I. Yu

发表

Generation and analysis of the thiazide‐sensitive Na+‐Cl− cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome

Shu-Wha Lin, S. Sasaki, T. Chao, 2010, Human mutation.

Gene targeting and expression analysis of mouse Tem1/endosialin using a lacZ reporter.

Shu-Wha Lin, Hsiang-Po Huang, L. You, 2011, Gene expression patterns : GEP.

A Nucleolus-Predominant piggyBac Transposase, NP-mPB, Mediates Elevated Transposition Efficiency in Mammalian Cells

Shu-Wha Lin, I. Yu, Tsung-Lin Yang, 2014, PloS one.

Phosphorylation regulates NCC stability and transporter activity in vivo.

Shu-Wha Lin, S. Sasaki, Yuh-Feng Lin, 2013, Journal of the American Society of Nephrology : JASN.

Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility

Shu-Wha Lin, P. Kuo, Chien-Yu Lin, 2016, Scientific Reports.

Serine protease hepsin regulates hepatocyte size and hemodynamic retention of tumor cells by hepatocyte growth factor signaling in mice

Pan‐Chyr Yang, Shu-Wha Lin, Hsiang-Po Huang, 2012, Hepatology.

Functional and structural deficits of the dentate gyrus network coincide with emerging spontaneous seizures in an Scn1a mutant Dravet Syndrome model during development

Y. Yanagawa, O. Khorkova, Shu-Wha Lin, 2015, Neurobiology of Disease.

Activation of Aryl Hydrocarbon Receptor by Kynurenine Impairs Progression and Metastasis of Neuroblastoma.

H. Juan, Chi-hao Chang, I. Yu, 2019, Cancer research.

The effects of wild bitter gourd fruit extracts on ICAM-1 expression in pulmonary epithelial cells of C57BL/6J mice and microRNA-221/222 knockout mice: Involvement of the miR-221/-222/PI3K/AKT/NF-κB pathway.

Hsin-Ching Sung, Shu-Wha Lin, Ming-Hsien Chiang, 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Resveratrol attenuates ICAM-1 expression and monocyte adhesiveness to TNF-α-treated endothelial cells: evidence for an anti-inflammatory cascade mediated by the miR-221/222/AMPK/p38/NF-κB pathway

Hsin-Ching Sung, Shu-Wha Lin, Chiang-Wen Lee, 2017, Scientific Reports.

Structure-guided design of novel orthosteric inhibitors of integrin αIIbβ3 that prevent thrombosis but preserve hemostasis

M. Arnaout, J. Xiong, Shu-Wha Lin, 2019, bioRxiv.

Insights into phenotypic differences between humans and mice with p.T721M and other C-terminal variants of the SLC26A4 gene

Shu-Wha Lin, I. Yu, Chuan-Jen Hsu, 2021, Scientific Reports.

Toward the Pathogenicity of the SLC26A4 p.C565Y Variant Using a Genetically Driven Mouse Model

Shu-Wha Lin, I. Yu, Chuan-Jen Hsu, 2021, International journal of molecular sciences.

Toward the Pathogenicity of the SLC26A4 p.C565Y Variant Using a Genetically Driven Mouse Model

Shu-Wha Lin, I. Yu, Chuan-Jen Hsu, 2020, bioRxiv.

Differences in the Pathogenicity of the p.H723R Mutation of the Common Deafness-Associated SLC26A4 Gene in Humans and Mice

J. Wong, Shu-Wha Lin, I. Yu, 2013, PloS one.

Mutation screening of the EYA1, SIX1, and SIX5 genes in an east asian cohort with branchio‐oto‐renal syndrome

W. Hwu, I. Yu, Chuan-Jen Hsu, 2012, The Laryngoscope.

Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells

Shu-Wha Lin, Chien-Yu Lin, I. Yu, 2019, PloS one.

Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis

M. Arnaout, J. Xiong, Shu-Wha Lin, 2020, Nature Communications.

Sensory nerve degeneration in a mouse model mimicking early manifestations of familial amyloid polyneuropathy due to transthyretin Ala97Ser

S. Hsieh, I. Yu, Hung-Wei Kan, 2018, Neuropathology and applied neurobiology.

FIX-Triple, a gain-of-function factor IX variant, improves haemostasis in mouse models without increased risk of thrombosis

J. Kao, Shu-Wha Lin, Hua-Lin Wu, 2010, Thrombosis and Haemostasis.

The Lupus‐Associated Fcγ Receptor IIb–I232T Polymorphism Results in Impairment in the Negative Selection of Low‐Affinity Germinal Center B Cells Via c‐Abl in Mice

Jyun-Pei Jhou, Shiang-Jong Tzeng, I. Yu, 2018, Arthritis & rheumatology.

Regulation of the dopaminergic system in a murine model of aromatic l-amino acid decarboxylase deficiency

Y. Chien, W. Hwu, H. Ichinose, 2013, Neurobiology of Disease.

TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis, and resistance to arachidonate-induced death.

Shu-Wha Lin, Hua-Lin Wu, I. Yu, 2004, Blood.

Genetic Elimination of Connective Tissue Growth Factor in the Forebrain Affects Subplate Neurons in the Cortex and Oligodendrocytes in the Underlying White Matter

Yi-Ling Lu, I. Yu, Li-Jen Lee, 2019, Front. Neuroanat..

Genetic Depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor Signalling Prevents Microvascular Dysfunction in Ischaemia/Reperfusion Injury

I. Yu, C. Chien, Po-Yuan Chang, 2018, Thrombosis and Haemostasis.

Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice

M. O’Bryan, Yen-Lin Chen, I. Yu, 2020, PLoS genetics.

Targeting spike protein-induced TLR/NET axis by COVID-19 therapeutic NRICM102 ameliorates pulmonary embolism and fibrosis

K. Tsai, I. Yu, Wenjuan Wei, 2022, Pharmacological Research.

and resistance to arachidonate-induced death TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis

Shu-Wha Lin, I. Yu, Kenneth K. Wu, 2013 .

Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis

Shu-Wha Lin, Hua-Lin Wu, Shuei-Liong Lin, 2020, Scientific Reports.

Genetic Modification of Donor Hepatocytes Improves Therapeutic Efficacy for Hemophilia B in Mice

Hsuan‐Shu Lee, Po-Huang Lee, Shu-Wha Lin, 2010, Cell transplantation.

A Knock-In Npm1 Mutation in Mice Results in Myeloproliferation and Implies a Perturbation in Hematopoietic Microenvironment

Hsiu-Mei Lin, Shu-Wha Lin, M. Tsai, 2012, PloS one.

Lack of Thromboxane Synthase Prevents Hypertension and Fetal Growth Restriction after High Salt Treatment during Pregnancy

Shu-Wha Lin, Chie-Pein Chen, I. Yu, 2016, PloS one.

Mice Lacking Connective Tissue Growth Factor in the Forebrain Exhibit Delayed Seizure Response, Reduced C-Fos Expression and Different Microglial Phenotype Following Acute PTZ Injection

I. Yu, Li-Jen Lee, Kuang-Yung Lee, 2020, International journal of molecular sciences.

Severe metabolic acidosis causes early lethality in NBC1 W516X knock-in mice as a model of human isolated proximal renal tubular acidosis.

Shu-Wha Lin, G. Seki, Shih-Hua Lin, 2011, Kidney international.

Deletion of cadherin‐17 enhances intestinal permeability and susceptibility to intestinal tumour formation

Y. Jeng, L. Yu, I. Yu, 2018, The Journal of pathology.

Current animal models of hemophilia: the state of the art

Shu-Wha Lin, I. Yu, Yung‐Li Yang, 2016, Thrombosis Journal.

Incorporation of the factor IX Padua mutation into FIX-Triple improves clotting activity in vitro and in vivo

Y. Jeng, Shu-Wha Lin, M. Tao, 2013, Thrombosis and Haemostasis.

Chimaeric mice with disruption of the gene coding for phosphatidylinositol glycan class A (Pig‐a) were defective in embryogenesis and spermatogenesis

Shu-Wha Lin, Pei-Hsin Huang, I. Yu, 2000, British journal of haematology.

Metabolic , Endocrine and Genitourinary Pathobiology The Expression Level of Septin 12 Is Critical for Spermiogenesis

P. Yen, Shu-Wha Lin, P. Kuo, 2010 .

The expression level of septin12 is critical for spermiogenesis.

P. Yen, Shu-Wha Lin, P. Kuo, 2009, The American journal of pathology.

Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis

M. Arnaout, J. Xiong, Shu-Wha Lin, 2020, Nature Communications.

Alteration of colonic epithelial cell differentiation in mice deficient for glucosaminyl N-deacetylase/N-sulfotransferase 4

Shu-Wha Lin, I. Yu, Tzu-Ming Jao, 2016, Oncotarget.

Establishment of a Knock-In Mouse Model with the SLC26A4 c.919-2A>G Mutation and Characterization of Its Pathology

Xi Lin, Chen-Chi Wu, Jau-Min Wong, 2011, PloS one.

Rescue of the genetically engineered Cul4b mutant mouse as a potential model for human X-linked mental retardation.

Shu-Wha Lin, Chien-Yu Lin, I. Yu, 2012, Human molecular genetics.

Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon

A. Rudensky, Yih-Leong Chang, Chen‐Tu Wu, 2014, Nature Communications.

P53 ICE CRIM mouse: a tool to generate mutant allelic series in somatic cells and germ lines for cancer studies

Shu-Wha Lin, I. Yu, Tsung-Lin Yang, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mice Deficient in Hepsin, a Serine Protease, Exhibit Normal Embryogenesis and Unchanged Hepatocyte Regeneration Ability

Shu-Wha Lin, I. Yu, Shu‐Rung Lin, 2000, Thrombosis and Haemostasis.

L2dtl Is Essential for Cell Survival and Nuclear Division in Early Mouse Embryonic Development*

H. Hsu, Shu-Wha Lin, H. Pan, 2007, Journal of Biological Chemistry.

Sun1 deficiency leads to cerebellar ataxia in mice

K. Jeang, Chia-yen Chen, Shu-Wha Lin, 2015, Disease Models & Mechanisms.

A Pre-conditioning Strategy to Augment Retention and Engraftment Rate of Donor Cells during Hepatocyte Transplantation.

J. Sheu, Shu-Wha Lin, I. Yu, 2020, Transplantation.

R26R-GR: A Cre-Activable Dual Fluorescent Protein Reporter Mouse

R. Behringer, Shu-Wha Lin, R. Favaro, 2012, PloS one.

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

Aly A. Khan, A. Rudensky, Hsi-Yuan Huang, 2018, Nature Communications.

SEPT12-Microtubule Complexes Are Required for Sperm Head and Tail Formation

Shu-Wha Lin, P. Kuo, I. Yu, 2013, International journal of molecular sciences.

The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation

T. Lawrence, M. Tsai, I. Yu, 2017, Nature Communications.

Aryl Hydrocarbon Receptor Downregulates MYCN Expression and Promotes Cell Differentiation of Neuroblastoma

H. Juan, Hsuan-Cheng Huang, Y. Jeng, 2014, PloS one.

A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner.

Yuheng Lu, Christina S Leslie, C. Leslie, 2015, Immunity.

SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos.

Shu-Wha Lin, P. Kuo, I. Yu, 2011, Fertility and sterility.

Mice Deficient in Collapsin Response Mediator Protein-1 Exhibit Impaired Long-Term Potentiation and Impaired Spatial Learning and Memory

J. Shih, Shu-Wha Lin, W. Fu, 2007, The Journal of Neuroscience.

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

Aly A. Khan, A. Rudensky, Hsi-Yuan Huang, 2018, Nature Communications.

A Single miRNA-mRNA Int eraction Affects the Immune Response in a Context-and Cell-Type-Specific Manner Highlights

C. Leslie, A. Rudensky, Paula D. Bos, 2015 .

NRICM101 ameliorates SARS-CoV-2–S1-induced pulmonary injury in K18-hACE2 mice model

K. Tsai, I. Yu, Wenjuan Wei, 2023, Frontiers in Pharmacology.

Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells

Shu-Wha Lin, Chien-Yu Lin, I. Yu, 2019, PloS one.

FIX-Triple, a gain-of-function factor IX variant, improves haemostasis in mouse models without increased risk of thrombosis

J. Kao, Shu-Wha Lin, Hua-Lin Wu, 2010, Thrombosis and Haemostasis.

Determinants of Synaptic Efficacy Dendritic Excitability and Neuronal Morphology as

H. Kröger, I. Timofeev, M. Migliore, 2015 .

Incorporation of the factor IX Padua mutation into FIX-Triple improves clotting activity in vitro and in vivo

Y. Jeng, Shu-Wha Lin, M. Tao, 2013, Thrombosis and Haemostasis.

Wdhd1 is essential for early mouse embryogenesis.

Shu-Wha Lin, I. Yu, Tsung-Lin Yang, 2021, Biochimica et biophysica acta. Molecular cell research.