J. Maléth

发表

Ca2+ Influx Channel Inhibitor SARAF Protects Mice From Acute Pancreatitis.

S. Muallem, D. Schwartz, A. Son, 2019, Gastroenterology.

Blood–brain barrier dysfunction in l-ornithine induced acute pancreatitis in rats and the direct effect of l-ornithine on cultured brain endothelial cells

Á. Kittel, L. Cervenak, J. Maléth, 2022, Fluids and barriers of the CNS.

Spilanthol Inhibits Inflammatory Transcription Factors and iNOS Expression in Macrophages and Exerts Anti-inflammatory Effects in Dermatitis and Pancreatitis

P. Hegyi, É. Szabó, J. Maléth, 2019, International journal of molecular sciences.

CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis.

S. Muallem, G. Lukács, P. Hegyi, 2016, Reviews of physiology, biochemistry and pharmacology.

Caspase‐9 acts as a regulator of necroptotic cell death

R. Király, F. Erdélyi, G. Szabó, 2021, The FEBS journal.

[Long-term proton pump inhibitor therapy and osteoporosis. Is there a real danger?].

P. Hegyi, J. Maléth, 2013, Orvosi hetilap.

Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.

M. Zaccolo, G. Lukács, J. Mayerle, 2015, Gastroenterology.

Advances in the optimization of therapeutic drug monitoring using serum, tissue and faecal anti-tumour necrosis factor concentration in patients with inflammatory bowel disease treated with TNF-α antagonists

K. Farkas, F. Nagy, T. Molnár, 2021, Expert opinion on biological therapy.

Intracellular Ca2+ Signalling in the Pathogenesis of Acute Pancreatitis: Recent Advances and Translational Perspectives

Á. Varga, J. Maléth, T. Madácsy, 2020, International journal of molecular sciences.

Ca2+ toxicity and mitochondrial damage in acute pancreatitis: translational overview

P. Hegyi, J. Maléth, 2016, Philosophical Transactions of the Royal Society B: Biological Sciences.

Calcium signaling in pancreatic ductal epithelial cells: an old friend and a nasty enemy.

P. Hegyi, J. Maléth, 2014, Cell calcium.

2019/07/05 Functionality, membrane integrity and rheological properties are altered in red blood cells of smoking pregnant mother

P. Horváth, P. Hegyi, J. Maléth, 2020 .

Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating

S. Muallem, Malini Ahuja, J. Maléth, 2014, Nature Communications.

Na+/Ca2+ exchangers regulate the migration and proliferation of human gastric myofibroblasts.

P. Hegyi, Z. Rakonczay, T. Wittmann, 2013, American journal of physiology. Gastrointestinal and liver physiology.

The Role of Pancreatic Ductal Secretion in Protection Against Acute Pancreatitis in Mice*

P. Hegyi, Z. Rakonczay, T. Wittmann, 2014, Critical care medicine.

Intraductal acidosis in acute biliary pancreatitis.

P. Hegyi, Z. Rakonczay, J. Maléth, 2013, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

Non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells

P. Hegyi, Z. Rakonczay, J. Maléth, 2010, Gut.

Bile acids, ethanol and fatty acids deteriorate pancreatic ductal fluid and bicarbonate secretion

P. Hegyi, L. Tretter, J. Maléth, 2020 .

Novel mitochondrial transition pore inhibitor N‐methyl‐4‐isoleucine cyclosporin is a new therapeutic option in acute pancreatitis

P. Hegyi, Z. Rakonczay, L. Tretter, 2019, The Journal of physiology.

IMPORTANT THERAPEUTIC TARGETS IN ACUTE PANCREATITIS

L. Puskás, J. Mayerle, M. Lerch, 2019 .

Fentanyl but Not Morphine or Buprenorphine Improves the Severity of Necrotizing Acute Pancreatitis in Rats

P. Hegyi, Z. Rakonczay, B. Tóth, 2022, International journal of molecular sciences.

Mislocalization of CFTR expression in acute pancreatitis and the beneficial effect of VX‐661 + VX‐770 treatment on disease severity

P. Hegyi, Z. Rakonczay, J. Maléth, 2021, The Journal of physiology.

Online Laboratory Investigations

P. Hegyi, Z. Rakonczay, T. Wittmann, 2014 .

Bile acid‐ and ethanol‐mediated activation of Orai1 damages pancreatic ductal secretion in acute pancreatitis

T. Crul, P. Hegyi, Á. Varga, 2022, The Journal of physiology.

Decreased calmodulin recruitment triggers PMCA4 dysfunction and pancreatic injury in cystic fibrosis

P. Hegyi, Z. Rakonczay, Á. Varga, 2020, bioRxiv.

TRPM2‐mediated extracellular Ca2+ entry promotes acinar cell necrosis in biliary acute pancreatitis

P. Hegyi, Z. Rakonczay, Á. Varga, 2020, The Journal of physiology.

Pancreatic Ductal Cell Function

P. Hegyi, J. Maléth, 2019 .

Genetic analysis of the bicarbonate secreting anion exchanger SLC26A6 in chronic pancreatitis.

G. Veres, J. Gervain, P. Hegyi, 2015, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

Ductal Mucus Obstruction and Reduced Fluid Secretion Are Early Defects in Chronic Pancreatitis

J. Mayerle, J. Kühn, P. Hegyi, 2018, Front. Physiol..

Pancreatic Ductal Bicarbonate Secretion: Challenge of the Acinar Acid Load

P. Hegyi, Z. Rakonczay, J. Maléth, 2011, Front. Physio..

Endoplasmic Reticulum‐Plasma Membrane Contact Sites as an Organizing Principle for Compartmentalized Calcium and cAMP Signaling

T. Crul, J. Maléth, 2021, International journal of molecular sciences.

Mouse pancreatic ductal organoid culture as a relevant model to study exocrine pancreatic ion secretion

P. Hegyi, Z. Rakonczay, Á. Varga, 2019, Laboratory Investigation.

Nanocomposite-based dual enzyme system for broad-spectrum scavenging of reactive oxygen species

J. Maléth, M. Pavlović, I. Szilágyi, 2021, Scientific Reports.

Confinement of Triple-Enzyme-Involved Antioxidant Cascade in Two-Dimensional Nanostructure

M. Skwarczynski, I. Toth, D. Sebők, 2023, ACS materials letters.

Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.

B. Kuster, R. Rad, C. Cohrs, 2021, Cell stem cell.

The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function

Joseph P. Yuan, Min Seuk Kim, S. Muallem, 2013, The Journal of cell biology.

cAMP and Ca²⁺ signaling in secretory epithelia: crosstalk and synergism.

S. Muallem, Malini Ahuja, J. Maléth, 2014, Cell calcium.

Central role of mitochondrial injury in the pathogenesis of acute pancreatitis

P. Hegyi, Z. Rakonczay, J. Maléth, 2013, Acta physiologica.

Galanin, a potent inhibitor of pancreatic bicarbonate secretion, is involved in the induction and progression of cerulein-induced experimental acute pancreatitis.

P. Hegyi, Z. Rakonczay, J. Maléth, 2011, Pancreas.

Bidirectional Relationship Between Reduced Blood pH and Acute Pancreatitis: A Translational Study of Their Noxious Combination

G. Veres, P. Hegyi, Z. Rakonczay, 2018, Front. Physiol..

Poly(ADP-Ribose) Polymerase 1 Promotes Inflammation and Fibrosis in a Mouse Model of Chronic Pancreatitis

P. Hegyi, É. Szabó, J. Maléth, 2021, International journal of molecular sciences.

Molecular and Cellular Mechanisms of Disease

P. Hegyi, Z. Rakonczay, J. Maléth, 2022 .

Trypsin reduces pancreatic ductal bicarbonate secretion by inhibiting CFTR Cl⁻ channels and luminal anion exchangers.

J. Mayerle, M. Lerch, P. Hegyi, 2011, Gastroenterology.

Kynurenic Acid and Its Analogue SZR-72 Ameliorate the Severity of Experimental Acute Necrotizing Pancreatitis

L. Vécsei, P. Hegyi, Z. Rakonczay, 2021, Frontiers in Immunology.

Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: The Role of Oxidative Stress-Induced DNA Damage Signaling

P. Hegyi, J. Maléth, L. Virág, 2022, Biomedicines.

Thiopurines impair the apical plasma membrane expression of CFTR in pancreatic ductal cells via RAC1 inhibition

T. Crul, P. Hegyi, Á. Varga, 2023, Cellular and Molecular Life Sciences.

Spatiotemporally limited BDNF and GDNF overexpression rescues motoneurons destined to die and induces elongative axon growth

A. Nógrádi, J. Maléth, D. Hercher, 2014, Experimental Neurology.

Sustained Maternal Smoking Triggers Endothelial-Mediated Oxidative Stress in the Umbilical Cord Vessels, Resulting in Vascular Dysfunction

P. Hegyi, J. Maléth, N. Bódi, 2021, Antioxidants.

The formin DAAM is required for coordination of the actin and microtubule cytoskeleton in 2 axonal growth cones 3

Ede Migh, P. Hegyi, Beáta Bugyi, 2017 .

OGG1 Inhibition Reduces Acinar Cell Injury in a Mouse Model of Acute Pancreatitis

P. Hegyi, J. Maléth, L. Virág, 2022, Biomedicines.

The ER/PM microdomain, PI(4,5)P₂ and the regulation of STIM1-Orai1 channel function.

S. Muallem, Malini Ahuja, J. Maléth, 2015, Cell calcium.

Impaired cytoplasmic domain interactions cause co-assembly defect and loss of function in the p.Glu293Lys KNCJ2 variant isolated from an Andersen-Tawil Syndrome patient.

A. Labro, J. Maléth, I. Nagy, 2020, Cardiovascular research.

Cigarette smoke extract inhibits fluid and HCO–3 secretion and CFTR activity in guinea pig pancreatic ductal cells

P. Hegyi, Z. Rakonczay, J. Maléth, 2014 .

Impaired regulation of PMCA activity by defective CFTR expression promotes epithelial cell damage in alcoholic pancreatitis and hepatitis

P. Hegyi, Z. Rakonczay, Á. Varga, 2022, Cellular and Molecular Life Sciences.

Failure in the compensatory mechanism in red blood cells due to sustained smoking during pregnancy.

P. Horváth, P. Hegyi, J. Maléth, 2019, Chemico-biological interactions.

Anoctamin 8 tethers endoplasmic reticulum and plasma membrane for assembly of Ca2+ signaling complexes at the ER/PM compartment

S. Muallem, Malini Ahuja, J. Maléth, 2019, The EMBO journal.

The TRPCs-STIM1-Orai interaction.

Min Seuk Kim, I. So, S. Muallem, 2014, Handbook of experimental pharmacology.

Cystic Fibrosis of the Pancreas: The Role of CFTR Channel in the Regulation of Intracellular Ca2+ Signaling and Mitochondrial Function in the Exocrine Pancreas

J. Maléth, T. Madácsy, P. Pallagi, 2018, Front. Physiol..

Analysis of Research Activity in Gastroenterology: Pancreatitis Is in Real Danger

P. Hegyi, Z. Rakonczay, A. Párniczky, 2016, PloS one.

Functional Anatomical Changes in Ulcerative Colitis Patients Determine Their Gut Microbiota Composition and Consequently the Possible Treatment Outcome

C. Pál, K. Farkas, F. Nagy, 2020, Pharmaceuticals.

Microtubule organization in presynaptic boutons relies on the formin DAAM

Ede Migh, K. Medzihradszky, P. Hegyi, 2018, Development.

Breakdown of bioenergetics evoked by mitochondrial damage in acute pancreatitis: Mechanisms and consequences.

P. Hegyi, Z. Rakonczay, J. Maléth, 2015, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

Effects of alcohol on pancreatic ductal function

P. Hegyi, Z. Rakonczay, J. Maléth, 2016 .

Effects of ethanol and ethanol metabolites on the pancreatic ductal bicarbonate secretion

P. Hegyi, Z. Rakonczay, J. Maléth, 2016 .

A novel, protective role of ursodeoxycholate in bile-induced pancreatic ductal injury.

P. Hegyi, J. Maléth, M. Katona, 2016, American journal of physiology. Gastrointestinal and liver physiology.

Pancreatic epithelial fluid and bicarbonate secretion is significantly elevated in the absence of peripheral serotonin

P. Hegyi, J. Maléth, A. Balázs, 2015, Gut.

P046 Disease modelling of Inflammatory Bowel Disease by human colon organoids

K. Farkas, T. Molnár, J. Maléth, 2021 .

Anoctamin8 Tethers the Endoplasmic Reticulum and Plasma Membranes to Assemble Ca 2+ Signaling Complexes at ER/PM Junctions

Guofeng, S. Muallem, Malini Ahuja, 2020 .

Effects of bowel cleansing on the composition of the gut microbiota in inflammatory bowel disease patients and healthy controls

K. Farkas, T. Molnár, E. Ari, 2023, Therapeutic advances in gastroenterology.

Orai1 calcium channel inhibition prevents progression of chronic pancreatitis

T. Crul, K. Stauderman, Á. Varga, 2023, JCI insight.

The formin DAAM is required for coordination of the actin and microtubule cytoskeleton in axonal growth cones

Ede Migh, P. Hegyi, Beáta Bugyi, 2017, Development.

Su1249 Non-Oxidative Ethanol Metabolites Induce Intracellular ATP Depletion and Inhibit Pancreatic Ductal Bicarbonate Secretion in Human Pancreatic Ductal Epithelial Cell Line

P. Hegyi, T. Wittmann, J. Maléth, 2012 .

Bile acids inhibit Na+/H+ exchanger and Cl−/HCO3− exchanger activities via cellular energy breakdown and Ca2+ overload in human colonic crypts

P. Hegyi, Z. Rakonczay, K. Farkas, 2014, Pflügers Archiv - European Journal of Physiology.

Human pancreatic ductal organoids with controlled polarity provide a novel ex vivo tool to study epithelial cell physiology

Á. Varga, J. Maléth, F. Ayaydin, 2023, Cellular and Molecular Life Sciences.