K. Gee

发表

CCD-3693: an orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the rat.

R. B. Carter, P. Wood, D. Edgar, 1997, The Journal of pharmacology and experimental therapeutics.

Regional distribution of a Ro5 4864 binding site that is functionally coupled to the gamma-aminobutyric acid/benzodiazepine receptor complex in rat brain.

B. McEwen, K. Gee, R. Brinton, 1988, The Journal of pharmacology and experimental therapeutics.

Enaminone Modulators of Extrasynaptic α4β3δ γ-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning

F. Dudek, K. Gee, J. McDonough, 2019, Front. Pharmacol..

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.

R. B. Carter, P. Wood, J. Lambert, 1997, The Journal of pharmacology and experimental therapeutics.

Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one

M. Bolger, K. Gee, D. Belelli, 1989 .

Enaminone amides as novel orally active GABAA receptor modulators.

K. Gee, D. Hogenkamp, E. R. Whittemore, 2007, Journal of medicinal chemistry.

Limited central side effects of a β-subunit subtype-selective GABAA receptor allosteric modulator

K. Gee, F. Porreca, Jennifer Xie, 2014, Journal of psychopharmacology.

Allosteric modulation of nicotinic and GABAA receptor subtypes differentially modify autism-like behaviors in the BTBR mouse model

K. Gee, D. Hogenkamp, Timothy B C Johnstone, 2017, Neuropharmacology.

Differentiation of benzodiazepine receptor agonist and antagonist: sparing of [3H]benzodiazepine antagonist binding following the photolabelling of benzodiazepine receptors.

H. Yamamura, K. Gee, 1982, European journal of pharmacology.

Role of β2/3-specific GABA-A receptor isoforms in the development of hippocampus kindling epileptogenesis

K. Gee, D. Reddy, D. Hogenkamp, 2018, Epilepsy & Behavior.

Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury

C. Atkins, K. Gee, D. Titus, 2019, PloS one.

Reversible lipidization for the oral delivery of leu-enkephalin

K. Gee, W. Shen, D. Hogenkamp, 2006, Journal of drug targeting.

Studies of Central Nervous System Cholinergic Receptors in Alzheimer’s Disease (AD)

K. Gee, M. Watson, J. Culberson, 1990 .

Modulation of Human Recombinant GABAA Receptors by Pregnanediols

J. A. Peters, J. Lambert, K. Gee, 1996, Neuropharmacology.

A putative receptor for neurosteroids on the GABAA receptor complex: the pharmacological properties and therapeutic potential of epalons.

K. Gee, N. Lan, L. McCauley, 1995, Critical reviews in neurobiology.

Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex

K. Gee, N. Lan, D. Belelli, 1990, Neuroscience & Biobehavioral Reviews.

Characterization of [3H][2-D-penicillamine, 5-D-penicillamine]-enkephalin binding to delta opiate receptors in the rat brain and neuroblastoma--glioma hybrid cell line (NG 108-15).

V. Hruby, H. Yamamura, H. Mosberg, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Selective actions of certain neuroactive pregnanediols at the gamma-aminobutyric acid type A receptor complex in rat brain.

K. Gee, N. Lan, J. Hawkinson, 1995, Molecular pharmacology.

5α-pregnan-3α,20α-diol behaves like a partial agonist in the modulation of GABA-stimulated chlride ion uptake by synaptoneurosomes

K. Gee, D. Belelli, 1989 .

Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action.

B. McEwen, M. Bolger, K. Gee, 1988, The Journal of pharmacology and experimental therapeutics.

Detection and Characterization of Epalon Receptors: Novel Recognition Sites for Neuroactive Steroids That Modulate the GABAA Receptor Complex

K. Gee, L. McCauley, 1994 .

GABA-dependent modulation of the Cl- ionophore by steroids in rat brain.

B. McEwen, K. Gee, R. Brinton, 1987, European journal of pharmacology.

Interactions of pyrethroid insecticides with chloride ionophore-associated binding sites.

H. Yamamura, K. Gee, L. Lawrence, 1985, Neurotoxicology.

Characterization of peripheral benzodiazepine type sites in a cultured murine BV‐2 microglial cell line

E. Carboni, K. Gee, P. L. Wood, 1996, Glia.

Vibrissa Deflections Neurons in the Rat Thalamic Reticular Nucleus to High Responsiveness and Direction Sensitivity of

J. Belluzzi, D. Simons, S. Temereanca, 2015 .

First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288

R. Freedman, A. Olincy, K. Gee, 2017, Journal of psychopharmacology.

Effect of seizures kindled by subconvulsant doses of pentylenetetrazol on dopamine receptor binding and dopamine-sensitive adenylate cyclase in the rat

K. Gee, M. Hollinger, E. Killam, 1981, Experimental Neurology.

Effect of amygdaloid kindling on dopamine-sensitive adenylate cyclase activity in rat brain

K. Gee, M. Hollinger, S. Giri, 1980, Experimental Neurology.

Modification of dopaminergic receptor sensitivity in rat brain after amygdaloid kindling

K. Gee, J. Bowyer, M. Hollinger, 1979, Experimental Neurology.

[3H]oxytocin binding sites in the rat brain demonstrated by quantitative light microscopic autoradiography.

H. Yamamura, K. Gee, J. Wamsley, 1984, European journal of pharmacology.

The neuroactive steroid 3α-hydroxy-5β-pregnan-20-one is a two-component modulator of ligand binding to the GABAA receptor

M. Bolger, K. Gee, N. Lan, 1994 .

Selective anxiolytics: are the actions related to partial "agonist" activity or a preferential affinity for benzodiazepine receptor subtypes?

H. Yamamura, K. Gee, 1983, Advances in biochemical psychopharmacology.

Conformationally constrained cyclic enkephalin analogs with pronounced delta opioid receptor agonist selectivity.

V. Hruby, T. Burks, J. Galligan, 1983, Life sciences.

Cyclic penicillamine containing enkephalin analogs display profound delta receptor selectivities.

V. Hruby, T. Burks, J. Galligan, 1983, Life Science.

A steroid recognition site is functionally coupled to an expressed GABA(A)-benzodiazepine receptor.

P. Seeburg, K. Gee, N. Lan, 1990, European journal of pharmacology.

Complex interactions between the steroid derivative RU 5135 and the GABAA-receptor complex.

K. Gee, C. Cadoni, 1992, European journal of pharmacology.

Allosteric modulators of the δ GABAA receptor subtype demonstrate a therapeutic effect in morphine-antinociceptive tolerance and withdrawal in mice

K. Gee, D. Hogenkamp, R. Yoshimura, 2022, Neuropharmacology.

Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one

K. Gee, N. Lan, S. Wieland, 1991, Brain Research.

Response-rate suppression in operant paradigm as predictor of soporific potency in rats and identification of three novel sedative-hypnotic neuroactive steroids.

R. B. Carter, D. Edgar, W. Seidel, 1999, The Journal of pharmacology and experimental therapeutics.

Gamma-aminobutyric acidA receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation.

K. Gee, N. Lan, 1991, Molecular pharmacology.

Regional distribution of putative vasopressin receptors in rat brain and pituitary by quantitative autoradiography.

H. Yamamura, K. Gee, T. Davis, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Positive allosteric modulators of the GABAA receptor: differential interaction of benzodiazepines and neuroactive steroids with ethanol

R. B. Carter, P. Wood, K. Gee, 1999, Psychopharmacology.

Partial agonism by 3alpha,21-dihydroxy-5beta-pregnan-20-one at the gamma-aminobutyric acidA receptor neurosteroid site.

C. Park, K. Gee, N. Lan, 1997, The Journal of pharmacology and experimental therapeutics.

A comparison of Ro 16-6028 with benzodiazepine receptor 'full agonists' on GABAA receptor function.

K. Gee, D. Finn, 1993, European journal of pharmacology.

Pharmacological profile of a 17β-heteroaryl-substituted neuroactive steroid

K. Gee, D. Hogenkamp, M. Tran, 2014, Psychopharmacology.

Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of α7 nicotinic acetylcholine receptors.

Gavin D. Bascom, K. Gee, D. Hogenkamp, 2013, Journal of medicinal chemistry.

The monoamine oxidase (MAO) inhibitor tranylcypromine enhances nicotine self-administration in rats through a mechanism independent of MAO inhibition

James D. Belluzzi, J. Belluzzi, F. Leslie, 2011, Neuropharmacology.

Light microscopic autoradiographic visualization of [3H]-arginine vasopressin binding sites in rat brain.

H. Yamamura, K. Gee, T. Davis, 1983, Life sciences.

Heterogeneity of Benzodiazepine Receptors

H. Yamamura, K. Gee, W. Roeske, 1984 .

Comparison of the distribution of convulsant/barbiturate and benzodiazepine receptors using light microscopic autoradiography.

H. Yamamura, K. Gee, J. Wamsley, 1983, Life sciences.

Anxiolytic and anticonvulsant activity of a synthetic neuroactive steroid Co 3-0593

L. Stein, J. Belluzzi, P. Wood, 1997, Psychopharmacology.

Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor

J. Lambert, K. Gee, D. Belelli, 2019, Neurobiology of Stress.

Realizing the therapeutic potential of GABAAR-active neurosteroids

J. Lambert, K. Gee, D. Belelli, 2019 .

The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid.

K. Gee, D. Finn, Deborah A. Finn, 1994, The Journal of pharmacology and experimental therapeutics.

The influence of estrus cycle on neurosteroid potency at the gamma-aminobutyric acidA receptor complex.

K. Gee, D. Finn, 1993, The Journal of pharmacology and experimental therapeutics.

Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.

T F Burks, R Hurst, V J Hruby, 1983, Proceedings of the National Academy of Sciences of the United States of America.

An allosteric model for benzodiazepine receptor function.

H. Yamamura, K. Gee, W. Roeske, 1983, Biochemical pharmacology.

Synthesis and in Vitro Activity of 3β-Substituted-3α-hydroxypregnan-20-ones: Allosteric Modulators of the GABAA Receptor†

M. Bolger, K. Gee, N. Lan, 1997 .

Characterization of the anticonvulsant properties of Ganaxolone (CCD 1042; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high-affinity, steroid modulator of the γ-aminobutyric acid(A) receptor

R. B. Carter, P. Wood, J. Lambert, 1997 .

Synthesis and in vitro Activity of 3β-Substituted-3α- hydroxypregnan-20-ones: Allosteric Modulators of the GABAA Receptor.

M. Bolger, K. Gee, N. Lan, 1997 .

Allosteric Modulation of Related Ligand-Gated Ion Channels Synergistically Induces Long-Term Potentiation in the Hippocampus and Enhances Cognition

J. Belluzzi, J. Yakel, K. Gee, 2011, Journal of Pharmacology and Experimental Therapeutics.

The neuroactive steroid 3 alpha-hydroxy-5 beta-pregnan-20-one is a two-component modulator of ligand binding to the GABAA receptor.

M. Bolger, K. Gee, N. Lan, 1994, European journal of pharmacology.

Photoaffinity Labeling of Benzodiazepine Receptors in Rat Brain with Flunitrazepam Alters the Affinity of Benzodiazepine Receptor Agonist But Not Antagonist Binding

H. Yamamura, K. Gee, 1983, Journal of neurochemistry.

Differential effect of gamma-aminobutyric acid on benzodiazepine receptor subtypes labeled by [3H]propyl beta-carboline-3-carboxylate in rat brain.

H. Yamamura, K. Gee, F. Ehlert, 1983, The Journal of pharmacology and experimental therapeutics.

Benzodiazepines and peptides stimulate pregnenolone synthesis in brain mitochondria.

C. Park, J. Tomich, J. Shively, 1995, European journal of pharmacology.

Steroids in relation to epilepsy and anaesthesia.

K. Gee, N. Lan, T. Bäckström, 1990, Ciba Foundation symposium.

Phenylquinolines PK 8165 and PK 9084 allosterically modulate [35S]t-butylbicyclophosphorothionate binding to a chloride ionophore in rat brain via a novel Ro5 4864 binding site.

K. Gee, 1987, Journal of Pharmacology and Experimental Therapeutics.

t‐[3H]Butylbicycloorthobenzoate: New Radioligand Probe for the γ‐Aminobutyric Acid–Regulated Chloride Ionophore

J. Casida, H. Yamamura, K. Gee, 1985, Journal of neurochemistry.

Loreclezole modulates [35S]t-butylbicyclophosphorothionate and [3H]flunitrazepam binding via a distinct site on the GABAA receptor complex.

K. Gee, J. Friend, B. Xue, 1996, European journal of pharmacology.

Differential Effects of 4′‐Chlorodiazepam on Expressed Human GABAA Receptors

K. Gee, N. Lan, Jie‐Sheng Chen, 1995, Journal of neurochemistry.

Heterotropic Cooperativity Between Putative Recognition Sites for Progesterone Metabolites and the Atypical Benzodiazepine Ro 5–4864

K. Gee, D. Belelli, L. McCauley, 1990, Journal of neurochemistry.

Benzodiazepine anticonvulsant action: gamma-aminobutyric acid-dependent modulation of the chloride ionophore.

H. Yamamura, K. Gee, L. J. Lawrence, 1984, Biochemical and biophysical research communications.

Positive allosteric modulators of nonbenzodiazepine &ggr;-aminobutyric acidA receptor subtypes for the treatment of chronic pain

K. Gee, F. Porreca, Chaoling Qu, 2018, Pain.

Modifying quinolone antibiotics yields new anxiolytics

K. Gee, J. Wang, D. Hogenkamp, 2004, Nature Medicine.

[D-Pen2, L-Cys5]enkephalinamide and[D-Pen2, D-Cys5] enkephalinamide, conformationally constrained cyclic enkephalinamide analogs with delta receptor specificity.

V. Hruby, T. Burks, J. Galligan, 1982, Biochemical and biophysical research communications.

Anxiolytic properties of endogenously occurring pregnanediols in two rodent models of anxiety

E. Carboni, K. Gee, N. Lan, 1996, Psychopharmacology.

Negative Allosteric Modulation of Nicotinic Acetylcholine Receptors Blocks Nicotine Self-Administration in Rats

J. Belluzzi, F. Leslie, K. Gee, 2007, Journal of Pharmacology and Experimental Therapeutics.

Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators

K. Gee, D. Hogenkamp, E. R. Whittemore, 2007, Proceedings of the National Academy of Sciences.

Limiting Activity at β1-Subunit-Containing GABAA Receptor Subtypes Reduces Ataxia

J. Belluzzi, K. Gee, D. Hogenkamp, 2010, Journal of Pharmacology and Experimental Therapeutics.

Long-Term Potentiation in the Hippocampus and Enhances Cognition Allosteric Modulation of Related Ligand-Gated Ion Channels Synergistically Induces

J. Belluzzi, T. Dunwiddie, E. Albuquerque, 2015 .

Rol5-4513 differentially affects ethanol-induced hypnosis and hypothermia

K. Gee, R. Alkana, P. Syapin, 1987, Brain Research Bulletin.

Neuroactive Steroid Actions at the GABAA Receptor

K. Gee, N. Lan, 1994, Hormones and Behavior.

Differential Responses of Expressed Recombinant Human γ‐Aminobutyric AcidA Receptors to Neurosteroids

M. Bolger, K. Gee, N. Lan, 1991, Journal of neurochemistry.

Identification and characterization of a pregnane steroid recognition site that is functionally coupled to an expressed GABAA receptor

M. Bolger, K. Gee, N. Lan, 1991, Neurochemical Research.

Steroid modulation of the GABA/benzodiazepine receptor-linked chloride lonophore

K. Gee, 2008, Molecular Neurobiology.

Soporific effect of the neurosteroid pregnanolone in relation to the substance's plasma level: a pilot study.

H. Schulz, M. Jobert, K. Gee, 1996, Neuropsychobiology.

Influence of the estrus cycle on the discrimination of apparent neuroactive steroid site subtypes on the gamma-aminobutyric acidA receptor complex in the rat.

K. Gee, L. McCauley, 1995, The Journal of pharmacology and experimental therapeutics.

A novel pyrazoloquinoline that interacts with brain benzodiazepine receptors: characterization of some in vitro and in vivo properties of CGS 9896.

H. Yamamura, K. Gee, 1982, Life sciences.

Modulation of the chloride ionophore by benzodiazepine receptor ligands: influence of gamma-aminobutyric acid and ligand efficacy.

H. Yamamura, K. Gee, L. J. Lawrence, 1986, Molecular pharmacology.

Complex interactions between pregnenolone sulfate and the t-butylbicyclophosphorothionate-labeled chloride ionophore in rat brain

D. S. Joy, K. Gee, D. Belelli, 1989, Brain Research.

5 alpha-pregnan-3 alpha,20 alpha-diol behaves like a partial agonist in the modulation of GABA-stimulated chloride ion uptake by synaptoneurosomes.

K. Gee, D. Belelli, 1989, European journal of pharmacology.

The effect of GABA on in vitro binding of two novel non-benzodiazepines, PK 8165 and CGS 8216, to benzodiazepine receptors in the rat brain.

M. Morelli, H. Yamamura, K. Gee, 1982, Life sciences.

Potency of lipid and protein formulation of 5 alpha-pregnanolone at induction of anaesthesia and the corresponding regional brain distribution.

K. Gee, T. Bäckström, G. Wahlström, 1995, British journal of anaesthesia.

Effects of chronic delta-9-tetrahydrocannabinol (THC) administration on neurotransmitter concentrations and receptor binding in the rat brain.

W. Slikker, A. Scallet, M. Paule, 1989, Neurotoxicology.

Anticonvulsant profile of the progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one.

M. Bolger, K. Gee, D. Belelli, 1989, European journal of pharmacology.

3 alpha-Hydroxy-3 beta-trifluoromethyl-5 alpha-pregnan-20-one (Co 2-1970): a partial agonist at the neuroactive steroid site of the gamma-aminobutyric acidA receptor.

K. Gee, N. Lan, J. Hawkinson, 1996, Molecular pharmacology.

PK 8165 and PK 9084, two quinoline derivatives with anxiolytic properties, antagonize the anticonvulsant effects of diazepam

H. Yamamura, K. Gee, R. Brinton, 1983, Brain Research.

The influence of temperature and gamma-aminobutyric acid on benzodiazepine receptor subtypes in the hippocampus of the rat.

H. Yamamura, K. Gee, F. Ehlert, 1982, Biochemical and biophysical research communications.

The effect of temperature on CL 218872 and propyl beta-carboline-3-carboxylate inhibition of [3H]-flunitrazepam binding in rat brain.

M. Morelli, H. Yamamura, K. Gee, 1982, Biochemical and biophysical research communications.

High affinity inhibition of [3H]-flunitrazepam binding to brain benzodiazepine receptors by CGS 9896, a novel pyrazoloquinoline.

R. O'brien, H. Yamamura, K. Gee, 1982, Biochemical and biophysical research communications.

CL 218872 antagonism of diazepam induced loss of righting reflex: evidence for partial agonistic activity at the benzodiazepine receptor.

H. Yamamura, K. Gee, R. Brinton, 1983, Life sciences.

Anxiolytic activity of the progesterone metabolite 5 alpha-pregnan-3 alpha-o1-20-one.

K. Gee, N. Lan, S. Wieland, 1991, Brain research.

Benzodiazepine receptor heterogeneity: possible molecular basis and functional significance.

H. Yamamura, K. Gee, W. Roeske, 1984, Federation proceedings.

Regional heterogeneity of benzodiazepine receptors at 37 degrees C: an in vitro study in various regions of the rat brain.

H. Yamamura, K. Gee, 1982, Life sciences.

Behavioral characterization of Co 134444 (3α-hydroxy-21-(1'-imidazolyl)-3β-methoxymethyl-5α-pregnan-20-one), a novel sedative-hypnotic neuroactive steroid

R. B. Carter, K. Gee, N. Lan, 2001, Psychopharmacology.

Light microscopic autoradiographic identification of picrotoxin/barbiturate binding sites in rat brain with [35S]t-butyl-bicyclophosphothionate.

H. Yamamura, K. Gee, J. Wamsley, 1983, European journal of pharmacology.