T. Suzuki, T. Ohnishi, 2007, Molecular Psychiatry.

Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency

H. Hashimoto, T. Matsuda, Y. Ago, 2016, Psychopharmacology.

PACAP provides colonic protection against dextran sodium sulfate induced colitis

H. Hashimoto, N. Shintani, A. Baba, 2008, Journal of cellular physiology.

Presence of Endogenous PACAP-38 Ameliorated Intestinal Cold Preservation Tissue Injury

D. Reglodi, H. Hashimoto, A. Baba, 2010, Journal of Molecular Neuroscience.

The pivotal role of pituitary adenylate cyclase-activating polypeptide for lactate production and secretion in astrocytes during fear memory

J. Kehr, Thuy Van Thi Nguyen, H. Hashimoto, 2021, Pharmacological Reports.

Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro

T. Shirao, Y. Sekino, T. Shofuda, 2021, Molecular Brain.

Pituitary Adenylate Cyclase-Activating Polypeptide Is Upregulated in Murine Skin Inflammation and Mediates Transient Receptor Potential Vanilloid-1-Induced Neurogenic Edema.

D. Reglodi, M. Steinhoff, T. Bíró, 2015, The Journal of investigative dermatology.

Probing the VIPR2 Microduplication Linkage to Schizophrenia in Animal and Cellular Models

J. Waschek, H. Hashimoto, S. Asano, 2021, Frontiers in Neuroscience.

Increased Behavioral and Neuronal Responses to a Hallucinogenic Drug in PACAP Heterozygous Mutant Mice

T. Miyakawa, R. Hashimoto, D. Reglodi, 2014, PloS one.

Pituitary adenylate cyclase-activating polypeptide plays a key role in nitroglycerol-induced trigeminovascular activation in mice

J. Tajti, D. Reglodi, É. Szőke, 2012, Neurobiology of Disease.

Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism

H. Hashimoto, T. Matsuda, A. Hayata-Takano, 2014, Pharmacology Biochemistry and Behavior.

(R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism

K. Hashimoto, S. Nakagawa, H. Hashimoto, 2019, The international journal of neuropsychopharmacology.

Prenatal Exposure to Histone Deacetylase Inhibitors Affects Gene Expression of Autism-Related Molecules and Delays Neuronal Maturation

H. Hashimoto, T. Matsuda, T. Kawanai, 2016, Neurochemical Research.

Structural and Morphometric Comparison of the Molar Teeth in Pre-eruptive Developmental Stage of PACAP-Deficient and Wild-Type Mice

A. Tamas, D. Reglodi, T. Juhász, 2014, Journal of Molecular Neuroscience.

Role of endogenous pituitary adenylate cyclase activating polypeptide (PACAP) in myelination of the rodent brain: Lessons from PACAP-deficient mice

D. Reglodi, H. Hashimoto, N. Shintani, 2011, International Journal of Developmental Neuroscience.

Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers

D. Reglodi, B. Gaszner, V. Csernus, 2016, Neuroscience.

The behavioral phenotype of pituitary adenylate-cyclase activating polypeptide-deficient mice in anxiety and depression tests is accompanied by blunted c-Fos expression in the bed nucleus of the stria terminalis, central projecting Edinger–Westphal nucleus, ventral lateral septum, and dorsal raphe n

D. Reglodi, B. Gaszner, H. Hashimoto, 2012, Neuroscience.

Roles of PACAP and PHI as inhibitory neurotransmitters in the circular muscle of mouse antrum

H. Hashimoto, N. Shintani, A. Baba, 2005, Pflügers Archiv.

Structure of the gene encoding the mouse pituitary adenylate cyclase-activating polypeptide receptor.

H. Hashimoto, A. Baba, S. Nagata, 1995, Gene.

Galantamine and donepezil differently affect isolation rearing-induced deficits of prepulse inhibition in mice

H. Hashimoto, A. Baba, T. Matsuda, 2008, Psychopharmacology.

[Altered higher brain function in PACAP-knockout mice].

H. Hashimoto, N. Shintani, A. Baba, 2004, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor‐β (TGF‐β) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro

R. Hashimoto, J. Waschek, H. Hashimoto, 2015, Journal of neurochemistry.

Recent studies on the trimethyltin actions in central nervous systems.

H. Hashimoto, N. Shintani, A. Baba, 2007, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine

H. Okano, R. Hashimoto, M. Kikuchi, 2017, Schizophrenia Research.

Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse

H. Okada, H. Hashimoto, A. Kasai, 2016, Translational Psychiatry.

Prenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brain

H. Hashimoto, T. Matsuda, T. Nakazawa, 2017, Molecular Autism.

Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZWT/Q1038R mouse model of autism spectrum disorder

R. Hashimoto, H. Hashimoto, T. Nakazawa, 2021, Molecular brain.

Distribution of Secretin Receptors in the Rat Central Nervous System: an in situ Hybridization Study

H. Hashimoto, Z. Tóth, K. Köves, 2013, Journal of Molecular Neuroscience.

Intranasal Application of Secretin, Similarly to Intracerebroventricular Administration, Influences the Motor Behavior of Mice Probably Through Specific Receptors

H. Hashimoto, Z. Tóth, K. Köves, 2012, Journal of Molecular Neuroscience.

Modeling of psychiatric disorders using induced pluripotent stem cell-related technologies.

R. Hashimoto, H. Hashimoto, T. Nakazawa, 2019, Journal of pharmacological sciences.

PACAP is transiently expressed in anterior pituitary gland of rats: In situ hybridization and cell immunoblot assay studies

H. Hashimoto, A. Baba, K. Köves, 2008, Peptides.

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Regulates the Hypothalamo-Pituitary-Thyroid (HPT) Axis via Type 2 Deiodinase in Male Mice.

D. Reglodi, P. Egri, C. Fekete, 2016, Endocrinology.

cDNA cloning of a mouse pituitary adenylate cyclase-activating polypeptide receptor.

H. Hashimoto, A. Baba, T. Matsuda, 1996, Biochimica et biophysica acta.

CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice

Masataka Nakamura, J. Waschek, H. Hashimoto, 2015, Behavioural Brain Research.

The 5-HT2C Receptor as a Target for Schizophrenia

H. Meltzer, H. Hashimoto, Liwen Sun, 2011 .

Psychopharmacology of combined activation of the serotonin1A and &sgr;1 receptors

H. Hashimoto, T. Matsuda, Y. Ago, 2017, European journal of pharmacology.

Impaired long-term potentiation in vivo in the dentate gyrus of pituitary adenylate cyclase-activating polypeptide (PACAP) or PACAP type 1 receptor-mutant mice

H. Hashimoto, N. Shintani, A. Baba, 2003, Neuroreport.

Increased ethanol preference and serotonin 1A receptor-dependent attenuation of ethanol-induced hypothermia in PACAP-deficient mice.

H. Hashimoto, N. Shintani, A. Baba, 2010, Biochemical and biophysical research communications.

Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction

K. Ohi, Masataka Nakamura, H. Hashimoto, 2016, Behavioural Brain Research.

Central CRTH2, a Second Prostaglandin D2 Receptor, Mediates Emotional Impairment in the Lipopolysaccharide and Tumor-Induced Sickness Behavior Model

R. Hashimoto, Masataka Nakamura, H. Hashimoto, 2014, The Journal of Neuroscience.

Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice

S. Narumiya, Y. Urade, Masataka Nakamura, 2020, Communications Biology.

Involvement of Na+–Ca2+ Exchanger in Reperfusion‐induced Delayed Cell Death of Cultured Rat Astrocytes

J. Azuma, H. Hashimoto, A. Baba, 1996, The European journal of neuroscience.

Decreased expression of hippocampal Na+/Ca2+ exchanger isoform-1 by pentylenetetrazole kindling in mice

H. Hashimoto, T. Matsuda, T. Kawanai, 2015, Epilepsy Research.

Characterization of the Thermoregulatory Response to Pituitary Adenylate Cyclase-Activating Polypeptide in Rodents

A. Tamas, G. Toth, D. Reglodi, 2014, Journal of Molecular Neuroscience.

Impaired response to hypoxia in the respiratory center is a major cause of neonatal death of the PACAP‐knockout mouse

S. Shioda, S. Arata, H. Hashimoto, 2013, The European journal of neuroscience.

Depression‐like behavior in the forced swimming test in PACAP‐deficient mice: amelioration by the atypical antipsychotic risperidone

R. Hashimoto, M. Takeda, K. Nagai, 2009, Journal of neurochemistry.

Lack of light-induced elevation of renal sympathetic nerve activity and plasma corticosterone levels in PACAP-deficient mice

K. Nagai, M. Tanida, Y. Isojima, 2008, Neuroscience Letters.

Lack of Trimethyltin (TMT)‐Induced Elevation of Plasma Corticosterone in PACAP‐Deficient Mice

H. Hashimoto, N. Shintani, A. Baba, 2006, Annals of the New York Academy of Sciences.

Serotonergic Inhibition of Intense Jumping Behavior in Mice Lacking PACAP (Adcyap1−/−)

H. Hashimoto, N. Shintani, A. Baba, 2006, Annals of the New York Academy of Sciences.

Overexpression of PACAP in the pancreas failed to rescue early postnatal mortality in PACAP-null mice

H. Hashimoto, N. Shintani, A. Baba, 2004, Regulatory Peptides.

PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus

M. Nakata, T. Yada, H. Hashimoto, 2004, Neuroscience Letters.

[In vivo functional analysis of the neuropeptide PACAP using gene-targeted mice].

H. Hashimoto, N. Shintani, 2003, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice

H. Hashimoto, T. Matsuda, T. Nakazawa, 2017, Behavioural Brain Research.

Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior

K. Shirahige, T. Miyakawa, T. Yamashita, 2017, The Journal of experimental medicine.

Reduced hypothermic and hypnotic responses to ethanol in PACAP-deficient mice

H. Hashimoto, N. Shintani, A. Baba, 2004, Regulatory Peptides.

Involvement of intracellular Ca2+ elevation but not cyclic AMP in PACAP-induced p38 MAP kinase activation in PC12 cells

H. Hashimoto, N. Shintani, A. Baba, 2002, Regulatory Peptides.

Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes

S. Wakana, Makoto Sato, S. Yamaguchi, 2020, Nature Communications.

Postsynaptic 5-hydroxytryptamine(1A) receptor activation increases in vivo dopamine release in rat prefrontal cortex.

H. Hashimoto, A. Baba, Y. Koyama, 2000, British journal of pharmacology.

Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway

Kotaro Sakamoto, H. Hashimoto, T. Nakazawa, 2023, Peptides.

KB-R7943 inhibits store-operated Ca(2+) entry in cultured neurons and astrocytes.

H. Hashimoto, A. Baba, Y. Koyama, 2000, Biochemical and biophysical research communications.

Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP)

T. Atsumi, S. Shioda, Dandan Song, 2015, Journal of Neuroinflammation.

Small-molecule non-peptide antagonists of the PACAP receptor attenuate acute restraint stress-induced anxiety-like behaviors in mice.

I. Takasaki, H. Hashimoto, A. Hayata-Takano, 2022, Biochemical and biophysical research communications.

Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background

D. Reglodi, B. Gaszner, V. Csernus, 2017, Neuroscience.

Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide

A. Tamas, D. Reglodi, M. Tanida, 2015, Neuroscience.

Environmental factors during early developmental period influence psychobehavioral abnormalities in adult PACAP-deficient mice

H. Hashimoto, N. Shintani, A. Baba, 2010, Behavioural Brain Research.

PACAP Protects the Adolescent and Adult Mice Brain from Ethanol Toxicity and Modulates Distinct Sets of Genes Regulating Similar Networks

H. Vaudry, H. Hashimoto, D. Vaudry, 2017, Molecular Neurobiology.

Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice

H. Hashimoto, T. Matsuda, Y. Ago, 2015, Behavioural pharmacology.

Over-expression of pancreatic pituitary adenylate cyclase-activating polypeptide (PACAP) aggravates cerulein-induced acute pancreatitis in mice.

Akinobu Suzuki, H. Kiyama, H. Hashimoto, 2009, Journal of pharmacological sciences.

Role of Prefrontal Serotonergic and Dopaminergic Systems in Encounter-Induced Hyperactivity in Methamphetamine-Sensitized Mice

H. Hashimoto, T. Matsuda, Y. Ago, 2016, The international journal of neuropsychopharmacology.

Inhibition of Self‐Renewal and Induction of Neural Differentiation by PACAP in Neural Progenitor Cells

Takeshi Shimada, H. Hashimoto, N. Shintani, 2006, Annals of the New York Academy of Sciences.

Early Neurobehavioral Development of Mice Lacking Endogenous PACAP

A. Tamas, D. Reglodi, T. Juhász, 2017, Journal of Molecular Neuroscience.

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Is Involved in Adult Mouse Hippocampal Neurogenesis After Stroke

S. Shioda, H. Hashimoto, A. Miyazaki, 2016, Journal of Molecular Neuroscience.

Endogenous pituitary adenylate cyclase activating polypeptide is involved in suppression of edema in the ischemic brain.

S. Shioda, H. Hashimoto, N. Shintani, 2010, Acta neurochirurgica. Supplement.

Role of endogenous pituitary adenylate cyclase-activating polypeptide in adult hippocampal neurogenesis

H. Hashimoto, A. Baba, T. Matsuda, 2011, Neuroscience.

Involvements of PHI-nitric oxide and PACAP-BK channel in the sustained relaxation of mouse gastric fundus.

H. Hashimoto, N. Shintani, A. Baba, 2008, European journal of pharmacology.

The melanocortin system is involved in regulating autonomic nerve activity through central pituitary adenylate cyclase-activating polypeptide

M. Tanida, H. Hashimoto, N. Shintani, 2011, Neuroscience Research.

Expression pattern of messenger RNAs for prostanoid receptors in glial cell cultures

Makoto Sawada, Hitoshi Hashimoto, Akio Suzumura, 1996, Brain Research.

Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid‐induced autism

H. Hashimoto, T. Matsuda, Y. Ago, 2016, Autism research : official journal of the International Society for Autism Research.

Serotonin 5-HT7 Receptor Blockade Reverses Behavioral Abnormalities in PACAP-Deficient Mice and Receptor Activation Promotes Neurite Extension in Primary Embryonic Hippocampal Neurons

K. Ogata, H. Hashimoto, N. Shintani, 2012, Journal of Molecular Neuroscience.

Development / Plasticity / Repair Pituitary Adenylate Cyclase-Activating Polypeptide Is Required for the Development of Spinal Sensitization and Induction of Neuropathic Pain

S. Matsumura, E. Okuda‐Ashitaka, S. Ito, 2004 .

Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST

H. Hashimoto, T. Nakazawa, A. Kasai, 2019, Nature Protocols.

High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates

Takeharu Nagai, Shun Yamaguchi, Katsumasa Fujita, 2017, Neuron.

Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats

S. Kasparov, H. Hashimoto, T. Nakagawa, 2018, Neuropsychopharmacology.

PACAP is an Endogenous Protective Factor—Insights from PACAP-Deficient Mice

A. Lakatos, A. Tamas, D. Reglodi, 2012, Journal of Molecular Neuroscience.

Accelerated pre‐senile systemic amyloidosis in PACAP knockout mice – a protective role of PACAP in age‐related degenerative processes

R. Casadonte, M. Kriegsmann, R. Longuespée, 2018, The Journal of pathology.

Comparative Protein Composition of the Brains of PACAP-Deficient Mice Using Mass Spectrometry-Based Proteomic Analysis

A. Tamas, D. Reglodi, B. Gaszner, 2014, Journal of Molecular Neuroscience.

Effects of Pituitary Adenylate Cyclase Activating Polypeptide on Human Sperm Motility

A. Tamas, G. Toth, D. Reglodi, 2012, Journal of Molecular Neuroscience.

A. Tamas, D. Reglodi, H. Hashimoto, 2013, Neurotoxicity Research.

Pituitary adenylate cyclase-activating polypeptide plays an anti-inflammatory role in endotoxin-induced airway inflammation: In vivo study with gene-deleted mice

D. Reglodi, É. Szőke, H. Hashimoto, 2011, Peptides.

Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) show increased susceptibility to in vivo renal ischemia/reperfusion injury

A. Tamas, D. Reglodi, B. Rácz, 2011, Neuropeptides.

Impaired nocifensive behaviours and mechanical hyperalgesia, but enhanced thermal allodynia in pituitary adenylate cyclase-activating polypeptide deficient mice

D. Reglodi, B. Gaszner, H. Hashimoto, 2010, Neuropeptides.

Mice deficient in neuropeptide PACAP demonstrate increased sensitivity to in vitro kidney hypoxia.

A. Tamas, D. Reglodi, B. Rácz, 2010, Transplantation Proceedings.

Pituitary Adenylate Cyclase-Activating Polypeptide Deficiency Enhances Oxazolone-Induced Allergic Contact Dermatitis in Mice

D. Reglodi, H. Hashimoto, A. Baba, 2010, Journal of Molecular Neuroscience.

Mice Deficient in Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) are More Susceptible to Retinal Ischemic Injury In Vivo

A. Tamas, G. Toth, D. Reglodi, 2011, Neurotoxicity Research.

Neuroprotective Effect of Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide on Spinal Cord Injury

T. Atsumi, Akira Yoshikawa, S. Shioda, 2012, Journal of Molecular Neuroscience.

PACAP-Deficient Mice Exhibit Light Parameter–Dependent Abnormalities on Nonvisual Photoreception and Early Activity Onset

K. Nagai, Y. Isojima, H. Hashimoto, 2010, PloS one.

The Female Encounter Test: A Novel Method for Evaluating Reward-Seeking Behavior or Motivation in Mice

H. Hashimoto, T. Matsuda, Y. Ago, 2015, The international journal of neuropsychopharmacology.

Effect of PACAP on Heat Exposure

H. Hashimoto, Satoshi Hirako, H. Ohtaki, 2023, International journal of molecular sciences.

Altered Notch Signaling in Developing Molar Teeth of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)-Deficient Mice

A. Tamas, D. Reglodi, B. Gaszner, 2018, Journal of Molecular Neuroscience.

Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor

S. Shioda, S. Numazawa, H. Hashimoto, 2016, Scientific Reports.

Role of Pituitary Adenylate-Cyclase Activating Polypeptide and Tac1 gene derived tachykinins in sensory, motor and vascular functions under normal and neuropathic conditions

J. Stewart, J. Quinn, D. Reglodi, 2013, Peptides.

Involvement of p38 MAP kinase pathway in the synergistic activation of PACAP mRNA expression by NGF and PACAP in PC12h cells.

H. Hashimoto, A. Baba, K. Tanaka, 2001, Biochemical and biophysical research communications.

PACAP activates Rac1 and synergizes with NGF to activate ERK1/2, thereby inducing neurite outgrowth in PC12 cells.

H. Katoh, M. Negishi, H. Hashimoto, 2004, Brain research. Molecular brain research.

Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus Is Responsible for Food Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice

H. Hashimoto, N. Shintani, T. Nakamachi, 2020, Molecular Neurobiology.

p13 overexpression in pancreatic β-cells ameliorates type 2 diabetes in high-fat-fed mice.

R. Hashimoto, Soken Tsuchiya, Y. Sugimoto, 2015, Biochemical and biophysical research communications.

Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus Is Responsible for Food Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice

H. Hashimoto, N. Shintani, T. Nakamachi, 2020, Molecular Neurobiology.

An enriched environment ameliorates memory impairments in PACAP-deficient mice

H. Hashimoto, N. Shintani, A. Baba, 2014, Behavioural Brain Research.

Corrigendum: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders

Masahiko Watanabe, M. Kano, T. Manabe, 2016, Nature Communications.

Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice

H. Hashimoto, N. Shintani, A. Baba, 2007, Peptides.

Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission

H. Onoe, S. Chaki, A. Nakazato, 2011, Psychopharmacology.

Ritanserin reverses repeated methamphetamine‐induced behavioral and neurochemical sensitization in mice

H. Hashimoto, A. Baba, T. Matsuda, 2007, Synapse.

Effect of taurine on angiotensin II-induced expression of immediate early response genes in primary cultured neonatal rat heart cells.

J. Azuma, H. Hashimoto, A. Baba, 1996, Advances in experimental medicine and biology.

Pituitary adenylate cyclase-activating polypeptide (PACAP) receptor mRNA in the rat adrenal gland: localization by in situ hybridization and identification of splice variants.

H. Hashimoto, A. Baba, T. Matsuda, 1997, Japanese journal of pharmacology.

High-Fat Diet Augments VPAC 1 Receptor-Mediated PACAP Action on the Liver , Inducing LAR Expression and Insulin Resistance

M. Nakata, T. Yada, H. Hashimoto, 2016 .

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

K. Yamakawa, H. Kasai, I. Graef, 2024, eLife.

GnRH-induced PACAP and PAC1 receptor expression in pituitary gonadotrophs: A possible role in the regulation of gonadotropin subunit gene expression

H. Hashimoto, N. Shintani, A. Baba, 2010, Peptides.

Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism

H. Hashimoto, T. Matsuda, T. Nakazawa, 2017, Hormones and Behavior.

Identification and characterization of parathyroid hormone/parathyroid hormone-related peptide receptor in cultured astrocytes.

H. Hashimoto, A. Baba, S. Nagata, 1994, Biochemical and biophysical research communications.

Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation

K. Ogata, J. Waschek, H. Hashimoto, 2019, The Journal of Neuroscience.

The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses isolation rearing-induced abnormal behaviors in mice.

H. Onoe, S. Chaki, A. Nakazato, 2012, Journal of pharmacological sciences.

Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice

H. Onoe, S. Chaki, A. Nakazato, 2011, Neuropharmacology.

Compensatory Recovery of Blood Glucose Levels in KKAy Mice Fed a High-Fat Diet: Insulin-Sparing Effects of PACAP Overexpression in β Cells

H. Hashimoto, N. Shintani, A. Baba, 2012, Journal of Molecular Neuroscience.

Modification of cocaine‐induced behavioral and neurochemical effects by serotonin1A receptor agonist/antagonist in mice

H. Hashimoto, A. Baba, T. Matsuda, 2006, Synapse.

High-Fat Diet Augments VPAC1 Receptor-Mediated PACAP Action on the Liver, Inducing LAR Expression and Insulin Resistance

M. Nakata, T. Yada, H. Hashimoto, 2016, Journal of diabetes research.

Behavioral characterization of mice overexpressing human dysbindin-1

T. Nabeshima, R. Hashimoto, M. Takeda, 2014, Molecular Brain.

Pituitary adenylate cyclase-activating polypeptide does not colocalize with vasoactive intestinal polypeptide in the hypothalamic magnocellular nuclei and posterior pituitary of cats and rats

A. Arimura, H. Hashimoto, A. Baba, 2003, Endocrine.

mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model

H. Kouji, H. Hashimoto, T. Nakazawa, 2019, Pharmacology Biochemistry and Behavior.

Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model

H. Hashimoto, T. Matsuda, Y. Ago, 2015, Behavioural Brain Research.

Anti‐anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma‐1 receptors in picrotoxin‐treated mice

H. Hashimoto, T. Matsuda, Y. Ago, 2017, British journal of pharmacology.

Desensitization, surface expression, and glycosylation of a functional, epitope-tagged type I PACAP (PAC(1)) receptor.

H. Hashimoto, N. Shintani, A. Baba, 2000, Biochimica et biophysica acta.

Is it possible to minimize overdrainage complications with gravitational units in patients with idiopathic normal pressure hydrocephalus? Protocol of the randomized controlled SVASONA Trial (ISRCTN51046698).

V. Rohde, M. Schuhmann, T. Kuroiwa, 2010, Acta neurochirurgica. Supplement.

An antihyperkinetic action by the serotonin 1A-receptor agonist osemozotan co-administered with psychostimulants or the non-stimulant atomoxetine in mice.

M. Kubo, H. Hashimoto, N. Shintani, 2009, Journal of pharmacological sciences.

Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice

H. Hashimoto, T. Matsuda, T. Nakazawa, 2017, Psychopharmacology.

Regulation of emotional behaviors by juvenile environmental factors.

H. Hashimoto, T. Matsuda, T. Nakazawa, 2017, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response.

K. Nunomura, H. Hashimoto, N. Shintani, 2018, Biochemical and biophysical research communications.

Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST

Hitoshi Hashimoto, Atsushi Kasai, Kaoru Seiriki, 2019, Nature Protocols.

Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model

H. Hashimoto, T. Matsuda, Y. Ago, 2015, Behavioural Brain Research.

Corrigendum.

Masahiko Watanabe, T. Manabe, K. Ohi, 2019, European heart journal.

Na(+)-Ca(2+) exchanger isoforms in rat neuronal preparations: different changes in their expression during postnatal development.

H. Hashimoto, A. Baba, Y. Koyama, 2000, Brain research.

Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice

H. Hashimoto, T. Matsuda, Y. Ago, 2015, Behavioural pharmacology.

Critical involvement of the orbitofrontal cortex in hyperlocomotion induced by NMDA receptor blockade in mice.

S. Yamaguchi, H. Hashimoto, T. Nakazawa, 2016, Biochemical and biophysical research communications.

Role of the 5-HT1A autoreceptor in the enhancement of fluvoxamine-induced increases in prefrontal dopamine release by adrenalectomy/castration in mice.

H. Hashimoto, T. Matsuda, Y. Ago, 2015, Journal of pharmacological sciences.