Xinyuanyuan Sun

发表

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

R. Hilgenfeld, C. Drosten, S. Becker, 2020, Science.

Inhibition of SARS-CoV-2 main protease by allosteric drug-binding

Diana C. F. Monteiro, H. Chapman, C. Betzel, 2020, bioRxiv.

Massive X-ray screening reveals two allosteric drug binding sites of SARS-CoV-2 main protease

Diana C. F. Monteiro, H. Chapman, C. Betzel, 2020 .

Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication

A. Marchand, R. Hilgenfeld, E. Decroly, 2022, Molecules.

X-ray Structure of Main Protease of the Novel Coronavirus SARS-CoV-2 Enables Design of α-Ketoamide Inhibitors

R. Hilgenfeld, Linlin Zhang, D. Lin, 2020, bioRxiv.

Substrate specificity profiling of SARS-CoV-2 main protease enables design of activity-based probes for patient-sample imaging

R. Hilgenfeld, W. Młynarski, Linlin Zhang, 2020, bioRxiv.

Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design

R. Hilgenfeld, Linlin Zhang, Xinyuanyuan Sun, 2020, medRxiv.

SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging

R. Hilgenfeld, J. Neyts, W. Młynarski, 2020, Nature Chemical Biology.

Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts

R. Hilgenfeld, S. Olsen, J. Neyts, 2021, Scientific reports.

From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease

R. Hilgenfeld, Linlin Zhang, Xinyuanyuan Sun, 2022, Molecules.

Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease

Hannah J. Maple, R. Hilgenfeld, J. Neyts, 2022, Journal of medicinal chemistry.

Protection against Virulent Infectious Bronchitis Virus Challenge Conferred by a Recombinant Baculovirus Co-Expressing S1 and N Proteins

Xinyuanyuan Sun, Yuan Yuan, P. Wei, 2018, Viruses.

Greater Protection against Virulent Infectious Bronchitis Virus Challenge Conferred by Recombinant Baculovirus Co-expressing S 1 and N Proteins

Xinyuanyuan Sun, Yuan Yuan, P. Wei, 2018 .

Ebselen derivatives are very potent dual inhibitors of SARS-CoV-2 proteases - PLpro and Mpro in in vitro studies

R. Hilgenfeld, S. Olsen, Linlin Zhang, 2020, bioRxiv.

Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease

Diana C. F. Monteiro, H. Chapman, C. Betzel, 2020, bioRxiv.

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

Diana C. F. Monteiro, H. Chapman, C. Betzel, 2021, Science.

Evaluation of the inhibitory potential of essential oils and aromatic extracts on SARS-CoV-2 Mpro and PLpro

R. Hilgenfeld, S. Olsen, Linlin Zhang, 2021 .

Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase

S. Olsen, J. Jemielity, Linlin Zhang, 2023, Scientific reports.

H172Y mutation perturbs the S1 pocket and nirmatrelvir binding of SARS-CoV-2 main protease through a nonnative hydrogen bond

Jana K. Shen, R. Hilgenfeld, Xinyuanyuan Sun, 2022, Research square.

Integrative Approach to Dissect the Drug Resistance Mechanism of the H172Y Mutation of SARS-CoV-2 Main Protease

Jana K. Shen, Mingzhe Shen, P. Mahinthichaichan, 2023, J. Chem. Inf. Model..

An Integrative Approach to Dissect the Drug Resistance Mechanism of the H172Y Mutation of SARS-CoV-2 Main Protease

Jana K. Shen, Mingzhe Shen, P. Mahinthichaichan, 2023, bioRxiv.