R. Bindels

发表

Dominant isolated renal magnesium loss is caused by misrouting of the Na(+),K(+)-ATPase gamma-subunit.

H. van Bokhoven, L. P. Van den Heuvel, N. Knoers, 2000, Nature genetics.

The Structural Unit of the Thiazide-sensitive NaCl Cotransporter Is a Homodimer*

L. P. Van den Heuvel, N. Knoers, P. Willems, 2003, Journal of Biological Chemistry.

Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5.

F. Kersten, V. Vallon, J. Hoenderop, 2003, The Journal of clinical investigation.

Regulation of the Mouse Epithelial Ca2+ Channel TRPV6 by the Ca2+-sensor Calmodulin*

A. Weidema, B. Nilius, J. Hoenderop, 2004, Journal of Biological Chemistry.

The ß-Glucuronidase Klotho Hydrolyzes and Activates the TRPV5 Channel

J. Hoenderop, R. Bindels, R. Bindels, 2005, Science.

Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia.

Sabine Tejpar, E. Van Cutsem, S. Tejpar, 2007, The Journal of clinical investigation.

Impaired routing of wild type FXYD2 after oligomerisation with FXYD2-G41R might explain the dominant nature of renal hypomagnesemia.

T. Friedrich, N. Knoers, H. Swarts, 2008, Biochimica et biophysica acta.

Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

D. Alessi, R. Gourlay, Helen I. Woodroof, 2014, The Biochemical journal.

Regulation of the Epithelial Mg2+ Channel TRPM6 by Estrogen and the Associated Repressor Protein of Estrogen Receptor Activity (REA)*

J. Hoenderop, R. Bindels, A. W. van der Kemp, 2009, Journal of Biological Chemistry.

The impact of formative testing on study behaviour and study performance of (bio)medical students: a smartphone application intervention study

T. Eijsvogels, J. Hoenderop, R. Bindels, 2015, BMC medical education.

Na/Pi cotransporter (Npt2) gene disruption increases duodenal calcium absorption and expression of epithelial calcium channels 1 and 2

J. Hoenderop, A. Hartog, R. Bindels, 2002, Pflügers Archiv.

Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the beta-subunit of the amiloride-sensitive epithelial sodium channel.

M. Burnier, S. Pradervand, J. Gatzy, 1999, Proceedings of the National Academy of Sciences of the United States of America.

The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption.

A. Uitterlinden, H. Pols, J. Hoenderop, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Functional expression of mutations in the human NaCl cotransporter: evidence for impaired routing mechanisms in Gitelman's syndrome.

L. P. Van den Heuvel, N. Knoers, P. Willems, 2002, Journal of the American Society of Nephrology : JASN.

Bone Resorption Inhibitor Alendronate Normalizes the Reduced Bone Thickness of TRPV5−/− Mice

H. Weinans, J. Hoenderop, R. Bindels, 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy

S. Gallati, T. Slowinski, A. Schaller, 2012, Proceedings of the National Academy of Sciences.

Klotho prevents renal calcium loss.

J. Hoenderop, R. Bindels, J. V. van Leeuwen, 2009, Journal of the American Society of Nephrology : JASN.

Deregulated Renal Calcium and Phosphate Transport during Experimental Kidney Failure

M. Vervloet, B. van de Sluis, J. Hoenderop, 2015, PloS one.

Effects of the EGFR Inhibitor Erlotinib on Magnesium Handling.

S. Tejpar, G. M. Mulder, H. van Goor, 2010, Journal of the American Society of Nephrology : JASN.

Mutations in CYP24A1 and idiopathic infantile hypercalcemia.

M. Konrad, H. Fehrenbach, J. Hoenderop, 2011, The New England journal of medicine.

Murine TNF&Dgr;ARE Crohn's disease model displays diminished expression of intestinal Ca2+ transporters

G. Kollias, J. Hoenderop, R. Bindels, 2008, Inflammatory bowel diseases.

Murine TNF ARE Crohn ’ s Disease Model Displays Diminished Expression of Intestinal Ca 2 Transporters

G. Kollias, J. Hoenderop, R. Bindels, 2008 .

Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5.

F. Kersten, V. Vallon, J. Hoenderop, 2003, The Journal of clinical investigation.

Tissue transglutaminase inhibits the TRPV5-dependent calcium transport in an N-glycosylation-dependent manner

J. Hoenderop, S. Verkaart, R. Bindels, 2012, Cellular and Molecular Life Sciences.

The beta-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6.

J. Hoenderop, R. Bindels, Q. Chang, 2008, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

RGS2 Inhibits the Epithelial Ca2+ Channel TRPV6*

J. Hoenderop, R. Bindels, T. Lambers, 2006, Journal of Biological Chemistry.

Hereditary tubular transport disorders: implications for renal handling of Ca2+ and Mg2+.

J. Hoenderop, R. Bindels, H. Dimke, 2009, Clinical science.

Increased expression of renal TRPM6 compensates for Mg2+ wasting during furosemide treatment

J. Hoenderop, R. Bindels, A. W. van der Kemp, 2012, Clinical kidney journal.

Duodenal calcium absorption in vitamin D receptor–knockout mice: Functional and molecular aspects

P. Carmeliet, S. Kato, D. Collen, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Expression profiling of claudins in the human gastrointestinal tract in health and during inflammatory bowel disease

K. Kaukinen, J. Hoenderop, R. Bindels, 2013, Scandinavian journal of gastroenterology.

Expression pro fi ling of claudins in the human gastrointestinal tract in health and during in fl ammatory bowel disease

K. Kaukinen, J. Hoenderop, R. Bindels, 2012 .

Influence of exogenous growth hormone administration on circulating concentrations of α-klotho in healthy and chronic kidney disease subjects: a prospective, single-center open case-control pilot study

G. Navis, M. Vervloet, A. Heijboer, 2018, BMC Nephrology.

(Patho)physiological implications of the novel epithelial Ca2+ channels TRPV5 and TRPV6

B. Nilius, J. Hoenderop, R. Bindels, 2003, Pflügers Archiv.

TRPV5 gene polymorphisms in renal hypercalciuria.

P. Houillier, M. Goossens, J. Hoenderop, 2009, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

PACSINs Bind to the TRPV 4 Cation Channel PACSIN 3 MODULATES THE SUBCELLULAR LOCALIZATION OF TRPV

S. Heller, C. Grimm, B. Nilius, 2006 .

Fast and Slow Inactivation Kinetics of the Ca2+Channels ECaC1 and ECaC2 (TRPV5 and TRPV6)

A. Weidema, R. Vennekens, B. Nilius, 2002, The Journal of Biological Chemistry.

Critical role of the epithelial Ca2+ channel TRPV5 in active Ca2+ reabsorption as revealed by TRPV5/calbindin-D28K knockout mice.

J. Hoenderop, R. Bindels, A. W. van der Kemp, 2006, Journal of the American Society of Nephrology : JASN.

Fibroblast growth factor 23 modifies the pharmacological effects of angiotensin receptor blockade in experimental renal fibrosis

G. Navis, M. Vervloet, J. van den Born, 2016, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Modulation of the epithelial Ca2+ channel ECaC by extracellular pH

R. Vennekens, B. Nilius, G. Droogmans, 2001, Pflügers Archiv.

The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis.

C. Wagner, A. Velic, J. Hoenderop, 2009, Journal of the American Society of Nephrology : JASN.

Activation of the Ca2+-sensing receptor stimulates the activity of the epithelial Ca2+ channel TRPV5.

D. Riccardi, J. Hoenderop, R. Bindels, 2009, Cell calcium.

The impact of dietary magnesium restriction on magnesiotropic and calciotropic genes.

J. Hoenderop, R. Bindels, W. Pulskens, 2013, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Drug-induced alterations in Mg2+ homoeostasis.

J. Hoenderop, L. Monnens, R. Bindels, 2012, Clinical science.

The epithelial Mg2+ channel transient receptor potential melastatin 6 is regulated by dietary Mg2+ content and estrogens.

L. P. Van den Heuvel, N. Knoers, J. Hoenderop, 2006, Journal of the American Society of Nephrology : JASN.

Prednisolone-induced Ca2+ malabsorption is caused by diminished expression of the epithelial Ca2+ channel TRPV6.

J. Hoenderop, R. Bindels, T. Naber, 2007, American journal of physiology. Gastrointestinal and liver physiology.

Modulation of the epithelial calcium channel, ECaC, by intracellular Ca2+.

R. Vennekens, B. Nilius, G. Droogmans, 2001, Cell calcium.

PACSINs Bind to the TRPV4 Cation Channel

S. Heller, C. Grimm, B. Nilius, 2006, Journal of Biological Chemistry.

The carboxyl terminus of the epithelial Ca2+ channel ECaC1 is involved in Ca2+-dependent inactivation

R. Vennekens, B. Nilius, G. Droogmans, 2003, Pflügers Archiv.

Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism

M. Zillikens, J. Hoenderop, R. Bindels, 2016, Oncotarget.

Prednisolone-induced Ca malabsorption is caused by diminished expression of the epithelial Ca channel TRPV6

J. Hoenderop, R. Bindels, T. Naber, 2006 .

The epithelial sodium/proton exchanger, NHE3, is necessary for renal and intestinal calcium (re)absorption.

J. Hoenderop, M. Doschak, G. Shull, 2012, American journal of physiology. Renal physiology.

2009 Homer W. Smith Award: Minerals in motion: from new ion transporters to new concepts.

R. Bindels, 2010, Journal of the American Society of Nephrology : JASN.

Molecular determinants of magnesium homeostasis: insights from human disease.

J. Hoenderop, R. Bindels, R. T. Alexander, 2008, Journal of the American Society of Nephrology : JASN.

Segmental transport of Ca²⁺ and Mg²⁺ along the gastrointestinal tract.

J. Hoenderop, L. Monnens, R. Bindels, 2015, American journal of physiology. Gastrointestinal and liver physiology.

New TRPM6 missense mutations linked to hypomagnesemia with secondary hypocalcemia

B. Dworniczak, M. Konrad, S. Laínez, 2013, European Journal of Human Genetics.

Novel molecular pathways in renal Mg2+ transport: a guided tour along the nephron

J. Hoenderop, R. Bindels, H. Dimke, 2010, Current opinion in nephrology and hypertension.

Characterization of a Madin-Darby canine kidney cell line stably expressing TRPV5

S. V. D. van de Graaf, J. Hoenderop, R. Bindels, 2005, Pflügers Archiv.

Epithelial Transport Characterization of a Madin-Darby canine kidney cell line stably expressing TRPV 5

J. Hoenderop, R. Bindels, C. N. Topala, 2005 .

80K-H as a New Ca2+ Sensor Regulating the Activity of the Epithelial Ca2+ Channel Transient Receptor Potential Cation Channel V5 (TRPV5)*

B. Nilius, J. Hoenderop, R. Bindels, 2004, Journal of Biological Chemistry.

The immunophilin FKBP52 inhibits the activity of the epithelial Ca2+ channel TRPV5.

J. Hoenderop, R. Bindels, C. N. Topala, 2006, American journal of physiology. Renal physiology.

The immunophilin FKBP 52 inhibits the activity of the epithelial Ca 2 channel TRPV 5

J. Hoenderop, R. Bindels, C. N. Topala, 2006 .

Identification and Characterization of a Novel Protein Family as a New Component of TRPM8 Regulation

R. Bindels, Y. Launoit, A. F. Pla, 2015 .

PACSINs Bind to the TRPV4 Cation Channel PACSIN 3 MODULATES THE SUBCELLULAR LOCALIZATION OF TRPV4 *

S. Heller, C. Grimm, B. Nilius, 2006 .

Novel NCC mutants and functional analysis in a new cohort of patients with Gitelman syndrome

R. Pfundt, L. Hoefsloot, N. Knoers, 2011, European Journal of Human Genetics.

Gitelman’s syndrome: towards genotype-phenotype correlations?

O. Devuyst, R. Bindels, Q. Chang, 2007, Pediatric Nephrology.

Dimeric architecture of the human bumetanide-sensitive Na-K-Cl Co-transporter.

F. Kersten, L. P. Van den Heuvel, N. Knoers, 2003, Journal of the American Society of Nephrology : JASN.

Functional expression of the human thiazide-sensitive NaCl cotransporter in Madin-Darby canine kidney cells.

L. P. Van den Heuvel, N. Knoers, P. Willems, 2003, Journal of the American Society of Nephrology : JASN.

Mutations in the human Na-K-2Cl cotransporter (NKCC2) identified in Bartter syndrome type I consistently result in nonfunctional transporters.

F. Kersten, L. P. Van den Heuvel, N. Knoers, 2003, Journal of the American Society of Nephrology : JASN.

The renal connecting tubule: Resolved and unresolved issues in Ca(2+) transport.

J. Hoenderop, R. Bindels, Nicolas Markadieu, 2011, The international journal of biochemistry & cell biology.

Effects of chemical chaperones on partially retarded NaCl cotransporter mutants associated with Gitelman's syndrome in a mouse cortical collecting duct cell line.

M. Goossens, L. P. Van den Heuvel, N. Knoers, 2004, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption.

M. Freichel, V. Flockerzi, J. Hoenderop, 2012, American journal of physiology. Gastrointestinal and liver physiology.

Liver GI-00089-2012 Revised 0 Functional TRPV 6 channels are crucial for transepithelial Ca 2 + absorption

M. Freichel, V. Flockerzi, J. Hoenderop, 2012 .

Coexistence of normotensive primary aldosteronism in two patients with Gitelman's syndrome and novel thiazide-sensitive Na-Cl cotransporter mutations.

N. Chen, H. Ren, R. Bindels, 2009, European journal of endocrinology.

channel TRPV6 2+ by diminished expression of the epithelial Ca malabsorption is caused

J. Hoenderop, R. Bindels, T. Naber, 2007 .

Hoenderop channel TRPV 6 2 + by diminished expression of the epithelial Ca malabsorption is caused 2 + Prednisolone-induced Ca

R. Bindels, T. Naber, S. Huybers, 2006 .

Vascular calcification in chronic kidney disease: new developments in drug therapy.

R. Bindels, S. Huybers, 2007, Kidney international.

Involvement of claudin 3 and claudin 4 in idiopathic infantile hypercalcaemia: a novel hypothesis?

J. Hoenderop, L. Monnens, R. Bindels, 2010, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Function and expression of the epithelial Ca2+ channel family: comparison of mammalian ECaC1 and 2

R. Vennekens, B. Nilius, G. Droogmans, 2001, The Journal of physiology.

RGS 2 Inhibits the Epithelial Ca 2 Channel TRPV 6 *

J. Hoenderop, R. Bindels, T. Lambers, 2006 .

Renal physiology: TRPC5 inhibition to treat progressive kidney disease

R. Bindels, J. Wijst, Jenny Wijst, 2018, Nature Reviews Nephrology.

Learning Physiology From Inherited Kidney Disorders.

O. Devuyst, R. Bindels, J. van der Wijst, 2019, Physiological reviews.

TRPM6 Forms the Mg2+ Influx Channel Involved in Intestinal and Renal Mg2+ Absorption*

B. Nilius, T. Voets, G. Droogmans, 2004, Journal of Biological Chemistry.

Tissue-specific expression and in vivo regulation of zebrafish orthologues of mammalian genes related to symptomatic hypomagnesemia

G. Flik, J. Hoenderop, R. Bindels, 2013, Pflügers Archiv - European Journal of Physiology.

EGF increases TRPM6 activity and surface expression.

J. Hoenderop, R. Bindels, S. Thébault, 2009, Journal of the American Society of Nephrology : JASN.

TRP channel–associated factors are a novel protein family that regulates TRPM8 trafficking and activity

Y. De Launoit, M. Benahmed, D. Gordienko, 2015, The Journal of cell biology.

Calbindin‐D28K dynamically controls TRPV5‐mediated Ca2+ transport

D. Clapham, B. Nilius, T. Voets, 2006, The EMBO journal.

Calbindin-D 28K dynamically controls TRPV5-mediated Ca 2 þ transport

D. Clapham, B. Nilius, T. Voets, 2006 .

Current understanding of mammalian TRP homologues.

R. Vennekens, B. Nilius, T. Voets, 2002, Cell calcium.

Calcium and phosphate homeostasis: Concerted interplay of new regulators

J. Hoenderop, R. Bindels, K. Renkema, 2008, Annals of medicine.

Transcriptional and functional analyses of SLC12A3 mutations: new clues for the pathogenesis of Gitelman syndrome.

K. Dahan, O. Devuyst, J. Hoenderop, 2007, Journal of the American Society of Nephrology : JASN.

Proteomic profile of urinary extracellular vesicles identifies AGP1 as a potential biomarker of primary aldosteronism.

J. Hoenderop, R. Bindels, C. Carvajal, 2021, Endocrinology.

De novo gain-of-function and loss-of-function mutations of SCN8A in patients with intellectual disabilities and epilepsy

S. Dib-Hajj, S. Waxman, P. Praamstra, 2015, Journal of Medical Genetics.

Autosomal-Recessive Mutations in SLC34A1 Encoding Sodium-Phosphate Cotransporter 2A Cause Idiopathic Infantile Hypercalcemia.

M. Konrad, E. Levtchenko, C. Wagner, 2016, Journal of the American Society of Nephrology : JASN.

TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk.

A. Hofman, A. Uitterlinden, F. Rivadeneira, 2013, Bone.

Interleukin 18 function requires both interleukin 18 receptor and Na-Cl co-transporter

P. Libby, Jian Liu, D. Ellison, 2015, Nature Medicine.

CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia.

H. Debaix, O. Devuyst, D. Günzel, 2011, American journal of human genetics.

Fibroblast growth factor 23 modi fi es the pharmacological effects of angiotensin receptor blockade in experimental renal fi brosis

G. Navis, M. Vervloet, J. Hillebrands, 2016 .

Functional implications of mutations in the human renal outer medullary potassium channel (ROMK2) identified in Bartter syndrome

N. Knoers, R. Bindels, L. Heuvel, 2001, Pflügers Archiv.

The epithelial calcium channels, TRPV5 & TRPV6: from identification towards regulation.

B. Nilius, J. Hoenderop, R. Bindels, 2003, Cell calcium.

A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia.

N. Knoers, J. Hoenderop, R. Bindels, 2009, The Journal of clinical investigation.

Dominant isolated renal magnesium loss is caused by misrouting of the Na+,K+-ATPase γ-subunit

H. Bokhoven, N. Knoers, L. Monnens, 2000, Nature Genetics.

Extracellular pH Dynamically Controls Cell Surface Delivery of Functional TRPV5 Channels

J. Hoenderop, E. Oancea, R. Bindels, 2006, Molecular and Cellular Biology.

CaT1 and the Calcium Release-activated Calcium Channel Manifest Distinct Pore Properties*

R. Penner, A. Fleig, R. Vennekens, 2001, The Journal of Biological Chemistry.

Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio.

J. Hoenderop, R. Bindels, J. V. van Leeuwen, 2015, Bone.

Renal expression of parvalbumin is critical for NaCl handling and response to diuretics

H. Debaix, B. Schwaller, O. Devuyst, 2007, Proceedings of the National Academy of Sciences.

The transient receptor potential channel TRPV6 is dynamically expressed in bone cells but is not crucial for bone mineralization in mice

M. Eijken, M. Freichel, V. Flockerzi, 2012, Journal of cellular physiology.

A molecular switch controlling renal sodium and potassium excretion

R. Bindels, 2003, Nature Genetics.

Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1).

A. D. den Hollander, L. P. Van den Heuvel, F. Claverie-Martin, 2000, Genomics.

Epithelial calcium channel: gate-keeper of active calcium reabsorption.

J. Hoenderop, R. Bindels, M. Suzuki, 2000, Current opinion in nephrology and hypertension.

Aromatase Deficiency Causes Altered Expression of Molecules Critical for Calcium Reabsorption in the Kidneys of Female Mice

J. Zerwekh, M. Kuro-o, R. Bindels, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Molecular determinants of permeation through the cation channel TRPM6.

B. Nilius, J. Hoenderop, W. T. Groenestege, 2007, Cell calcium.

Fast and Slow Inactivation Kinetics of the Ca 2 Channels ECaC 1 and ECaC 2 ( TRPV 5 and TRPV 6 ) ROLE OF THE INTRACELLULAR LOOP LOCATED BETWEEN TRANSMEMBRANE SEGMENTS 2

A. Weidema, R. Vennekens, B. Nilius, 2002 .

channel TRPV5 2+ epithelial Ca The immunophilin FKBP52 inhibits the activity of the

Dimitra Gkika, Catalin N. Topala, Joost G. J. Hoenderop, 2006 .

Genetic renal disorders with hypomagnesemia and hypocalciuria.

L. P. Van den Heuvel, N. Knoers, I. Meij, 2003, Journal of nephrology.

University of Groningen Impaired routing of wild type FXYD2 after oligomerisation with FXYD2-G41R might explain the dominant nature of renal hypomagnesemia Cairo, Edinio

T. Friedrich, N. Knoers, H. Swarts, 2008 .

Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio.

J. Hoenderop, R. Bindels, J. V. van Leeuwen, 2015, Bone.