J. Sands

发表

Evidence that the inhibition of Na+/K(+)-ATPase activity by FK506 involves calcineurin.

J. Lea, J. Sands, S. J. McMahon, 1994, Kidney international.

Vasopressin effects on urea and H2O transport in inner medullary collecting duct subsegments.

M. Knepper, H. Nonoguchi, J. Sands, 1987, The American journal of physiology.

Urea permeability of mammalian inner medullary collecting duct system and papillary surface epithelium.

M. Knepper, J. Sands, M. A. Knepper, 1987, The Journal of clinical investigation.

Current concepts of the countercurrent multiplication system.

J. Sands, J. Kokko, 1996, Kidney international. Supplement.

Renal Actions of Vasopressin

M. Knepper, J. Sands, H. Valtin, 2011 .

Urinary concentrating ability in patients with Jk(a-b-) blood type who lack carrier-mediated urea transport.

R. Gunn, J. Gargus, J. Sands, 1992, Journal of the American Society of Nephrology : JASN.

Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct.

H. W. Harris, E. Brown, S. Hebert, 1997, The Journal of clinical investigation.

The Urine Concentrating Mechanism and Urea Transporters

J. Sands, H. Layton, 2013 .

NSAIDs Alter Phosphorylated Forms of AQP2 in the Inner Medullary Tip

Baoxue Yang, J. Sands, Huiwen Ren, 2015, PloS one.

Activation of the cAMP/PKA pathway induces UT-A1 urea transporter monoubiquitination and targets it for lysosomal degradation.

Guangping Chen, J. Sands, Hua Su, 2013, American journal of physiology. Renal physiology.

Urea transport in MDCK cells that are stably transfected with UT-A1.

R. Gunn, J. Sands, O. Fröhlich, 2004, American journal of physiology. Cell physiology.

The N-terminal 81-aa fragment is critical for UT-A1 urea transporter bioactivity.

Guangping Chen, J. Sands, D. Eaton, 2010, Journal of epithelial biology & pharmacology.

GDE5 inhibition accumulates intracellular glycerophosphocholine and suppresses adipogenesis at a mitotic clonal expansion stage.

J. Sands, N. Yanaka, T. Izumi, 2019, American journal of physiology. Cell physiology.

PKC-α contributes to high NaCl-induced activation of NFAT5 (TonEBP/OREBP) through MAPK ERK1/2.

M. Burg, J. Sands, J. Ferraris, 2015, American journal of physiology. Renal physiology.

Osmolarity-stimulated urea transport in rat terminal IMCD: role of intracellular calcium.

R. Star, J. Sands, A. Gillin, 1993, The American journal of physiology.

The TonE/TonEBP Pathway Mediates Tonicity-responsive Regulation of UT-A Urea Transporter Expression*

Y. Nakayama, J. Sands, S. Bagnasco, 2000, The Journal of Biological Chemistry.

Molecular approaches to urea transporters.

J. Sands, 2002, Journal of the American Society of Nephrology : JASN.

Identification of a Novel UT-B Urea Transporter in Human Urothelial Cancer

Baoxue Yang, Guangping Chen, J. Sands, 2017, Front. Physiol..

Genetic restoration of aldose reductase to the collecting tubules restores maturation of the urine concentrating mechanism.

S. Tam, S. Chung, Hong Guo, 2006, American journal of physiology. Renal physiology.

Vasopressin in the Kidney—Historical Aspects

J. Sands, L. Schlanger, 2009 .

E3 ligase MDM2 mediates urea transporter A1 ubiquitination under either constitutive or stimulatory conditions.

J. Sands, Chun Zhang, H. Su, 2019, American journal of physiology. Renal physiology.

Small GTPase Rab14 down‐regulates UT‐A1 urea transport activity through enhanced clathrin‐dependent endocytosis

Guangping Chen, J. Sands, O. Fröhlich, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Water Balance In Elderly Population

J. Sands, J. Bailey, L. Schlanger, 2022 .

Renal expression of the ammonia transporters, Rhbg and Rhcg, in response to chronic metabolic acidosis.

J. Sands, J. Verlander, R. Seshadri, 2006, American journal of physiology. Renal physiology.

Changes in subcellular distribution of the ammonia transporter, Rhcg, in response to chronic metabolic acidosis.

J. Sands, J. Verlander, R. Seshadri, 2006, American journal of physiology. Renal physiology.

The kidney research national dialogue: gearing up to move forward.

B. Freedman, S. Somlo, J. Bonventre, 2014, Clinical journal of the American Society of Nephrology : CJASN.

Increased susceptibility to acute kidney injury due to endoplasmic reticulum stress in mice lacking tumor necrosis factor-α and its receptor 1.

G. Striker, F. Grosjean, J. Sands, 2011, Kidney international.

Inhibition of urea transporter ameliorates uremic cardiomyopathy in chronic kidney disease

Xiaonan H. Wang, J. Sands, Nawazish Naqvi, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Impaired urine concentration and absence of tissue ACE: involvement of medullary transport proteins.

Anne K. Mongiu, K. Bernstein, J. Sands, 2002, American journal of physiology. Renal physiology.

Understanding renal physiology leads to therapeutic advances in renal disease.

J. Sands, 2015, Physiology.

Geriatric nephrology: old or new subspecialty.

J. Sands, J. Bailey, L. Schlanger, 2009, Clinics in geriatric medicine.

Ethical challenges in nephrology: a call for action

V. Jha, D. Harris, G. London, 2020, Nature Reviews Nephrology.

A prospective evaluation of the glomerular filtration rate in older adults with frequent nighttime urination.

J. Ouslander, J. Sands, T. Johnson, 2002, The Journal of urology.

Hydration Interventions Among Agricultural Workers

V. Hertzberg, L. Elon, J. Sands, 2022, Journal of occupational and environmental medicine.

COVID-19 and Agricultural Workers: A Descriptive Study

V. Hertzberg, L. Elon, J. Sands, 2021, Journal of Immigrant and Minority Health.

Modulation of kidney urea transporter UT-A3 activity by alpha2,6-sialylation

Guangping Chen, J. Sands, Xiang Song, 2016, Pflügers Archiv - European Journal of Physiology.

Vasopressin regulation of multisite phosphorylation of UT-A1 in the inner medullary collecting duct.

J. Sands, Mitsi A Blount, D. Gumina, 2015, American journal of physiology. Renal physiology.

Mature N‐linked glycans facilitate UT‐A1 urea transporter lipid raft compartmentalization

Guangping Chen, J. Sands, O. Fröhlich, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts.

J. Sands, O. Fröhlich, Mitsi A Blount, 2006, Journal of the American Society of Nephrology : JASN.

97- and 117-kDa forms of collecting duct urea transporter UT-A1 are due to different states of glycosylation.

M. Knepper, J. Sands, C. Chou, 2001, American journal of physiology. Renal physiology.

Safety and efficacy of low-dose subcutaneous erythropoietin in hemodialysis patients.

J. Bailey, W. Mitch, J. Sands, 1997, Journal of the American Society of Nephrology : JASN.

Urea transport processes are induced in rat IMCD subsegments when urine concentrating ability is reduced.

J. Sands, Akihiko Kato, 1999, American journal of physiology. Renal physiology.

Stimulation of UT-A1-mediated transepithelial urea flux in MDCK cells by lithium.

R. Gunn, J. Sands, O. Fröhlich, 2008, American journal of physiology. Renal physiology.

Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus.

R. Walker, J. Sands, J. Leader, 2008, American journal of physiology. Renal physiology.

Down-regulation of urea transporters in the renal inner medulla of lithium-fed rats.

R. Gunn, B. Roberts, J. Sands, 2002, Kidney international.

Effect of age and testosterone on the vasopressin and aquaporin responses to dehydration in Fischer 344/Brown-Norway F1 rats.

C. Sladek, J. Sands, J. Klein, 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

Electrolytes in the aging.

J. Sands, J. Bailey, L. Schlanger, 2010, Advances in chronic kidney disease.

Dominantly inherited cardioskeletal myopathy with lysosomal glycogen storage and normal acid maltase levels.

J. Sands, I. Trounce, B. Crotty, 1986, Brain : a journal of neurology.

Metformin improves urine concentration in rodents with nephrogenic diabetes insipidus.

J. Sands, Huiwen Ren, J. Klein, 2016, JCI insight.

Acidosis mediates the upregulation of UT-A protein in livers from uremic rats.

B. Roberts, J. Sands, J. Klein, 2002, Journal of the American Society of Nephrology : JASN.

Regulation of aldose reductase, sorbitol dehydrogenase, and taurine cotransporter mRNA in rat medulla.

S. Price, J. Sands, S. Martial, 1995, Journal of the American Society of Nephrology : JASN.

Urea and Ammonia Metabolism and the Control of Renal Nitrogen Excretion.

W. Mitch, J. Sands, I. Weiner, 2015, Clinical journal of the American Society of Nephrology : CJASN.

Effect of Dapagliflozin Treatment on Fluid and Electrolyte Balance in Diabetic Rats

Juan Wang, J. Sands, J. Klein, 2016, The American journal of the medical sciences.

FK506 involves calcineurin

J. Sands, S. J. McMahon, J. Tumlin, 1994 .

Urea Transporters in Health and Disease

J. Sands, J. Klein, 2020 .

Advances in understanding the urine-concentrating mechanism.

J. Sands, H. Layton, 2014, Annual review of physiology.

Urine Concentration and Dilution

R. Fenton, J. Sands, H. Layton, 2012 .

Urea transport in the kidney.

J. Sands, Mitsi A Blount, J. Klein, 2011, Comprehensive Physiology.

CHAPTER 40 – The Urine Concentrating Mechanism and Urea Transporters

J. Sands, H. Layton, 2008 .

Critical role of urea in the urine-concentrating mechanism.

J. Sands, 2007, Journal of the American Society of Nephrology : JASN.

Renal urea transporters

J. Sands, 2004, Current opinion in nephrology and hypertension.

Long-term regulation of renal urea transporter protein expression in rat.

M. Knepper, J. Sands, C. Ecelbarger, 1998, Journal of the American Society of Nephrology : JASN.

Localization of the urea transporter UT-B protein in human and rat erythrocytes and tissues.

R. Gunn, J. Sands, J. Verlander, 2001, American journal of physiology. Cell physiology.

clathrin-coated pit pathways dependent and mediated by both caveolae- and Internalization of UT-A1 urea transporter is dynamin

Guangping Chen, J. Sands, Xiuyan Feng, 2016 .

Internalization of UT-A1 urea transporter is dynamin dependent and mediated by both caveolae- and clathrin-coated pit pathways.

Guangping Chen, J. Sands, Xiuyan Feng, 2010, American journal of physiology. Renal physiology.

Cloning and regulation of expression of the rat kidney urea transporter (rUT2).

M. Hediger, W. S. Lee, M. Knepper, 1995, The Journal of clinical investigation.

Potential role of purinergic signaling in urinary concentration in inner medulla: insights from P2Y2 receptor gene knockout mice.

D. Kohan, B. Kishore, Yue Zhang, 2008, American journal of physiology. Renal physiology.

Protein abundance of urea transporters and aquaporin 2 change differently in nephrotic pair-fed vs. non-pair-fed rats.

Xiaonan H. Wang, J. Sands, D. Eaton, 2012, American journal of physiology. Renal physiology.

Urea transporters are distributed in endothelial cells and mediate inhibition of L-arginine transport.

J. Sands, L. Wagner, C. Baylis, 2002, American journal of physiology. Renal physiology.

High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation

M. Rauh, A. Nishiyama, F. Luft, 2017, The Journal of clinical investigation.

Erlotinib Preserves Renal Function and Prevents Salt Retention in Doxorubicin Treated Nephrotic Rats

J. Sands, Raed N Bou Matar, J. Klein, 2013, PloS one.

Effects of Angiotensin II on Erythropoietin Production in the Kidney and Liver

H. Nonoguchi, Yuichi Sato, M. Mukoyama, 2021, Molecules.

Urine concentrating and diluting ability during aging.

J. Sands, 2012, The journals of gerontology. Series A, Biological sciences and medical sciences.

Urinary concentration and dilution in the aging kidney.

J. Sands, 2009, Seminars in nephrology.

GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation.

H. Wiig, J. Sands, S. Bachmann, 2017, Journal of the American Society of Nephrology : JASN.

The UT-A1 Urea Transporter Interacts with Snapin, a SNARE-associated Protein*

A. Rehm, Guangping Chen, J. Sands, 2007, Journal of Biological Chemistry.

Imaging Renal Urea Handling in Rats at Millimeter Resolution Using Hyperpolarized Magnetic Resonance Relaxometry

M. Lustig, P. Larson, J. Kurhanewicz, 2015, Tomography.

Monitoring urea transport in rat kidney in vivo using hyperpolarized ¹³C magnetic resonance imaging.

J. Kurhanewicz, D. Vigneron, J. Sands, 2012, American journal of physiology. Renal physiology.

Effects of Roxadustat on Erythropoietin Production in the Rat Body

H. Nonoguchi, M. Mukoyama, Y. Izumi, 2022, Molecules.

Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct.

M. Knepper, H. Nonoguchi, J. Sands, 1988, The Journal of clinical investigation.

Functional Anatomy of the Kidney

J. Sands, J. Verlander, 2010 .

Cloning and characterization of two new isoforms of the rat kidney urea transporter: UT-A3 and UT-A4.

R. Gunn, A. Karakashian, J. Sands, 1999, Journal of the American Society of Nephrology : JASN.

Renal actions of atria1 natriuretic factor: a mathematical modeling study

R. Mejia, M. Knepper, J. Sands, 2008 .

Urine Concentrating Mechanism: Measured Permeability Values in Medullary Nephron Segments and Urea Transport Processes

J. Sands, 2002 .

Vasopressin rapidly increases phosphorylation of UT-A1 urea transporter in rat IMCDs through PKA.

J. Sands, J. Klein, Chi Zhang, 2002, American journal of physiology. Renal physiology.

Glucocorticoids mediate a decrease in AVP-regulated urea transporter in diabetic rat inner medulla.

S. Price, J. Sands, J. Bailey, 1997, The American journal of physiology.

Syntaxin specificity of aquaporins in the inner medullary collecting duct.

T. Weimbs, J. Sands, O. Fröhlich, 2009, American journal of physiology. Renal physiology.

Forskolin stimulation promotes urea transporter UT‐A1 ubiquitination, endocytosis and degradation in MDCK cells

Guangping Chen, J. Sands, O. Fröhlich, 2012, American journal of physiology. Renal physiology.

Glucocorticoids downregulate the vasopressin-regulated urea transporter in rat terminal inner medullary collecting ducts.

J. Sands, M. Naruse, J. Klein, 1997, Journal of the American Society of Nephrology : JASN.

Aquaporin 2: not just for moving water.

J. Sands, 2012, Journal of the American Society of Nephrology : JASN.

Regulation of renal urea transporters.

J. Sands, Jeff M. Sands, 1999, Journal of the American Society of Nephrology : JASN.

Net acid transport by isolated perfused inner medullary collecting ducts.

M. Flessner, M. Knepper, H. Nonoguchi, 1990, The American journal of physiology.

Aldosterone decreases UT-A1 urea transporter expression via the mineralocorticoid receptor.

J. Sands, Xiaoqing Luo, J. Bailey, 2004, Journal of the American Society of Nephrology : JASN.

Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters.

Baoxue Yang, Hong Zhou, Tian-luo Lei, 2014, American journal of physiology. Renal physiology.

UT-A Urea Transporter Protein in Heart: Increased Abundance During Uremia, Hypertension, and Heart Failure

B. Roberts, J. Sands, A. McDonough, 2001, Circulation research.

UT-A1/A3 Knockout Mice Show Reduced Fibrosis Following Unilateral Ureteral Obstruction.

Xiaonan H. Wang, J. Sands, J. Klein, 2020, American journal of physiology. Renal physiology.

Water, Water Everywhere: A New Cause and a New Treatment for Nephrogenic Diabetes Insipidus.

J. Sands, 2016, Journal of the American Society of Nephrology : JASN.

Downregulation of renal TonEBP in hypokalemic rats.

Soo-Hyun Park, J. Sands, W. Kim, 2007, American journal of physiology. Renal physiology.

Studies of the uricosuric action of the hypolipidemic drug halofenate

B. Emmerson, J. Sands, P. Ravenscroft, 1973, Clinical pharmacology and therapeutics.

Aldosterone Decreases Vasopressin-Stimulated Water Reabsorption in Rat Inner Medullary Collecting Ducts

J. Sands, J. Klein, Fuying Ma, 2020, Cells.

Lithium intoxication.

J. Sands, R. T. Timmer, 1999, Journal of the American Society of Nephrology : JASN.

Regulation of renal urea transport by vasopressin.

J. Sands, Mitsi A Blount, J. Klein, 2011, Transactions of the American Clinical and Climatological Association.

ENaC activity is increased in isolated, split-open cortical collecting ducts from protein kinase Cα knockout mice.

J. Sands, D. Eaton, H. Bao, 2014, American journal of physiology. Renal physiology.

Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene.

M. Janech, A. Karakashian, J. Sands, 2001, American journal of physiology. Renal physiology.

UT-A urea transporter protein expressed in liver: upregulation by uremia.

J. Sands, J. Bailey, J. Klein, 1999, Journal of the American Society of Nephrology : JASN.

uncontrolled diabetes mellitus in rats Changes in renal medullary transport proteins during

J. Sands, J. Klein, Dongun Kim, 2016 .

Molecular mechanisms of urea transport in health and disease

J. Sands, Mitsi A Blount, J. Klein, 2012, Pflügers Archiv - European Journal of Physiology.

Vasopressin increases urea permeability in the initial IMCD from diabetic rats.

J. Sands, S. Wall, J. Klein, 2005, American journal of physiology. Renal physiology.

Changes in renal medullary transport proteins during uncontrolled diabetes mellitus in rats.

J. Sands, J. Klein, Dongun Kim, 2003, American journal of physiology. Renal physiology.

Regulated expression of renal and intestinal UT-B urea transporter in response to varying urea load.

J. Sands, J. Bailey, S. Bagnasco, 2005, American journal of physiology. Renal physiology.

Weekly subcutaneous erythropoietin maintains hematocrit in chronic hemodialysis patients.

J. Sands, K. Parker, 1993, Journal of the American Society of Nephrology : JASN.

Role of protein kinase C-α in hypertonicity-stimulated urea permeability in mouse inner medullary collecting ducts.

J. Sands, J. Klein, Yanhua Wang, 2013, American journal of physiology. Renal physiology.

Lack of protein kinase C-α leads to impaired urine concentrating ability and decreased aquaporin-2 in angiotensin II-induced hypertension.

J. Sands, Mitsi A Blount, J. Klein, 2012, American journal of physiology. Renal physiology.

Special Feature: Hemolytic-Uremic Syndrome Following “Crack” Cocaine Inhalation

J. Sands, J. Tumlin, A. Someren, 1990 .

Hemolytic-uremic syndrome following "crack" cocaine inhalation.

J. Sands, J. Tumlin, A. Someren, 1990, The American journal of the medical sciences.

Disseminated infection caused by Cunninghamella bertholletiae in a patient with beta-thalassemia. Case report and review of the literature.

T. Ley, A. Nienhuis, J. Sands, 2020, Annals of internal medicine.

Comparison of cloned facilitated urea transportersa

J. Sands, 1999 .

An AMPK activator as a therapeutic option for congenital nephrogenic diabetes insipidus

I. Khanna, J. Sands, J. Klein, 2021, JCI insight.

Adrenomedullin Inhibits Osmotic Water Permeability in Rat Inner Medullary Collecting Ducts

Guangping Chen, J. Sands, J. Klein, 2020, Cells.

Urea transporters UT-A1 and UT-A3 accumulate in the plasma membrane in response to increased hypertonicity.

J. Sands, Mitsi A Blount, J. Klein, 2008, American journal of physiology. Renal physiology.

Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation.

Guangping Chen, S. Price, J. Sands, 2008, American journal of physiology. Renal physiology.

Forskolin stimulates phosphorylation and membrane accumulation of UT-A3.

J. Sands, D. Tchapyjnikov, Mitsi A Blount, 2007, American journal of physiology. Renal physiology.

Expression of urea transporters in potassium-depleted mouse kidney.

M. Knepper, J. Sands, K. Madsen, 2003, American journal of physiology. Renal physiology.

Cloning and characterization of the human urea transporter UTA 1 and mapping of the human Slc 14 a 2 gene

M. Janech, A. Karakashian, J. Sands, 2001 .

Urea transport in the kidney.

J. Sands, A. Gillin, Gillin Ag, 1993, Seminars in nephrology.

Expression of transporters involved in urine concentration recovers differently after cessation of lithium treatment.

J. Sands, Rong Zhou, Mitsi A Blount, 2010, American journal of physiology. Renal physiology.

Molecular Mechanisms of Urea Transport

J. Sands, 2003, The Journal of Membrane Biology.

DISEASE OF THE MONTH Lithium Intoxication

J. Sands, R. T. Timmer, 1999 .

Changes in aquaporin-2 protein contribute to the urine concentrating defect in rats fed a low-protein diet.

J. Wilcox, J. Sands, M. Naruse, 1996, The Journal of clinical investigation.

Effect of nitrogen intake on nitrogen recycling and urea transporter abundance in lambs.

J. Marini, J. Sands, M. Van Amburgh, 2004, Journal of animal science.

MEMBRANE POTENTIALS AND ELEMENTAL MICROANALYSIS OF RENAL PAPILLARY CELLS

J. Sands, L. Teresi, R. Beeuwkes, 1981 .

Loss of N-Linked Glycosylation Reduces Urea Transporter UT-A1 Response to Vasopressin*

Guangping Chen, J. Sands, O. Fröhlich, 2006, Journal of Biological Chemistry.

Evidence for sodium-dependent active urea secretion in the deepest subsegment of the rat inner medullary collecting duct.

J. Sands, A. Kato, 1998, The Journal of clinical investigation.

Adaptive physiological water conservation explains hypertension and muscle catabolism in experimental chronic renal failure

M. Rauh, A. Nishiyama, F. Luft, 2021, Acta physiologica.

Characteristics of osmolarity-stimulated urea transport in rat IMCD.

J. Sands, A. Gillin, 1992, The American journal of physiology.

Urea transporters in kidney and erythrocytes.

R. Gunn, J. Sands, R. T. Timmer, 1997, The American journal of physiology.

Significance of urea transport: the pioneering studies of Bodil Schmidt-Nielsen.

J. Sands, J. Kokko, 2006, American journal of physiology. Renal physiology.

Upregulation of urea transporter UT-A2 and water channels AQP2 and AQP3 in mice lacking urea transporter UT-B.

Baoxue Yang, J. Sands, J. Klein, 2004, Journal of the American Society of Nephrology : JASN.

Mammalian urea transporters.

J. Sands, 2003, Annual review of physiology.

Active urea transport in the rat inner medullary collecting duct: functional characterization and initial expression cloning.

J. Sands, S. Martial, T. Isozaki, 1996, Kidney international.

Urea transport in initial IMCD of rats fed a low-protein diet: functional properties and mRNA abundance.

S. Price, J. Sands, S. Martial, 1995, The American journal of physiology.

Sodium-dependent net urea transport in rat initial inner medullary collecting ducts.

J. Lea, J. Sands, J. Tumlin, 1994, The Journal of clinical investigation.

Protein restriction sequentially induces new urea transport processes in rat initial IMCD.

C. Swanson, J. Sands, T. Isozaki, 1994, The American journal of physiology.

Glucocorticoids inhibit transcription and expression of the UT-A urea transporter gene.

J. Sands, S. Bagnasco, T. Peng, 2002, American journal of physiology. Renal physiology.

Concentration dependence of urea and thiourea transport in rat inner medullary collecting duct.

M. Knepper, H. Nonoguchi, J. Sands, 1990, The American journal of physiology.

Genes and proteins of urea transporters.

J. Sands, Mitsi A Blount, 2014, Sub-cellular biochemistry.

Cloning of the rat Slc14a2 gene and genomic organization of the UT-A urea transporter.

A. Karakashian, J. Sands, M. Naruse, 2001, Biochimica et biophysica acta.

Anatomy and Physiology of the Kidneys

J. Sands, J. Verlander, 2004 .

Altered expression of urea transporters in response to ureteral obstruction.

J. Frøkiaer, S. Nielsen, M. Knepper, 2004, American journal of physiology. Renal physiology.

Immunohistochemical localization of urea transporters A and B in the rat cochlea

S. Lim, J. Sands, S. Yeo, 2003, Hearing Research.

Differential expression of individual UT-A urea transporter isoforms in rat kidney.

J. Sands, S. Bagnasco, T. Peng, 2000, Journal of the American Society of Nephrology : JASN.

Active sodium-urea counter-transport is inducible in the basolateral membrane of rat renal initial inner medullary collecting ducts.

J. Sands, A. Kato, 1998, The Journal of clinical investigation.

Goodpasture's Syndrome in Indentical Twins

P. Kincaid‐smith, J. Sands, A. D'apice, 1978 .

Goodpasture's syndrome in identical twins.

P. Kincaid‐smith, J. Sands, A. D'apice, 1978, Annals of internal medicine.

Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats.

H. W. Harris, E. Brown, S. Hebert, 1998, American journal of physiology. Renal physiology.

Functional characterization of the central hydrophilic linker region of the urea transporter UT-A1: cAMP activation and snapin binding.

J. Sands, O. Fröhlich, J. Klein, 2010, American journal of physiology. Cell physiology.

Urea Transporter B and MicroRNA‐200c Differ in Kidney Outer Versus Inner Medulla Following Dehydration

Xiaonan H. Wang, Juan Wang, J. Sands, 2016, The American journal of the medical sciences.

activity by cyclosporin A

J. Sands, J. Tumlin, 1993 .

Nephron segment-specific inhibition of Na+/K(+)-ATPase activity by cyclosporin A.

J. Sands, J. Tumlin, 1993, Kidney international.

Maturation of aldose reductase expression in the neonatal rat inner medulla.

G. Schwartz, J. Sands, A. Radice, 1992, The Journal of clinical investigation.

Novel activators of aquaporin 2 membrane expression for the treatment of nephrogenic diabetes insipidus: less is more. Focus on "High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration".

J. Sands, Mitsi A Blount, 2014, American journal of physiology. Cell physiology.

Regulation of urea transporter proteins in kidney and liver.

J. Sands, 2000, The Mount Sinai journal of medicine, New York.

The physiology of urinary concentration: an update.

Jeff M Sands, Harold E Layton, J. Sands, 2009, Seminars in nephrology.

14.01 – Functional Anatomy of the Kidney☆

J. Sands, 2018 .

Angiotensin II increases vasopressin-stimulated facilitated urea permeability in rat terminal IMCDs.

J. Sands, J. Klein, A. Kato, 2000, American journal of physiology. Renal physiology.

Expression of urea transporters in the developing rat kidney.

M. Knepper, J. Sands, Ju-Young Jung, 2002, American journal of physiology. Renal physiology.

Activation of protein kinase Cα increases phosphorylation of the UT-A1 urea transporter at serine 494 in the inner medullary collecting duct.

J. Sands, Mitsi A Blount, D. Gumina, 2015, American journal of physiology. Cell physiology.

Activation of protein kinase C increases phosphorylation of the UTA 1 urea transporter at serine 494 in the inner medullary collecting duct

J. Sands, Mitsi A Blount, D. Gumina, 2015 .

Role of vasopressin in diabetes mellitus-induced changes in medullary transport proteins involved in urine concentration in Brattleboro rats.

J. Sands, J. Klein, Dongun Kim, 2004, American journal of physiology. Renal physiology.

Long-term treatment with cyclosporine decreases aquaporins and urea transporters in the rat kidney.

S. Lim, J. Kim, B. Sun, 2004, American journal of physiology. Renal physiology.

Dietary Sodium Intake in Heart Failure

Divya Gupta, Jeff M Sands, Javed Butler, 2012, Circulation.

Tissue distribution of UT-A and UT-B mRNA and protein in rat.

R. Gunn, J. Sands, J. Klein, 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

A novel type of urea transporter, UT-C, is highly expressed in proximal tubule of seawater eel kidney.

Guangping Chen, J. Sands, A. Kato, 2005, American journal of physiology. Renal physiology.

Aging and the Kidney: Clinical and Pathophysiologic Issues

J. Sands, J. Bailey, L. Schlanger, 2020, Chronic Renal Disease.

H. Pontzer, D. Raichlen, S. Tanner, 2019, American journal of physical anthropology.

MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation.

Guangping Chen, S. Price, J. Sands, 2008, American journal of physiology. Renal physiology.

Chapter 11 – Aging and the Kidney: Clinical and Pathophysiological Issues

J. Sands, J. Bailey, L. Schlanger, 2015 .

Urea transporter UT-A1 and aquaporin-2 proteins decrease in response to angiotensin II or norepinephrine-induced acute hypertension.

J. Sands, J. Klein, Young-Hee Kim, 2006, American journal of physiology. Renal physiology.

Long-term regulation of inner medullary collecting duct urea transport in rat.

M. Knepper, J. Sands, Akihiko Kato, 1998, Journal of the American Society of Nephrology : JASN.

Hormone effects on NaCl permeability of rat inner medullary collecting duct.

M. Knepper, H. Nonoguchi, J. Sands, 1988, The American journal of physiology.

Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts.

J. Sands, Mitsi A Blount, J. Klein, 2016, American journal of physiology. Renal physiology.

Aldose reductase activities in microdissected rat renal tubule segments.

M. Knepper, J. Sands, Y. Terada, 1989, The American journal of physiology.

Nephrogenic diabetes insipidus.

D. Bichet, J. Sands, 2006, Advances in chronic kidney disease.

Expression of Na-K-ATPase α- β-subunit mRNA and protein isoforms in the rat nephron

J. Sands, J. Tumlin, R. Medford, 1994 .

Neuronal expression of sodium/bicarbonate cotransporter NBCn1 (SLC4A7) and its response to chronic metabolic acidosis.

J. Sands, I. Rajbhandari, H. Park, 2010, American journal of physiology. Cell physiology.

Expression of Na-K-ATPase alpha- and beta-subunit mRNA and protein isoforms in the rat nephron.

J. Sands, J. Tumlin, R. Medford, 1994, The American journal of physiology.

The Physiology of Water Homeostasis

D. Mount, J. Sands, H. Layton, 2013 .

Na-K-Cl cotransport in apical membrane of rabbit renal papillary surface epithelium.

M. Knepper, J. Sands, K. Spring, 1986, The American journal of physiology.

ANF inhibits NaCl and fluid absorption in cortical collecting duct of rat kidney.

M. Knepper, H. Nonoguchi, J. Sands, 1989, The American journal of physiology.

Acute calcineurin inhibition with tacrolimus increases phosphorylated UT-A1.

J. Sands, Mitsi A Blount, J. Klein, 2012, American journal of physiology. Renal physiology.

Physiology in Medicine: a Series of Articles Linking Medicine with Science Physiology in Medicine: Nephrogenic Diabetes Insipidus Web-only Cme Quiz Conversion of Figures into Slides

D. Bichet, J. Sands, D. J. Benos, 2022 .

Nephrogenic Diabetes Insipidus st[Water and Urea Transport

J. Sands, D. Bichet, 2006 .

Immunolocalization of phospholipase C isoforms in rat kidney.

M. Marrero, D. Ertoy, J. Lea, 1998, Kidney international.

Acute changes in intracellular ions or pH and regulation of aldose reductase activity.

J. Sands, D. Schrader, 1991, Journal of the American Society of Nephrology : JASN.

Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane.

Baoxue Yang, J. Sands, Huiwen Ren, 2016, American journal of physiology. Renal physiology.

Urea transporters and sweat response to uremia

J. Sands, J. Bailey, J. Klein, 2016, Physiological reports.

V. Hertzberg, M. Tansey, L. Elon, 2021, Biological research for nursing.

Defining kidney biology to understand renal disease.

A. McMahon, Dennis Brown, O. Weisz, 2014, Clinical journal of the American Society of Nephrology : CJASN.

Effect of aging on vasopressin and aquaporin responses to dehydration in Fischer 344-brown-Norway F1 rats.

C. Sladek, J. Sands, J. Jacobs, 1997, The American journal of physiology.

Suppression subtractive hybridization analysis of low-protein diet- and vitamin D-induced gene expression from rat kidney inner medullary base.

Guangping Chen, J. Sands, O. Fröhlich, 2010, Physiological genomics.

Urea transport processes are induced in rat IMCD subsegments when urine concentrating ability is reduced.

J. Sands, A. Kato, 1999, American Journal of Physiology.

Low protein diet alters urea transport and cell structure in rat initial inner medullary collecting duct.

J. Sands, J. Verlander, T. Isozaki, 1993, The Journal of clinical investigation.

Autonomic Regulation of Cardiovascular Function in Health and Disease MEETING PROGRAM

H. Raff, M. Joyner, I. Llewellyn-Smith, 2011 .

Ultrastructural localization of UT-A and UT-B in rat kidneys with different hydration status.

S. Lim, M. Knepper, J. Sands, 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

Water Channel Physiology and Pathophysiology Symposium: Introduction

J. Sands, 1998 .

N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct.

J. Sands, J. Klein, S. Steele, 2011, American journal of physiology. Renal physiology.

Translating kidney fibrosis: Role of the EP2 receptor

J. Sands, 2019, Acta physiologica.

Glucagon infusion alters the hyperpolarized 13C‐urea renal hemodynamic signature

J. Sands, C. Laustsen, Haiyun Qi, 2018, NMR in biomedicine.

Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels.

R. Stan, J. Sands, B. Thomson, 2017, Journal of the American Society of Nephrology : JASN.

Independence of urea and water transport in rat inner medullary collecting duct.

M. Knepper, J. Sands, C. Chou, 1989, American Journal of Physiology.

Downregulation of urea transporter UT-A1 activity by 14-3-3 protein.

H. Fu, Yuhong Du, Guangping Chen, 2015, American journal of physiology. Renal physiology.

Protein kinase C regulates urea permeability in the rat inner medullary collecting duct.

J. Sands, J. Klein, C. Liedtke, 2010, American journal of physiology. Renal physiology.

Regulation of UT-A1-mediated transepithelial urea flux in MDCK cells.

R. Gunn, J. Sands, O. Fröhlich, 2006, American journal of physiology. Cell physiology.

Expression of salt and urea transporters in rat kidney during cisplatin-induced polyuria.

B. Kishore, J. Sands, C. Ecelbarger, 2001, Kidney international.

Urea may regulate urea transporter protein abundance during osmotic diuresis.

J. Sands, J. Klein, Dongun Kim, 2005, American journal of physiology. Renal physiology.

Renal actions of atrial natriuretic factor: a mathematical modeling study.

R. Mejia, M. Knepper, J. Sands, 1989, The American journal of physiology.

Caveolin-1 directly interacts with UT-A1 urea transporter: the role of caveolae/lipid rafts in UT-A1 regulation at the cell membrane.

Guangping Chen, J. Sands, Xiuyan Feng, 2009, American journal of physiology. Renal physiology.

Physiological insights into novel therapies for nephrogenic diabetes insipidus.

J. Sands, J. Klein, 2016, AJP - Renal Physiology.

The Health Status of Hispanic Agricultural Workers in Georgia and Florida

V. Hertzberg, L. Elon, J. Sands, 2022, Journal of Immigrant and Minority Health.

Progress in the Detection of Erythropoietin in Blood, Urine, and Tissue

H. Nonoguchi, Y. Izumi, K. Kawahara, 2023, Molecules.

High urea induces depression and LTP impairment through mTOR signalling suppression caused by carbamylation

Baoxue Yang, Shuai Zhu, Jing Li, 2019, EBioMedicine.

Glucocorticoids mediate a decrease in AVP-regulated urea transporter in diabetic rat inner medulla.

S. Price, J. Sands, J. Bailey, 1997, American journal of physiology. Renal physiology.

Urine concentration in the diabetic mouse requires both urea and water transporters.

J. Sands, Mitsi A Blount, J. Klein, 2013, American journal of physiology. Renal physiology.

Urea and NaCl regulate UT-A1 urea transporter in opposing directions via TonEBP pathway during osmotic diuresis.

J. Sands, H. Kwon, Hyun-wook Lee, 2009, American journal of physiology. Renal physiology.

Adrenalectomy Blocks the Compensatory Increases in UT-A1 and AQP2 in Diabetic Rat Kidney

J. Sands, J. Klein, S. Kozlowski, 2006, The Journal of Membrane Biology.

Transgenic Restoration of Urea Transporter A1 Confers Maximal Urinary Concentration in the Absence of Urea Transporter A3.

J. Sands, Mitsi A Blount, J. Klein, 2016, Journal of the American Society of Nephrology : JASN.

Protein kinase C-α mediates hypertonicity-stimulated increase in urea transporter phosphorylation in the inner medullary collecting duct.

J. Sands, J. Klein, Christopher F. Martin, 2012, American journal of physiology. Renal physiology.

Phosphorylation of UTA 1 on serine 486 correlates with membrane accumulation and urea transport activity in both rat IMCDs and cultured cells

J. Sands, O. Fröhlich, Mitsi A Blount, 2010 .

ductspermeability in mouse inner medullary collecting

J. Sands, J. Klein, Yanhua Wang, 2016 .

Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts.

J. Sands, S. Wall, Mitsi A Blount, 2009, Journal of the American Society of Nephrology : JASN.

Candesartan Differentially Regulates Epithelial Sodium Channel in Cortex Versus Medulla of Streptozotocin-Induced Diabetic Rats.

C. Ecelbarger, J. Sands, S. Tiwari, 2009, Journal of epithelial biology & pharmacology.

Candesartan augments compensatory changes in medullary transport proteins in the diabetic rat kidney.

S. Price, J. Sands, Mitsi A Blount, 2008, American journal of physiology. Renal physiology.

Using the payback framework to evaluate the outcomes of pilot projects supported by the Georgia Clinical and Translational Science Alliance

Dorothy R Carter, E. Nehl, J. Sands, 2020, Journal of Clinical and Translational Science.

Urine-concentrating ability in the aging kidney.

J. Sands, 2003, Science of aging knowledge environment : SAGE KE.

Activation of protein kinase C-α and Src kinase increases urea transporter A1 α-2, 6 sialylation.

Baoxue Yang, Guangping Chen, J. Sands, 2015, Journal of the American Society of Nephrology : JASN.

Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC.

J. Sands, D. Eaton, H. Bao, 2019, American journal of physiology. Renal physiology.

Urea gradient-associated fluid absorption with sigma urea = 1 in rat terminal collecting duct.

M. Knepper, H. Nonoguchi, J. Sands, 1990, American Journal of Physiology.

Atrial natriuretic factor does not improve the outcome of cadaveric renal transplantation.

W. Mitch, J. Sands, J. Whelchel, 1991, Journal of the American Society of Nephrology : JASN.

Urea transport in the kidney.

J. Sands, Mitsi A Blount, J. Klein, 2011, Comprehensive Physiology.

Lack of protein kinase C-α leads to impaired urine concentrating ability and decreased aquaporin-2 in angiotensin II-induced hypertension.

J. Sands, Mitsi A Blount, J. Klein, 2012, American journal of physiology. Renal physiology.

Dietary Sodium Intake in Heart Failure

Carolyn M. Reilly, C. Yancy, M. Gheorghiade, 2012, Circulation.

MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation.

Guangping Chen, J. Sands, J. Klein, 2008, American journal of physiology. Renal physiology.

Molecular mechanisms of urea transport in health and disease

J. Sands, Mitsi A Blount, J. Klein, 2012, Pflügers Archiv - European Journal of Physiology.

Phosphorylation of UT-A1 on serine 486 correlates with membrane accumulation and urea transport activity in both rat IMCDs and cultured cells.

J. Sands, Mitsi A Blount, J. Klein, 2010, American journal of physiology. Renal physiology.

Overview and historical perspective.

Baoxue Yang, J. Sands, 2014, Sub-cellular biochemistry.

Metformin improves urine concentration in rodents with nephrogenic diabetes insipidus.

J. Sands, Huiwen Ren, J. Klein, 2016, JCI insight.

Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus.

R. Walker, J. Sands, J. Leader, 2008, American journal of physiology. Renal physiology.

Small GTPase Rab14 down‐regulates UT‐A1 urea transport activity through enhanced clathrin‐dependent endocytosis

Guangping Chen, J. Sands, Heping Ma, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Protein kinase C-α mediates hypertonicity-stimulated increase in urea transporter phosphorylation in the inner medullary collecting duct.

J. Sands, J. Klein, Christopher F. Martin, 2012, American journal of physiology. Renal physiology.

An independent effect of osmolality on urea transport in rat terminal inner medullary collecting ducts.

J. Sands, J M Sands, D C Schrader, 1991, The Journal of clinical investigation.

Effect of Dapagliflozin Treatment on Fluid and Electrolyte Balance in Diabetic Rats

Juan Wang, J. Sands, J. Klein, 2016, The American journal of the medical sciences.

Reversal of renal failure in Wegener's granulomatosis cy heparin.

J. Sands, A. Whitaker, I. Bunce, 1973, The American journal of the medical sciences.

kidney Expression of urea transporters in the developing rat

J. Sands, Ju-Young Jung, Young-Hee Kim, 2016 .

Effects of water restriction on gene expression in mouse renal medulla: identification of 3betaHSD4 as a collecting duct protein.

Kumar Sharma, James B Hoying, Jeff M Sands, 2006, American journal of physiology. Renal physiology.