G. Cozier

发表

Characterization of the membrane quinoprotein glucose dehydrogenase from Escherichia coli and characterization of a site-directed mutant in which histidine-262 has been changed to tyrosine.

C. Anthony, G. Cozier, R. A. Salleh, 1999, The Biochemical journal.

ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV

E. Sturrock, K. Acharya, G. Cozier, 2020, Clinical science.

Chimeric microtubule disruptors.

B. Potter, K. Acharya, A. Purohit, 2010, Chemical communications.

The toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae

K. Acharya, R. Isaac, G. Cozier, 2017, Scientific Reports.

Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition.

C. Eyermann, K. Chibale, G. Basarab, 2022, Journal of medicinal chemistry.

Structural basis for the inhibition of human angiotensin‐1 converting enzyme by fosinoprilat

E. Sturrock, K. Acharya, G. Cozier, 2022, The FEBS journal.

How a DNA mimic catches and cleaves NF-κB

K. Acharya, G. Cozier, K. Acharya, 2018, The Journal of Biological Chemistry.

Regulation of CK2 Activity by Phosphatidylinositol Phosphates*

V. Korolchuk, G. Banting, G. Cozier, 2005, Journal of Biological Chemistry.

Engineering the Phosphoinositide-binding Profile of a Class I Pleckstrin Homology Domain*

P. Cullen, G. Cozier, D. Bouyoucef, 2003, Journal of Biological Chemistry.

A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug Discovery

A. M. Riley, P. Nordlund, Mark P Thomas, 2012, ACS chemical biology.

Modular phosphoinositide-binding domains – their role in signalling and membrane trafficking

P. Cullen, G. Banting, G. Cozier, 2001, Current Biology.

Crystal structure of a peptidyl‐dipeptidase K‐26‐DCP from Actinomycete in complex with its natural inhibitor

K. Acharya, G. Cozier, B. Bachmann, 2016, The FEBS journal.

The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme.

S. Fienberg, K. Chibale, E. Sturrock, 2018, Journal of medicinal chemistry.

Studying the spatial and temporal regulation of Ras GTPase-activating proteins.

P. Cullen, G. Cozier, S. Kupzig, 2006, Methods in Enzymology.

GAP1IP4BP contains a novel group I pleckstrin homology domain that directs constitutive plasma membrane association.

P. Cullen, G. Banting, G. Cozier, 2000, The Journal of biological chemistry.

Structural basis for the C-domain-selective angiotensin-converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb).

E. Sturrock, K. Acharya, G. Cozier, 2019, The Biochemical journal.

Crystal structures of angiotensin converting enzyme from Anopheles gambiae in its native form and with a bound inhibitor.

K. Acharya, R. Isaac, G. Cozier, 2019, The Biochemical journal.

Structure of the quinoprotein glucose dehydrogenase of Escherichia coli modelled on that of methanol dehydrogenase from Methylobacterium extorquens.

C. Anthony, G. Cozier, 1995, The Biochemical journal.

The structure of the quinoprotein alcohol dehydrogenase of Acetobacter aceti modelled on that of methanol dehydrogenase from Methylobacterium extorquens.

C. Anthony, G. Cozier, I. Giles, 1995, The Biochemical journal.

Membrane targeting by pleckstrin homology domains.

P. Cullen, G. Cozier, D. Bouyoucef, 2004, Current topics in microbiology and immunology.

The Phox Homology (PX) Domain-dependent, 3-Phosphoinositide-mediated Association of Sorting Nexin-1 with an Early Sorting Endosomal Compartment Is Required for Its Ability to Regulate Epidermal Growth Factor Receptor Degradation*

R. Teasdale, P. Cullen, P. Gleeson, 2002, The Journal of Biological Chemistry.

Molecular modelling and site-directed mutagenesis of the inositol 1,3,4,5-tetrakisphosphate-binding pleckstrin homology domain from the Ras GTPase-activating protein GAP1IP4BP.

R. Sessions, P. Cullen, G. Cozier, 2000, The Biochemical journal.

Angiotensin‐converting enzyme open for business: structural insights into the subdomain dynamics

E. Sturrock, K. Acharya, G. Cozier, 2020, The FEBS journal.

Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin—Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme

E. Sturrock, K. Acharya, G. Cozier, 2020, Journal of medicinal chemistry.

ACE-domain selectivity extends beyond direct interacting residues at the active site

E. Sturrock, K. Acharya, G. Cozier, 2020, The Biochemical journal.

Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-Domain: Implications for Drug Design.

E. Sturrock, K. Acharya, G. Cozier, 2018, Journal of medicinal chemistry.

GFP fusion proteins to study signaling in live cells.

P. Cullen, G. Cozier, S. Walker, 2004, Methods in molecular biology.

Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template.

B. Potter, K. Acharya, A. Purohit, 2010, Journal of medicinal chemistry.

Identification of a Ras GTPase‐activating protein regulated by receptor‐mediated Ca2+ oscillations

Guy A Rutter, Takashi Tsuboi, G. Rutter, 2004, The EMBO journal.

Investigation into the Mechanism of Homo- and Heterodimerization of Angiotensin-Converting Enzyme

E. Sturrock, K. Acharya, G. Cozier, 2018, Molecular Pharmacology.

Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family

P. Nordlund, B. Potter, G. Cozier, 2016, Biochemistry.

Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein

A. M. Riley, C. Camacho, D. Svergun, 2023, Science Signaling.

Photochemical Fingerprinting Is a Sensitive Probe for the Detection of Synthetic Cannabinoid Receptor Agonists; toward Robust Point-of-Care Detection

Benedict C. May, Matthew N. Grayson, R. Crespo‐Otero, 2023, Analytical chemistry.

Crystal structures of sampatrilat and sampatrilat‐Asp in complex with human ACE – a molecular basis for domain selectivity

K. Chibale, E. Sturrock, K. Acharya, 2018, The FEBS journal.

Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors.

G. Cozier, N. Thiyagarajan, M. Baker, 2010, Biochemistry.