C. Bovolenta

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Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1

Luigi Naldini, Michael C. Holmes, Chiara Bovolenta, 2017, Science Translational Medicine.

Constitutive activation of STATs upon in vivo human immunodeficiency virus infection.

A. Lazzarin, E. Vicenzi, C. Bovolenta, 1999, Blood.

Virus Infection Constitutive Activation of STATs Upon In Vivo Human Immunodeficiency

A. Lazzarin, E. Vicenzi, C. Bovolenta, 1999 .

Naturally occurring C-terminally truncated STAT5 is a negative regulator of HIV-1 expression.

M. Giacca, A. Lazzarin, P. Lievens, 2007, Blood.

Epidermal growth factor induces, in the ELα4−2 cell line, herpes simplex virus-1 α4 gene transcription in the absence of the viral trans-activator VP16

M. Tognon, C. Bovolenta, E. Liboi, 1991 .

The F12-Vif derivative Chim3 inhibits HIV-1 replication in CD4+ T lymphocytes and CD34+-derived macrophages by blocking HIV-1 DNA integration.

F. Gubinelli, C. Bovolenta, R. Lupo, 2009, Blood.

Expression and Activation of a C-Terminal Truncated Isoform of STAT5 (STAT5Δ) Following Interleukin 2 Administration or AZT Monotherapy in HIV-Infected Individuals

A. Lazzarin, C. Bovolenta, G. Poli, 2001 .

Retroviral Interference on STAT Activation in Individuals Coinfected with Human T Cell Leukemia Virus Type 2 and HIV-1

M. Sassi, C. Bovolenta, G. Poli, 2002, The Journal of Immunology.

Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: evidence for an IL-10-induced pathway that is independent of STAT protein activation.

A. Yoshimura, A. Suzuki, C. Bovolenta, 1999, Blood.

Mediastinal large-cell lymphoma with sclerosis

A. Scarpa, G. Zamboni, F. Menestrina, 2004, Virchows Archiv A.

Mutational analysis of the HIV-1 auxiliary protein Vif identifies independent domains important for the physical and functional interaction with HIV-1 reverse transcriptase

G. Maga, C. Bovolenta, R. Lupo, 2009, Nucleic acids research.

The F12-Vif derivative Chim3 inhibits HIV-1 replication in CD4 (cid:1) T lymphocytes and CD34 (cid:1) -derived macrophages by blocking HIV-1 DNA integration

F. Gubinelli, C. Bovolenta, R. Lupo, 2009 .

Activation of distinct transcription factors in neutrophils by bacterial LPS, interferon-gamma, and GM-CSF and the necessity to overcome the action of endogenous proteases.

C. Bovolenta, M. Cassatella, P. McDonald, 1998, Biochemistry.

Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family.

J. Coligan, K. Sakaguchi, E. Appella, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Human T-cell leukemia virus type 2 induces survival and proliferation of CD34(+) TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte macrophage-colony-stimulating factor.

C. Bovolenta, G. Poli, C. Casoli, 2002, Blood.

Human T-cell leukemia virus type 2 induces survival and proliferation of CD 34 TF-1 cells through activation of STAT 1 and STAT 5 by secretion of interferon-and granulocyte macrophage – colony-stimulating factor

C. Bovolenta, G. Poli, C. Casoli, 2001 .

A selective defect of IFN-gamma- but not of IFN-alpha-induced JAK/STAT pathway in a subset of U937 clones prevents the antiretroviral effect of IFN-gamma against HIV-1.

C. Bovolenta, F. Novelli, P. Biswas, 1999, Journal of immunology.

A Selective Defect of IFN-γ- But Not of IFN-α-Induced JAK/STAT Pathway in a Subset of U937 Clones Prevents the Antiretroviral Effect of IFN-γ Against HIV-1

C. Bovolenta, F. Novelli, P. Biswas, 1999, The Journal of Immunology.

Against HIV-1 γ Effect of IFN-U 937 Clones Prevents the Antiretroviral-Induced JAK / STAT Pathway in a Subset of α-But Not of IFN-γ A Selective Defect of IFN -

C. Bovolenta, F. Novelli, P. Biswas, 1998 .

Monocytes by IL-10 Differentially in Human Neutrophils and Response Region ( GRR ) Are Regulated γ Gene and STAT Protein Binding to the IFN-RI / CD 64 ) γ High Affinity Receptor for IgG ( Fc

C. Bovolenta, M. Cassatella, S. Gasperini, 1998 .

High Affinity Receptor for IgG (FcγRI/CD64) Gene and STAT Protein Binding to the IFN-γ Response Region (GRR) Are Regulated Differentially in Human Neutrophils and Monocytes by IL-10

C. Bovolenta, M. Cassatella, S. Gasperini, 1998, The Journal of Immunology.

Multiple cis-acting elements are required for proper transcription of the mouse V delta 1 T cell receptor promoter.

J. Coligan, C. Bovolenta, A. Punturieri, 1993, Journal of immunology.

IFN‐γ and IL‐12 differentially regulate CC‐chemokine secretion and CCR5 expression in human T lymphocytes

J. Casanova, G. Trinchieri, G. Forni, 2002, Journal of Leukocyte Biology.

RD2-MolPack-Chim3, a packaging cell line for stable production of lentiviral vectors for anti-HIV gene therapy.

C. Bordignon, F. Mavilio, C. Bovolenta, 2013, Human gene therapy methods.

Chim3 confers survival advantage to CD4+ T cells upon HIV-1 infection by preventing HIV-1 DNA integration and HIV-1-induced G2 cell-cycle delay.

F. Gubinelli, C. Bovolenta, L. Alberici, 2010, Blood.

Lentiviral Vector Gene Therapy Protects XCGD Mice From Acute Staphylococcus aureus Pneumonia and Inflammatory Response.

C. Brombin, C. Di Serio, A. Bragonzi, 2016, Molecular therapy : the journal of the American Society of Gene Therapy.

Transcriptional enhancers induce insertional gene deregulation independently from the vector type and design.

A. Schambach, Claudia Cattoglio, F. Mavilio, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

Production of lentiviral vectors

Otto-Wilhelm Merten, Matthias Hebben, Chiara Bovolenta, 2016, Molecular therapy. Methods & clinical development.

Heterogeneity of Signal Transducer and Activator of Transcription Binding Sites in the Long-Terminal Repeats of Distinct HIV-1 Subtypes

B. Berkhout, P. Lievens, E. Vicenzi, 2007, The open virology journal.

Vectofusin-1 Promotes RD114-TR-Pseudotyped Lentiviral Vector Transduction of Human HSPCs and T Lymphocytes

A. Galy, C. Bordignon, C. Bovolenta, 2017, Molecular therapy. Methods & clinical development.

Codon Optimization Leads to Functional Impairment of RD114-TR Envelope Glycoprotein

M. Pema, C. Bordignon, C. Bovolenta, 2017, Molecular therapy. Methods & clinical development.

RD-MolPack technology for the constitutive production of self-inactivating lentiviral vectors pseudotyped with the nontoxic RD114-TR envelope

M. Pema, C. Bordignon, C. Bovolenta, 2016, Molecular therapy. Methods & clinical development.

Defective nef alleles in a cohort of hemophiliacs with progressing and nonprogressing HIV-1 infection.

F. Veglia, E. Santagostino, E. Vicenzi, 1999, Virology.

The Binding Subunit of Pertussis Toxin Inhibits HIV Replication in Human Macrophages and Virus Expression in Chronically Infected Promonocytic U1 Cells1

R. Rappuoli, M. Bukrinsky, A. Lazzarin, 2001, The Journal of Immunology.

Therapeutic genes for anti-HIV/AIDS gene therapy.

C. Bovolenta, L. Alberici, S. Porcellini, 2013, Current pharmaceutical biotechnology.

T Lymphocytes transduced with a lentiviral vector expressing F12-Vif are protected from HIV-1 infection in an APOBEC3G-independent manner.

Fulvio Mavilio, Chiara Bovolenta, Maurizio Federico, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

In vivo administration of recombinant IL-2 to individuals infected by HIV down-modulates the binding and expression of the transcription factors ying-yang-1 and leader binding protein-1/late simian virus 40 factor.

A. Lazzarin, C. Bovolenta, G. Poli, 1999, Journal of immunology.

Positive Selection of Apoptosis-resistant Cells Correlates with Activation of Dominant-Negative STAT5*

L. Testolin, P. Lievens, L. Benussi, 1998, The Journal of Biological Chemistry.

Vesicular stomatitis virus infection induces a nuclear DNA-binding factor specific for the interferon-stimulated response element

J. Coligan, Y. Kanno, K. Ozato, 1995, Journal of virology.

interferon-stimulated response element . nuclear DNA-binding factor specific for the Vesicular stomatitis virus infection induces a

J. Coligan, Y. Kanno, K. Ozato, 1995 .

IFN-gamma and IL-12 differentially regulate CC-chemokine secretion and CCR5 expression in human T lymphocytes.

J. Casanova, G. Trinchieri, G. Forni, 2002, Journal of Leukocyte Biology.

Selective association of a 22-38 kDa glycoprotein with MHC class II DP antigen on activated human lymphocytes at the plasma membrane.

M. Giunta, C. Bovolenta, M. Libonati, 1996, Molecular immunology.

Envelope-Dependent Restriction of Human Immunodeficiency Virus Type 1 Spreading in CD4+ T Lymphocytes: R5 but Not X4 Viruses Replicate in the Absence of T-Cell Receptor Restimulation

E. Vicenzi, C. Bovolenta, F. Sinigaglia, 1999, Journal of Virology.

Virus 40 Factor and Leader Binding Protein-1/Late Simian of the Transcription Factors Ying-Yang-1 Down-Modulates the Binding and Expression to Individuals Infected by HIV In Vivo Administration of Recombinant IL-2

A. Lazzarin, C. Bovolenta, S. Ghezzi, 1999 .

Mutational analysis of the HIV-1 auxiliary protein Vif identifies independent domains important for the physical and functional interaction with HIV-1 reverse transcriptase

G. Maga, C. Bovolenta, R. Lupo, 2014, Nucleic acids research.

Granulocyte colony‐stimulating factor induces the binding of STAT1 and STAT3 to the IFNγ response region within the promoter of the FcγRI/CD64 gene in human neutrophils

C. Bovolenta, M. Cassatella, S. Gasperini, 1996 .

Leukemia Virus Type 2 and HIV-1 in Individuals Coinfected with Human T Cell Retroviral Interference on STAT Activation

M. Sassi, C. Bovolenta, G. Poli, 2002 .

High affinity receptor for IgG (Fc gamma RI/CD64) gene and STAT protein binding to the IFN-gamma response region (GRR) are regulated differentially in human neutrophils and monocytes by IL-10.

C. Bovolenta, M. Cassatella, S. Gasperini, 1998, Journal of immunology.

Expression and activation of a C-terminal truncated isoform of STAT5 (STAT5 Delta) following interleukin 2 administration or AZT monotherapy in HIV-infected individuals.

A. Lazzarin, C. Bovolenta, G. Poli, 2001, Clinical immunology.

540. Vectofusin-1 Significantly Enhances Transduction of Ex-Vivo Activated T Cells With RD114-TR-Pseudotyped Lentiviral Vectors Derived from the RD3-MolPack Stable Packaging Cells

A. Galy, C. Bordignon, C. Bovolenta, 2015 .