J. V. van Leeuwen

发表

Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5.

F. Kersten, V. Vallon, J. Hoenderop, 2003, The Journal of clinical investigation.

Coordinated control of renal Ca(2+) transport proteins by parathyroid hormone.

J. Hoenderop, R. Bindels, M. Friedlaender, 2005, Kidney international.

Hydroxychloroquine decreases human MSC‐derived osteoblast differentiation and mineralization in vitro

M. Zillikens, J. V. van Leeuwen, B. V. D. van der Eerden, 2017, Journal of cellular and molecular medicine.

Fibroblast growth factor-2 in serum-free medium is a potent mitogen and reduces dedifferentiation of human ear chondrocytes in monolayer culture.

H. Weinans, J. Verhaar, H. Jahr, 2004, Matrix biology : journal of the International Society for Matrix Biology.

Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study.

A. Hofman, A. Uitterlinden, C. De Laet, 2004, Bone.

Estrogen Receptor β (ESR2) Polymorphisms in Interaction With Estrogen Receptor α (ESR1) and Insulin‐Like Growth Factor I (IGF1) Variants Influence the Risk of Fracture in Postmenopausal Women

Fernando Rivadeneira, Albert Hofman, Lisette Stolk, 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Design principles of nuclear receptor signaling: how complex networking improves signal transduction

Frank J Bruggeman, Hans V Westerhoff, Jacky L Snoep, 2010, Molecular systems biology.

Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2.

J. Nickel, T. Mueller, J. V. van Leeuwen, 2018, Materials science & engineering. C, Materials for biological applications.

High content imaging in the screening of biomaterial-induced MSC behavior.

M. Reinders, C. V. van Blitterswijk, J. de Boer, 2013, Biomaterials.

Vitamin D receptor gene haplotype is associated with body height and bone size.

A. Uitterlinden, J. V. van Meurs, F. Rivadeneira, 2007, The Journal of clinical endocrinology and metabolism.

ADAMTS5-/- mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes.

H. Weinans, S. Clockaerts, J. V. van Leeuwen, 2007, Osteoarthritis and cartilage.

A role for subchondral bone changes in the process of osteoarthritis; a micro-CT study of two canine models

Harrie Weinans, H. Weinans, F. Lafeber, 2008, BMC musculoskeletal disorders.

Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis

H. Weinans, J. V. van Leeuwen, G. V. van Osch, 2010, Arthritis Research & Therapy.

Development of osteoarthritic features in estrogen receptor knockout mice.

J. Gustafsson, H. Weinans, J. V. van Leeuwen, 2009, Osteoarthritis and cartilage.

Estrogen modulates iodoacetate‐induced gene expression in bovine cartilage explants

H. Weinans, H. Jahr, J. V. van Leeuwen, 2010, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Role of extracellular calcium in the regulation of 1,25-dihydroxyvitamin D3 formation in cultured human keratinocytes.

M. Ponec, H. Pols, J. V. van Leeuwen, 1994, Biochimica et biophysica acta.

Vitamin D and gene networks in human osteoblasts

J. van de Peppel, J. V. van Leeuwen, 2014, Frontiers in physiology.

Estradiol formation by human osteoblasts via multiple pathways: Relation with osteoblast function

H. Pols, M. Coughtrie, J. V. van Leeuwen, 1999, Journal of cellular biochemistry.

Intrinsic differentiation potential of adolescent human tendon tissue: an in-vitro cell differentiation study

H. Weinans, J. Verhaar, N. Kops, 2007, BMC musculoskeletal disorders.

5-HIAA excretion is not associated with bone metabolism in carcinoid syndrome patients.

S. V. van Dijk, R. V. van Schaik, J. V. van Leeuwen, 2012, Bone.

The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption.

A. Uitterlinden, H. Pols, J. Hoenderop, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss

M. Eijken, M. Cooper, A. Filer, 2009, Annals of the rheumatic diseases.

Bone Resorption Inhibitor Alendronate Normalizes the Reduced Bone Thickness of TRPV5−/− Mice

H. Weinans, J. Hoenderop, R. Bindels, 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The Effect of Vitamin D Supplementation on the Bone Mineral Density of the Femoral Neck Is Associated with Vitamin D Receptor Genotype

A. Uitterlinden, M. Ooms, W. Graafmans, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Activin A Suppresses Osteoblast Mineralization Capacity by Altering Extracellular Matrix (ECM) Composition and Impairing Matrix Vesicle (MV) Production*

Jeroen A. A. Demmers, M. Eijken, J. V. van Leeuwen, 2013, Molecular & Cellular Proteomics.

Follistatin Effects in Migration, Vascularization, and Osteogenesis in vitro and Bone Repair in vivo

J. V. van Leeuwen, B. V. D. van der Eerden, G. V. van Osch, 2019, Front. Bioeng. Biotechnol..

Comparative proteomic profiling of human osteoblast‐derived extracellular matrices identifies proteins involved in mesenchymal stromal cell osteogenic differentiation and mineralization

J. van de Peppel, J. V. van Leeuwen, B. V. D. van der Eerden, 2018, Journal of cellular physiology.

Human Osteoblast-Derived Extracellular Matrix with High Homology to Bone Proteome Is Osteopromotive.

Jeroen A. A. Demmers, J. van de Peppel, J. V. van Leeuwen, 2018, Tissue engineering. Part A.

Identification of Three Early Phases of Cell-Fate Determination during Osteogenic and Adipogenic Differentiation by Transcription Factor Dynamics

H. Westerhoff, A. V. van Wijnen, J. van de Peppel, 2017, Stem cell reports.

Iodothyronine deiodinase enzyme activities in bone

T. Visser, J. V. van Leeuwen, G. Williams, 2008, Bone.

A Cross-Sectional Study on Biochemical Parameters of Bone Turnover and Vitamin D Metabolites in Healthy Dutch Children and Young Adults

W. Hop, H. Pols, J. V. van Leeuwen, 2002, Hormone Research in Paediatrics.

Human mesenchymal stromal cells in adhesion to cell‐derived extracellular matrix and titanium: Comparative kinome profile analysis

J. van de Peppel, M. Peppelenbosch, G. Fuhler, 2018, Journal of cellular physiology.

ERK activation and αvβ3 integrin signaling through Shc recruitment in response to mechanical stimulation in human osteoblasts

H. Weinans, S. Chien, J. V. van Leeuwen, 2002 .

Osteoclastogenic capacity of peripheral blood mononuclear cells is not different between women with and without osteoporosis.

M. Zillikens, J. V. van Leeuwen, B. V. D. van der Eerden, 2017, Bone.

Case-control analysis of bone resorption markers, disability, and hip fracture risk: the Rotterdam study

A. Hofman, D. Grobbee, H. Pols, 1996, BMJ.

Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction.

A. Hofman, A. Uitterlinden, J. V. van Meurs, 2004, JAMA.

Klotho prevents renal calcium loss.

J. Hoenderop, R. Bindels, J. V. van Leeuwen, 2009, Journal of the American Society of Nephrology : JASN.

In vitro cytotoxicity evaluation of porous TiO₂-Ag antibacterial coatings for human fetal osteoblasts.

J. Duszczyk, J. V. van Leeuwen, S. Zaat, 2012, Acta biomaterialia.

Age-dependent sex differences in calcium and phosphate homeostasis

A. Uitterlinden, M. Ikram, M. Zillikens, 2021, Endocrine connections.

Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathway

M. Eijken, J. van de Peppel, J. V. van Leeuwen, 2015, Proceedings of the National Academy of Sciences.

Evidence for the functional involvement of protein kinase C in the action of 1,25-dihydroxyvitamin D3 in bone.

H. Pols, J. V. van Leeuwen, A. Staal, 1992, The Journal of biological chemistry.

Stretch‐induced phosphorylation of ERK1/2 depends on differentiation stage of osteoblasts

H. Weinans, J. Verhaar, H. Pols, 2004, Journal of cellular biochemistry.

The vitamin D analog ZK191784 normalizes decreased bone matrix mineralization in mice lacking the calcium channel TRPV5

J. Hoenderop, R. Bindels, T. Nijenhuis, 2013, Journal of cellular physiology.

Characterization of vitamin D-deficient klotho(-/-) mice: do increased levels of serum 1,25(OH)2D3 cause disturbed calcium and phosphate homeostasis in klotho(-/-) mice?

J. Hoenderop, R. Bindels, A. W. van der Kemp, 2012, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5.

F. Kersten, V. Vallon, J. Hoenderop, 2003, The Journal of clinical investigation.

Interaction Between the Vitamin D Receptor Gene and Collagen Type Iα1 Gene in Susceptibility for Fracture

A. Hofman, A. Uitterlinden, C. V. van Duijn, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

RELATION OF ALLELES OF THE COLLAGEN TYPE I a 1 GENE TO BONE DENSITY AND THE RISK OF OSTEOPOROTIC FRACTURES IN POSTMENOPAUSAL WOMEN

A. Hofman, A. Uitterlinden, S. Grant, 2000 .

A two-receptor model for the action of parathyroid hormone on osteoblasts: a role for intracellular free calcium and cAMP.

J. V. van Leeuwen, C. Löwik, J. M. Meer, 1985, Cell calcium.

Dietary 135-fold cholecalciferol supplementation severely disturbs the endochondral ossification in growing dogs.

H. DeLuca, W. E. van den Brom, M. Tryfonidou, 2003, Domestic animal endocrinology.

Hydroxychloroquine affects bone resorption both in vitro and in vivo

Wai Lam, M. Zillikens, J. V. van Leeuwen, 2018, Journal of cellular physiology.

Interaction between vitamin D receptor genotype and estrogen receptor alpha genotype influences vertebral fracture risk.

A. Hofman, A. Uitterlinden, H. Pols, 2003, The Journal of clinical endocrinology and metabolism.

A New Concept Underlying Stem Cell Lineage Skewing That Explains the Detrimental Effects of Thiazolidinediones on Bone

M. Eijken, J. van de Peppel, J. V. van Leeuwen, 2010, Stem cells.

Inhibition of hypoxia‐induced Mucin 1 alters the proteomic composition of human osteoblast‐produced extracellular matrix, leading to reduced osteogenic and angiogenic potential

J. V. van Leeuwen, B. V. D. van der Eerden, M. Koedam, 2021, Journal of cellular physiology.

Long‐term fluoxetine administration does not result in major changes in bone architecture and strength in growing rats

H. Weinans, J. Reseland, J. V. van Leeuwen, 2007, Journal of Cellular Biochemistry.

Inhibition of insulin- and insulin-like growth factor-I-stimulated growth of human breast cancer cells by 1,25-dihydroxyvitamin D3 and the vitamin D3 analogue EB1089.

H. Pols, J. V. van Leeuwen, J. Birkenhäger, 1996, European journal of cancer.

Evidence for Involvement of 17β‐Estradiol in Intestinal Calcium Absorption Independent of 1,25‐Dihydroxyvitamin D3 Level in the Rat

H. Pols, J. V. van Leeuwen, S. Christakos, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Adverse Effects of Diabetes Mellitus on the Skeleton of Aging Mice.

M. De la Fuente, F. Mulero, S. Portal-Nuñez, 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

Distinct effects on the conformation of estrogen receptor alpha and beta by both the antiestrogens ICI 164,384 and ICI 182,780 leading to opposite effects on receptor stability.

H. Pols, J. V. van Leeuwen, G. Kuiper, 1999, Biochemical and biophysical research communications.

Opposing actions of rosiglitazone and resveratrol on mineralization in human vascular smooth muscle cells.

M. Eijken, J. V. van Leeuwen, H. Chiba, 2011, Journal of molecular and cellular cardiology.

Identification of acid-sensing ion channels in bone.

H. Weinans, H. Jahr, J. V. van Leeuwen, 2005, Biochemical and biophysical research communications.

Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a.

H. Pols, H. Jahr, H. Chiba, 2006, The Journal of endocrinology.

Stretch‐induced inhibition of Wnt/β‐catenin signaling in mineralizing osteoblasts

M. Eijken, H. Weinans, J. Verhaar, 2010, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Stretch‐induced modulation of matrix metalloproteinases in mineralizing osteoblasts via extracellular signal‐regulated kinase‐1/2

H. Weinans, J. Verhaar, H. Pols, 2006, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Mucin 1 (Muc1) Deficiency in Female Mice Leads to Temporal Skeletal Changes During Aging

J. V. van Leeuwen, B. V. D. van der Eerden, M. Schreuders-koedam, 2018, JBMR plus.

1,25-dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis.

J. V. van Leeuwen, E. Lubberts, J. Hazes, 2010, Arthritis and rheumatism.

The effects of MC903 on 1,25-(OH)2D3 receptor binding, 24-hydroxylase activity and in vitro bone resorption.

H. Pols, J. V. van Leeuwen, J. Birkenhäger, 1991, Bone and mineral.

Adjacent genes, for COL2A1 and the vitamin D receptor, are associated with separate features of radiographic osteoarthritis of the knee.

A. Hofman, C. V. van Duijn, C. Duijn, 2000, Arthritis and rheumatism.

Consequences of vitamin D receptor gene polymorphisms for growth inhibition of cultured human peripheral blood mononuclear cells by 1,25‐dihydroxyvitamin D3

H. Pols, J. V. van Leeuwen, A. Uitterlinden, 2000, Clinical endocrinology.

Effects of vitamin D3 supplementation and UVb exposure on the growth and plasma concentration of vitamin D3 metabolites in juvenile bearded dragons (Pogona vitticeps).

J. J. van den Borne, J. V. van Leeuwen, D. Oonincx, 2010, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Blood vitamin D(3) metabolite concentrations of adult female bearded dragons (Pogona vitticeps) remain stable after ceasing UVb exposure.

A. Heijboer, J. V. van Leeuwen, G. Bosch, 2013, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Basic and translational research

J. V. van Leeuwen, E. Lubberts, J. Hazes, 2011 .

Vitamin D receptor genotype is associated with radiographic osteoarthritis at the knee.

A. Hofman, C. Duijn, E. Odding, 1997, The Journal of clinical investigation.

UV exposure inhibits intestinal tumor growth and progression to malignancy in intestine‐specific Apc mutant mice kept on low vitamin D diet

F. D. de Gruijl, J. V. van Leeuwen, E. Robanus-Maandag, 2015, International journal of cancer.

1α,25-dihydroxyvitamin D3 and rosiglitazone synergistically enhance osteoblast-mediated mineralization.

H. Chiba, J. V. van Leeuwen, B. V. D. van der Eerden, 2013, Gene.

Conformational change and enhanced stabilization of the vitamin D receptor by the 1,25-dihydroxyvitamin D3 analog KH1060.

H. Pols, J. V. van Leeuwen, J. Birkenhäger, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6.

J. Hoenderop, R. Bindels, A. W. van der Kemp, 2006, American journal of physiology. Renal physiology.

Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism

M. Zillikens, J. Hoenderop, R. Bindels, 2016, Oncotarget.

Regulation of the epithelial Ca2+ channels in small intestine as studied by quantitative mRNA detection.

J. Hoenderop, R. Bindels, A. W. van der Kemp, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice.

H. Weinans, J. Hoenderop, R. Bindels, 2005, Journal of the American Society of Nephrology : JASN.

Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes.

A. Uitterlinden, J. V. van Meurs, J. Ioannidis, 2004, JAMA.

Evidence that both 1α,25‐dihydroxyvitamin D3 and 24‐hydroxylated D3 enhance human osteoblast differentiation and mineralization

H. Chiba, J. V. van Leeuwen, H. Chiba, 2006, Journal of cellular biochemistry.

How About Vitamin D Receptor Polymorphisms?

A. Uitterlinden, H. Pols, J. V. van Leeuwen, 1998, Osteoporosis International.

Extended Report

M. Eijken, M. Cooper, C. Buckley, 2009 .

Structure function analysis of vitamin D analogs with C-ring modifications.

H. Pols, R. Bouillon, J. V. van Leeuwen, 1992, The Journal of biological chemistry.

Diverse effects of cyclic AMP variants on osteogenic and adipogenic differentiation of human mesenchymal stromal cells.

C. V. van Blitterswijk, J. de Boer, N. Groen, 2012, Tissue engineering. Part A.

Bioinformatics-based selection of a model cell type for in vitro biomaterial testing.

C. V. van Blitterswijk, J. de Boer, N. Groen, 2012, Biomaterials.

Anti-tumor effects of 1,25-dihydroxyvitamin D3 and vitamin D analogs.

H. Pols, J. V. van Leeuwen, G. V. D. van den Bemd, 2000, Current pharmaceutical design.

An age-dependent interaction with leptin unmasks ghrelin's bone-protective effects.

Yuxiang Sun, Roy G. Smith, A. J. van der Lely, 2012, Endocrinology.

Dexamethasone in osteogenic medium strongly induces adipocyte differentiation of mouse bone marrow stromal cells and increases osteoblast differentiation

J. V. van Leeuwen, P. Hardouin, C. Chauveau, 2015, BMC Cell Biology.

Contribution of several metabolites of the vitamin D analog 20-epi-22-oxa-24a,26a,27a-tri-homo-1,25-(OH)(2) vitamin D(3) (KH 1060) to the overall biological activity of KH1060 by a shared mechanism of action.

F. Dilworth, H. DeLuca, H. Pols, 2000, Biochemical pharmacology.

A human vitamin D receptor mutation causes rickets and impaired Th1/Th17 responses.

J. V. van Leeuwen, E. Lubberts, S. Drop, 2014, Bone.

Sorting living mesenchymal stem cells using a TWIST1 RNA-based probe depends on incubation time and uptake capacity

J. van de Peppel, J. V. van Leeuwen, C. Voskamp, 2019, Cytotechnology.

IFNβ impairs extracellular matrix formation leading to inhibition of mineralization by effects in the early stage of human osteoblast differentiation

M. Eijken, J. van de Peppel, H. Chiba, 2012, Journal of cellular physiology.

Estrogen receptor polymorphism predicts the onset of natural and surgical menopause.

A. Hofman, J. V. van Leeuwen, A. Uitterlinden, 1999, The Journal of clinical endocrinology and metabolism.

Microfluidic evidence of synergistic effects between mesenchymal stromal cell-derived biochemical factors and biomechanical forces to control endothelial cell function.

J. van de Peppel, R. Hoogenboezem, E. Bindels, 2022, Acta biomaterialia.

Evidence of vitamin D and interferon‐β cross‐talk in human osteoblasts with 1α,25‐dihydroxyvitamin D3 being dominant over interferon‐β in stimulating mineralization

J. van de Peppel, H. Chiba, J. V. van Leeuwen, 2012, Journal of cellular physiology.

Moderate cholecalciferol supplementation depresses intestinal calcium absorption in growing dogs.

H. DeLuca, W. E. van den Brom, M. Tryfonidou, 2002, The Journal of nutrition.

Bidirectional regulation of the 1,25-dihydroxyvitamin D3 receptor by phorbol ester-activated protein kinase-C in osteoblast-like cells: interaction with adenosine 3',5'-monophosphate-induced up-regulation of the 1,25-dihydroxyvitamin D3 receptor.

H. Pols, J. V. van Leeuwen, J. Birkenhäger, 1992, Endocrinology.

Heterologous up-regulation of the 1,25-dihydroxyvitamin D3 receptor by parathyroid hormone (PTH) and PTH-like peptide in osteoblast-like cells.

T. Visser, H. Pols, J. V. van Leeuwen, 1988, Biochemical and biophysical research communications.

Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation

M. Mcmurdo, T. V. D. van der Cammen, J. V. van Leeuwen, 2009, British Journal of Nutrition.

Osteoblast differentiation and control by vitamin D and vitamin D metabolites.

J. V. van Leeuwen, H. Pols, M. van Driel, 2004, Current pharmaceutical design.

Evidence for coordinated regulation of osteoblast function by 1,25-dihydroxyvitamin D3 and parathyroid hormone.

H. Pols, J. V. van Leeuwen, J. Birkenhäger, 1996, Biochimica et biophysica acta.

Parathyroid hormone sensitizes long bones to the stimulation of bone resorption by 1,25‐dihydroxyvitamin D3

J. V. van Leeuwen, J. Birkenhäger, H. Pols, 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Detection of sequence variability of the collagen type IIα 1 3′ variable number of tandem repeat

A. Uitterlinden, J. V. van Meurs, P. Slagboom, 2000, Electrophoresis.

Zika virus alters osteogenic lineage progression of human mesenchymal stromal cells

M. Koopmans, A. V. van Wijnen, A. Nair, 2022, Journal of cellular physiology.

Zika virus infects human osteoclasts and blocks differentiation and bone resorption

M. Koopmans, J. V. van Leeuwen, B. V. D. van der Eerden, 2022, Emerging microbes & infections.

Long‐term serotonin administration leads to higher bone mineral density, affects bone architecture, and leads to higher femoral bone stiffness in rats

H. Weinans, J. V. van Leeuwen, J. Waarsing, 2006, Journal of cellular biochemistry.

The Association between Common Vitamin D Receptor Gene Variations and Osteoporosis: A Participant-Level Meta-Analysis

A. Uitterlinden, J. V. van Meurs, J. Ioannidis, 2006, Annals of Internal Medicine.

Cartilage damage pattern in relation to subchondral plate thickness in a collagenase-induced model of osteoarthritis.

H Weinans, J H Waarsing, H. Weinans, 2008, Osteoarthritis and cartilage.

Mechanism and Function of High Vitamin D Receptor Levels in Genetic Hypercalciuric Stone‐Forming Rats

H. DeLuca, J. V. van Leeuwen, M. Favus, 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Oxygen‐induced transcriptional dynamics in human osteoblasts are most prominent at the onset of mineralization

J. van de Peppel, J. V. van Leeuwen, Claudia Nicolaije, 2013, Journal of cellular physiology.

Stimulation of osteogenic differentiation in human osteoprogenitor cells by pulsed electromagnetic fields: an in vitro study

H. Weinans, J. Verhaar, H. Jahr, 2010, BMC musculoskeletal disorders.

Subclinical hypocalcaemia in captive Asian elephants (Elephas maximus)

J. H. van der Kolk, R. V. van Schaik, J. V. van Leeuwen, 2008, Veterinary Record.

Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells.

H. Pols, J. Gustafsson, J. V. van Leeuwen, 1997, Endocrinology.

Differential Expression of Estrogen Receptors α and β mRNA During Differentiation of Human Osteoblast SV-HFO Cells.

H. Pols, J. Gustafsson, J. V. van Leeuwen, 1997, Endocrinology.

The Role of Body Mass Index, Insulin, and Adiponectin in the Relation Between Fat Distribution and Bone Mineral Density

A. Uitterlinden, F. Rivadeneira, C. V. van Duijn, 2009, Calcified Tissue International.

A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells.

J. Schrooten, C. V. van Blitterswijk, J. de Boer, 2012, Biomaterials.

Identification of small molecules as novel anti-adipogenic compounds based on Connectivity Map

Nicholas J. Lyons, J. van de Peppel, J. V. van Leeuwen, 2022, Frontiers in Endocrinology.

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.

R. Kanaar, T. Kuijpers, M. Raaijmakers, 2016, Cell stem cell.

Distinct conformations of vitamin D receptor/retinoid X receptor-alpha heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes.

G. Stein, J. Lian, H. DeLuca, 1996, Molecular endocrinology.

Homocysteine levels and the risk of osteoporotic fracture.

A. Hofman, A. Uitterlinden, J. V. van Meurs, 2004, The New England journal of medicine.

Vitamin D Binding Protein Genotype and Osteoporosis

A. Hofman, A. Uitterlinden, J. V. van Meurs, 2009, Calcified Tissue International.

The importance of oestrogens in males

H. Pols, F. de Jong, J. V. van Leeuwen, 2003, Clinical endocrinology.

Calcifying vascular smooth muscle cells and osteoblasts: independent cell types exhibiting extracellular matrix and biomineralization-related mimicries

M. Eijken, J. van de Peppel, J. V. van Leeuwen, 2014, BMC Genomics.

Using the Connectivity Map to discover compounds influencing human osteoblast differentiation

M. Eijken, J. van de Peppel, J. V. van Leeuwen, 2018, Journal of cellular physiology.

Evidence for multiple peroxisome proliferator‐activated receptor γ transcripts in bone: Fine‐tuning by hormonal regulation and mRNA stability

M. Eijken, J. V. van Leeuwen, H. Chiba, 2008, FEBS letters.

Lack of associations between serum leptin, a polymorphism in the gene for the β3‐adrenergic receptor and glucose tolerance in the Dutch population.

S. Lamberts, F. de Jong, W. Blum, 1998, Clinical endocrinology.

Serum Phosphate Is Associated With Fracture Risk: The Rotterdam Study and MrOS

A. Hofman, A. Uitterlinden, M. Zillikens, 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Estrogen receptor alpha gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women.

A. Hofman, A. Uitterlinden, J. V. van Meurs, 2003, Arthritis and rheumatism.

Identification of microRNAs in human plasma.

J. van de Peppel, C. Kockx, J. V. van Leeuwen, 2015, Methods in molecular biology.

Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice

H. Weinans, A. Schilling, J. Hoeijmakers, 2011, AGE.

Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study.

A. Uitterlinden, J. V. van Meurs, J. Ioannidis, 2008, Bone.

Genetics and biology of vitamin D receptor polymorphisms.

A. Uitterlinden, J. V. van Meurs, H. Pols, 2004, Gene.

Proteomic analysis of human osteoblastic cells: relevant proteins and functional categories for differentiation.

M. Eijken, T. Luider, J. V. van Leeuwen, 2010, Journal of proteome research.

Effect of parathyroid hormone and parathyroid hormone fragments on the intracellular ionized calcium concentration in an osteoblast cell line.

J. V. van Leeuwen, C. Löwik, M. Bos, 1988, Bone and mineral.

Identification of Chloride Intracellular Channel Protein 3 as a Novel Gene Affecting Human Bone Formation

M. Eijken, J. van de Peppel, J. V. van Leeuwen, 2017, JBMR plus.

TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk.

A. Hofman, A. Uitterlinden, F. Rivadeneira, 2013, Bone.

High Bone Mineral Density and Fracture Risk in Type 2 Diabetes as Skeletal Complications of Inadequate Glucose Control

Gabriëlle H S Buitendijk, O. Franco, A. Hofman, 2013, Diabetes Care.

Bone mineral density and vertebral fracture history are associated with incident and progressive radiographic knee osteoarthritis in elderly men and women: the Rotterdam Study.

A. Hofman, A. Uitterlinden, J. Verhaar, 2005, Bone.

Osteoarthritis of the knee is associated with vertebral and nonvertebral fractures in the elderly: the Rotterdam Study.

A. Hofman, A. Uitterlinden, J. Verhaar, 2003, Arthritis and rheumatism.

Promoter and 3'-untranslated-region haplotypes in the vitamin d receptor gene predispose to osteoporotic fracture: the rotterdam study.

A. Hofman, A. Uitterlinden, J. V. van Meurs, 2005, American journal of human genetics.

GPM6B regulates osteoblast function and induction of mineralization by controlling cytoskeleton and matrix vesicle release

M. Eijken, J. van de Peppel, J. V. van Leeuwen, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Two‐day‐treatment of Activin‐A leads to transient change in SV‐HFO osteoblast gene expression and reduction in matrix mineralization

M. Eijken, J. van de Peppel, J. V. van Leeuwen, 2019, Journal of cellular physiology.

Osteoarthritis induction leads to early and temporal subchondral plate porosity in the tibial plateau of mice: an in vivo microfocal computed tomography study.

Harrie Weinans, Jan H Waarsing, H. Weinans, 2011, Arthritis and rheumatism.

Population analysis of the collagen type IIα1 3′ variable number of tandem repeat polymorphism by heteroduplex genotyping

A. Uitterlinden, H. Pols, J. V. van Leeuwen, 1998, Electrophoresis.

Wnt signaling acts and is regulated in a human osteoblast differentiation dependent manner

A. Uitterlinden, M. Eijken, H. Pols, 2008, Journal of cellular biochemistry.

Different roles for calcium and cyclic AMP in the action of PTH: studies in bone explants and isolated bone cells.

P. Boonekamp, J. V. van Leeuwen, C. Löwik, 1988, Bone.

25-Hydroxyvitamin D and osteoarthritis: A meta-analysis including new data.

A. Hofman, A. Uitterlinden, J. V. van Meurs, 2016, Seminars in arthritis and rheumatism.

Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth

Jeroen A. A. Demmers, J. van de Peppel, A. Nigg, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Unraveling the human bone microenvironment beyond the classical extracellular matrix proteins: a human bone protein library.

M. Eijken, J. Verhaar, J. V. van Leeuwen, 2011, Journal of proteome research.

1α,25‐dihydroxyvitamin D3 stimulates activin A production to fine‐tune osteoblast‐induced mineralization

M. Eijken, J. V. van Leeuwen, B. V. D. van der Eerden, 2013, Journal of cellular physiology.

ERK activation and alpha v beta 3 integrin signaling through Shc recruitment in response to mechanical stimulation in human osteoblasts.

H. Weinans, S. Chien, J. V. van Leeuwen, 2002, Journal of cellular biochemistry.

Evidence for direct effects of prolactin on human osteoblasts: Inhibition of cell growth and mineralization

D. Seriwatanachai, J. V. van Leeuwen, N. Krishnamra, 2009, Journal of cellular biochemistry.

Modulation of responsiveness to cAMP stimulating agonists by phorbol ester in fetal rat osteoblasts

J. V. van Leeuwen, M. Bos, M. P. M. Herrmann‐Erlee, 1991, Journal of cellular physiology.

A bibliometric overview of craniosynostosis research development.

J. V. van Leeuwen, M. van Veelen, I. Mathijssen, 2021, European journal of medical genetics.

Osteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells

A. V. van Wijnen, J. van de Peppel, A. Dudakovic, 2016, Scientific Reports.

Common Genetic Variation of the Low‐Density Lipoprotein Receptor‐Related Protein 5 and 6 Genes Determines Fracture Risk in Elderly White Men

A. Hofman, A. Uitterlinden, J. V. van Meurs, 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Large-Scale Evidence for the Effect of the COLIA1 Sp1 Polymorphism on Osteoporosis Outcomes: The GENOMOS Study

A. Uitterlinden, J. V. van Meurs, J. Ioannidis, 2006, PLoS medicine.

Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment - a systematic approach.

H Weinans, S. Bierma-Zeinstra, H. Weinans, 2008, Osteoarthritis and cartilage.

Effect of calcium and cholecalciferol supplementation on several parameters of calcium status in plasma and urine of captive Asian (Elephas maximus) and African elephants (Loxodonta africana).

J. H. van der Kolk, J. V. van Leeuwen, W. Schaftenaar, 2013, Journal of zoo and wildlife medicine.

Preliminary validation of assays to measure parameters of calcium metabolism in captive Asian and African elephants in western Europe

J. H. van der Kolk, J. V. van Leeuwen, W. Schaftenaar, 2011, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.

A large‐scale population‐based study of the association of vitamin D receptor gene polymorphisms with bone mineral density

A. Hofman, A. Uitterlinden, C. V. van Duijn, 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Cyclical etidronate in the prevention of bone loss in corticosteroid-treated primary biliary cirrhosis. A prospective, controlled pilot study.

W. Hop, H. Pols, J. V. van Leeuwen, 1997, Journal of hepatology.

Paracrine Signaling by Extracellular Vesicles via Osteoblasts

J. V. van Leeuwen, Jess Morhayim, M. van Driel, 2016, Current Molecular Biology Reports.

Extracellular vesicles: specialized bone messengers.

J. V. van Leeuwen, Jess Morhayim, Marta Baroncelli, 2014, Archives of biochemistry and biophysics.

Identification of osteolineage cell‐derived extracellular vesicle cargo implicated in hematopoietic support

C. Voermans, A. V. van Wijnen, J. van de Peppel, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Molecular characterization of human osteoblast-derived extracellular vesicle mRNA using next-generation sequencing.

A. V. van Wijnen, J. van de Peppel, A. Dudakovic, 2017, Biochimica et biophysica acta. Molecular cell research.

H. Weinans, A. Schilling, J. Hoeijmakers, 2012, PloS one.

Parathyroid hormone‐induced ornithine decarboxylase activity in fetal rat osteoblasts

J. V. van Leeuwen, M. Bos, M.P.M. Herrmann‐Erlee, 1989, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Basic techniques in human mesenchymal stem cell cultures: differentiation into osteogenic and adipogenic lineages, genetic perturbations, and phenotypic analyses.

M. Eijken, J. V. van Leeuwen, B. V. D. van der Eerden, 2011, Current protocols in stem cell biology.

Antagonistic effects of transforming growth factor-beta on vitamin D3 enhancement of osteocalcin and osteopontin transcription: reduced interactions of vitamin D receptor/retinoid X receptor complexes with vitamin E response elements.

G. Stein, J. Lian, H. DeLuca, 1996, Endocrinology.

Antiestrogens inhibit in vitro bone resorption stimulated by 1,25-dihydroxyvitamin D3 and the vitamin D3 analogs EB1089 and KH1060.

H. Pols, J. V. van Leeuwen, J. Birkenhäger, 1995, Endocrinology.

A Central Dinucleotide within Vitamin D Response Elements Modulates DNA Binding and Transactivation by the Vitamin D Receptor in Cellular Response to Natural and Synthetic Ligands*

G. Stein, J. Lian, H. Pols, 2002, The Journal of Biological Chemistry.

Vitamin D and Bone: A Story of Endocrine and Auto/Paracrine Action in Osteoblasts

J. V. van Leeuwen, M. van Driel, 2023, Nutrients.

11β-Hydroxysteroid Dehydrogenase Expression and Glucocorticoid Synthesis Are Directed by a Molecular Switch during Osteoblast Differentiation

A. Uitterlinden, M. Eijken, M. Cooper, 2005 .

Immunolocalization and quantification of noncollagenous bone matrix proteins in methylmethacrylate-embedded adult human bone in combination with histomorphometry.

A. Houtsmuller, F. Bosman, H. Pols, 1998, Bone.

Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women.

A. Hofman, A. Uitterlinden, J. V. van Meurs, 2005, European journal of endocrinology.

SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin.

A. Hofman, A. Uitterlinden, J. V. van Meurs, 2009, Free radical biology & medicine.

Ghrelin and bone.

A. J. van der Lely, P. Delhanty, J. V. van Leeuwen, 2007, Vitamins and hormones.

Understanding age-induced cortical porosity in women: Is a negative BMU balance in quiescent osteons a major contributor?

M. Ding, J. Delaissé, T. L. Andersen, 2018, Bone.

Quantification of subchondral bone changes in a murine osteoarthritis model using micro-CT.

H Weinans, J H Waarsing, H. Weinans, 2006, Biorheology.

Understanding Age‐Induced Cortical Porosity in Women: The Accumulation and Coalescence of Eroded Cavities Upon Existing Intracortical Canals Is the Main Contributor

M. Ding, J. Delaissé, T. L. Andersen, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Independent and interrelated regulation of ornithine decarboxylase by calcium and cAMP in fetal rat osteoblasts.

J. V. van Leeuwen, M. Bos, M. Herrmann‐Erlee, 1988, Cell calcium.

Involvement of cAMP and calcium in the induction of ornithine decarboxylase activity in an osteoblast cell line

J. V. van Leeuwen, M. Bos, M. P. M. Herrmann‐Erlee, 1988, Journal of cellular physiology.

Association of 5' estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk.

A. Hofman, A. Uitterlinden, J. V. van Meurs, 2003, Human molecular genetics.

Regulation of Osteocalcin Production and Bone Resorption by 1,25‐Dihydroxyvitamin D3 in Mouse Long Bones: Interaction with the Bone‐Derived Growth Factors TGF‐β and IGF‐I

J. V. van Leeuwen, A. Staal, J. Birkenhäger, 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio.

J. Hoenderop, R. Bindels, J. V. van Leeuwen, 2015, Bone.

Zika virus infection perturbs osteoblast function

M. Koopmans, J. V. van Leeuwen, B. V. D. van der Eerden, 2018, Scientific Reports.

Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy

H. Weinans, J. Hoeijmakers, H. van Steeg, 2010, AGE.

Genetic manipulation of the ghrelin signaling system in male mice reveals bone compartment specificity of acylated and unacylated ghrelin in the regulation of bone remodeling.

Yuxiang Sun, Roy G. Smith, A. J. van der Lely, 2014, Endocrinology.

Vitamin D Status, Bone Mineral Density, and the Development of Radiographic Osteoarthritis of the Knee: The Rotterdam Study

A. Hofman, A. Uitterlinden, J. Verhaar, 2009, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.

NELL-1, HMGB1, and CCN2 Enhance Migration and Vasculogenesis, But Not Osteogenic Differentiation Compared to BMP2.

J. V. van Leeuwen, G. V. van Osch, H. Walles, 2017, Tissue engineering. Part A.

HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis

J. van de Peppel, J. V. van Leeuwen, B. V. D. van der Eerden, 2023, Stem Cell Research & Therapy.

THE INFLUENCE OF ULTRAVIOLET-B RADIATION ON THE GROWTH OF MARABOU STORK (LEPTOPTILOS CRUMENIFERUS) NESTLINGS IN RELATION TO PLASMA CALCIUM, PHOSPHORUS, AND VITAMIN D3 CONCENTRATIONS

J. V. van Leeuwen, W. Schaftenaar, 2015, Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.

Role of calcium and cAMP in heterologous up-regulation of the 1,25-dihydroxyvitamin D3 receptor in an osteoblast cell line.

H. Pols, J. V. van Leeuwen, J. Birkenhäger, 1990, Cell calcium.

Modulatory function of protein kinase C in the activation of ornithine decarboxylase and in cAMP production in rat osteoblasts

J. V. van Leeuwen, M. Bos, M. Herrmann‐Erlee, 1989, Journal of cellular physiology.

Vitamin D control of osteoblast function and bone extracellular matrix mineralization.

H. Pols, J. V. van Leeuwen, H. Pols, 2001, Critical reviews in eukaryotic gene expression.

The transient receptor potential channel TRPV6 is dynamically expressed in bone cells but is not crucial for bone mineralization in mice

M. Eijken, M. Freichel, V. Flockerzi, 2012, Journal of cellular physiology.

1α,25‐(OH)2D3 acts in the early phase of osteoblast differentiation to enhance mineralization via accelerated production of mature matrix vesicles

M. Eijken, H. Chiba, J. V. van Leeuwen, 2010, Journal of cellular physiology.

Cdx‐2 Polymorphism in the Promoter Region of the Human Vitamin D Receptor Gene Determines Susceptibility to Fracture in the Elderly

A. Hofman, A. Uitterlinden, J. V. van Meurs, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

OP0141 1,25(OH)2D3 modulates gene expression involved in cytokine production, proliferation, survival and migration of TH17 cells from patients with rheumatoid arthritis

J. V. van Leeuwen, E. Lubberts, J. Hazes, 2013 .

Regulation of 1,25-dihydroxyvitamin D3 receptor gene expression by parathyroid hormone and cAMP-agonists.

H. Pols, J. V. van Leeuwen, J. Birkenhäger, 1992, Biochemical and biophysical research communications.

Functional involvement of calcium in the homologous up‐regulation of the 1,25‐dihydroxyvitamin D3 receptor in osteoblast‐like cells

J. V. van Leeuwen, J. Birkenhäger, H. Pols, 1990, FEBS letters.

Consequences of vitamin D receptor regulation for the 1,25-dihydroxyvitamin D3-induced 24-hydroxylase activity in osteoblast-like cells: initiation of the C24-oxidation pathway.

H. Pols, J. V. van Leeuwen, A. Staal, 1997, Bone.

The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men.

A. Hofman, A. Uitterlinden, J. V. van Meurs, 2007, The Journal of clinical endocrinology and metabolism.

Better knowledge on vitamin D and calcium in older people is associated with a higher serum vitamin D level and a higher daily dietary calcium intake

N. van der Velde, T. V. D. van der Cammen, J. V. van Leeuwen, 2012 .

Pro-osteogenic trophic effects by PKA activation in human mesenchymal stromal cells.

C. V. van Blitterswijk, J. de Boer, N. Groen, 2011, Biomaterials.

Dexamethasone in osteogenic medium strongly induces adipocyte differentiation of mouse bone marrow stromal cells and increases osteoblast differentiation

J. V. van Leeuwen, P. Hardouin, C. Chauveau, 2015, BMC Cell Biology.

Paracrine Signaling by Extracellular Vesicles via Osteoblasts

J. V. van Leeuwen, Jess Morhayim, M. van Driel, 2016, Current Molecular Biology Reports.

Sexual dimorphisms in serum calcium and phosphate concentrations in the Rotterdam Study

A. Uitterlinden, M. Zillikens, J. V. van Leeuwen, 2023, Scientific reports.

Decreased oxygen tension lowers reactive oxygen species and apoptosis and inhibits osteoblast matrix mineralization through changes in early osteoblast differentiation

J. V. van Leeuwen, M. Koedam, Johannes P T M van Leeuwen, 2012, Journal of cellular physiology.

Height in pre- and postmenopausal women is influenced by estrogen receptor alpha gene polymorphisms.

Albert Hofman, André G Uitterlinden, A. Hofman, 2004, The Journal of clinical endocrinology and metabolism.

Spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo.

C. V. van Blitterswijk, J. de Boer, V. Subramaniam, 2015, Biomaterials.

Simultaneous induction of apoptosis, collagen type I expression and mineralization in the developing coronal suture following FGF4 and FGF2 application.

J. V. van Leeuwen, I. Mathijssen, C. Vermeij-Keers, 2000, Journal of craniofacial genetics and developmental biology.

A small molecule approach to engineering vascularized tissue.

O. Myklebost, C. V. van Blitterswijk, J. de Boer, 2013, Biomaterials.

Supporting data of spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo

C. V. van Blitterswijk, J. de Boer, V. Subramaniam, 2015, Data in Brief.

Protein arginine methyltransferases PRMT1, PRMT4/CARM1 and PRMT5 have distinct functions in control of osteoblast differentiation

G. Stein, J. Davie, A. V. van Wijnen, 2023, Bone reports.

Cancer and bone: a complex complex.

J. V. van Leeuwen, M. van Driel, 2014, Archives of biochemistry and biophysics.

The T‐13910C polymorphism in the lactase phlorizin hydrolase gene is associated with differences in serum calcium levels and calcium intake

A. Hofman, J. V. van Meurs, F. Rivadeneira, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

TNF blockade requires 1,25(OH)2D3 to control human Th17-mediated synovial inflammation

J. V. van Leeuwen, E. Lubberts, J. Hazes, 2012, Annals of the rheumatic diseases.

Basic and translational research

J. V. van Leeuwen, E. Lubberts, J. Hazes, 2011 .

Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio.

J. Hoenderop, R. Bindels, J. V. van Leeuwen, 2015, Bone.

Serum Phosphate Is Associated With Fracture Risk: The Rotterdam Study and MrOS

M. Zillikens, H. Pols, J. V. van Leeuwen, 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Iodothyronine deiodinase enzyme activities in bone

T. Visser, J. V. van Leeuwen, S. Shalet, 2008, Bone.

A New Concept Underlying Stem Cell Lineage Skewing That Explains the Detrimental Effects of Thiazolidinediones on Bone

M. Eijken, J. van de Peppel, J. V. van Leeuwen, 2010, Stem cells.

Opposing actions of rosiglitazone and resveratrol on mineralization in human vascular smooth muscle cells.

M. Eijken, J. V. van Leeuwen, H. Chiba, 2011, Journal of molecular and cellular cardiology.

Large-Scale Evidence for the Effect of the COLIA1 Sp1 Polymorphism on Osteoporosis Outcomes: The GENOMOS Study

J. V. van Meurs, J. Ioannidis, A. Díez-Pérez, 2006, PLoS medicine.

UV exposure inhibits intestinal tumor growth and progression to malignancy in intestine‐specific Apc mutant mice kept on low vitamin D diet

F. D. de Gruijl, J. V. van Leeuwen, E. Robanus-Maandag, 2015, International journal of cancer.

Identification of Chloride Intracellular Channel Protein 3 as a Novel Gene Affecting Human Bone Formation

M. Eijken, J. van de Peppel, J. V. van Leeuwen, 2017, JBMR Plus.

Role of protein kinase C (PKC) in bone resorption: effect of the specific PKC inhibitor 1-alkyl-2-methylglycerol.

J. V. van Leeuwen, W. Most, M. Bos, 1992, Biochemical and biophysical research communications.

Bone Resorption Inhibitor Alendronate Normalizes the Reduced Bone Thickness of TRPV5−/− Mice

H. Weinans, J. Hoenderop, R. Bindels, 2008, Journal of Bone and Mineral Research.

Genetic manipulation of the ghrelin signaling system in male mice reveals bone compartment specificity of acylated and unacylated ghrelin in the regulation of bone remodeling.

Yuxiang Sun, Roy G. Smith, A. J. van der Lely, 2014, Endocrinology.

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.

R. Kanaar, T. Kuijpers, M. Raaijmakers, 2016, Cell stem cell.

Diverse effects of cyclic AMP variants on osteogenic and adipogenic differentiation of human mesenchymal stromal cells.

C. V. van Blitterswijk, J. de Boer, N. Groen, 2012, Tissue engineering. Part A.