Z. Ling

D. Pipeleers, Z. Ling, B. Keymeulen, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Cell Mass Increase Associated with Formation of Glucose‐Controlling β‐Cell Mass in Device‐Encapsulated Implants of hiPS‐Derived Pancreatic Endoderm

N. Bouché, D. Pipeleers, Z. Ling, 2019, Stem cells translational medicine.

HLA incompatibility and immunogenicity of human pancreatic islet preparations cocultured with blood cells of healthy donors.

D. Pipeleers, Z. Ling, B. Roep, 2005, Human immunology.

Composition and function of macroencapsulated human embryonic stem cell-derived implants: comparison with clinical human islet cell grafts.

E. Szepessy, D. Pipeleers, Z. Ling, 2014, American journal of physiology. Endocrinology and metabolism.

Stem Cell Marker Prominin-1/AC133 Is Expressed in Duct Cells of the Adult Human Pancreas

W. Huttner, L. Bouwens, D. Corbeil, 2008, Pancreas.

Effect of glucose on production and release of proinsulin conversion products by cultured human islets.

B. van den Bogaert, D. Pipeleers, Z. Ling, 1998, The Journal of clinical endocrinology and metabolism.

Prolonged exposure of pancreatic beta cells to raised glucose concentrations results in increased cellular content of islet amyloid polypeptide precursors

D. Pipeleers, F. Schuit, Z. Ling, 1999, Diabetologia.

Metabolic activation of glucose low-responsive beta-cells by glyceraldehyde correlates with their biosynthetic activation in lower glucose concentration range but not at high glucose.

D. Pipeleers, Z. Ling, G. Martens, 2006, Endocrinology.

An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65

D. Pipeleers, Z. Ling, F. Gorus, 2018, PloS one.

Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture

D. Pipeleers, Z. Ling, J. Hannaert, 2004, Diabetologia.

Preservation of glucose-responsive islet beta-cells during serum-free culture.

D. Pipeleers, Z. Ling, Daniel Pipeleers, 1994, Endocrinology.

Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients

C. Mathieu, D. Pipeleers, Z. Ling, 2009, Diabetes.

AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase.

D. Pipeleers, H. Heimberg, L. Hue, 2003, Journal of molecular endocrinology.

Screening for Insulitis in Adult Autoantibody-Positive Organ Donors

D. Pipeleers, Z. Ling, P. in’t Veld, 2007, Diabetes.

Role of Pancreatic -Cells in the Process of -Cell Death

L. Bouwens, D. Pipeleers, Z. Ling, 2001 .

I n t e r l e u k i n - 1 -Induced Alteration in a - C e l l Phenotype Can Reduce Cellular Sensitivity to Conditions That Cause Necrosis but Not to Cytokine-Induced Apoptosis

D. Pipeleers, Z. Ling, D. Eizirik, 2000 .

Effects of Chronically Elevated Glucose Levels on the Functional Properties of Rat Pancreatic β-Cells

D. Pipeleers, F. Schuit, Z. Ling, 1996, Diabetes.

Pancreatic beta cells in insulin-dependent diabetes.

D. Pipeleers, Z. Ling, Daniel Pipeleers, 1992, Diabetes/metabolism reviews.

Contribution of postnatally formed small beta cell aggregates to functional beta cell mass in adult rat pancreas

D. Pipeleers, Z. Ling, K. Hellemans, 2010, Diabetologia.

Expression and Functional Activity of Glucagon, Glucagon-Like Peptide I, and Glucose-Dependent Insulinotropic Peptide Receptors in Rat Pancreatic Islet Cells

D. Pipeleers, H. Heimberg, B. Thorens, 1996, Diabetes.

Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells.

D. Pipeleers, H. Heimberg, P. Huypens, 2005, Life sciences.

AMP-activated protein kinase can induce apoptosis of insulin-producing MIN 6 cells through stimulation of c-Jun-N-terminal kinase

D. Pipeleers, H. Heimberg, L. Hue, 2003 .

The Changes in Adenine Nucleotides Measured in Glucose-stimulated Rodent Islets Occur in β Cells but Not in α Cells and Are Also Observed in Human Islets*

D. Pipeleers, F. Schuit, Z. Ling, 1998, The Journal of Biological Chemistry.

β-Cell Replication Is Increased in Donor Organs From Young Patients After Prolonged Life Support

P. Haentjens, D. Pipeleers, Z. Ling, 2010, Diabetes.

Glucagon-like peptide-1 stimulates GABA formation by pancreatic beta-cells at the level of glutamate decarboxylase.

Rui Mao, D. Pipeleers, Z. Ling, 2007, American journal of physiology. Endocrinology and metabolism.

Correlation between GABA release from rat islet beta-cells and their metabolic state.

D. Pipeleers, F. Schuit, Z. Ling, 2002, American journal of physiology. Endocrinology and metabolism.

their metabolic state

D. Pipeleers, F. Schuit, Z. Ling, 2001 .

Dual Glucagon Recognition by Pancreatic β-Cells via Glucagon and Glucagon-Like Peptide 1 Receptors

D. Pipeleers, F. Schuit, Z. Ling, 1998, Diabetes.

Ectopic Expression of E2F1 Stimulates β-Cell Proliferation and Function

D. Pipeleers, H. Heimberg, U. Ziebold, 2010, Diabetes.

Inhibition of human pancreatic islet insulin release by receptor-selective somatostatin analogs directed to somatostatin receptor subtype 5.

D. Pipeleers, J. Taylor, M. Culler, 1999, Biochemical pharmacology.

Clinical Immunosuppressants Inhibit Inflammatory, Proliferative, and Reprogramming Potential, But not Angiogenesis of Human Pancreatic Duct Cells

C. Mathieu, D. Pipeleers, H. Heimberg, 2015, Cell transplantation.

Comparison of Sirolimus Alone With Sirolimus Plus Tacrolimus in Type 1 Diabetic Recipients of Cultured Islet Cell Grafts

C. Mathieu, B. Maes, D. Pipeleers, 2008, Transplantation.

Beta Cell Count Instead of Beta Cell Mass to Assess and Localize Growth in Beta Cell Population following Pancreatic Duct Ligation in Mice

D. Pipeleers, Z. Ling, G. Stangé, 2012, PloS one.

Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice

D. Drucker, D. Pipeleers, F. Schuit, 2001, Virchows Archiv.

Glibenclamide treatment recruits beta-cell subpopulation into elevated and sustained basal insulin synthetic activity.

Qidi Wang, D. Pipeleers, Z. Ling, 2006, Diabetes.

Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control

D. Pipeleers, Z. Ling, Evert J. Kroon, 2018, Stem cell reports.

Use of Culture to Reach Metabolically Adequate Beta-cell Dose by Combining Donor Islet Cell Isolates for Transplantation in Type 1 Diabetes Patients

C. Mathieu, D. Pipeleers, Z. Ling, 2020, Transplantation.

Function and composition of pancreatic islet cell implants in omentum of type 1 diabetes patients

D. Pipeleers, Z. Ling, B. Roep, 2021, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Heterogeneity of Human Pancreatic Islet Isolation Around Europe: Results of a Survey Study

F. Pattou, M. Engelse, E. D. de Koning, 2020, Transplantation.

Early Alteration of Kidney Function in Nonuremic Type 1 Diabetic Islet Transplant Recipients Under Tacrolimus-Mycophenolate Therapy

C. Mathieu, D. Pipeleers, Z. Ling, 2014, Transplantation.

Human Pancreatic Islet Preparations Release HMGB1: (Ir)Relevance for Graft Engraftment

A. Secchi, O. Korsgren, L. Piemonti, 2013, Cell transplantation.

Predictive Factors of Allosensitization After Immunosuppressant Withdrawal in Recipients of Long-Term Cultured Islet Cell Grafts

F. Claas, D. Pipeleers, Z. Ling, 2013, Transplantation.

Potential of Protein Phosphatase Inhibitor 1 As Biomarker of Pancreatic β-Cell Injury In Vitro and In Vivo

D. Pipeleers, F. Schuit, Z. Ling, 2013, Diabetes.

DB121507 2683..2688

D. Pipeleers, F. Schuit, Z. Ling, 2013 .

Adaptive im m unity in pancreatic islet transplantation

D. Pipeleers, Z. Ling, B. Roep, 2006 .

Species and epitope specificity of two 65 kDa glutamate decarboxylase time-resolved fluorometric immunoassays.

Å. Lernmark, C. Hampe, D. Pipeleers, 2007, Journal of immunological methods.

Glibenclamide activates translation in rat pancreatic beta cells through calcium-dependent mTOR, PKA and MEK signalling pathways

D. Pipeleers, H. Heimberg, Z. Ling, 2008, Diabetologia.

Nestin Is Expressed in Vascular Endothelial Cells in the Adult Human Pancreas

O. Madsen, P. Serup, T. Klein, 2003, Journal of Histochemistry and Cytochemistry.

Increase Functional β-Cell Mass in Subcutaneous Alginate Capsules With Porcine Prenatal Islet Cells but Loss With Human Adult Islet Cells

D. Pipeleers, Z. Ling, B. Keymeulen, 2018, Diabetes.

Glucose inhibits GABA release by pancreatic beta-cells through an increase in GABA shunt activity.

D. Pipeleers, Z. Ling, I. Smolders, 2006, American journal of physiology. Endocrinology and metabolism.

Different regulated expression of the tyrosine phosphatase-like proteins IA-2 and phogrin by glucose and insulin in pancreatic islets: relationship to development of insulin secretory responses in early life.

H. Steinbrenner, D. Pipeleers, S. Piquer, 2002, Diabetes.

Comparison of cellular and medium insulin and GABA content as markers for living beta-cells.

D. Pipeleers, Z. Ling, Chen Wang, 2005, American journal of physiology. Endocrinology and metabolism.

Beta-cell transplantation restores metabolic control and quality of life in a patient with subcutaneous insulin resistance.

C. Mathieu, B. Maes, D. Pipeleers, 2004, Diabetes care.

A View on Beta Cell Transplantation in Diabetes

C. Mathieu, L. Chatenoud, D. Pipeleers, 2002, Annals of the New York Academy of Sciences.

Identification of Donor Origin and Condition of Transplanted Islets in Situ in the Liver of a Type 1 Diabetic Recipient

F. Claas, Z. Ling, B. Roep, 2017, Cell transplantation.

HLA-A*24 Carrier Status and Autoantibody Surges Posttransplantation Associate With Poor Functional Outcome in Recipients of an Islet Allograft

D. Pipeleers, Z. Ling, B. Roep, 2016, Diabetes Care.

Plasma GAD65, a Marker for Early β-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients.

Å. Lernmark, Rui Mao, C. Hampe, 2015, The Journal of clinical endocrinology and metabolism.

Feasibility, Safety, and Efficacy of Percutaneous Transhepatic Injection of β-Cell Grafts

G. Marchal, C. Mathieu, D. Pipeleers, 2005 .

Feasibility, safety, and efficacy of percutaneous transhepatic injection of beta-cell grafts.

G. Marchal, C. Mathieu, D. Pipeleers, 2005, Journal of vascular and interventional radiology : JVIR.

Human islet cell implants in a nude rat model of diabetes survive better in omentum than in liver with a positive influence of beta cell number and purity

D. Pipeleers, Z. Ling, I. Vermeulen, 2010, Diabetologia.

Intercellular Differences in Interleukin 1β-Induced Suppression of Insulin Synthesis and Stimulation of Noninsulin Protein Synthesis by Rat Pancreatic β-Cells.

D. Pipeleers, F. Schuit, Z. Ling, 1998, Endocrinology.

Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of C-Jun NH2-terminal kinase signaling.

J. Haefliger, G. Waeber, D. Pipeleers, 2003, Diabetes.

Specific Expression of Bax-ω in Pancreatic β-Cells Is Down-Regulated by Cytokines before the Onset of Apoptosis.

D. Pipeleers, H. Heimberg, Z. Ling, 2002, Endocrinology.

Lower beta cell yield from donor pancreases after controlled circulatory death prevented by shortening acirculatory warm ischemia time and by using IGL-1 cold preservation solution

D. Pipeleers, Z. Ling, B. Keymeulen, 2021, PloS one.

Beta Cell Replication Is Increased In Donor Organs From Young Patients Following Prolonged Life Support.

P. Haentjens, Z. Ling, F. Gorus, 2010 .

β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas

R. Scharfmann, L. Bouwens, D. Pipeleers, 2008, Cell.

Dual glucagon recognition by pancreatic beta-cells via glucagon and glucagon-like peptide 1 receptors.

D. Pipeleers, F. Schuit, Z. Ling, 1998, Diabetes.

Use of hyperglycemic clamp to assess pancreatectomy and islet cell autotransplant in patient with heterotaxy syndrome and dorsal pancreas agenesis leading to chronic pancreatitis

D. Pipeleers, V. Vandecaveye, Z. Ling, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Reduced glutamate decarboxylase activity in rat islet β cells which survived streptozotocin‐induced cytotoxicity

D. Pipeleers, Z. Ling, W. Malaisse, 1993, FEBS letters.

Physiologic relevance of heterogeneity in the pancreatic beta-cell population

D. Pipeleers, F. Schuit, Z. Ling, 1994, Diabetologia.

Utility of Islet Cell Preparations From Donor Pancreases After Euthanasia

D. Pipeleers, Z. Ling, B. Keymeulen, 2022, Cell transplantation.

Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury.

N. Welsh, D. Pipeleers, Z. Ling, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Transplantation of Purified Islet Cells in Diabetic Rats: III. Immunosuppressive Effect of Cyclosporin

D. Pipeleers, Z. Ling, M. Pipeleers-Marichal, 1991, Diabetes.

Glucose induces oscillatory Ca2+ signalling and insulin release in human pancreatic beta cells

P. Lund, D. Pipeleers, A. Berts, 1994, Diabetologia.

The MicroRNA Landscape of Acute Beta Cell Destruction in Type 1 Diabetic Recipients of Intraportal Islet Grafts

J. Vandesompele, P. Mestdagh, D. Pipeleers, 2021, Cells.

Combined Analysis of GAD65, miR-375, and Unmethylated Insulin DNA Following Islet Transplantation in Patients With T1D

D. Pipeleers, S. Tersey, R. Mirmira, 2018, The Journal of clinical endocrinology and metabolism.

GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress.

B. Yusta, D. Drucker, Hongyun Li, 2006, Cell metabolism.

LC-MS/MS identification of doublecortin as abundant beta cell-selective protein discharged by damaged beta cells in vitro.

S. Couillard-Després, L. Aigner, D. Pipeleers, 2013, Journal of proteomics.

Plasticity of Adult Human Pancreatic Duct Cells by Neurogenin3-Mediated Reprogramming

D. Pipeleers, H. Heimberg, F. Nielsen, 2012, PloS one.

Interaction of lnterleukin-1 With Islet β-Cells: Distinction Between Indirect, Aspecific Cytotoxicity and Direct, Specific Functional Suppression

Z. Ling, P. Veld, D. Pipeleers, 1993, Diabetes.

Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR.

Qidi Wang, D. Pipeleers, H. Heimberg, 2008, Biochemical pharmacology.

Conversion of Human Pancreatic Acinar Cells Toward a Ductal-Mesenchymal Phenotype and the Role of Transforming Growth Factor &bgr; and Activin Signaling

L. Bouwens, Evelien de Waele, Z. Ling, 2014, Pancreas.

Functional characteristics of neonatal rat β cells with distinct markers.

J. Nielsen, D. Pipeleers, Z. Ling, 2013, Journal of molecular endocrinology.

Correlation between β cell mass and glycemic control in type 1 diabetic recipients of islet cell graft

C. Mathieu, D. Pipeleers, Z. Ling, 2006, Proceedings of the National Academy of Sciences.

GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress

B. Yusta, D. Drucker, Hongyun Li, 2006 .

Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient

D. Pipeleers, L. Schoonjans, Z. Ling, 2013, Diabetologia.

Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation.

D. Pipeleers, Z. Ling, 1996, The Journal of clinical investigation.

Brussel Plasticity of adult human pancreatic duct cells by neurogenin 3-mediated reprogramming

D. Pipeleers, H. Heimberg, F. Nielsen, 2012 .

SLC30A8 polymorphism and BMI complement HLA-A*24 as risk factors for poor graft function in islet allograft recipients

D. Pipeleers, Z. Ling, B. Roep, 2018, Diabetologia.

Evidence of Tissue Repair in Human Donor Pancreas After Prolonged Duration of Stay in Intensive Care

Z. Ling, P. in’t Veld, G. Stangé, 2019, Diabetes.

Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis.

D. Pipeleers, H. Heimberg, Ying Cai, 2004, Biochemical pharmacology.

Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas.

O. Madsen, P. Serup, M. Katoh, 2003, Gene expression.

Age and Early Graft Function Relate With Risk-Benefit Ratio of Allogenic Islet Transplantation Under Antithymocyte Globulin-Mycophenolate Mofetil-Tacrolimus Immune Suppression

C. Mathieu, D. Pipeleers, Z. Ling, 2017, Transplantation.

Glucocorticoids and checkpoint tyrosine kinase inhibitors stimulate rat pancreatic beta cell proliferation differentially

Z. Assefa, Z. Ling, K. Hellemans, 2019, PloS one.

Minimal Functional β-Cell Mass in Intraportal Implants That Reduces Glycemic Variability in Type 1 Diabetic Recipients

C. Mathieu, D. Pipeleers, Z. Ling, 2013, Diabetes Care.

Differential Expression of Rat Insulin I and II Messenger Ribonucleic Acid after Prolonged Exposure of Islet β-Cells to Elevated Glucose Levels.

D. Pipeleers, H. Heimberg, F. Schuit, 1998, Endocrinology.

Interaction of glibenclamide and metformin at the level of translation in pancreatic β cells.

Qidi Wang, D. Pipeleers, Ying Cai, 2011, The Journal of endocrinology.

In vitro profiling of endocrine cell death using UCHL1 and GAD65 as soluble biomarkers

G. Ateş, Z. Ling, F. Gorus, 2016, bioRxiv.

Direct effect of glucocorticoids on glucose-activated adult rat β-cells increases their cell number and their functional mass for transplantation.

D. Pipeleers, Z. Assefa, Z. Ling, 2016, American journal of physiology. Endocrinology and metabolism.

Glucose Regulates Rat Beta Cell Number through Age-Dependent Effects on Beta Cell Survival and Proliferation

D. Pipeleers, Z. Assefa, Z. Ling, 2014, PloS one.

Interleukin-1β Inhibits Proinsulin Conversion in Rat β-Cells Via a Nitric Oxide-Dependent Pathway

Z. Ling, Y. Zambre, C. Schravendijk, 2001, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.