H. Su

发表

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Hualiang Jiang, Yechun Xu, Jian Li, 2020, Science.

Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation.

Xianglei Zhang, Guofeng Chen, Yechun Xu, 2020, Journal of medicinal chemistry.

From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4.

Weiliang Zhu, Qiu-feng Liu, H. Su, 2018, European journal of medicinal chemistry.

Application of ITC-Based Characterization of Thermodynamic and Kinetic Association of Ligands With Proteins in Drug Design

Yechun Xu, H. Su, 2018, Front. Pharmacol..

Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure–Activity Relationships, Antiviral Activity, and X-ray Structure Determination

Yechun Xu, A. Poso, M. Gütschow, 2022, Journal of medicinal chemistry.

Identification of C270 as a novel site for allosteric modulators of SARS-CoV-2 papain-like protease

Qiang Shao, H. Su, Guofeng Chen, 2022, bioRxiv.

Cocktail polysaccharides isolated from Ecklonia kurome against the SARS-CoV-2 infection

Bo Zhang, Yechun Xu, Xinwen Chen, 2021, Carbohydrate Polymers.

Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.

Yechun Xu, Jian Li, Heng Li, 2020, European journal of medicinal chemistry.

Structure-based design of a novel inhibitor of the ZIKA virus NS2B/NS3 protease.

H. Su, Fei Cheng, Yi Zou, 2022, Bioorganic chemistry.

In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2

Jian Li, Wenhao Dai, H. Su, 2022, Antiviral Research.

Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes

H. Su, Dingding Gao, He-Yao Wang, 2019, Endocrine.

Dipyridamole interacts with the N-terminal domain of HSP90 and antagonizes the function of the chaperone in multiple cancer cell lines.

H. Su, Naixia Zhang, Y. Zhong, 2022, Biochemical pharmacology.

Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase.

Qiu-feng Liu, H. Su, Yin-chun Ji, 2022, Journal of medicinal chemistry.

Flavonoids from the roots and rhizomes of Sophoratonkinensis and their in vitro anti-SARS-CoV-2 activity

Sheng Yao, Hang Xie, H. Su, 2023, Chinese Journal of Natural Medicines.

Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2

Kaixian Chen, Hualiang Jiang, Yechun Xu, 2021, Journal of medicinal chemistry.

Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients

Kunqian Yu, Hualiang Jiang, Geng-fu Xiao, 2020, Acta Pharmacologica Sinica.

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

Yan Zhang, Hualiang Jiang, Sheng-Ce Tao, 2020, bioRxiv.

Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis.

Yechun Xu, Wei Tang, Hang Xie, 2021, Angewandte Chemie.

In silico screening-based discovery of novel covalent inhibitors of the SARS-CoV-2 3CL protease

Qiang Shao, H. Su, Tianqing Nie, 2022, European Journal of Medicinal Chemistry.

Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease

Hualiang Jiang, Yechun Xu, Qiang Shao, 2021, Nature Communications.

Drug discovery and development targeting the life cycle of SARS-CoV-2

Hualiang Jiang, Yechun Xu, H. Su, 2021, Fundamental Research.

Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro

Kunqian Yu, Hualiang Jiang, Yechun Xu, 2020, bioRxiv.

Structure-Based Design, Synthesis and Biological Evaluation of Peptidomimetic Aldehydes as a Novel Series of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease

Hualiang Jiang, Yechun Xu, Jian Li, 2020, bioRxiv.

Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation

Yechun Xu, Wei Tang, Heng Li, 2021, Journal of advanced research.

USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines

Yechun Xu, H. Su, Hu Zhou, 2020, The FEBS journal.

Discovery of Polyphenolic Natural Products as SARS-CoV-2 Mpro Inhibitors for COVID-19

T. Kronenberger, Hang Xie, S. Pöhlmann, 2023, Pharmaceuticals.

Allosteric Regulation of Hsp90α’s Activity by Small Molecules Targeting the Middle Domain of the Chaperone

Yechun Xu, Zhijun Liu, H. Su, 2020, iScience.

Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method

M. Witt, H. Su, C. Ke, 2021, Journal of Pharmaceutical and Biomedical Analysis.

What coronavirus 3C‐like protease tells us: From structure, substrate selectivity, to inhibitor design

Yechun Xu, Qiang Shao, Hang Xie, 2021, Medicinal research reviews.

Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors.

Yechun Xu, Jianhua Shen, Qiu-feng Liu, 2016, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moiety

H. Su, Lei-ke Zhang, Xiangrui Jiang, 2023, Bioorganic & medicinal chemistry.

From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4

Weiliang Zhu, Yechun Xu, Qiu-feng Liu, 2018 .

Unraveling the catalytic mechanism of SARS-CoV-2 papain-like protease with allosteric modulation of C270 mutation using multiscale computational approaches

Qiang Shao, H. Su, M. Xiong, 2023, Chemical science.

Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CLpro inhibitors against SARS-CoV-2

H. Su, Lei-ke Zhang, Xiangrui Jiang, 2023, European journal of medicinal chemistry.

Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease

H. Su, Guofeng Chen, Jian He, 2023, International journal of molecular sciences.

Spatiotemporal and global profiling of DNA–protein interactions enables discovery of low-affinity transcription factors

Jian Zhang, Ke Yan, Minjia Tan, 2023, Nature Chemistry.

Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2

Lu Liu, Jian Li, Fang Bai, 2023, European Journal of Medicinal Chemistry.

Discovery and Mechanism Study of SARS-CoV-2 3C-like Protease Inhibitors with a New Reactive Group.

Hui Li, Jian Li, Hong Liu, 2023, Journal of medicinal chemistry.

Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19

J. Qi, Yi Shi, Sheng Yao, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir

Gengfu Xiao, Yan Zhang, H. Su, 2023, Nature communications.

Crystal structure of human FABP4 complexed with ligand 4-Fluoro-3-((4-methoxynaphthalene)-1-sulfonamido) benzoic acid

Weiliang Zhu, Yechun Xu, Qiu-feng Liu, 2018 .

Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors.

H. Su, Xianglei Zhang, Guofeng Chen, 2023, European journal of medicinal chemistry.

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Yi Jiang, H. Su, Guanghui Tian, 2020, Science.

Multi-omics for COVID-19: driving development of therapeutics and vaccines

Cai-Guang Yang, C. Yi, Chunying Chen, 2023, National science review.