P. Willems

发表

Hormone-stimulated Ca2+ reabsorption in rabbit kidney cortical collecting system is cAMP-independent and involves a phorbol ester-insensitive PKC isotype.

J. Hoenderop, J. De Pont, R. Bindels, 1999, Kidney international.

Localization of the epithelial Ca(2+) channel in rabbit kidney and intestine.

J. Hoenderop, R. Bindels, A. Doucet, 2000, Journal of the American Society of Nephrology : JASN.

Calcitriol controls the epithelial calcium channel in kidney.

F. Sweep, J. Hoenderop, R. Bindels, 2001, Journal of the American Society of Nephrology : JASN.

The Structural Unit of the Thiazide-sensitive NaCl Cotransporter Is a Homodimer*

L. P. Van den Heuvel, N. Knoers, P. Willems, 2003, Journal of Biological Chemistry.

Impaired routing of wild type FXYD2 after oligomerisation with FXYD2-G41R might explain the dominant nature of renal hypomagnesemia.

T. Friedrich, N. Knoers, H. Swarts, 2008, Biochimica et biophysica acta.

A Conformation-specific Interhelical Salt Bridge in the K+ Binding Site of Gastric H,K-ATPase*

E. Krieger, H. Swarts, J. De Pont, 2004, Journal of Biological Chemistry.

The E1/E2‐Preference of Gastric H,K‐ATPase Mutants

H. Swarts, P. Willems, J. B. Koenderink, 2003, Annals of the New York Academy of Sciences.

The role of Lys791 and Asn792 in gastric H,K-ATPase.

H. Swarts, J. De Pont, P. Willems, 2003, Annals of the New York Academy of Sciences.

Structure-Activity Relationships of Na,K-ATPase and H,K-ATPase

H. Swarts, P. Willems, J. B. Koenderink, 2002 .

K+-independent Gastric H+,K+-ATPase Activity

H. Swarts, J. De Pont, P. Willems, 2001, The Journal of Biological Chemistry.

The insulin receptor tyrosine kinase domain in a chimaeric epidermal growth factor-insulin receptor generates Ca2+ signals through the PLC-gamma1 pathway.

P. Willems, W. Frankhuizen, J. Maassen, 1999, Biochimica et biophysica acta.

Functional expression of mutations in the human NaCl cotransporter: evidence for impaired routing mechanisms in Gitelman's syndrome.

L. P. Van den Heuvel, N. Knoers, P. Willems, 2002, Journal of the American Society of Nephrology : JASN.

Lipid effects on neutrophil calcium signaling induced by opsonized particles: platelet activating factor is only part of the story.

P. Willems, A. Tool, D. Roos, 2004, Clinical nutrition.

Mutation of aspartate 804 of Na(+),K(+)-ATPase modifies the cation binding pocket and thereby generates a high Na(+)-ATPase activity.

H. Swarts, J. De Pont, P. Willems, 2000, Biochemistry.

J. De Pont, P. Willems, S. E. van Emst-de Vries, 1990, European journal of biochemistry.

Regulation of GLUT1-mediated glucose uptake by PKCλ-PKCβII interactions in 3T3-L1 adipocytes

C. Sweep, P. Span, M. Bazuine, 2004 .

Inhibition of protein kinase CbetaII increases glucose uptake in 3T3-L1 adipocytes through elevated expression of glucose transporter 1 at the plasma membrane.

C. Sweep, P. Span, A. Schürmann, 2003, Molecular endocrinology.

TRH signal transduction in melanotrope cells of Xenopus laevis.

B. Jenks, E. Roubos, P. Willems, 2002, General and comparative endocrinology.

AFLUID March 47/3

J. Hoenderop, R. Bindels, P. Willems, 2000 .

Immune function and leukocyte sequestration under the influence of parenteral lipid emulsions in healthy humans: a placebo-controlled crossover study.

W. Oyen, J. Jansen, P. Willems, 2008, The American journal of clinical nutrition.

Hormone-stimulated Ca2+transport in rabbit kidney: multiple sites of inhibition by exogenous ATP.

J. Hoenderop, R. Bindels, P. Willems, 1999, American journal of physiology. Renal physiology.

Adenosine-stimulated Ca2+reabsorption is mediated by apical A1 receptors in rabbit cortical collecting system.

J. Hoenderop, R. Bindels, P. Willems, 1998, American journal of physiology. Renal physiology.

Co-ordinated control of apical calcium influx and basolateral calcium efflux in rabbit cortical collecting system.

F. Lang, R. Bindels, P. Willems, 1997, Cell calcium.

Functional expression of the human thiazide-sensitive NaCl cotransporter in Madin-Darby canine kidney cells.

L. P. Van den Heuvel, N. Knoers, P. Willems, 2003, Journal of the American Society of Nephrology : JASN.

U73122 and U73343 inhibit receptor-mediated phospholipase D activation downstream of phospholipase C in CHO cells.

J. De Pont, P. Willems, A. Patel, 1998, European journal of pharmacology.

Effects of chemical chaperones on partially retarded NaCl cotransporter mutants associated with Gitelman's syndrome in a mouse cortical collecting duct cell line.

M. Goossens, L. P. Van den Heuvel, N. Knoers, 2004, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Atrial natriuretic peptide-stimulated Ca 21 reabsorption in rabbit kidney requires membrane-targeted, cGMP-dependent protein kinase type II (cortical collecting ductyconnecting tubuleyadenovirusysodium transportyENaC)

S. Lohmann, S. Gambaryan, J. Hoenderop, 1999 .

Two technetium-99m-labeled cholecystokinin-8 (CCK8) peptides for scintigraphic imaging of CCK receptors.

W. Oyen, O. Boerman, M. Béhé, 2004, Bioconjugate chemistry.

Diradylglycerol formation in cholecystokinin-stimulated rabbit pancreatic acini. Assessment of precursor phospholipids by means of molecular species analysis.

B. Engelmann, J. De Pont, P. Willems, 1996, European journal of biochemistry.

Cross‐linking of Both Types of IgG Fc Receptors, FcγyRI and FcγyRII, Enhances Intracellular Free Ca2+ in the Monocytic Cell Line U937

T. Huizinga, P. Willems, C. Jacobs, 1990, Scandinavian journal of immunology.

Basal Mg(2+)-dependent ATPase activity of rat liver microsomes is not influenced by ambient free Ca2+.

P. Willems, A. Theuvenet, G. J. Visser, 1993, European journal of biochemistry.

Regulation of GLUT 1-mediated glucose uptake by PKC λ – PKC β II interactions in 3 T 3L 1 adipocytes

M. Bazuine, C. Tack, P. Willems, 2017 .

Ca2+ signals during early lymphocyte activation in carp Cyprinus carpio L.

G. Flik, P. Willems, J. Saeij, 1998, The Journal of experimental biology.

Ca 2 + SIGNALS DURING EARLY LYMPHOCYTE ACTIVATION IN CARP CYPRINUS

G. Flik, P. Willems, J. Saeij, 1998 .

Pertussis toxin stimulates cholecystokinin-induced cyclic AMP formation but is without effect on secretagogue-induced calcium mobilization in exocrine pancreas.

J. De Pont, P. Willems, R. H. Tilly, 1987, Biochimica et biophysica acta.

Stimulatory and inhibitory effects of TMB-8 on pancreatic enzyme secretion.

J. De Pont, P. Willems, I. G. van Nooij, 1986, Biochimica et biophysica acta.

Parenteral medium-chain triglyceride-induced neutrophil activation is not mediated by a Pertussis Toxin sensitive receptor.

P. Willems, H. Roelofs, G. Wanten, 2009, Clinical nutrition.

Human GAAP modulates intracellular calcium fluxes

J. Parys, Geoffrey L. Smith, A. Postigo, 2009 .

Time-resolved quantitative analysis of CCK1 receptor-induced intracellular calcium increase

J. Camp, G. Smagghe, P. Willems, 2012, Peptides.

Time-resolved quantitative analysis of CCK 1 receptor-induced intracellular 10 calcium increase 11

J. Camp, P. Willems, D. Staljanssens, 2011 .

FXYD2 and Na,K-ATPase Expression in Isolated Human Proximal Tubular Cells: Disturbed Upregulation on Renal Hypomagnesemia?

E. Levtchenko, H. Swarts, J. De Pont, 2009, Journal of Membrane Biology.

Localization and regulation by vitamin D of calcium transport proteins in rabbit cortical collecting system.

J. Fransen, A. Yu, J. Lytton, 1996, The American journal of physiology.

Permeation and Gating Properties of the Novel Epithelial Ca2+ Channel*

R. Vennekens, B. Nilius, G. Droogmans, 2000, The Journal of Biological Chemistry.

Synchronized Ca2+ signaling by intercellular propagation of Ca2+ action potentials in NRK fibroblasts.

E. J. V. van Zoelen, P. Willems, A. D. de Roos, 1997, American journal of physiology. Cell physiology.

The human non-gastric H,K-ATPase has a different cation specificity than the rat enzyme.

H. Swarts, J. De Pont, P. Willems, 2007, Biochimica et biophysica acta.

Calcium oscillations in melanotrope cells of Xenopus laevis are differentially regulated by cAMP-dependent and cAMP-independent mechanisms.

B. Jenks, E. Roubos, P. Willems, 1996, Cell calcium.

Action of stimulatory and inhibitory α-MSH secretagogues on spontaneous calcium oscillations in melanotrope cells of Xenopus laevis

B. Jenks, E. Roubos, P. Willems, 1994, Pflügers Archiv.

The development of the pars intermedia and its role in the regulation of dermal melanophores in the larvae of the amphibian Xenopus laevis.

B. Jenks, P. Willems, B. M. V. Verburg-van Kemenade, 1984, General and comparative endocrinology.

Molecular Identification of the Apical Ca2+Channel in 1,25-Dihydroxyvitamin D3-responsive Epithelia*

S. V. D. van de Graaf, J. Hoenderop, R. Bindels, 1999, The Journal of Biological Chemistry.

The development of a superfusion system for studying intracellular and secretory processes in embryos

P. Willems, H. Goverde, H. J. Goverde, 1994, In Vitro Cellular & Developmental Biology - Animal.

Cholecystokinin-stimulated enzyme secretion from dispersed rabbit pancreatic acinar cells: phosphorylation-dependent changes in potency and efficacy

P. Willems, J. Pont, S. E. Vries, 1995, Pflügers Archiv.

Rat pancreatic acinar cells express a cytosolic phospholipase D1b isoform that is not regulated by cholecystokinin

P. Willems, S. E. van Emst-de Vries, R. Bosch, 2001, Pflügers Archiv.

Reduced cholecystokinin receptor phosphorylation and restored signalling in protein kinase C down-regulated rat pancreatic acinar cells

L. Miller, J. De Pont, P. Willems, 1998, Pflügers Archiv.

GTP-sensitivity of the energy-dependent Ca2+ storage pool in permeabilized pancreatic acinar cells.

J. De Pont, P. Willems, F. H. van de Put, 1991, Cell calcium.

Effects of phorbol ester and cholecystokinin on the intracellular distribution of protein kinase C in rabbit pancreatic acini.

J. De Pont, P. Willems, S. E. van Emst-de Vries, 1991, European journal of biochemistry.

The diacylglycerol kinase inhibitor, R59022, potentiates cholecystokinin-induced enzyme secretion from rabbit pancreatic acini.

J. De Pont, P. Willems, S. E. van Emst-de Vries, 1990, European journal of biochemistry.

Phorbol ester inhibits cholecystokinin octapeptide-induced amylase secretion and calcium mobilization, but is without effect on secretagogue-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in rabbit pancreatic acini.

J. De Pont, P. Willems, H. Haenen, 1987, Biochimica et biophysica acta.

Protein kinase C‐mediated inhibition of transmembrane signalling through CCKA and CCKB receptors

J. De Pont, P. Willems, R. Smeets, 1998 .

Potentiating role of cyclic AMP in pancreatic enzyme secretion, demonstrated by means of forskolin.

J. De Pont, P. Willems, S. L. Bonting, 1984, Biochimica et biophysica acta.

Mutational analysis of the putative devazepide binding site of the CCK(A) receptor.

A. IJzerman, J. De Pont, P. Willems, 1997, European journal of pharmacology.

Spontaneous calcium oscillations in Xenopus laevis melanotrope cells are mediated by omega-conotoxin sensitive calcium channels.

B. Jenks, E. Roubos, P. Willems, 1994, Cell calcium.

Differences in uptake, storage and release properties between inositol trisphosphate-sensitive and -insensitive Ca2+ stores in permeabilized pancreatic acinar cells.

J. De Pont, P. Willems, P. Nagy, 1995, Cell calcium.

Differences in uptake , storage and release properties between inositol trisphosphatesensitive trisphosphatesensitive trisphosphatesensitive andinsensitive andinsensitive andinsensitive Ca 2 + stores in permeabilized pancreatic acinar cells

P. Willems, P. Nagy, J. Pont, 2022 .

Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a novel actor in invasive growth, controls matrix metalloproteinase activity.

P. Willems, G. V. van Muijen, G. Swart, 2005, Cancer research.

Inhibitory and Stimulatory Interactions Between Endogenous Gonadotropin-Releasing Hormones in the African Catfish (Clarias gariepinus)1

P. Willems, R. Schulz, H. Goos, 2000, Biology of reproduction.

Gonadotrophs but not somatotrophs carry gonadotrophin-releasing hormone receptors: receptor localisation, intracellular calcium, and gonadotrophin and GH release.

S. M. Kolk, O. Lescroart, I. Roelants, 1997, The Journal of endocrinology.

Dose-dependent recruitment of pancreatic acinar cells during receptor-mediated calcium mobilization.

J. De Pont, P. Willems, C. van Os, 1993, Cell calcium.

Neuropeptide Y inhibits Ca2+ oscillations, cyclic AMP, and secretion in melanotrope cells of Xenopus laevis via a Y1 receptor

B. Jenks, E. Roubos, P. Willems, 1995, Peptides.

Binding characteristics of the muscarinic receptor subtype in rabbit pancreas.

J. De Pont, P. Willems, J. F. Rodrigues de Miranda, 1990, Journal of receptor research.

Asn 792 Participates in the Hydrogen Bond Network Around the K (cid:1) -binding Pocket of Gastric H,K-ATPase*

E. Krieger, H. Swarts, P. Willems, 2005 .

Inhibition of inositol 1,4,5-trisphosphate-induced Ca2+ release in permeabilized pancreatic acinar cells by hormonal and phorbol ester pretreatment.

J. De Pont, P. Willems, C. van Os, 1989, The Journal of biological chemistry.

Protein kinase C activation inhibits receptor- evoked inositol trisphosphate formation and induction of cytosolic calcium oscillations by decreasing the affinity-state of the cholecysto- kinin receptor in pancreatic acinar cells

P. Willems, J. Pont, R. Smeets, 2017 .

Receptor-evoked Ca2+ mobilization in pancreatic acinar cells: Evidence for a regulatory role of protein kinase C by a mechanism involving the transition of high-affinity receptors to a low-affinity state

J. Hoenderop, P. Willems, J. Pont, 1993, Pflügers Archiv.

Protein kinase C activation inhibits receptor-evoked inositol trisphosphate formation and induction of cytosolic calcium oscillations by decreasing the affinity-state of the cholecystokinin receptor in pancreatic acinar cells.

J. De Pont, P. Willems, R. Smeets, 1995, Cell calcium.

Prompt inhibition of fMLP-induced Ca2+ mobilization by parenteral lipid emulsions in human neutrophils.

P. Willems, A. Rops, T. Naber, 2002, Journal of lipid research.

Nutritional lipid emulsions modulate cellular signaling and activation of human neutrophils.

P. Willems, T. Naber, G. Wanten, 2001, Journal of lipid research.

Toward a comprehensive molecular model of active calcium reabsorption.

J. Hoenderop, R. Bindels, R. Bindels, 2000, American journal of physiology. Renal physiology.

The Non-gastric H,K-ATPase Is Oligomycin-sensitive and Can Function as an H+,NH4+-ATPase*

H. Swarts, J. De Pont, P. Willems, 2005, Journal of Biological Chemistry.

Synchronized calcium spiking resulting from spontaneous calcium action potentials in monolayers of NRK fibroblasts

P. Willems, A. Theuvenet, A. D. Roos, 1997 .

Effect of protein kinase C activation and down-regulation on active calcium transport.

R. Bindels, P. Willems, C. van Os, 1993, Kidney international.

Vasopressin-stimulated Ca2+ reabsorption in rabbit cortical collecting system: effects on cAMP and cytosolic Ca2+

R. Bindels, P. Willems, J. van Baal, 1996, Pflügers Archiv.

Effect of the aminosteroid, U73122, on Ca2+ uptake and release properties of rat liver microsomes.

P. Willems, J. Pont, F. V. D. Put, 1995, European journal of biochemistry.

Induction of Ca2+ oscillations by selective, U73122-mediated, depletion of inositol-trisphosphate-sensitive Ca2+ stores in rabbit pancreatic acinar cells

P. Willems, J. Pont, R. Engbersen, 1994, Pflügers Archiv.

The non-gastric H,K-ATPase as a tool to study the ouabain-binding site in Na,K-ATPase

H. Swarts, P. Willems, J. B. Koenderink, 2008, Pflügers Archiv - European Journal of Physiology.

Conversion of the Low Affinity Ouabain-binding Site of Non-gastric H,K-ATPase into a High Affinity Binding Site by Substitution of Only Five Amino Acids*

H. Swarts, J. De Pont, P. Willems, 2006, Journal of Biological Chemistry.

Probenecid interferes with renal oxidative metabolism: A potential pitfall in its use as an inhibitor of drug transport

F. Russel, P. Willems, P. Smits, 2000, British journal of pharmacology.

Endogenously produced prostanoids stimulate calcium reabsorption in the rabbit cortical collecting system.

R. Bindels, P. Willems, J. van Baal, 1996, The Journal of physiology.

Chimeras of X+,K+-ATPases

H. C. Stronks, H. Swarts, P. Willems, 2001, The Journal of Biological Chemistry.

Conformation-dependent inhibition of gastric H+,K+-ATPase by SCH 28080 demonstrated by mutagenesis of glutamic acid 820.

H. Swarts, J. De Pont, P. Willems, 1999, Molecular pharmacology.

High-affinity ouabain binding by a chimeric gastric H+,K+-ATPase containing transmembrane hairpins M3-M4 and M5-M6 of the alpha 1-subunit of rat Na+,K+-ATPase.

H. Swarts, J. De Pont, P. Willems, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Hormonal regulation of phospholipase D activity in Ca(2+) transporting cells of rabbit connecting tubule and cortical collecting duct.

J. Hoenderop, J. De Pont, R. Bindels, 2001, Biochimica et biophysica acta.

beta-Adrenergic relaxation in mesenteric resistance arteries of spontaneously hypertensive and Wistar-Kyoto rats: the role of precontraction and intracellular Ca2+.

T. Thien, P. Willems, W. Blankesteijn, 1996, Journal of cardiovascular pharmacology.

Purification and isotype analysis of protein kinase C from rat liver nuclei.

J. De Pont, P. Willems, S. E. van Emst-de Vries, 1998, The international journal of biochemistry & cell biology.

Ruthenium red selectively depletes inositol 1,4,5-trisphosphate-sensitive calcium stores in permeabilized rabbit pancreatic acinar cells

J. Hoenderop, P. Willems, J. Pont, 1993, The Journal of Membrane Biology.

Ca2(+)-sensitivity of inositol 1,4,5-trisphosphate-mediated Ca2+ release in permeabilized pancreatic acinar cells.

J. De Pont, P. Willems, C. van Os, 1990, The Biochemical journal.

R-Ras Alters Ca2+ Homeostasis by Increasing the Ca2+ Leak across the Endoplasmic Reticular Membrane*

W. Koopman, J. De Pont, P. Willems, 2003, The Journal of Biological Chemistry.

Heterogeneity between intracellular Ca2+ stores as the underlying principle of quantal Ca2+ release by inositol 1,4,5-trisphosphate in permeabilized pancreatic acinar cells.

J. De Pont, P. Willems, F. H. van de Put, 1994, The Journal of biological chemistry.

Membrane-initiated Ca(2+) signals are reshaped during propagation to subcellular regions.

B. Jenks, E. Roubos, R. Errington, 2001, Biophysical journal.

Mutational analysis of the potential phosphorylation sites for protein kinase C on the CCKA receptor

E. Ronken, J. De Pont, P. Willems, 1998, British journal of pharmacology.

Recovery from TPA inhibition of receptor-mediated Ca2+ mobilization is paralleled by down-regulation of protein kinase C-alpha in CHO cells expressing the CCK-A receptor.

J. De Pont, P. Willems, R. Smeets, 1996, Cell calcium.

POTENTIALS IN NRK FIBROBLASTS C 1901

P. Willems, G. Roos, J. Everardus, 2018 .

PROPAGATING C a 2 1 ACTION POTENTIALS IN NRK FIBROBLASTS C 1901

P. Willems, G. Roos, J. Everardus, 2018 .

N RK f ibroblasts

P. Willems, A. Theuvenet, A. D. Roos, 1997 .

Reconstruction of the Complete Ouabain-binding Pocket of Na,K-ATPase in Gastric H,K-ATPase by Substitution of Only Seven Amino Acids*

E. Krieger, H. Swarts, J. De Pont, 2005, Journal of Biological Chemistry.

Heterogeneity of intracellular calcium responses to parathyroid hormone and thrombin in primary osteoblast-like cells and UMR106-01 cells: correlations with culture conditions, intracellular calcium concentration and differentiation state.

D. Ypey, A. van der Plas, P. Nijweide, 1993, Cell calcium.

Native LDL potentiate TNF alpha and IL-8 production by human mononuclear cells.

L. Jacobs, M. Netea, B. Kullberg, 2002, Journal of lipid research.

Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCα independently of Rho-like GTPases

C. Figdor, John G. Collard, P. Willems, 2004, Journal of Cell Science.

Phe783, Thr797, and Asp804 in Transmembrane Hairpin M5-M6 of Na+,K+-ATPase Play a Key Role in Ouabain Binding*

H. Swarts, J. De Pont, P. Willems, 2003, Journal of Biological Chemistry.

Mutational analysis of ouabain interaction with the M5-M6 hairpin of Na,K-ATPase.

H. Swarts, J. De Pont, P. Willems, 2003, Annals of the New York Academy of Sciences.

The epithelial calcium channel, ECaC, is activated by hyperpolarization and regulated by cytosolic calcium.

J. Hoenderop, R. Bindels, P. Willems, 1999, Biochemical and biophysical research communications.

Atrial natriuretic peptide-stimulated Ca2+ reabsorption in rabbit kidney requires membrane-targeted, cGMP-dependent protein kinase type II.

S. Lohmann, S. Gambaryan, J. Hoenderop, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of GLUT1-mediated glucose uptake by PKClambda-PKCbeta(II) interactions in 3T3-L1 adipocytes.

C. Sweep, P. Span, M. Bazuine, 2004, The Biochemical journal.

LCT/MCT-(Lipofundin(r)) and pure MCT-, but not LCT-(Intralipid®) or structured Fat Emulsion 73403®, induce oxygen radical formation and potentiate the zymosan‐induced increase in cytosolic Ca2+ in human neutrophils in a protein kinase C‐dependent manner

J. Jansen, P. Willems, T. Naber, 1998 .

Oxidized low-density lipoprotein induces calcium influx in polymorphonuclear leukocytes.

L. V. van Tits, P. Demacker, A. Stalenhoef, 2000, Free radical biology & medicine.

Controls Matrix Metalloproteinase Activity ( ALCAM / CD 166 / MEMD ) , a Novel Actor in Invasive Growth , Activated Leukocyte Cell Adhesion Molecule

P. Willems, G. Swart, M. Bergers, 2005 .

Xenopus laevis via a Y t Receptor

B. Jenks, E. Roubos, P. Willems, 1995 .

University of Groningen Impaired routing of wild type FXYD2 after oligomerisation with FXYD2-G41R might explain the dominant nature of renal hypomagnesemia Cairo, Edinio

T. Friedrich, N. Knoers, H. Swarts, 2008 .

Exploring levels of hexosamine biosynthesis pathway intermediates and protein kinase C isoforms in muscle and fat tissue of zucker diabetic fatty rats

C. Sweep, P. Span, P. Willems, 2003, Endocrine.