D. Toft

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A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23.

J. Johnson, D. Toft, D. Toft, 1994, The Journal of biological chemistry.

Recent Advances in the Study of hsp90 Structure and Mechanism of Action

D. Toft, 1998, Trends in Endocrinology & Metabolism.

The Hsp90 chaperone complex as a novel target for cancer therapy.

M. Goetz, C. Erlichman, M. Ames, 2003, Annals of oncology : official journal of the European Society for Medical Oncology.

Steroid receptor interactions with heat shock protein and immunophilin chaperones.

W. Pratt, D. Toft, David O. Toft, 1997, Endocrine reviews.

The Assembly and Intermolecular Properties of the hsp70-Hop-hsp90 Molecular Chaperone Complex*

D. Toft, M. Hernández, W. Sullivan, 2002, The Journal of Biological Chemistry.

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor.

Minoru Yoshida, June-Tai Wu, C. Nicchitta, 2005, Molecular cell.

Defining the Requirements for Hsp40 and Hsp70 in the Hsp90 Chaperone Pathway*

D. Toft, Nela S Cintron, 2006, Journal of Biological Chemistry.

An acetylation site in the middle domain of Hsp90 regulates chaperone function.

N. Rosen, L. Neckers, L. Karnitz, 2007, Molecular cell.

HSP40 Binding Is the First Step in the HSP90 Chaperoning Pathway for the Progesterone Receptor*

D. Toft, A. Chadli, M. Hernández, 2002, The Journal of Biological Chemistry.

A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src.

J. Brugge, W. Yonemoto, D. Toft, 1985, The Journal of biological chemistry.

Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein.

W. Pratt, E. R. Sánchez, D. Toft, 1985, The Journal of biological chemistry.

Identification of the 90 kDa substrate of rat liver type II casein kinase with the heat shock protein which binds steroid receptors.

J. J. Dougherty, D. Toft, A. Iannotti, 1987, Biochimica et biophysica acta.

Reconstitution of progesterone receptor with heat shock proteins.

D. Toft, D. F. Smith, D. Schowalter, 1990, Molecular endocrinology.

Purification of unactivated progesterone receptor and identification of novel receptor-associated proteins.

D. Toft, D. F. Smith, L. E. Faber, 1990, The Journal of biological chemistry.

Assembly of progesterone receptor with heat shock proteins and receptor activation are ATP mediated events.

W. Welch, D. Toft, D. F. Smith, 1992, The Journal of biological chemistry.

Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70

K. Zaitsu, D. Toft, D. F. Smith, 1993, Molecular and cellular biology.

Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes

J. Johnson, D. Toft, T. Beito, 1994, Molecular and cellular biology.

The 23-kDa Acidic Protein in Reticulocyte Lysate Is the Weakly Bound Component of the hsp Foldosome That Is Required for Assembly of the Glucocorticoid Receptor into a Functional Heterocomplex with hsp90 (*)

W. Pratt, J. Johnson, D. Toft, 1995, The Journal of Biological Chemistry.

Binding of p23 and hsp90 during assembly with the progesterone receptor.

J. Johnson, D. Toft, D. Toft, 1995, Molecular endocrinology.

Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A.

D. Edwards, S. Nordeen, D. Toft, 1995, Molecular endocrinology.

p23, a simple protein with complex activities

D. Toft, S. Felts, 2003, Cell stress & chaperones.

Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein p23

R. Morimoto, B. Freeman, D. Toft, 1996, Science.

Phase I study of 17-allylamino-17 demethoxygeldanamycin, gemcitabine and/or cisplatin in patients with refractory solid tumors

C. Erlichman, P. Haluska, R. Qin, 2011, Investigational New Drugs.

Estrogen response in the hFOB 1.19 human fetal osteoblastic cell line stably transfected with the human estrogen receptor gene

B. Riggs, B. L. Riggs, D. Toft, 1995, Journal of cellular biochemistry.

A distinction between 3-methylcholanthrene and estrogen binding in the uterus.

D. Toft, T. Spelsberg, 1972, Cancer research.

ATP-dependent chaperoning activity of reticulocyte lysate.

R. Hurst, D. Toft, R. Matts, 1994, The Journal of biological chemistry.

Relationship of the 90-kDa murine heat shock protein to the untransformed and transformed states of the L cell glucocorticoid receptor.

S. Meshinchi, W. Pratt, E. R. Sánchez, 1987, The Journal of biological chemistry.

Hsp90 Inhibition Depletes Chk1 and Sensitizes Tumor Cells to Replication Stress*

Sonnet J. H. Arlander, B. Vroman, L. Karnitz, 2003, Journal of Biological Chemistry.

P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors.

S. Schreiber, M. Albers, D. Toft, 1993, Biochemistry.

Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70

R. Minchin, D. Toft, D. Mok, 2004, Cell stress & chaperones.

Nucleotides and Two Functional States of hsp90*

E. Alnemri, D. Toft, G. Litwack, 1997, The Journal of Biological Chemistry.

Cisplatin abrogates the geldanamycin-induced heat shock response

C. Erlichman, W. Lingle, D. Toft, 2008, Molecular Cancer Therapeutics.

Up-regulation of heat shock protein 27 induces resistance to 17-allylamino-demethoxygeldanamycin through a glutathione-mediated mechanism.

C. Erlichman, D. Toft, A. McCollum, 2006, Cancer research.

Response of human breast cancer cells to heat shock and chemotherapeutic drugs.

W. McGuire, S. Fuqua, D. Toft, 1992, Cancer research.

Requirement of Heat Shock Protein 90 for Human Hepatitis B Virus Reverse Transcriptase Function

D. Toft, Jianming Hu, Xingtai Wang, 2004, Journal of Virology.

P-Glycoprotein-mediated resistance to Hsp90-directed therapy is eclipsed by the heat shock response.

K. Ballman, C. Erlichman, R. Jenkins, 2008, Cancer research.

Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions.

D. Toft, David F. Smith, 2008, Molecular endocrinology.

Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer.

J. Sloan, M. Goetz, A. Adjei, 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

The Influence of ATP and p23 on the Conformation of hsp90*

D. Toft, B. Owen, W. Sullivan, 2002, The Journal of Biological Chemistry.

Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones.

Sreenath V. Sharma, L. Neckers, S. Akinaga, 1999, Molecular endocrinology.

The Importance of ATP Binding and Hydrolysis by Hsp90 in Formation and Function of Protein Heterocomplexes*

D. Toft, J. Grenert, B. D. Johnson, 1999, The Journal of Biological Chemistry.

Cooperative action of Hsp70, Hsp90, and DnaJ proteins in protein renaturation.

E. Alnemri, B. Freeman, D. Toft, 1996, Biochemistry.

Hop Modulates hsp70/hsp90 Interactions in Protein Folding*

D. Toft, B. D. Johnson, E. Ross, 1998, The Journal of Biological Chemistry.

HSP70 and HSP90 expression in leucocytes after exercise in moderately trained humans.

M. Joyner, D. Toft, S. Shastry, 2002, Acta physiologica Scandinavica.

GCUNC45 Is the First Hsp90 Co-chaperone to Show α/β Isoform Specificity*

D. Toft, A. Chadli, S. Felts, 2008, Journal of Biological Chemistry.

The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes

D. Toft, B. Stensgard, Jill R. Johnson, 1996, The Journal of Steroid Biochemistry and Molecular Biology.

Mutational analysis of hsp90 binding to the progesterone receptor.

D. Toft, W. Sullivan, 1993, The Journal of biological chemistry.

Identification of a complex between centrin and heat shock proteins in CSF-arrested Xenopus oocytes and dissociation of the complex following oocyte activation.

D. Toft, J. Salisbury, B. Madden, 1995, Developmental biology.

Immunofluorescence colocalization of the 90-kDa heat-shock protein and microtubules in interphase and mitotic mammalian cells.

M. Welsh, E. Bresnick, W. Pratt, 1989, European journal of cell biology.

Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70-Based Chaperone Machinery 1

W. Pratt, D. Toft, 2003, Experimental biology and medicine.

hsp70 interacting protein Hip does not affect glucocorticoid receptor folding by the hsp90-based chaperone machinery except to oppose the effect of BAG-1.

John Calvin Reed, S. Takayama, M. Galigniana, 2000, Biochemistry.

The Assembly of Progesterone Receptor-hsp90 Complexes Using Purified Proteins*

D. Toft, B. Stensgard, H. Kosano, 1998, The Journal of Biological Chemistry.

The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation*

Timothy A. J. Haystead, E. Sausville, T. Haystead, 1997, The Journal of Biological Chemistry.

Phase I study of tanespimycin in combination with bortezomib in patients with advanced solid malignancies

Erin L. Schenk, C. Erlichman, D. Northfelt, 2013, Investigational New Drugs.

ATP sensitive tryptophans of hsp90.

T. Burghardt, D. Toft, B. Bartha, 1998, Biophysical chemistry.

A Phase I Trial of Twice-Weekly 17-Allylamino-Demethoxy-Geldanamycin in Patients with Advanced Cancer

S. Mandrekar, C. Erlichman, A. Adjei, 2006, Clinical Cancer Research.

D. Donner, P. Nguyen, J. Trepel, 2000, The Journal of Biological Chemistry.

Preparation of monoclonal antibodies to the avian progesterone receptor.

D. Toft, W. Sullivan, T. Beito, 1986, Endocrinology.

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin.

L. Neckers, S. Soga, S. Akinaga, 1998, Cell stress & chaperones.

Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants.

D. Toft, D. F. Smith, W. Sullivan, 1998, Cell stress & chaperones.

Hsp90 Chaperone Activity Requires the Full-length Protein and Interaction among Its Multiple Domains*

D. Toft, M. Catelli, A. Chadli, 2000, The Journal of Biological Chemistry.

Chapter 7 – HEAT SHOCK PROTEINS AND STEROID HORMONE RECEPTORS

D. Toft, W. Sullivan, R. Riehl, 1987 .

Progesterone "receptors" in the cytoplasm and nucleus of chick oviduct target tissue.

B. O’Malley, D. Toft, M. R. Sherman, 1970, Proceedings of the National Academy of Sciences of the United States of America.

An improved method for the measurement of 1,25-(OH)2D3 in human plasma.

B. Roos, D. Toft, S. Hodgson, 1978, Endocrine research communications.

Accelerated recovery of postischemic stunned myocardium after induced expression of myocardial heat-shock protein (HSP70).

J. J. Morris, D. Toft, T. Morita, 1995, The Journal of thoracic and cardiovascular surgery.

The A and B forms of the chicken progesterone receptor arise by alternate initiation of translation of a unique mRNA.

B. O’Malley, O. Conneely, D. Toft, 1987, Biochemical and biophysical research communications.

Binding of heat shock proteins to the avian progesterone receptor

W. Welch, D. Toft, D. F. Smith, 1989, Molecular and cellular biology.

A specific progesterone receptor in the hamster uterus: physiologic properties and regulation during the estrous cycle.

B. O’Malley, D. Toft, C. Strott, 1974, Endocrinology.

Characterization and physiological variation of estrogen receptors in rabbit corpora lutea throughout pregnancy and pseudopregnancy: the effect of hysterectomy and sustained estradiol treatment.

J. Miller, D. Toft, 1983, Biology of reproduction.

Immunological evidence that the nonhormone binding component of avian steroid receptors exists in a wide range of tissues and species.

D. Toft, W. Sullivan, V. Bauer, 1985, Biochemistry.

Immunocytochemical localization of estrogen-induced progestin receptors in guinea pig brain

J. Turcotte, D. Toft, J. C. King, 1988, Brain Research.

The production of antibodies against the conserved cysteine region of steroid receptors and their use in characterizing the avian progesterone receptor.

D. Lubahn, D. Toft, D. F. Smith, 1988, Endocrinology.

Characterization of a cytoplasmic receptor for 5alpha-dihydrotestosterone in the caput epididymidis of intact rabbits.

D. Toft, M. Orgebin-Crist, B. J. Danzo, 1973, Endocrinology.

FKBP51 Promotes Assembly of the Hsp90 Chaperone Complex and Regulates Androgen Receptor Signaling in Prostate Cancer Cells

H. Frierson, B. Paschal, Chun-song Yang, 2010, Molecular and Cellular Biology.

Molecular cloning of the chicken progesterone receptor

B. O’Malley, R. Cook, G. Greene, 1986, Science.

Activity of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cells

G. Yang, J. Dering, R. Finn, 2008, British Journal of Cancer.

of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cells.

G. Yang, J. Dering, C. Ginther, 2008 .

Inhibition of progesterone receptor activation by sodium molybdate.

D. Toft, H. Nishigori, 1980, Biochemistry.

Phosphorylation in vivo of chicken oviduct progesterone receptor.

J. J. Dougherty, R. Puri, D. Toft, 1982, The Journal of biological chemistry.

Inactivation of avian progesterone receptor binding to ATP-Sepharose by pyridoxal 5'-phosphate.

V. Moudgil, D. Toft, H. Nishigori, 1978, Biochemical and biophysical research communications.

Inhibition of the binding of progesterone receptor to nuclei: effects of o-phenanthroline and rifamycin AF/013.

D. Toft, P. Lohmar, 1975, Biochemical and biophysical research communications.

Binding of ATP to the progesterone receptor.

V. Moudgil, D. Toft, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Progesterone-binding components of chick oviduct. VIII. Receptor activation and hormone-dependent binding to purified nuclei.

B. O’Malley, R. Buller, D. Toft, 1975, The Journal of biological chemistry.

Characterization of the avian progesterone receptor through the use of inhibitors.

V. Moudgil, D. Toft, H. Nishigori, 1979, Advances in experimental medicine and biology.

Composition, assembly and activation of the avian progesterone receptor

D. Toft, David F. Smith, 1992, The Journal of Steroid Biochemistry and Molecular Biology.

A Sex Steroid Receptor in the Water Mold Achlya ambisexualis

D. Toft, R. Riehl, 1986 .

Effect of culture medium composition on pheromone receptor levels in Achlya ambisexualis.

D. Toft, R. Riehl, 1985, Journal of steroid biochemistry.

Concentration of cytosolic estrogen receptors in patients with postmenopausal osteoporosis.

B. J. Davidson, B. Riggs, D. Toft, 1980, American journal of obstetrics and gynecology.

Requirement for activation in the binding of progesterone receptor to ATP-Sepharose.

D. Toft, J. B. Miller, 1978, Biochemistry.

Binding of ATP to Progesterone Receptors: Properties and Functional Significance of This Interaction *

V. Moudgil, D. Toft, Josephine B. Miller, 1977, Annals of the New York Academy of Sciences.

The properties and functional significance of ATP binding to progesterone receptors.

V. Moudgil, D. Toft, P. Lohmar, 1976, Journal of steroid biochemistry.

Structure-function properties of the chicken progesterone receptor A synthesized from complementary deoxyribonucleic acid.

M. Carson, B. O’Malley, M. Tsai, 1987, Molecular endocrinology.

Chemical modification of the avian progesterone receptor by pyridoxal 5'-phosphate.

D. Toft, H. Nishigori, 1979, The Journal of biological chemistry.

Hormone-dependent phosphorylation of the avian progesterone receptor.

D. Toft, W. Sullivan, B. Madden, 1988, The Journal of biological chemistry.

Progesterone-binding protein of chick oviduct. VI. Interaction of purified progesterone-receptor components with nuclear constituents.

B. O’Malley, D. Toft, W. Schrader, 1972, The Journal of biological chemistry.

In Vitro Assembly of the Avian Progesterone Receptor

D. Toft, D. F. Smith, W. Sullivan, 1994 .

Polypeptide components of two 8 S forms of chicken oviduct progesterone receptor.

J. J. Dougherty, R. Puri, D. Toft, 1984, The Journal of biological chemistry.

Transformation of mammary cytoplasmic glucocorticoid receptor under cell-free conditions.

G. Shyamala, D. Toft, W. McBlain, 1981, Biochemistry.

Interaction of progesterone receptor with immobilized adenosine triphosphate.

V. Moudgil, D. Toft, 1977, Biochimica et biophysica acta.

[14] Receptor identification by density gradient centrifugation

D. Toft, M. R. Sherman, 1975 .

Testosterone binding in the chick oviduct.

R. Harrison, D. Toft, 1973, Biochemical and biophysical research communications.

Receptors for glucocorticoids in lung tissue.

D. Toft, F. Chytil, 1973, Archives of biochemistry and biophysics.

Transformation of highly purified avian progesterone receptor.

R. Puri, D. Toft, 1984, Endocrinology.

Immunologic analysis of human breast cancer progesterone receptors. 2. Structure, phosphorylation, and processing.

D. Edwards, K. Horwitz, P. Sheridan, 1987, Biochemistry.

Purification of Nontransformed Avian Progesterone Receptor

D. Toft, David F. Smith, 1990 .

Immunocytochemical study of progesterone receptors in hyperplastic and neoplastic endometrial tissues.

A. Ferenczy, G. Shyamala, D. Toft, 1988, Cancer research.

Progesterone-binding components of chick oviduct. II. Nuclear components.

B. O’Malley, D. Toft, M. R. Sherman, 1971, The Journal of biological chemistry.

Role of the cochaperone Tpr2 in Hsp90 chaperoning.

D. Toft, C. Uhl, W. Obermann, 2008, Biochemistry.

Studies with antibodies against the conserved cysteine region of progesterone receptor.

D. Toft, D. F. Smith, D. Mccormick, 1988, Journal of steroid biochemistry.

A phase I trial of 17-allylamino-geldanamycin (17AAG) in patients with advanced cancer.

S. Mandrekar, M. Goetz, C. Erlichman, 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

In vitro binding of retinol to rat-tissue components.

D. Toft, F. Chytil, M. M. Bashor, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Molecular chaperones function as steroid receptor nuclear mobility factors.

Cem Elbi, G. Hager, D. DeFranco, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of progesterone receptor activation by vanadate.

D. Toft, H. Nishigori, J. Alker, 1980, Archives of biochemistry and biophysics.

Analysis of the steroid receptor of Achlya ambisexualis.

D. Toft, R. Riehl, 1984, The Journal of biological chemistry.

Detection of a pheromone-binding protein in the aquatic fungus Achlya ambisexualis.

D. Toft, T. Mcmorris, R. Riehl, 1984, Experimental cell research.

Progesterone receptor concentration differences in the chick oviduct cells and apparent down-regulation by ligand. A semiquantitative immunohistochemical study.

D. Toft, T. Joensuu, P. Tuohimaa, 1989, Journal of Steroid Biochemistry.

Sequence and expression of a functional chicken progesterone receptor.

B. O’Malley, M. Tsai, O. Conneely, 1987, Molecular endocrinology.

Progesterone-induced avidin as a marker of cytodifferentiation in the oviduct: comparison to ovalbumin.

M. Kulomaa, D. Toft, T. Joensuu, 1990, Endocrinology.

Target tissue receptors for progesterone: the influence of estrogen treatment.

B. O’Malley, D. Toft, Bert W. O'Malley, 1972, Endocrinology.

Interaction of murine progesterone receptors with specific monoclonal antibodies to the avian progesterone receptor.

G. Shyamala, D. Toft, W. Sullivan, 1988, Journal of steroid biochemistry.

Hormone‐dependent processing of the avian progesterone receptor

D. Toft, David F. Smith, W. Sullivan, 1988, Journal of cellular biochemistry.

Hormone receptors: studies on the interaction of estrogen with the uterus.

J. Gorski, G. Shyamala, D. Toft, 1968, Recent progress in hormone research.

Functional requirement of p23 and Hsp90 in telomerase complexes.

G. Morin, M. White, J. Shay, 1999, Genes & development.

A receptor molecule for estrogens: studies using a cell-free system.

J. Gorski, G. Shyamala, D. Toft, 1967, Proceedings of the National Academy of Sciences of the United States of America.

The interaction of uterine estrogen receptors with DNA.

D. Toft, 1972, Advances in experimental medicine and biology.

Stabilization of the avian progesterone receptor by inhibitors.

D. Toft, H. Nishigori, 1979, Journal of steroid biochemistry.

Isolation of steroid receptor binding protein from chicken oviduct and production of monoclonal antibodies.

R. Puri, D. Toft, W. Sullivan, 1985, Biochemistry.

Estrogen receptors in the chick oviduct.

R. Harrison, D. Toft, 1975, Endocrinology.

A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization.

J. Gorski, S. Penman, D. Toft, 1966, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of an unusual sex steroid binding component from the chicken oviduct.

D. Toft, M. Ruh, 1984, Journal of steroid biochemistry.

Analysis of the Avian Progesterone Receptor with Inhibitors

V. Moudgil, D. Toft, H. Nishigori, 1980 .

A Specific Oviduct Target-Tissue Receptor For Progesterone: Identification, Characterization, Partial Purification, Inter-Compartmental Transfer Kinetics and Specific Interaction with the Genome

B. O’Malley, D. Toft, T. Spelsberg, 1971 .

Hepadnavirus assembly and reverse transcription require a multi‐component chaperone complex which is incorporated into nucleocapsids

C. Seeger, D. Toft, Jianming Hu, 1997, The EMBO journal.

In Vitro Reconstitution of Functional Hepadnavirus Reverse Transcriptase with Cellular Chaperone Proteins

D. Toft, Jianming Hu, Xingtai Wang, 2002, Journal of Virology.

Steroid receptors and their associated proteins.

D. Toft, D. F. Smith, D. F. Smith, 1993, Molecular endocrinology.

Chaperoning Checkpoint Kinase 1 (Chk1), an Hsp90 Client, with Purified Chaperones*

Sonnet J. H. Arlander, L. Karnitz, D. Toft, 2006, Journal of Biological Chemistry.

Progesterone binding in the mouse and rat uterus.

B. O’Malley, D. Toft, S. Glasser, 1972, Endocrinology.

In situ localization of progesterone receptors in normal mouse mammary glands: Absence of receptors in the connective and adipose stroma and a heterogeneous distribution in the epithelium

M. Barcellos-Hoff, G. Shyamala, D. Toft, 1997, The Journal of Steroid Biochemistry and Molecular Biology.

The interaction of uterine estrogen receptors with DNA.

D. Toft, 1972, Journal of steroid biochemistry.

Molecular chaperoning of steroid hormone receptors.

W. Pratt, D. Toft, U. Gehring, 1996, EXS.

Glucocorticoid receptors in mouse pituitary tumor cells. II. Nuclear binding.

D. Toft, D. Orth, H. Watanabe, 1974, Biochemistry.

Glucocorticoid receptors in pituitary tumor cells. I. Cytosol receptors.

D. Toft, D. Orth, H. Watanabe, 1973, The Journal of biological chemistry.

Binding of steroids to progesterone receptor proteins in chick oviduct and human uterus.

B. O’Malley, D. Toft, E. P. Burrows, 1974, The Journal of biological chemistry.

Effect of geldanamycin on androgen receptor function and stability

D. Toft, C. Young, D. Krishna Vanaja, 2002, Cell stress & chaperones.

A method of sequencing without subcloning and its application to the identification of a novel ORF with a sequence suggestive of a transcriptional regulator in the water mold Achlya ambisexualis.

D. Toft, S. Sommer, D. Schowalter, 1990, Genomics.

Nuclease resistance and the enrichment of native nuclear acceptor sites for the avian oviduct progesterone receptor.

D. Toft, T. Spelsberg, M. Horton, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Crystal Structure and Activity of Human p23, a Heat Shock Protein 90 Co-chaperone*

D. Toft, B. Owen, W. Sullivan, 2000, The Journal of Biological Chemistry.

Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies.

D. Edwards, K. Horwitz, L. Wei, 1987, Biochemistry.

Characterization of two 8 S forms of chick oviduct progesterone receptor.

J. J. Dougherty, D. Toft, 1982, The Journal of biological chemistry.

Regulation of Heat Shock Protein 90 ATPase Activity by Sequences in the Carboxyl Terminus*

D. Toft, B. Owen, W. Sullivan, 2002, The Journal of Biological Chemistry.

Interrelationships of nuclear and cytoplasmic estrogen receptors.

J. Gorski, G. Shyamala, D. Toft, 1969, Current Topics in Developmental Biology.

Functioning of the Hsp90 machine in chaperoning checkpoint kinase 1 (Chk1) and the progesterone receptor (PR)

L. Karnitz, D. Toft, S. Felts, 2007, Cell stress & chaperones.

Loss of proliferative potential during terminal differentiation coincides with the decreased abundance of a subset of heterogeneous ribonuclear proteins

R. Scott, P. Minoo, D. Toft, 1989, The Journal of cell biology.

Novel activation step required for transcriptional competence of progesterone receptor on chromatin templates.

S. Nordeen, D. Toft, V. Thackray, 2003, Molecular endocrinology.

Mutational analysis of Hsp90 alpha dimerization and subcellular localization: dimer disruption does not impede "in vivo' interaction with estrogen receptor.

E. Baulieu, D. Toft, M. Catelli, 1996, Journal of cell science.

Open-label, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of intravenously administered CNF1010 (17-(allylamino)-17-demethoxygeldanamycin [17-AAG]) in patients with solid tumors

M. Saif, C. Erlichman, D. Toft, 2013, Cancer Chemotherapy and Pharmacology.

The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies.

K. Yamamoto, B. Freeman, D. Toft, 2000, Genes & development.

Thiopurine S-methyltransferase pharmacogenetics: chaperone protein association and allozyme degradation.

R. Weinshilboum, Liewei Wang, D. Toft, 2003, Pharmacogenetics.

Corticoid binding component in rat brain

D. Toft, F. Chytil, 1972, Journal of neurochemistry.

Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding.

Hwa-Young Kim, H. Ke, Huanchen Wang, 2005, Structure.

Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90.

D. Toft, M. Catelli, A. Chadli, 2000, Proceedings of the National Academy of Sciences of the United States of America.

ATP-PPi exchange activity of progesterone receptor.

V. Moudgil, D. Toft, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Radiochemical probes for steroid hormone receptors.

H. Wahner, D. Toft, 1982, Journal of Nuclear Medicine.

Receptor identification by density gradient centrifugation.

D. Toft, M. R. Sherman, 1975, Methods in Enzymology.

Characterization of progesterone receptor binding to the 90- and 70-kDa heat shock proteins.

B. O’Malley, O. Conneely, D. Toft, 1991, The Journal of biological chemistry.

Immunological Analysis of the Avian Progesterone Receptor

D. Toft, David F. Smith, T. Beito, 1987 .

GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway

K. Horwitz, J. Graham, D. Toft, 2006, Molecular and Cellular Biology.

A Novel In Situ Assay for the Identification and Characterization of Soluble Nuclear Mobility Factors

G. Hager, D. DeFranco, C. Elbi, 2004, Science's STKE.

Evidence for a Mechanism of Repression of Heat Shock Factor 1 Transcriptional Activity by a Multichaperone Complex*

W. Pratt, D. Toft, R. Voellmy, 2001, The Journal of Biological Chemistry.

Immunocytochemical study of progesterone receptors in the human endometrium during the menstrual cycle.

A. Ferenczy, G. Shyamala, D. Toft, 1988, Laboratory investigation; a journal of technical methods and pathology.

Phase I study of CNF1010 (lipid formulation of 17-(allylamino)-17-demethoxygeldanamycin: 17-AAG) in patients with advanced solid tumors.

D. V. Von Hoff, M. Saif, C. Erlichman, 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Hsp90-containing multiprotein complexes in the eukaryotic microbe Achlya.

G. Perdew, D. Toft, S. Brunt, 1998, Cell stress & chaperones.

Biological response of the female strain Achlya ambisexualis 734 to dehydro-oogoniol and analogues

D. Toft, T. Mcmorris, Moon Surksik, 1993 .

Characterization of plant p23-like proteins for their co-chaperone activities

D. Toft, Zhongming Zhang, P. Krishna, 2010, Cell Stress and Chaperones.

A phase I trial of gemcitabine (Gem), 17-allylaminogeldanamycin (17-AAG) and cisplatin (CDDP) in solid tumor patients.

S. Mandrekar, A. Adjei, C. Erlichman, 2004, Journal of Clinical Oncology.

Phosphorylation of steroid receptors

J. J. Dougherty, R. Puri, D. Toft, 1985 .

The avian progesterone receptor: isolation and characterization of phosphorylated forms.

J. J. Dougherty, R. Puri, D. Toft, 1984, Journal of steroid biochemistry.

Purification of "nontransformed" avian progesterone receptor and preliminary characterization.

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