L. Moretta

L. Marchionni, G. Rossi, G. Netto, 2018, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

PD-L1 expression comparison between primary and relapsed non-small cell lung carcinoma using whole sections and clone SP263

G. Netto, M. Hoque, G. Zamboni, 2018, Oncotarget.

PD-L1 expression heterogeneity in non-small cell lung cancer: evaluation of small biopsies reliability

G. Rossi, G. Netto, G. Zamboni, 2017, Oncotarget.

Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity

P. Queirolo, W. Vermi, F. Facchetti, 2009, Proceedings of the National Academy of Sciences.

Hypoxia downregulates the expression of activating receptors involved in NK‐cell‐mediated target cell killing without affecting ADCC

L. Moretta, M. Mingari, M. Vitale, 2013, European journal of immunology.

NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis

L. Moretta, A. Moretta, S. Sivori, 1998, The Journal of experimental medicine.

The natural killer-related receptor for HLA-C expressed on T cells from CD3+ lymphoproliferative disease of granular lymphocytes displays either inhibitory or stimulatory function.

S. Sforzini, S. Ferrini, L. Moretta, 1996, Blood.

Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases.

D. Marguet, J. Cambier, R. Biassoni, 1996, Journal of immunology.

Analysis of NK cell/DC interaction in NK-type lymphoproliferative disease of granular lymphocytes (LDGL): role of DNAM-1 and NKp30.

L. Moretta, A. Moretta, R. Zambello, 2009, Experimental hematology.

Human natural killer cells exposed to IL-2, IL-12, IL-18, or IL-4 differently modulate priming of naive T cells by monocyte-derived dendritic cells.

S. Agaugué, L. Moretta, A. Moretta, 2008, Blood.

with Dendritic Cells or Tumors Mediate Functionally Divergent Interactions IL-12 or IL-4 Prime Human NK Cells to

L. Moretta, A. Moretta, F. Bellora, 2005 .

Activation of human NK cells by plasmacytoid dendritic cells and its modulation by CD4+ T helper cells and CD4+ CD25hi T regulatory cells

Andreas Radbruch, A. Thiel, L. Moretta, 2005, European journal of immunology.

NK-dependent DC maturation is mediated by TNF (cid:1) and IFN (cid:2) released upon engagement of the NKp30 triggering receptor

L. Moretta, M. Aricò, M. Vitale, 2005 .

Engagement of CD33 surface molecules prevents the generation of dendritic cells from both monocytes and CD34+ myeloid precursors

L. Moretta, G. Melioli, G. Spaggiari, 2000, European journal of immunology.

Expression of HLA class I-specific inhibitory receptors in human cytolytic T lymphocytes: a regulated mechanism that controls T-cell activation and function.

R. Bellomo, L. Moretta, M. Mingari, 2000, Human immunology.

Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles

M. López-Botet, E. Ciccone, L. Moretta, 1994, The Journal of experimental medicine.

Inhibitory receptors for HLA class I molecules on cytolytic T lymphocytes

L. Moretta, M. Mingari, C. Vitale, 1997, International journal of clinical & laboratory research.

Regulation of the Immune System Development by Glucocorticoids and Sex Hormones

N. Tumino, L. Moretta, L. Quatrini, 2021, Frontiers in Immunology.

X-Linked Lymphoproliferative Disease

L. Notarangelo, H. Ochs, S. Giliani, 2000, The Journal of experimental medicine.

Inhibition of Human NK Cell-Mediated Killing by CD1 Molecules1

S. Porcelli, L. Moretta, E. Carbone, 2000, The Journal of Immunology.

CD8+ cytolytic T lymphocytes become infected in vitro in the process of killing HIV‐1‐infected target cells

L. Moretta, A. De Maria, S. Colombini, 1994, European journal of immunology.

Clonal and frequency analyses of tumor-infiltrating T lymphocytes from human solid tumors.

S. Miescher, L. Moretta, V. V. von Fliedner, 1987, Journal of immunology.

shuttling to early endosomes is mediated by KIR3DL2 A novel KIR-associated function: evidence that CpG DNA uptake and

E. Romeo, A. Viola, C. Soldani, 2011 .

A novel KIR-associated function: evidence that CpG DNA uptake and shuttling to early endosomes is mediated by KIR3DL2.

E. Romeo, A. Viola, C. Soldani, 2010, Blood.

A non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation

F. Malavasi, V. Pistoia, L. Moretta, 2015, Oncotarget.

Successfully treated HIV-infected patients have differential expression of NK cell receptors (NKp46 and NKp30) according to AIDS status at presentation.

L. Moretta, A. De Maria, A. di Biagio, 2013, Immunology letters.

Increased natural cytotoxicity receptor expression and relevant IL‐10 production in NK cells from chronically infected viremic HCV patients

L. Moretta, A. De Maria, M. Mingari, 2007, European journal of immunology.

Targeting of T lymphocytes against egf‐receptor+ tumor cells by bispecific monoclonal antibodies: Requirement of CD3 molecule cross‐linking for t‐cell activation

S. Canevari, S. Sforzini, S. Ferrini, 1993, International journal of cancer.

KIR3DS1-Mediated Recognition of HLA-*B51: Modulation of KIR3DS1 Responsiveness by Self HLA-B Allotypes and Effect on NK Cell Licensing

L. Moretta, A. Moretta, S. Sivori, 2017, Front. Immunol..

Human natural killer cells in pregnancy

L. Moretta, M. Mingari, P. Vacca, 2012 .

Transplantation Induces Profound Changes in the Transcriptional Asset of Hematopoietic Stem Cells: Identification of Specific Signatures Using Machine Learning Techniques

A. Verri, A. Barla, N. Montserrat, 2020, Journal of clinical medicine.

Natural killer cell acceptance of H-2 mismatch bone marrow grafts in transgenic mice expressing HLA-Cw3 specific killer cell inhibitory receptor (CD158b)

R. Biassoni, P. Ferrier, L. Moretta, 1997 .

Recognition of virus-infected cells by natural killer cell clones is controlled by polymorphic target cell elements

Eric O Long, E. Ciccone, L. Moretta, 1993, The Journal of experimental medicine.

Evidence of a natural killer (NK) cell repertoire for (allo) antigen recognition: definition of five distinct NK-determined allospecificities in humans

J. Guardiola, E. Ciccone, L. Moretta, 1992, The Journal of experimental medicine.

Human CD3−CD16+ natural killer cells express the hGATA‐3 T cell transcription factor and an unrearranged 2.3‐kb TcR δ transcript

P. Romeo, R. Biassoni, S. Ferrini, 1993, European journal of immunology.

Distribution of T cells bearing different forms of the T cell receptor gamma/delta in normal and pathological human tissues.

S. Pileri, B. Falini, P. Pelicci, 1989, Journal of immunology.

Identification and molecular characterization of a natural mutant of the p50.2/KIR2DS2 activating NK receptor that fails to mediate NK cell triggering

R. Biassoni, L. Moretta, A. Moretta, 2000, European journal of immunology.

Coexpression of two functionally independent p58 inhibitory receptors in human natural killer cell clones results in the inability to kill all normal allogeneic target cells.

L. Moretta, A. Moretta, S. Sivori, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Mobilization of healthy donors with plerixafor affects the cellular composition of T-cell receptor (TCR)-αβ/CD19-depleted haploidentical stem cell grafts

S. Rutella, F. Locatelli, L. Moretta, 2014, Journal of Translational Medicine.

Analysis of the role of interferon‐gamma, interleukin 2 and a third factor distinct from interferon‐gamma and interleukin 2 on human B cell proliferation. Evidence that they act at different times after B cell activation

C. Liang, L. Moretta, S. Romagnani, 1986, European journal of immunology.

Clonal Analysis of Human T Lymphocytes Inducing B Cell Growth

L. Moretta, M. Mingari, 1986 .

MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2.

L. Moretta, G. Spaggiari, H. Abdelrazik, 2009, Blood.

Lorenzo Moretta 2 of MSC-derived prostaglandin E selectively interfering with the generation of immature DCs : central role MSCs inhibit monocyte-derived DC maturation and function

L. Moretta, G. Spaggiari, H. Abdelrazik, 2009 .

Human Congenital Infection With Trypanosoma cruzi Induces Phenotypic and Functional Modifications of Cord Blood NK Cells

L. Moretta, Y. Carlier, C. Truyens, 2006, Pediatric Research.

Expression of the DNAM-1 ligands Nectin-2 (CD112) and Poliovirus receptor (CD155) on dendritic cells: relevance for Natural Killer/dendritic cells interaction. Running title: Nectin-2 and PVR expression on DC

Alessandro, L. Moretta, P. Romagnani, 2005 .

NK cells: a lesson from mismatched hematopoietic transplantation.

Alessandro, L. Ruggeri, A. Velardi, 2002, Trends in immunology.

The leukocyte Ig-like receptor (LIR)-1 for the cytomegalovirus UL18 protein displays a broad specificity for different HLA class I alleles: analysis of LIR-1 + NK cell clones.

L. Moretta, D. Cosman, A. Moretta, 1999, International immunology.

Interleukin-2 mediated restoration of natural killer cell function in a patient with Griscelli syndrome

A. Plebani, L. Moretta, M. Mingari, 2000, European Journal of Pediatrics.

Phenotypic and functional analysis of CD4+ NKRP1A+ human T lymphocytes. Direct evidence that the NKRP1A molecule is involved in transendothelial migration

L. Moretta, A. Poggi, M. Zocchi, 1997, European journal of immunology.

Phenotypic and functional analysis of CD4+ NKRP1A+ human T lymphocytes. Direct evidence that the NKRP1A molecule is involved in transendothelial migration.

L. Moretta, A. Poggi, M. Zocchi, 1997, European journal of immunology.

Structural basis for a major histocompatibility complex class Ib–restricted T cell response

L. K. Ely, T. Beddoe, J. McCluskey, 2006, Nature Immunology.

Interferon-γ-dependent inhibition of B cell activation by bone marrow-derived mesenchymal stem cells in a murine model of systemic lupus erythematosus.

A. Martini, A. Uccelli, Simona Casazza, 2010, Arthritis and rheumatism.

Pediatric Tumors-Mediated Inhibitory Effect on NK Cells: The Case of Neuroblastoma and Wilms’ Tumors

I. Caruana, E. Munari, L. Moretta, 2021, Cancers.

ReviewThe immune checkpoint PD-1 in Natural Killer cells: expression

N. Tumino, E. Munari, L. Moretta, 2020 .

Surface receptors delivering opposite signals regulate the function of human NK cells.

R. Biassoni, L. Moretta, A. Moretta, 2000, Seminars in immunology.

The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer

R. Biassoni, L. Moretta, A. Moretta, 1996, The Journal of experimental medicine.

Phenotypic and functional analysis of human CD3 + and CD3− clones with “lymphokine‐activated killer” (LAK) activity. Frequent occurrence of CD3 + LAK clones which produce interleukin‐2

S. Ferrini, L. Moretta, A. Moretta, 1987, International journal of cancer.

Inhibitory receptors sensing HLA-G1 molecules in pregnancy: decidua-associated natural killer cells express LIR-1 and CD94/NKG2A and acquire p49, an HLA-G1-specific receptor.

R. Biassoni, L. Moretta, A. Moretta, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Specificity of human T lymphocytes expressing a gamma/delta T cell antigen receptor. Recognition of a polymorphic determinant of HLA class I molecules by a gamma/delta+ clone.

G. Ferrara, E. Ciccone, L. Moretta, 1989, Current topics in microbiology and immunology.

Erratum: The natural killer cell-mediated killing of autologous dendritic cells in confined to a cell subset expressing CD94/NKG2A, but lacking inhibitory killer Ig-like receptors (European Journal of Immunology (2003) vol. 33 (6) (1657-1666))

L. Moretta, A. Moretta, M. Vitale, 2003 .

CD45‐mediated regulation of LFA1 function in human natural killer cells. Anti‐CD45 monoclonal antibodies inhibit the calcium mobilization induced via LFA1 molecules

R. Pardi, L. Moretta, A. Poggi, 1993, European journal of immunology.

Alloantigen recognition by two human natural killer cell clones is associated with HLA-C or a closely linked gene.

J. Strominger, M. Colonna, E. Ciccone, 1992, Proceedings of the National Academy of Sciences of the United States of America.

HLA‐G recognition by human natural killer cells. Involvement of CD94 both as inhibitory and as activating receptor complex

D. Geraghty, P. Le Bouteiller, L. Moretta, 1997, European journal of immunology.

Specific recognition of human CD3-CD16+ natural killer cells requires the expression of an autosomic recessive gene on target cells

J. Guardiola, E. Ciccone, R. Biassoni, 1990, The Journal of experimental medicine.

Analysis of the expression of the 4F2 surface antigen in normal and neoplastic fibroblastic human cells of embryonic and adult origin.

A. Fauci, L. Moretta, Y. Malpièce, 1985, Experimental cell research.

4F2 monoclonal antibody recognizes a surface antigen on spread human fibroblasts of embryonic but not of adult origin

A. Fauci, L. Moretta, M. Mingari, 1984, The Journal of cell biology.

Selection and characterization of T-cell variants lacking molecules involved in T-cell activation (T3 T-cell receptor, T44, and T11): analysis of the functional relationship among different pathways of activation.

D. Olive, G. Pantaleo, L. Moretta, 1987, Proceedings of the National Academy of Sciences of the United States of America.

The analysis of the natural killer-like activity of human cytolytic T lymphocytes revealed HLA-E as a novel target for TCR alpha/beta-mediated recognition.

S. Anfossi, R. Biassoni, L. Moretta, 2001, European journal of immunology.

Tγδ Cells and their Subsets in Blood and Synovial Tissue from Rheumatoid Arthritis Patients

P. Lydyard, E. Ciccone, C. Grossi, 1990 .

The C gamma 1-encoded disulphide-linked and the C gamma 2-encoded nondisulphide-linked forms of the gamma/delta heterodimer use different gamma and delta variable regions [see comments]

B. Falini, P. Pelicci, M. Fagioli, 1990 .

Analysis of signal transducing mechanisms in CD3+ CD4- CD8- cells expressing the putative T cell receptor gamma gene product.

G. Pantaleo, R. Biassoni, L. Moretta, 1987, Journal of immunology.

Characterization of CD3+, CD4-, CD8- clones expressing the putative T cell receptor gamma gene product. Analysis of the activation pathways leading to interleukin 2 production and triggering of the lytic machinery

R. Sékaly, R. Biassoni, S. Ferrini, 1987, The Journal of experimental medicine.

Human CD3+4−8−WT31−T lymphocyte expressing the putative T cell receptor γ‐gene product. A limiting dilution and clonal analysis

E. Ciccone, S. Ferrini, L. Moretta, 1987 .

The molecular basis of Natural Killer (NK) cell recognition and function

R. Biassoni, L. Moretta, A. Moretta, 1996, Journal of Clinical Immunology.

P49, a putative HLA-G1 specific inhibitory NK receptor belonging to the immunoglobulin Superfamily.

R. Biassoni, L. Moretta, A. Moretta, 1999, Journal of reproductive immunology.

Stimulatory receptors in NK and T cells.

L. Moretta, A. Moretta, S. Sivori, 1998, Current topics in microbiology and immunology.

KIR2DS1-dependent acquisition of CCR7 and migratory properties by human NK cells interacting with allogeneic HLA-C2+ DCs or T-cell blasts.

L. Moretta, A. Moretta, S. Sivori, 2013, Blood.

IFN‐α‐mediated increase in cytolytic activity of maturing NK cell upon exposure to HSV‐infected myelomonocytes

L. Moretta, A. De Maria, A. Moretta, 2009, European journal of immunology.

A monoclonal antibody specific for a common determinant of the human T cell receptor gamma/delta directly activates CD3+WT31- lymphocytes to express their functional program(s)

G. Pantaleo, E. Ciccone, S. Ferrini, 1988, The Journal of experimental medicine.

MSC and innate immune cell interactions: A lesson from human decidua.

L. Moretta, M. Mingari, P. Vacca, 2015, Immunology letters.

Group 2 Innate Lymphoid Cells: A Double-Edged Sword in Cancer?

L. Cosmi, F. Annunziato, L. Moretta, 2020, Cancers.

Development in vitro of human CD4+ thymocytes into functionally mature Th2 cells. Exogenous interleukin‐12 is required for priming thymocytes to produce both Th1 cytokines and interleukin‐10

F. Annunziato, R. Manetti, L. Moretta, 1996, European journal of immunology.

Separation, phenotyping and limiting dilution analysis of T‐lymphocytes infiltrating human solid tumors

S. Miescher, T. Whiteside, L. Moretta, 1986, International journal of cancer.

Control of self‐reactive cytotoxic T lymphocytes expressing γδ T cell receptors by natural killer inhibitory receptors

M. Bonneville, H. Vié, M. López-Botet, 1997 .

Isolation and in vitro expansion of lymphocytes infiltrating non-small cell lung carcinoma: functional and molecular characterisation for their use in adoptive immunotherapy.

R. Biassoni, L. Moretta, G. Melioli, 1994, European journal of cancer.

Engagement of the leukocyte‐associated Ig‐like receptor‐1 induces programmed cell death and prevents NF‐κB nuclear translocation in human myeloid leukemias

L. Moretta, A. Poggi, M. Zocchi, 2000, European journal of immunology.

Immune suppression of hematopoiesis in aplastic anemia: activity of T-gamma lymphocytes.

L. Moretta, A. Bacigalupo, M. Mingari, 1980, Journal of immunology.

Phenotypic and functional heterogeneity of human peripheral blood T lymphocytes producing colony stimulating factor. A clonal and precursor frequency analysis.

G. Pantaleo, L. Moretta, A. Moretta, 1985, Journal of immunology.

CLONAL ANALYSIS OF T LYMPHOCYTES ISOLATED FROM OVARIAN CARCINOMA ASCITIC FLUID. PHENOTYPIC AND FUNCTIONAL CHARACTERIZATION OF T‐CELL CLONES CAPABLE OF LYSING AUTOLOGOUS CARCINOMA CELLS

A. Nicolin, R. Biassoni, S. Ferrini, 1985, International journal of cancer.

Frequent coexpression of cytolytic activity and lymphokine production among human T lymphocytes. Production of B cell growth factor and interleukin 2 by T8+ and T4+ cytolytic clones

G. Pantaleo, L. Moretta, A. Moretta, 1984, European journal of immunology.

Quantitative assessment of the pool size and subset distribution of cytolytic T lymphocytes within human resting or alloactivated peripheral blood T cell populations

G. Pantaleo, L. Moretta, A. Moretta, 1983, The Journal of experimental medicine.

CD56brightPerforinlow Noncytotoxic Human NK Cells Are Abundant in Both Healthy and Neoplastic Solid Tissues and Recirculate to Secondary Lymphoid Organs via Afferent Lymph

P. Paul, L. Moretta, M. Mingari, 2014, The Journal of Immunology.

Active thymus derived suppressor lymphocytes in human cord blood

M. Oldstone, L. Moretta, A. Tishon, 1977, Nature.

What we know and still ignore on COVID‐19 immune pathogenesis and a proposal based on the experience of allergic disorders

L. Moretta, E. Maggi, W. Canonica, 2021, Allergy.

‘Emergency exit' of bone-marrow-resident CD34+DNAM-1brightCXCR4+-committed lymphoid precursors during chronic infection and inflammation

F. Marincola, E. Wang, S. Boni, 2015, Nature Communications.

Surface antigens specifically expressed by activated T cells in humans

L. Moretta, M. Mingari, G. Corte, 1981, European journal of immunology.

Brief Definitive Report

E. Ciccone, L. Moretta, A. Moretta, 2022 .

Human Natural Killer ( NK ) Alloreactivity and Its Association with the Major Histocompatibility Complex : Ancestral Haplotypes Encode Particular NK-defmed Haplotypes

C. Witt, E. Ciccone, L. Moretta, 2003 .

P373 - The natural killer cell receptor specific for HLA-A allotypes: A novel member of the p58/p70 family of inhibitory receptors which is characterized by three Ig-like domains and is expressed as a 140 kD disulphide-linked dimer

R. Biassoni, L. Moretta, A. Moretta, 1996 .

The human natural killer cell receptor for major histocompatibility complex class I molecules. Surface modulation of p58 molecules and their linkage to CD3 ζ chain, FcϵRI γ chain and the p56lck kinase

E. Ciccone, L. Moretta, A. Moretta, 1994 .

Human natural killer (NK) alloreactivity and its association with the major histocompatibility complex: ancestral haplotypes encode particular NK-defined haplotypes

C. Witt, E. Ciccone, L. Moretta, 1993, The Journal of experimental medicine.

Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry

L. Luzzatto, V. Cetica, F. Locatelli, 2016, The Journal of allergy and clinical immunology.

Clonal analysis of joint fluid T lymphocytes in patients with juvenile rheumatoid arthritis.

L. Moretta, A. Poggi, A. De Maria, 1990, The Journal of rheumatology.

T.6. Mesenchymal Stem Cells Inhibit Natural Killer Cell Proliferation, Cytotoxicity and Cytokine Production: Role of Indoleamine 2,3-Dioxygenase and Prostaglandin E2

L. Moretta, M. Mingari, G. Spaggiari, 2009 .

TRANSPLANTATION Outcome of children with acute leukemia given HLA-haploidentical HSCT after ab T-cell and B-cell depletion

R. Masetti, F. Locatelli, R. Handgretinger, 2017 .

NK cell‐mediated lysis of autologous antigen‐presenting cells is triggered by the engagement of the phosphatidylinositol 3‐kinase upon ligation of the natural cytotoxicity receptors NKp30 and NKp46

L. Moretta, A. Poggi, M. Zocchi, 2001, European journal of immunology.

Dissection of lymphocyte function‐associated antigen 1‐dependent adhesion and signal transduction in human natural killer cells shown by the use of cholera or pertussis toxin

L. Moretta, A. Poggi, M. Zocchi, 1996, European journal of immunology.

Natural Killer‐like Cytotoxicity of Human T‐Cell Clones against Various Target Cells

M. López-Botet, L. Moretta, A. Moretta, 1983, Scandinavian journal of immunology.

CD31‐triggered rearrangement of the actin cytoskeleton in human natural killer cells

L. Moretta, A. Poggi, M. Zocchi, 1996, European journal of immunology.

Surface markers of resting and activated human T cells. Functional implications and experimental limits

G. Pantaleo, L. Moretta, A. Moretta, 2005, Springer Seminars in Immunopathology.

Characterization of human T-cell subpopulations as defined by specific receptors for immunoglobulins.

M. Ferrarini, M. Cooper, L. Moretta, 1978, Contemporary topics in immunobiology.

Surface markers of human T lymphocytes

L. Moretta, M. Mingari, 1982, La Ricerca in clinica e in laboratorio.

Receptors for Immunoglobulins on Resting and Activated Human T Cells

G. Canonica, L. Moretta, A. Bacigalupo, 1981, Immunological reviews.

Neuroblastoma-Derived TGF-β1 Modulates the Chemokine Receptor Repertoire of Human Resting NK Cells

F. Locatelli, L. Moretta, A. Moretta, 2013, The Journal of Immunology.

Group 3 innate lymphoid cells regulate neutrophil migration and function in human decidua

E. Fulcheri, E. Munari, A. Zamó, 2016, Mucosal Immunology.

Adult onset and atypical presentation of hemophagocytic lymphohistiocytosis in siblings carrying PRF1 mutations.

R. Clementi, L. Moretta, F. Liotta, 2002, Blood.

CD3+4−8−WT31− (T cell receptor γ+) cells and other unusual phenotypes are frequently detected among spontaneously interleukin 2‐responsive T lymphocytes present in the joint fluid in juvenile rheumatoid arthritis. A clonal analysis

L. Moretta, A. De Maria, A. Moretta, 1987 .

Familial hemophagocytic lymphohistiocytosis: a model for understanding the human machinery of cellular cytotoxicity

V. Cetica, L. Moretta, M. Aricò, 2011, Cellular and Molecular Life Sciences.

Melanoma immunoediting by NK cells

W. Vermi, L. Moretta, M. Mingari, 2012, Oncoimmunology.

How melanoma cells inactivate NK cells

L. Moretta, M. Mingari, M. Vitale, 2012, Oncoimmunology.

Sub-lingual administration of a polyvalent mechanical bacterial lysate (PMBL) in patients with moderate, severe, or very severe chronic obstructive pulmonary disease (COPD) according to the GOLD spirometric classification: A multicentre, double-blind, randomised, controlled, phase IV study (AIACE st

M. Cazzola, G. Canonica, L. Fabbri, 2015, Pulmonary pharmacology & therapeutics.

Imbalances of T cell subpopulations in patients with atopic diseases and effect of specific immunotherapy.

G. Canonica, L. Moretta, M. Colombatti, 1979, Journal of immunology.

Human T Cell Subpopulations in Normal and Pathologic Conditions

L. Moretta, A. Moretta, M. Mingari, 1979 .

Control of B cell lymphoma recognition via natural killer inhibitory receptors implies a role for human Vγ9/Vδ2 T cells in tumor immunity

H. Rammensee, G. Klein, P. Coulie, 1997, European journal of immunology.

HLA-G is a component of the chronic lymphocytic leukemia escape repertoire to generate immune suppression: impact of the HLA-G 14 base pair (rs66554220) polymorphism

D. Rossi, G. Gaidano, S. Deaglio, 2014, Haematologica.

Mesenchymal Stromal Cells Induce Peculiar Alternatively Activated Macrophages Capable of Dampening Both Innate and Adaptive Immune Responses

C. Romei, L. Moretta, C. Bottino, 2016, Stem cells.

Clonal analysis of CD4 CD8‐ human thymocytes expressing a T cell receptor γ/δ chain. Direct evidence for the de novo expression of CD8 surface antigen and of cytolytic activity against tumor targets*

L. Moretta, A. Moretta, M. Mingari, 1988, European journal of immunology.

Human T cells expressing the y/6 T-cell receptor (TcR-1): Ci,-and CY2-encoded forms of the receptor correlate with distinctive morphology, cytoskeletal organization, and growth characteristics

E. Ciccone, S. Ferrini, C. Grossi, 2022 .

Receptors for immunoglobulins and activation markers on human T lymphocytes.

L. Moretta, A. Moretta, M. Mingari, 1982, Clinics in haematology.

Targeting of T or NK lymphocytes against tumor cells by bispecific monoclonal antibodies: role of different triggering molecules.

S. Canevari, S. Ferrini, L. Moretta, 1992, International journal of cancer. Supplement = Journal international du cancer. Supplement.

Clonal analysis and in situ characterization of lymphocytes infiltrating human breast carcinomas

S. Miescher, T. Whiteside, L. Moretta, 2004, Cancer Immunology, Immunotherapy.

Immunotherapy and immunity to cancer: cellular mechanisms.

S. Ferrini, L. Moretta, G. Melioli, 1989, Current opinion in immunology.

NK-cell Editing Mediates Epithelial-to-Mesenchymal Transition via Phenotypic and Proteomic Changes in Melanoma Cell Lines.

Enrique J. deAndrés-Galiana, J. Fernández-Martínez, E. Munari, 2018, Cancer research.

Tp44 molecules involved in antigen-independent T cell activation are expressed on human plasma cells.

L. Moretta, D. Kozbor, A. Moretta, 1987, Journal of immunology.

Molecular heterogeneity of the 1.0‐kb Tβ transcript in natural killer and γ/δ lymphocytes

A. Carè, C. Peschle, P. Pelicci, 1991 .

Characterization of KIR + NK cell subsets with a monoclonal antibody selectively recognizing KIR2DL1 and blocking the specific interaction with HLA‐C

A. Muntasell, M. López-Botet, L. Moretta, 2022, HLA.

Epitope characterization of a monoclonal antibody that selectively recognizes KIR2DL1 allotypes

A. Muntasell, M. López-Botet, L. Moretta, 2022, HLA.

Phenotypic and Functional Characterization of NK Cells in αβT-Cell and B-Cell Depleted Haplo-HSCT to Cure Pediatric Patients with Acute Leukemia

A. Pession, F. Locatelli, L. Moretta, 2020, Cancers.

Activating KIRs and NKG2C in Viral Infections: Toward NK Cell Memory?

L. Moretta, A. Moretta, S. Sivori, 2015, Front. Immunol..

blasts human NK cells interacting with allogeneic HLA-C2+ DCs or T-cell KIR2DS1-dependent acquisition of CCR7 and migratory properties by

L. Moretta, A. Moretta, S. Sivori, 2013 .

Helper Innate Lymphoid Cells in Human Tumors: A Double-Edged Sword?

N. Tumino, E. Munari, L. Moretta, 2020, Frontiers in Immunology.

LymphSecondary Lymphoid Organs via Afferent Neoplastic Solid Tissues and Recirculate to NK Cells Are Abundant in Both Healthy and Noncytotoxic Human low Perforin bright CD56

P. Paul, L. Moretta, M. Mingari, 2014 .

NK-type lymphoproliferative disease of granular lymphocytes Phenotypic diversity of natural killer (NK) populations in patients with

E. Ciccone, L. Moretta, A. Moretta, 2011 .

Ontogeny, specific functions and receptors of human natural killer cells.

E. Ciccone, L. Moretta, A. Poggi, 1994, Immunology letters.

Phenotypic diversity of natural killer (NK) populations in patients with NK-type lymphoproliferative disease of granular lymphocytes.

E. Ciccone, L. Moretta, A. Moretta, 1993, Blood.

Existence of a natural killer (NK) cell repertoire for (allo)antigen recognition: definition of five distinct NK-determined allospecificities in humans.

J. Guardiola, E. Ciccone, L. Moretta, 1992, Pharmacological research.

CD 16 surface molecules regulate the cytolytic function of CD3−CD16+ human natural killer cells

E. Ciccone, L. Moretta, A. Moretta, 1989 .

CD16 surface molecules regulate the cytolytic function of CD3CD16+ human natural killer cells.

E. Ciccone, L. Moretta, A. Moretta, 1989, International journal of cancer.

Two subsets of human T lymphocytes expressing gamma/delta antigen receptor are identifiable by monoclonal antibodies directed to two distinct molecular forms of the receptor

E. Ciccone, S. Ferrini, L. Moretta, 1988, The Journal of experimental medicine.

Direct demonstration of the clonogenic potential of every human peripheral blood T cell. Clonal analysis of HLA-DR expression and cytolytic activity

G. Pantaleo, L. Moretta, A. Moretta, 1983, The Journal of experimental medicine.

General role of HLA class I molecules in the protection of target cells from lysis by natural killer cells: evidence that the free heavy chains of class I molecules are not sufficient to mediate the protective effect.

E. Ciccone, L. Moretta, A. Moretta, 1995, International immunology.

Surface receptors and functional interactions of human natural killer cells: from bench to the clinic

L. Moretta, A. Moretta, M. Mingari, 2003, Cellular and Molecular Life Sciences CMLS.

Alessandro, Silvano, R. Sékaly, 1987, The Journal of experimental medicine.

Specificity of human T lymphocytes expressing a γ/δ T cell antigen receptor. Recognition of a polymorphic determinant of HLA class I molecules by a γ/δ clone

G. Ferrara, E. Ciccone, L. Moretta, 1989, European journal of immunology.

Monoclonal antibodies which react with the T cell receptor γ/δ recognize different subsets of CD3WT31‐ T lymphocytes

E. Ciccone, S. Ferrini, L. Moretta, 1989 .

Brief Definitive Report ANTIBODY-INDUCED MODULATION OF THE CD3/T CELL RECEPTOR COMPLEX CAUSES T CELL REFRACTORINESS BY INHIBITING THE EARLY METABOLIC STEPS INVOLVED IN T CELL ACTIVATION

T. Pozzan, G. Pantaleo, L. Moretta, 1987 .

Modulation of surface T11 molecules induced by monoclonal antibodies: analysis of the functional relationship between antigen‐dependent and antigen‐independent pathways of human T cell activation

D. Olive, G. Pantaleo, L. Moretta, 1986, European journal of immunology.

Anticlonotypic monoclonal antibodies induce proliferation of clonotype- positive T cells in peripheral blood human T lymphocytes. Evidence for a phenotypic (T4/T8) heterogeneity of the clonotype-positive proliferating cells

G. Pantaleo, M. López-Botet, L. Moretta, 1985, The Journal of experimental medicine.

Involvement of T44 molecules in an antigen-independent pathway of T cell activation. Analysis of the correlations to the T cell antigen- receptor complex

G. Pantaleo, M. López-Botet, L. Moretta, 1985, The Journal of experimental medicine.

Selection and characterization of monoclonal antibodies to the idiotype‐like structure of an interleukin‐2‐producing human leukemia t‐cell line

G. Pantaleo, M. López-Botet, L. Moretta, 1985, International journal of cancer.

Involvement of T11 molecules in antigen receptormediated T lymphocyte functions: effect of anti‐T11 monoclonal antibody on functional capabilities of alloreactive T cell clones

G. Pantaleo, M. López-Botet, L. Moretta, 1985, European journal of immunology.

Involvement of T3 and T8 molecules in human T cell receptor function. Anti‐T3 or anti‐T8 antibodies do not block the antigen‐dependent activation of a subset of alloreactive cytolytic T cell precursors

G. Pantaleo, L. Moretta, A. Moretta, 1985, European journal of immunology.

Clonal heterogeneity in the requirement for T3, T4, and T8 molecules in human cytolytic T lymphocyte function

G. Pantaleo, L. Moretta, A. Moretta, 1984, The Journal of experimental medicine.

Proliferation of T8-positive cytolytic T lymphocytes in response to thyroglobulin in human autoimmune thyroiditis: analysis of cell interactions and culture requirements.

G. Canonica, L. Moretta, G. Giordano, 1985, Clinical immunology and immunopathology.

Analysis of KIR3DP1 Polymorphism Provides Relevant Information on Centromeric KIR Gene Content

F. Locatelli, L. Moretta, A. Moretta, 2018, The Journal of Immunology.

Hematopoietic stem cell transplantation: Improving alloreactive Bw4 donor selection by genotyping codon 86 of KIR3DL1/S1

P. Parham, F. Locatelli, P. Norman, 2016, European journal of immunology.

Hematopoietic stem cell transplantation : Improving alloreactive Bw 4 donor selection by genotyping codon 86 of KIR 3 DL 1 / S 1

P. Parham, F. Locatelli, P. Norman, 2016 .

Imbalance of T-cell subpopulations and defective pokeweed mitogen-induced B-cell differentiation after bone marrow transplantation in man.

L. Moretta, A. Bacigalupo, M. Mingari, 1981, Clinical immunology and immunopathology.

Haploidentical hemopoietic stem cell transplantation for the treatment of high-risk leukemias: how NK cells make the difference.

F. Locatelli, L. Moretta, R. Maccario, 2009, Clinical immunology.

Gntb-A, a Novel Sh2d1a-Associated Surface Molecule Contributing to the Inability of Natural Killer Cells to Kill Epstein-Barr Virus–Infected B Cells in X-Linked Lymphoproliferative Disease

L. Notarangelo, R. Biassoni, L. Moretta, 2001, The Journal of Experimental Medicine.

Immunobiology of human NK cells.

R. Biassoni, L. Moretta, A. Moretta, 2001, Transplantation proceedings.

Expression of human NKRP1A by CD34+ immature thymocytes: NKRP1A‐mediated regulation of proliferation and cytolytic activity

R. Biassoni, L. Moretta, A. Poggi, 1996, European journal of immunology.

Physical and functional independency of p70 and p58 natural killer (NK) cell receptors for HLA class I: their role in the definition of different groups of alloreactive NK cell clones.

A. Amoroso, L. Moretta, A. Moretta, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Fc-receptor heterogeneity of human suppressor T cells.

P. Lydyard, L. Moretta, A. Hayward, 1978, Journal of immunology.

Human T lymphocytes subpopulation as defined by alloantigens and FC receptors a comparative analysis.

G. Ferrara, L. Moretta, M. Colombatti, 1981, Human immunology.

Clonal analysis of T lymphocytes in spleens from patients with Hodgkin's disease. Frequent occurrence of unusual T4‐positive cells which co‐express cytolytic activity and production of interleukin‐2

L. Moretta, E. Maggi, S. Romagnani, 1986, International journal of cancer.

Suppressor Activity of T Cells Bearing Fc Receptors for IgG on Lymphoid Colony Formation

G. Canonica, G. Canonica, V. Pistoia, 1980, Scandinavian journal of immunology.

Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison

E. Reinherz, M. Cooper, L. Moretta, 1980, The Journal of experimental medicine.

Strategies to optimize the outcome of children given T-cell depleted HLA-haploidentical hematopoietic stem cell transplantation.

S. Rutella, A. Mastronuzzi, F. Locatelli, 2011, Best practice & research. Clinical haematology.

Natural Killer Cells in Healthy and Diseased Subjects

J. Coligan, R. Biassoni, L. Moretta, 2011, Journal of biomedicine & biotechnology.

Transplantation and innate immunity: the lesson of natural killer cells

F. Locatelli, L. Moretta, A. Bertaina, 2009, Italian journal of pediatrics.

can impair processing to the active form of perforin A single amino acid change, A91V, leads to conformational changes that

L. Notarangelo, L. Moretta, M. Aricò, 2013 .

On the pathogenesis of perforin defects and related immunodeficiencies.

R. Zinkernagel, H. Hengartner, L. Moretta, 2000, Immunology today.

Understanding human NK cell differentiation: clues for improving the haploidentical hematopoietic stem cell transplantation.

L. Moretta, M. Mingari, P. Vacca, 2013, Immunology letters.

Both CD133+ and CD133– medulloblastoma cell lines express ligands for triggering NK receptors and are susceptible to NK‐mediated cytotoxicity

A. Raso, L. Moretta, A. Moretta, 2007, European journal of immunology.

Membrane-bound and soluble IL-15/IL-15Ralpha complexes display differential signaling and functions on human hematopoietic progenitors.

S. Chouaib, R. Biassoni, S. Ferrini, 2005, Blood.

A pathogenic integrated view explaining the different endotypes of asthma and allergic disorders

L. Moretta, E. Maggi, B. Azzarone, 2022, Allergy.

Pseudorabies Virus US3 Protein Kinase Protects Infected Cells from NK Cell-Mediated Lysis via Increased Binding of the Inhibitory NK Cell Receptor CD300a

H. Favoreel, K. Laval, L. Moretta, 2015, Journal of Virology.

The Inhibitory Receptor IRp60 (CD300a) Is Expressed and Functional on Human Mast Cells1

I. Bachelet, F. Levi-Schaffer, L. Moretta, 2005, The Journal of Immunology.

Interleukin-2-Induced proliferation of CD4-CD8- human thymocytes.In vitro expression of CD3 and CD8 antigens and cytolytic activity

L. Moretta, M. Mingari, C. Bottino, 1988, La Ricerca in clinica e in laboratorio.

This information is current as Cells Expressed and Functional on Human Mast The Inhibitory Receptor IRp 60 ( CD 300 a ) Is Moretta and

I. Bachelet, F. Levi-Schaffer, L. Moretta, 2005 .

Antigen recognition by human T cell receptor gamma-positive lymphocytes. Specific lysis of allogeneic cells after activation in mixed lymphocyte culture

E. Ciccone, L. Moretta, A. Moretta, 1988, The Journal of experimental medicine.

Imbalances in T cell subpopulations in multiple sclerosis patients.

D. Gilden, D. Santoli, H. Koprowski, 1978, Journal of immunology.

Frequent T4-positive cells with cytolytic activity in spleens of patients with Hodgkin's disease (a clonal analysis).

A. Bosi, L. Moretta, E. Maggi, 1986, Journal of immunology.

A novel 120-kD surface antigen expressed by a subset of human lymphocytes. Evidence that lymphokine-activated killer cells express this molecule and use it in their effector function

L. Moretta, M. Zocchi, A. Moretta, 1987, The Journal of experimental medicine.

p49, a putative HLA class I‐specific inhibitory NK receptor belonging to the immunoglobulin superfamily

Michele Cilli, M. Cilli, R. Biassoni, 1998, European journal of immunology.

Stromal-like Wilms tumor cells induce human Natural Killer cell degranulation and display immunomodulatory properties towards NK cells

G. Ghiggeri, L. Moretta, G. Candiano, 2021, Oncoimmunology.

NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor.

L. Moretta, M. Aricò, A. Moretta, 2005, Blood.

Immunotherapy targeting inhibitory checkpoints: The role of NK and other innate lymphoid cells.

E. Munari, L. Moretta, L. Quatrini, 2022, Seminars in immunology.

NKRP1A molecule is involved in transendothelial migration of CD4+ human T lymphocytes.

L. Moretta, A. Poggi, M. Zocchi, 1997, Immunology letters.

In vitro expansion of CD3/TCR- human thymocyte populations that selectively lack CD3 delta gene expression: a phenotypic and functional analysis

R. Biassoni, R. Bellomo, L. Moretta, 1990, The Journal of experimental medicine.

Expression of a receptor for IgM by human T cells in vitro

M. Ferrarini, L. Moretta, M. Mingari, 1975, European journal of immunology.

Expression, crystallization and preliminary crystallographic analysis of the extracellular IgV-like domain of the human natural killer cell inhibitory receptor p75/AIRM1.

R. Mariuzza, R. Biassoni, L. Moretta, 2003, Acta crystallographica. Section D, Biological crystallography.

Physical and functional association of CD45 and CD3-TCR complex on CD1+ human thymocytes. Evidence that the engagement of CD45 molecules can prevent CD1+ thymocytes from apoptosis.

L. Moretta, A. Poggi, M. Zocchi, 1996, International immunology.

Specific functions of human NK cells.

E. Ciccone, L. Moretta, A. Moretta, 1992, Immunology letters.

Thymic origin of some natural killer cells: clonal proliferation of human CD3−16+ cells from CD3−4−8− thymocyte precursors requires the presence of H9 leukemic cells

R. Bellomo, L. Moretta, A. Poggi, 1992, International journal of clinical & laboratory research.

Bispecific monoclonal antibodies directed to CD16 and to a tumor‐associated antigen induce target‐cell lysis by resting NK cells and by a subset of NK clones

E. Ciccone, S. Ferrini, L. Moretta, 1991, International Journal of Cancer.

Functional analysis of cloned germinal center CD4+ cells with natural killer cell-related features. Divergence from typical T helper cells.

A. Velardi, C. Grossi, L. Moretta, 1986, Journal of immunology.

Natural Cytotoxicity of Human Fcγ‐Receptor‐positive T Lymphocytes after Surface Modulation with Immune Complexes

L. Moretta, P. Perlmann, G. Pape, 1979, Scandinavian journal of immunology.

PD-1 is expressed by and regulates human group 3 innate lymphoid cells in human decidua

D. Olive, E. Fulcheri, E. Munari, 2019, Mucosal Immunology.

Crystallization and preliminary crystallographic characterization of the extracellular Ig-like domain of human natural killer cell activating receptor NKp44.

M. Bolognesi, R. Biassoni, L. Moretta, 2002, Acta crystallographica. Section D, Biological crystallography.

HCMV-controlling NKG2C+ NK cells originate from novel circulating inflammatory precursors.

A. Luganini, G. Gribaudo, L. Moretta, 2021, The Journal of allergy and clinical immunology.

Legends of allergy and immunology: Giorgio Walter Canonica—Physician, scientist, and visionary leader

G. Passalacqua, E. Heffler, L. Moretta, 2021, Allergy.

Assignment of human natural killer (NK)‐like cells to the T cell lineage. Single allospecific T cell clones lyse specific or NK‐sensitive target cells via distinct recognition structures

G. Pantaleo, L. Moretta, A. Moretta, 1984, European journal of immunology.

displays either inhibitory or stimulatory function from CD3+ lymphoproliferative disease of granular lymphocytes The natural killer-related receptor for HLA-C expressed on T cells

S. Sforzini, L. Moretta, R. Zambello, 2011 .

Polymorphism in Human Cytomegalovirus UL40 Impacts on Recognition of Human Leukocyte Antigen-E (HLA-E) by Natural Killer Cells*

J. Rossjohn, J. Szer, S. Heatley, 2013, The Journal of Biological Chemistry.

Human T lymphocytes expressing TCR gamma/delta.

P. Pelicci, E. Ciccone, L. Moretta, 1990, Research in immunology.

Human thymocytes expressing gamma/delta T‐cell receptors

L. Moretta, M. Mingari, C. Bottino, 1989, International journal of cancer. Supplement = Journal international du cancer. Supplement.

Functional and morphologic characterization of human T lymphocytes expressing the TCR gamma /delta

E. Ciccone, C. Grossi, L. Moretta, 1992, Biotherapy.

Human lymphocytes expressing a TCR gamma/delta.

E. Ciccone, S. Ferrini, C. Grossi, 1990, Annali dell'Istituto superiore di sanita.

Myeloid derived suppressor cells in tumor microenvironment: Interaction with innate lymphoid cells.

N. Tumino, L. Moretta, P. Vacca, 2022, Seminars in immunology.

This information is current as Mechanism Apoptosis via an NKp 46-and Fas-Dependent Human NK Cells Induce Neutrophil

Marcenaro, F. Thorén, Rebecca Riise, 2012 .

IL-1β-releasing human acute myeloid leukemia blasts modulate natural killer cell differentiation from CD34+ precursors

L. Moretta, M. Mingari, C. Vitale, 2015, Haematologica.

Cell Function during Simian HIV Infection Cynomolgus Macaques: Monitoring of NK NK Cell Receptors in Rhesus and of NKG2D, NKp80, and NKG2C Triggering Molecular and Functional Characterization

R. Biassoni, B. Ensoli, L. Moretta, 2005 .

Ck226: a novel surface molecule involved in human t cell activation

L. Moretta, A. Poggi, M. Zocchi, 1989, European journal of immunology.

Relationship between expression of Fcγ receptors or la antigens and cytolytic activities of alloactivated human T cells

A. Fauci, L. Moretta, A. Moretta, 1983 .

Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture

B. Haynes, A. Fauci, R. Sékaly, 1981, The Journal of experimental medicine.

CYTOLYTIC T LYMPHOCYTES IN MIXED LYMPHOCYTE CULTURE

B. Haynes, A. Fauci, R. Sékaly, 1981 .

HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders.

C. Cancrini, S. Rutella, F. Locatelli, 2014, Blood.

Activation NK Cells upondimAcquire Features of CD 56 NK Cells Display Longer Telomeres and − Killer Ig-Like Receptor − CD 16 brightCD 56

A. Thiel, L. Moretta, T. Strowig, 2007 .

Dendritic cell editing by natural killer cells.

L. Moretta, G. Ferlazzo, 2014, Critical reviews in oncogenesis.

Human RORgtCD34 Cells Are Lineage-Specified Progenitors of Group 3 RORgt Innate Lymphoid Cells

U. Stervbo, J. Gröne, P. Durek, 2019 .

Human RORγt(+)CD34(+) cells are lineage-specified progenitors of group 3 RORγt(+) innate lymphoid cells.

U. Stervbo, J. Gröne, P. Durek, 2014, Immunity.

Control of self-reactive cytotoxic T lymphocytes expressing gamma delta T cell receptors by natural killer inhibitory receptors.

M. Bonneville, H. Vié, M. López-Botet, 1997, European journal of immunology.

Role of Ia antigens in the human autologous mixed lymphocyte reaction

L. Moretta, M. Mingari, 1982, European journal of immunology.

Tγδ Cell Subsets in Cord and Adult Blood

P. Lydyard, E. Ciccone, C. Grossi, 1990 .

Re‐targeting of human lymphocytes expressing the T‐cell receptor gamma/delta to ovarian carcinoma cells by the use of bispecific monoclonal antibodies

S. Ménard, S. Ferrini, L. Moretta, 1989, International journal of cancer.

Human T lymphocytes expressing gamma/delta T cell antigen receptor.

E. Ciccone, S. Ferrini, C. Grossi, 1989, Clinical immunology and immunopathology.

Analysis of CD3-associated molecules in CD4− 8− human T cell clones lacking the typical α/β T cell receptor

E. Ciccone, S. Ferrini, L. Moretta, 1987, La Ricerca in Clinica e in Laboratorio.

IL-1R8 silencing improves the anti-tumor function of freshly isolated human NK cells

C. Garlanda, A. Mantovani, L. Moretta, 2022, Journal for ImmunoTherapy of Cancer.

P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities

E. Ciccone, L. Moretta, A. Moretta, 1993, The Journal of experimental medicine.

Human natural killer cells: clonally distributed specific functions and triggering surface molecules.

E. Ciccone, L. Moretta, A. Moretta, 1992, Laboratory investigation; a journal of technical methods and pathology.

Regulation of IgG Antibody‐dependent Cellular Cytotoxicity in Vitro by IgM Antibodies

L. Moretta, P. Perlmann, H. Perlmann, 1981, Scandinavian journal of immunology.

Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function

E. Romeo, L. Moretta, A. Moretta, 2008, European journal of immunology.

Receptors involved in human NK cell activation in the process of natural cytotoxicity

R. Biassoni, L. Moretta, A. Moretta, 2001 .

IL‐12‐induced up‐regulation of NKRP1A expression in human NK cells and consequent NKRP1A‐ mediated down‐regulation of NK cell activation

L. Moretta, A. Poggi, E. Tomasello, 1998, European journal of immunology.

Mutant EL-4 thymoma cells polyclonally activate murine and human B cells via direct cell interaction.

H. Macdonald, R. Zubler, L. Moretta, 1985, Journal of immunology.

Phenotypic and functional characteristics of tumor‐associated lymphocytes in patients with malignant ascites receiving intraperitoneal infusions of recombinant interleukin‐2 (ril‐2)

L. Moretta, M. Sertoli, A. De Maria, 1989, International journal of cancer.

Intraperitoneal infusion of interleukin-2 in patients with malignant ascites: Phenotypic and functional effects on tumor-associated lymphocytes

L. Moretta, E. Baldini, G. Melioli, 1988, La Ricerca in clinica e in laboratorio.

Ultrastructural characteristics of human T cell clones with various cytolytic activities

C. Grossi, L. Moretta, A. Moretta, 1983, European journal of immunology.

How the Immune System Responds to Allergy Immunotherapy

L. Moretta, E. Maggi, I. Veneziani, 2022, Biomedicines.

B cell growth factor activity of immunoaffinity‐purified and recombinant human interleukin 2

R. Zubler, L. Moretta, A. Moretta, 1985, European journal of immunology.

Human T cell subpopulations defined by a monoclonal antibody. I. A small subset is responsible for proliferation to allogeneic cells or to soluble antigens and for helper activity for B cell differentiation.

L. Moretta, A. Moretta, M. Mingari, 1982, Journal of immunology.

Human T cell subpopulations defined by a monoclonal antibody. II. Evidence for cell cooperation in the response to alloantigens and generation of cytolytic cells.

L. Moretta, A. Moretta, M. Mingari, 1982, Journal of immunology.

Human CD3+4-8-WT31- T lymphocyte populations expressing the putative T cell receptor gamma-gene product. A limiting dilution and clonal analysis.

E. Ciccone, S. Ferrini, L. Moretta, 1987, European journal of immunology.

CD3+ WT31- peripheral T lymphocytes lack T44 (CD28), a surface molecule involved in activation of T cells bearing the alpha/beta heterodimer.

G. Pantaleo, E. Ciccone, L. Moretta, 1987, European journal of immunology.

Surface markers of cloned human T cells with various cytolytic activities

L. Moretta, B. Chapuis, A. Moretta, 1981, The Journal of experimental medicine.

B cell growth factor activity of interferon-gamma. Recombinant human interferon-gamma promotes proliferation of anti-mu-activated human B lymphocytes.

L. Moretta, E. Maggi, S. Romagnani, 1986, Journal of immunology.

Spontaneous cell-mediated cytotoxicity in humans. Distribution and characterization of the effector cell.

G. Trinchieri, D. Santoli, H. Koprowski, 1978, Clinical and experimental immunology.

Surface markers of human lymphokine‐activated killer cells and their precursors. Analysis at the population and clonal level

G. Pantaleo, S. Ferrini, L. Moretta, 1987, International journal of cancer.

Neuroblastoma Tumor-Associated Mesenchymal Stromal Cells Regulate the Cytolytic Functions of NK Cells

V. Calcaterra, G. Zuccotti, L. Moretta, 2022, Cancers.

Natural killer cells carry the germ‐line configuration of the T cell receptor δ chain gene and heterogeneously express six distinct δ transcripts

A. Carè, C. Peschle, P. Pelicci, 1990 .

Identification and Molecular Cloning of p 75 / AIRM 1 , A Novel Member of the Sialoadhesin Family That Functions as an Inhibitory Receptor in Human Natural Killer Cells

R. Biassoni, L. Moretta, A. Moretta, 1999 .

A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes.

S. Ehl, N. Binder, L. Moretta, 2012, Blood.

Possible targets on carcinoma for bMAb retargeting of lymphocyte or drug cytotoxicity.

S. Ménard, S. Ferrini, L. Moretta, 1992, International journal of cancer. Supplement = Journal international du cancer. Supplement.

Specificity of human T lymphocytes expressing a γ/δ T cell antigen receptor. Recognition of a polymorphic determinant of HLA class I molecules by a γ/δ clone

G. Ferrara, E. Ciccone, L. Moretta, 1989, Current topics in microbiology and immunology.

Cytolytic function of clonable T cells after human bone marrow transplantation.

M. Martelli, A. Velardi, C. Grossi, 1990, Blood.

Fc-receptors for IgG and IgM immunoglobulins on human T lymphocytes: mode of re-expression after proteolysis or interaction with immune complexes.

M. Ferrarini, L. Moretta, A. Moretta, 1978, Journal of immunology.

Familial Hemophagocytic Lymphohistiocytosis May Present during Adulthood: Clinical and Genetic Features of a Small Series

F. Gherlinzoni, V. Cetica, A. Bosi, 2012, PloS one.

Genotype–phenotype study of familial haemophagocytic lymphohistiocytosis type 3

V. Cetica, L. Moretta, M. Aricò, 2011, Journal of Medical Genetics.

Pathogenic Mechanisms of Vaccine-Induced Immune Thrombotic Thrombocytopenia in People Receiving Anti-COVID-19 Adenoviral-Based Vaccines: A Proposal

L. Moretta, E. Maggi, I. Veneziani, 2021, Frontiers in Immunology.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Amit A. Patel, F. Ginhoux, D. Busch, 2021, European journal of immunology.

Natural Killer Cells and Neuroblastoma: Tumor Recognition, Escape Mechanisms, and Possible Novel Immunotherapeutic Approaches

F. Locatelli, V. Pistoia, L. Moretta, 2014, Front. Immunol..

Loss of Fc receptors for IgG from human T lymphocytes exposed to IgG immune complexes

L. Moretta, M. Mingari, LORENZO MORETTA, 1978, Nature.

Human T lymphocyte subpopulations: studies of the mechanism by which T cells bearing Fc receptors for IgG suppress T-dependent B cell differentiation induced by pokeweed mitogen.

M. Cooper, L. Moretta, A. Moretta, 1979, Journal of immunology.

Molecular definition of group 1 innate lymphoid cells in the mouse uterus

A. Sharkey, L. Moretta, I. Filipovic, 2018, Nature Communications.

Receptors for IgG molecules on human lymphocytes forming spontaneous rosettes with sheep red cells

L. Moretta, M. Ferrarini, L. Moretta, 1975, European journal of immunology.

Subpopulations of human T cells identified by receptors for immunoglobulins and mitogen responsiveness.

M. Ferrarini, L. Moretta, A. Moretta, 1976, Journal of immunology.

Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG

P. Lydyard, M. Cooper, C. Grossi, 1977, The Journal of experimental medicine.

Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of alloreactive NK cells

F. Locatelli, L. Moretta, A. Moretta, 2013, Front. Immun..

The management of paediatric allergy: not everybody's cup of tea – 10–11th February 2012

S. Vieths, J. Brożek, R. Pawankar, 2013, Current opinion in allergy and clinical immunology.

Cell Separation Techniques

S. Ferrini, L. Moretta, 1998 .

Fc Receptors on Human T Lymphocytes: Loss of Fcμ and Expression of Fcγ Receptors by T Cells Stimulated in Mixed Lymphocyte Reaction

L. Moretta, A. Moretta, M. Colombatti, 1981 .

Human T‐Lymphocyte Subpopulations: Alterations in Systemic Lupus Erythematosus

D. Santoli, L. Moretta, P. Perlmann, 1979, Scandinavian journal of immunology.

CHAPTER 14 – CLINICAL RELEVANCE OF SUBPOPULATIONS OF HUMAN T LYMPHOCYTES

D. Santoli, H. Koprowski, L. Moretta, 1979 .

CD69-mediated pathway of lymphocyte activation: anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic T lymphocytes expressing T cell receptor alpha/beta

E. Ciccone, L. Moretta, A. Poggi, 1991, The Journal of experimental medicine.

The Immune Checkpoint PD-1 in Natural Killer Cells: Expression, Function and Targeting in Tumour Immunotherapy

N. Tumino, E. Munari, L. Moretta, 2020, Cancers.

Nidogen-1 is a novel extracellular ligand for the NKp44 activating receptor

L. Moretta, Genny Del Zotto, A. Moretta, 2018, Oncoimmunology.

Origin, phenotype and function of human natural killer cells in pregnancy.

L. Moretta, A. Moretta, M. Mingari, 2011, Trends in immunology.

Human T-lymphocyte subpopulations in Hashimoto's disease.

G. Canonica, L. Moretta, G. Giordano, 1981, The Journal of clinical endocrinology and metabolism.

Imbalances in T cell subpopulations associated with immunodeficiency and autoimmune syndromes

P. Lydyard, M. Cooper, C. Grossi, 1977, European journal of immunology.

Surface Phenotype of Helper and Suppressor Human T Cell Clones

G. Pantaleo, L. Moretta, A. Moretta, 1983 .

Surface markers of cloned human T cells with helper or suppressor activity on pokeweed mitogen‐driven B cell differentiation

G. Pantaleo, L. Moretta, A. Moretta, 1982, European journal of immunology.

Human natural killer cells: origin, clonality, specificity, and receptors.

E. Ciccone, R. Biassoni, L. Moretta, 1994, Advances in immunology.

Comparison of the colony-forming capacities of human T-lymphocyte subpopulations.

G. Canonica, V. Pistoia, L. Moretta, 1981, Clinical immunology and immunopathology.

Immunoregulatory T Cell Subpopulations in Man

L. Moretta, A. Moretta, M. Colombatti, 1980 .

NK cells and ILCs in tumor immunotherapy.

N. Tumino, F. Locatelli, L. Moretta, 2020, Molecular aspects of medicine.

Inhibitory checkpoints in human natural killer cells: IUPHAR Review 28

N. Tumino, E. Munari, L. Moretta, 2020, British journal of pharmacology.

Alloreactive natural killer cells in targeting high-risk leukaemias

F. Locatelli, L. Moretta, A. Moretta, 2008, Annals of the rheumatic diseases.

Human NK cells: from HLA class I‐specific killer Ig‐like receptors to the therapy of acute leukemias

F. Locatelli, L. Moretta, A. Moretta, 2008, Immunological reviews.

Histone deacetylase inhibitors sensitize tumour cells for cytotoxic effects of natural killer cells.

L. Moretta, B. Bröker, J. Beck, 2008, Cancer letters.

Identification, molecular cloning and functional characterization of NKp46 and NKp30 natural cytotoxicity receptors in Macaca fascicularis NK cells

R. Biassoni, B. Ensoli, L. Moretta, 2001, European journal of immunology.

Crosstalk between decidual NK and CD14+ myelomonocytic cells results in induction of Tregs and immunosuppression

N. Ragni, L. Moretta, M. Mingari, 2010, Proceedings of the National Academy of Sciences.

Human interleukin-2 promotes proliferation of activated B cells via surface receptors similar to those of activated T cells

T. Waldmann, R. Zubler, L. Moretta, 1984, Nature.

COVID-19 vaccines: where we stand and challenges ahead

M. Morrone, G. Remuzzi, R. Rappuoli, 2021, Cell Death & Differentiation.

The molecular bases of δ/αβ T cell–mediated antigen recognition

G. Besra, J. McCluskey, J. Rossjohn, 2014, The Journal of experimental medicine.

The molecular bases of delta/alpha beta T cell-mediated antigen recognition

G. Besra, J. McCluskey, J. Rossjohn, 2014 .

KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors

Wesley M. Marin, P. Parham, J. Trowsdale, 2020, Frontiers in Immunology.

Identification of PVR (CD155) and Nectin-2 (CD112) as Cell Surface Ligands for the Human DNAM-1 (CD226) Activating Molecule

L. Moretta, N. Reymond, A. Moretta, 2003, The Journal of experimental medicine.

NK Cells Recognize and Kill Human Glioblastoma Cells with Stem Cell-Like Properties1

P. L. Poliani, L. Moretta, A. Moretta, 2009, The Journal of Immunology.

Association Between Response to Nivolumab Treatment and Peripheral Blood Lymphocyte Subsets in Patients With Non-small Cell Lung Cancer

L. Moretta, F. Grossi, G. Rossi, 2020, Frontiers in Immunology.

Activated T lymphocytes in patients with multiple sclerosis

J. Golaz, A. Steck, L. Moretta, 1983, Neurology.

Heterogeneity of B cell growth factor (BCGF)-producing T cells in humans. Clonal analysis of BCGF-producing cells within T4+ and T8+ subsets and evidence for the involvement of different growth factors in different BCGF assays

L. Moretta, A. Poggi, M. Mingari, 1986, La Ricerca in clinica e in laboratorio.

Phenotypic and functional heterogeneity of human T lymphocytes producing B-cell growth factor(s): a clonal analysis.

L. Moretta, M. Mingari, E. Maggi, 1985, Clinical immunology and immunopathology.

Human NK cells: surface receptors, inhibitory checkpoints, and translational applications

E. Munari, L. Moretta, Genny Del Zotto, 2019, Cellular & Molecular Immunology.

Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells

R. Biassoni, L. Moretta, A. Malaspina, 1999, The Journal of experimental medicine.

Molecular Cloning of NKp46: A Novel Member of the Immunoglobulin Superfamily Involved in Triggering of Natural Cytotoxicity

R. Biassoni, L. Moretta, A. Malaspina, 1998, The Journal of experimental medicine.

Helper Innate Lymphoid Cells in Allogenic Hematopoietic Stem Cell Transplantation and Graft Versus Host Disease

N. Tumino, L. Moretta, L. Quatrini, 2020, Frontiers in Immunology.

Nutlin-3a Enhances Natural Killer Cell–Mediated Killing of Neuroblastoma by Restoring p53-Dependent Expression of Ligands for NKG2D and DNAM-1 Receptors

L. Di Marcotullio, V. Barnaba, S. Petrini, 2020, Cancer Immunology Research.

MYCN is an immunosuppressive oncogene dampening the expression of ligands for NK-cell-activating receptors in human high-risk neuroblastoma

R. Boldrini, F. Locatelli, V. Pistoia, 2017, Oncoimmunology.

PD-1/PD-L1 in Cancer: Pathophysiological, Diagnostic and Therapeutic Aspects

F. Ciompi, N. Tumino, M. Brunelli, 2021, International journal of molecular sciences.

Natural killer cells kill human melanoma cells with characteristics of cancer stem cells.

P. Queirolo, L. Moretta, M. Mingari, 2009, International immunology.

CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells.

L. Moretta, A. Moretta, S. Sivori, 2004, Proceedings of the National Academy of Sciences of the United States of America.

An Historical Overview: The Discovery of How NK Cells Can Kill Enemies, Recruit Defense Troops, and More

L. Moretta, A. De Maria, S. Sivori, 2019, Front. Immunol..

Characterization of Human Afferent Lymph Dendritic Cells from Seroma Fluids

S. Ferrone, M. Mesiti, L. Moretta, 2013, The Journal of Immunology.

responses plasmacytoid and monocyte-derived dendritic cells during innate immune Multidirectional interactions are bridging human NK cells with

A. Thiel, L. Moretta, C. Romagnani, 2013 .

Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses.

A. Thiel, L. Moretta, C. Romagnani, 2006, Blood.

Running title : Multiple interactions of NK cells with DCs

A. Thiel, L. Moretta, C. Romagnani, 2006 .

NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily

R. Biassoni, L. Moretta, A. Malaspina, 1999, The Journal of experimental medicine.

MiR‐22, a serum predictor of poor outcome and therapy response in diffuse large B‐cell lymphoma patients

M. Marino, A. Sacconi, M. Rizzo, 2021, British journal of haematology.

Characterization of Human NK Cell-Derived Exosomes: Role of DNAM1 Receptor in Exosome-Mediated Cytotoxicity against Tumor

N. Tumino, E. Munari, L. Moretta, 2020, Cancers.

Update: new CD antigens, 1996.

T. Springer, K. Sugamura, H. Zola, 1997, Tissue antigens.

HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation

M. Nitti, L. Moretta, M. Pronzato, 2017, Antioxidants.

PD-L1 expression in non-small cell lung cancer: evaluation of the diagnostic accuracy of a laboratory developed test using clone E1L3N in comparison with 22C3 and SP263 assays.

G. Netto, G. Zamboni, M. Brunelli, 2019, Human pathology.

PD-L1 Assays 22C3 and SP263 are Not Interchangeable in Non–Small Cell Lung Cancer When Considering Clinically Relevant Cutoffs: An Interclone Evaluation by Differently Trained Pathologists

Matteo Brunelli, Giulio Rossi, Enrico Munari, 2018, The American journal of surgical pathology.

CD34+ hematopoietic precursors are present in human decidua and differentiate into natural killer cells upon interaction with stromal cells

E. Fulcheri, L. Moretta, M. Mingari, 2011, Proceedings of the National Academy of Sciences.

HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes

L. Moretta, C. Romagnani, E. Millo, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Natural killer cells infiltrating human nonsmall‐cell lung cancer are enriched in CD56brightCD16− cells and display an impaired capability to kill tumor cells

G. Altavilla, L. Moretta, M. Mingari, 2008, Cancer.

Inhibitory Receptors and Checkpoints in Human NK Cells, Implications for the Immunotherapy of Cancer

N. Tumino, E. Munari, L. Moretta, 2020, Frontiers in Immunology.

Polymorphonuclear Myeloid-Derived Suppressor Cells Are Abundant in Peripheral Blood of Cancer Patients and Suppress Natural Killer Cell Anti-Tumor Activity

P. Paci, N. Tumino, E. Munari, 2022, Frontiers in Immunology.

Novel Munc13–4 mutations in children and young adult patients with haemophagocytic lymphohistiocytosis

L. Notarangelo, F. Dieli, L. Moretta, 2006, Journal of Medical Genetics.

CPHEN-15: Comprehensive phenotyping of human peripheral blood helper-ILCs by flow cytometry.

L. Moretta, Genny Del Zotto, L. Quatrini, 2023, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Organization and orientation of a human T cell receptor δ chain V gene segment that suggests an inversion mechanism is utilized in its rearrangement

T. Mak, E. Ciccone, L. Moretta, 1989, European journal of immunology.

A novel pathway of human B cell activation initiated by CK226 surface antigen

L. Moretta, A. Poggi, E. Maggi, 1990, European journal of immunology.

PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis.

L. Moretta, N. Reymond, A. Moretta, 2005, Molecular immunology.

The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions

R. Biassoni, L. Moretta, A. Poggi, 1996, The Journal of experimental medicine.

Mesenchymal stem cells expanded in human platelet lysate display a decreased inhibitory capacity on T‐ and NK‐cell proliferation and function

L. Moretta, Lorenzo Moretta, Laura Chiossone, 2011, European journal of immunology.

Legends of allergy and immunology: Alberto Mantovani, a visionary scientist unraveling the complexity of innate immunity in cancer and inflammation

S. Sozzani, L. Moretta, 2022, Allergy.

Effect of tumor cells and tumor microenvironment on NK‐cell function

L. Moretta, M. Mingari, M. Vitale, 2014, European journal of immunology.

CD56brightCD16− Killer Ig-Like Receptor− NK Cells Display Longer Telomeres and Acquire Features of CD56dim NK Cells upon Activation1

A. Thiel, L. Moretta, T. Strowig, 2007, The Journal of Immunology.

Origin and functions of human natural killer cells

E. Ciccone, L. Moretta, A. Poggi, 1994, International journal of clinical & laboratory research.

Killer Ig-like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation.

F. Locatelli, L. Moretta, A. Moretta, 2011, Blood.

IL-12 or IL-4 Prime Human NK Cells to Mediate Functionally Divergent Interactions with Dendritic Cells or Tumors1

L. Moretta, A. Moretta, F. Bellora, 2005, The Journal of Immunology.

Receptors for HLA class-I molecules in human natural killer cells.

R. Biassoni, L. Moretta, A. Moretta, 1996, Annual review of immunology.

CHAPTER 25 – SUBPOPULATIONS OF HUMAN T LYMPHOCYTES: FUNCTIONAL CHARACTERISTICS

G. Canonica, M. Cooper, L. Moretta, 1979 .

Killer immunoglobulin-like receptors.

L. Moretta, A. Moretta, 2004, Current opinion in immunology.

Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112).

E. Lanino, L. Moretta, A. Bacigalupo, 2005, Blood.

Mobilization of healthy donors with plerixafor affects the cellular composition of T-cell receptor (TCR)-αβ/CD19-depleted haploidentical stem cell grafts

S. Rutella, F. Locatelli, L. Moretta, 2014, Journal of Translational Medicine.

The small subset of CD56brightCD16– natural killer cells is selectively responsible for both cell proliferation and interferon‐γ production upon interaction with dendritic cells

A. Thiel, L. Moretta, C. Romagnani, 2004, European journal of immunology.

New nomenclature for MHC receptors

L. Moretta, E. O. Long, Eric O Long, 2001, Nature Immunology.

Generation of CFU-C/suppressor T cells in vitro: an experimental model for immune-mediated marrow failure.

L. Moretta, A. Bacigalupo, M. Mingari, 1981, Blood.

A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin.

L. Notarangelo, L. Moretta, M. Aricò, 2005, Blood.

Specific removal of alloreactive T-cells to prevent GvHD in hemopoietic stem cell transplantation: rationale, strategies and perspectives.

L. Moretta, G. Li Pira, F. Manca, 2016, Blood reviews.

NK Cells Mediate a Crucial Graft-versus-Leukemia Effect in Haploidentical-HSCT to Cure High-Risk Acute Leukemia.

F. Locatelli, L. Moretta, A. Moretta, 2018, Trends in immunology.

γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ+/CD19+ lymphocytes.

F. Locatelli, V. Pistoia, L. Moretta, 2015, Blood.

Peptides with dual binding specificity for HLA-A2 and HLA-E are encoded by alternatively spliced isoforms of the antioxidant enzyme peroxiredoxin 5.

G. Nicolini, A. Anichini, L. Moretta, 2009, International immunology.

Control of the HIV-1 DNA Reservoir Is Associated In Vivo and In Vitro with NKp46/NKp30 (CD335 CD337) Inducibility and Interferon Gamma Production by Transcriptionally Unique NK Cells

F. Marincola, E. Wang, M. Magnani, 2017, Journal of Virology.

Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion.

F. Locatelli, R. Masetti, R. Handgretinger, 2017, Blood.

gd T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR- ab 1 /CD19 1 lymphocytes

F. Locatelli, V. Pistoia, L. Moretta, 2016 .

NCR+ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures

L. Moretta, M. Truini, M. Mingari, 2015, Nature Communications.

Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition

J. Rossjohn, J. Vivian, Philippa M. Saunders, 2016, The Journal of experimental medicine.

NK cells at the interface between innate and adaptive immunity

L. Moretta, A. Moretta, S. Parolini, 2008, Cell Death and Differentiation.

Lymphokine production by T-cell clones after human bone marrow transplantation.

M. Martelli, A. Velardi, F. Grignani, 1989, Blood.

immune-mediated marrow failure Generation of CFU-C/suppressor T cells in vitro: an experimental model for

L. Moretta, A. Bacigalupo, M. Mingari, 2011 .

T-cell-mediated suppression of hemopoiesis.

L. Moretta, A. Bacigalupo, 1981, Immunology today.

HLA-class I-specific inhibitory receptors in HIV-1 infection.

L. Moretta, A. De Maria, A. De Maria, 2000, Human immunology.

Human NK receptors: From the molecules to the therapy of high risk leukemias

F. Locatelli, L. Moretta, A. Moretta, 2011, FEBS letters.

Transplantation of TcRαβ/CD19 Depleted Stem Cells From Haploidentical Donors: Robust Engraftment and Rapid Immune Reconstitution In Children with High Risk Leukemia

A. Schulz, F. Locatelli, R. Handgretinger, 2011 .

KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL.

F. Locatelli, R. Handgretinger, L. Moretta, 2014, Blood.

Human NK Cells and Herpesviruses: Mechanisms of Recognition, Response and Adaptation

L. Moretta, A. De Maria, S. Sivori, 2019, Front. Microbiol..

Diversity and structure of human T cell receptor delta chain genes in peripheral blood gamma/delta-bearing T lymphocytes

T. Mak, E. Ciccone, J. Reimann, 1989, The Journal of experimental medicine.

Selective Increase of a Subset of T Cell Receptor γδ T Lymphocytes in the Peripheral Blood of Patients with Human Immunodeficiency Virus Type 1 Infection

E. Ciccone, S. Ferrini, L. Moretta, 1992 .

Major histocompatibility complex class I‐specific receptors on human natural killer and T lymphocytes

R. Biassoni, L. Moretta, A. Poggi, 1997, Immunological reviews.

Anti-Leukemia Activity of Alloreactive NK Cells in Haploidentical HSCT in Pediatric Patients: Re-Defining the Role of Activating and Inhibitory KIR

M. Martinetti, E. Romeo, F. Locatelli, 2008 .

Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization

D. Olive, G. Tabellini, L. Moretta, 2017, The Journal of allergy and clinical immunology.

Natural killer cells in HIV-1 infection: Dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates

M. Daucher, A. Fauci, L. Moretta, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Persistence of Unintegrated HIV DNA Associates With Ongoing NK Cell Activation and CD34+DNAM-1brightCXCR4+ Precursor Turnover in Vertically Infected Patients Despite Successful Antiretroviral Treatment

M. Magnani, L. Moretta, A. De Maria, 2022, Frontiers in Immunology.

Human γδT Cells that Inhibit the In Vitro Growth of the Asexual Blood Stages of the Plasmodium falciparum Parasite Express Cytolytic and Proinflammatory Molecules

L. Mincheva-Nilsson, L. Moretta, M. Hammarström, 1999, Scandinavian journal of immunology.

Natural killer cells in HIV controller patients express an activated effector phenotype and do not up-regulate NKp44 on IL-2 stimulation

S. Boni, R. Biassoni, A. Riva, 2013, Proceedings of the National Academy of Sciences.

Amino acid substitutions can influence the natural killer (NK)-mediated recognition of HLA-C molecules. Role of serine-77 and lysine-80 in the target cell protection from lysis mediated by "group 2" or "group 1" NK clones

P. Parham, R. Biassoni, L. Moretta, 1995, The Journal of experimental medicine.

Receptors for IgM are expressed on acute lymphoblastic leukemic cells having T-cell characteristics.

P. Lydyard, L. Moretta, A. Moretta, 1977, Clinical immunology and immunopathology.

HLA class I-specific inhibitory receptors in human T lymphocytes: interleukin 15-induced expression of CD94/NKG2A in superantigen- or alloantigen-activated CD8+ T cells.

R. Bellomo, L. Moretta, A. Moretta, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Specific lysis of allogeneic cells after activation of CD3- lymphocytes in mixed lymphocyte culture

Eric O Long, E. Ciccone, R. Biassoni, 1988, The Journal of experimental medicine.

Occurrence of human immunodeficiency virus type 1 (HIV-1)-specific cytolytic T cell activity in apparently uninfected children born to HIV-1-infected mothers.

L. Moretta, A. De Maria, A. Maria, 1994, The Journal of infectious diseases.

Metformin exerts anti-cancerogenic effects and reverses epithelial-to-mesenchymal transition trait in primary human intrahepatic cholangiocarcinoma cells

A. D. De Rose, F. Giuliante, G. Carpino, 2021, Scientific Reports.

Regulatory Interactions of Human T Cells

M. Cooper, L. Moretta, A. Moretta, 1980 .

Regulatory Human T-Cell Subpopulations Defined by Receptors for IgG or IgM

M. Cooper, L. Moretta, 1980 .

Expression of HLA class I-specific inhibitory natural killer cell receptors in HIV-specific cytolytic T lymphocytes: impairment of specific cytolytic functions.

A. Fauci, S. Pilia, L. Moretta, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Function in Long-Term HIV-1-Infected Animals NK Cells and Conserved NK Cell Phenotype and Differential NKp30 Inducibility in Chimpanzee

J. Heeney, R. Biassoni, L. Moretta, 2011 .

HIV-1-Infected Animals Cell Phenotype and Function in Long-Term Chimpanzee NK Cells and Conserved NK Differential NKp 30 Inducibility in

J. Heeney, R. Biassoni, L. Moretta, 2007 .

HIV-1-infected animals phenotype and function in long-term chimpanzee NK cells and conserved NK cell Differential NKp 30 inducibility in

J. Heeney, L. Moretta, M. Mingari, 2007 .

Natural killer cell receptors regulate responses of HLA-E–restricted T cells

F. Luciani, Thi H. O. Nguyen, K. Kedzierska, 2021, Science Immunology.

A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation

R. Biassoni, L. Moretta, A. Moretta, 1996, European journal of immunology.

Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.

Eric O Long, R. Biassoni, L. Moretta, 1995, Immunity.

NKp44 expression, phylogenesis and function in non-human primate NK cells.

J. Heeney, R. Biassoni, B. Ensoli, 2009, International immunology.

Different checkpoints in human NK-cell activation.

L. Moretta, A. Moretta, M. Mingari, 2004, Trends in immunology.

Structure of the human NK cell triggering receptor NKp46 ectodomain.

A. Pesce, M. Bolognesi, R. Biassoni, 2003, Biochemical and biophysical research communications.

The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity.

M. Bolognesi, R. Biassoni, L. Moretta, 2003, Structure.

Analysis of natural killer cells in TAP2-deficient patients: expression of functional triggering receptors and evidence for the existence of inhibitory receptor(s) that prevent lysis of normal autologous cells.

J. Zimmer, H. de la Salle, L. Moretta, 2002, Blood.

Identification and Molecular Characterization of NKp 30 , a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells

R. Biassoni, L. Moretta, A. Malaspina, 1999 .

NK-cell receptors and recognition of MHC class I molecules.

J. Strominger, M. López-Botet, L. Moretta, 1996, Immunology today.

Differential disappearance of inhibitory natural killer cell receptors during HAART and possible impairment of HIV-1-specific CD8 cytotoxic T lymphocytes

L. Moretta, A. De Maria, M. Mingari, 2001, AIDS.

Human γδ T-Cells: From Surface Receptors to the Therapy of High-Risk Leukemias

N. Tumino, F. Locatelli, V. Pistoia, 2018, Frontiers in Immunology.

IL-1R8: A molecular brake of anti-tumor and anti-viral activity of NK cells and ILC.

C. Garlanda, L. Moretta, A. Mantovani, 2023, Seminars in immunology.

The Latest Approach of Immunotherapy with Endosomal TLR Agonists Improving NK Cell Function: An Overview

L. Moretta, E. Maggi, I. Veneziani, 2022, Biomedicines.

Comparison of different CpG oligodeoxynucleotide classes for their capability to stimulate human NK cells

L. Moretta, A. Moretta, S. Sivori, 2006, European journal of immunology.

Human lymphocyte surface markers.

A. Fauci, L. Moretta, A. Moretta, 1982, Seminars in hematology.

KIR B haplotype donors confer a reduced risk of relapse after haploidentical transplantation in children with acute lymphoblastic leukemia

F. Locatelli, R. Handgretinger, L. Moretta, 2014 .

The Emerging Role of HLA-E-Restricted CD8+ T Lymphocytes in the Adaptive Immune Response to Pathogens and Tumors

L. Moretta, C. Romagnani, M. Mingari, 2010, Journal of biomedicine & biotechnology.

TSC loss is a clonal event in eosinophilic solid and cystic renal cell carcinoma: a multiregional tumor sampling study

G. Netto, G. Zamboni, N. Tumino, 2021, Modern Pathology.

Boosting Natural Killer Cell-Based Immunotherapy with Anticancer Drugs: a Perspective.

F. Locatelli, V. Pistoia, L. Moretta, 2017, Trends in molecular medicine.

Impact of PD-L1 and PD-1 Expression on the Prognostic Significance of CD8+ Tumor-Infiltrating Lymphocytes in Non-Small Cell Lung Cancer

G. Rossi, G. Netto, F. Ciompi, 2021, Frontiers in Immunology.

Natural killer cell-mediated recognition of human trophoblast.

R. Biassoni, L. Moretta, A. Moretta, 1999, Seminars in cancer biology.

Low expression of inhibitory natural killer receptors in CD8 cytotoxic T lymphocytes in long-term non-progressor HIV-1-infected patients.

L. Moretta, A. De Maria, M. Mingari, 2003, AIDS.

Phenotypic and functional analysis of the HLA-class I-specific inhibitory receptors of natural killer cells isolated from peripheral blood of patients undergoing bone marrow transplantation from matched unrelated donors.

F. Benvenuto, R. Bellomo, F. Frassoni, 2000, The hematology journal : the official journal of the European Haematology Association.

p40/LAIR‐1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte‐monocyte colony‐stimulating factor

L. Moretta, A. Poggi, M. Zocchi, 1998, European journal of immunology.

The generation of human innate lymphoid cells is influenced by the source of hematopoietic stem cells and by the use of G‐CSF

F. Locatelli, L. Moretta, M. Mingari, 2016, European journal of immunology.

Peripheral Blood Mononuclear Cell Immunophenotyping in Fibrodysplasia Ossificans Progressiva Patients: Evidence for Monocyte DNAM1 Up‐regulation

R. Ravazzolo, R. Bocciardi, L. Moretta, 2018, Cytometry. Part B, Clinical cytometry.

The tumor microenvironment drives NK cell metabolic dysfunction leading to impaired antitumor activity

N. Tumino, L. Moretta, M. Mingari, 2022, International journal of cancer.

PD-1 in human NK cells: evidence of cytoplasmic mRNA and protein expression

N. Tumino, S. Petrini, E. Munari, 2018, Oncoimmunology.

T cell subpopulations after allogeneic bone marrow transplantation.

L. Moretta, A. Bacigalupo, M. Mingari, 1980, Haematology and blood transfusion.

CD3+ WT31− peripheral T lymphocytes lack T44 (CD28), a surface molecule involved in activation of T cells bearing the α/β heterodimer

G. Pantaleo, E. Ciccone, L. Moretta, 1987 .

Zoledronic acid boosts γδ T-cell activity in children receiving αβ+ T and CD19+ cell-depleted grafts from an HLA-haplo-identical donor

F. Locatelli, L. Moretta, P. Merli, 2016, Oncoimmunology.

Antibody-induced modulation of the CD3/T cell receptor complex causes T cell refractoriness by inhibiting the early metabolic steps involved in T cell activation

T. Pozzan, D. Olive, G. Pantaleo, 1987, The Journal of experimental medicine.

T cell nature of some lymphokine‐activated killer (LAK) cells. Frequency analysis of LAK precursors within human T cell populations and clonal analysis of LAK effector cells

L. Moretta, M. Mingari, D. Pende, 1986, European journal of immunology.

Interleukin 2 and interferon‐γ are not sufficient to induce natural killer‐like activity in human T cell clones

M. Toribio, M. López-Botet, L. Moretta, 1984 .

Glycoproteic nature of surface molecules of effector cells with lymphokine‐activated killer (LAK) activity. Evidence that T11, T8 or T3 molecules are not involved in tumor‐cell lysis by LAK effector T cells

G. Canonica, L. Moretta, M. Mingari, 1987, International journal of cancer.

Both the precursors and the effectors of human lymphokine-activated killer (LAK) cells may belong to T lymphocytes

S. Ferrini, L. Moretta, A. Poggi, 1986, La Ricerca in clinica e in laboratorio.

Immune Checkpoint Inhibitors: Anti-NKG2A Antibodies on Board.

L. Moretta, M. Mingari, G. Pietra, 2019, Trends in immunology.

Glucocorticoids and the cytokines IL-12, IL-15 and IL-18 present in the tumor microenvironment induce PD-1 expression on human Natural Killer cells.

N. Tumino, E. Munari, L. Moretta, 2020, The Journal of allergy and clinical immunology.

A conserved energetic footprint underpins recognition of human leukocyte antigen-E by two distinct αβ T cell receptors

T. Beddoe, J. Rossjohn, S. Gras, 2017, The Journal of Biological Chemistry.

Update of CD antigens, 1996.

T. Springer, K. Sugamura, H. Zola, 1997, Journal of immunology.

Distribution and properties of Fc receptors for IgG on different leucocyte populations in man.

D. Heumann, L. Moretta, M. Colombatti, 1981, Clinical and experimental immunology.

Subpopulations of human T lymphocytes.

A. Fauci, L. Moretta, 1980, Immunology today.

Phenotypic and functional heterogeneity of human T cell clones producing γ-interferon

S. Ferrini, L. Moretta, M. Mingari, 1985 .

Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity.

L. Moretta, M. Introna, A. Rambaldi, 2011, Blood.

Natural killer alloeffector responses in haploidentical hemopoietic stem cell transplantation to treat high-risk leukemias.

F. Locatelli, L. Moretta, A. Moretta, 2010, Tissue antigens.

CD56 Is a Pathogen Recognition Receptor on Human Natural Killer Cells

H. Einsele, M. Sauer, I. Leonhardt, 2017, Scientific Reports.

Specific recognition by CD3− NK cells: A limiting dilution analysis of the frequency of alloreactive CD3− lymphocyte precursors

E. Ciccone, L. Moretta, A. Moretta, 1989 .

Increased expression of non‐functional killer inhibitory receptor CD94 in CD8+ cells of myeloma patients

M. Boccadoro, A. Pileri, S. Mariani, 2000, British journal of haematology.

HLA-E and HLA-E-bound peptides: recognition by subsets of NK and T cells.

L. Moretta, C. Romagnani, M. Mingari, 2009, Current pharmaceutical design.

Cloning and proliferating precursor frequencies of tumor-infiltrating lymphocytes from human solid tumors.

S. Miescher, L. Moretta, V. V. von Fliedner, 1988, Transplantation proceedings.

NK Cells and PMN-MDSCs in the Graft From G-CSF Mobilized Haploidentical Donors Display Distinct Gene Expression Profiles From Those of the Non-Mobilized Counterpart

N. Tumino, L. Moretta, L. Quatrini, 2021, Frontiers in Immunology.

Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells

R. Biassoni, L. Moretta, A. Moretta, 1999, European journal of immunology.

Use of anti-CD3 and anti-CD16 bispecific monoclonal antibodies for the targeting of T and NK cells against tumor cells.

S. Canevari, S. Sforzini, S. Ferrini, 1993, Cancer detection and prevention.

P377 - The HLA-C-specific “activatory” or “inhibitory” natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions

R. Biassoni, L. Moretta, A. Poggi, 1996 .

Perturbations of natural killer cell regulatory functions in respiratory allergic diseases.

G. Canonica, L. Moretta, A. Moretta, 2008, The Journal of allergy and clinical immunology.

Learning how to discriminate between friends and enemies, a lesson from Natural Killer cells.

L. Moretta, A. Moretta, M. Vitale, 2004, Molecular immunology.

Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: Engagement of CD33 induces apoptosis of leukemic cells

D. Olive, L. Moretta, C. Romagnani, 2001, Proceedings of the National Academy of Sciences of the United States of America.

A Novel surface molecule expressed by long‐term cultured T and natural killer cells is involved in cell activation

E. Ciccone, R. Biassoni, S. Ferrini, 1991, European journal of immunology.

Human T cell receptor for IgM: specificity for the pentameric Fc fragment

M. Ferrarini, L. Moretta, M. Mingari, 1976, European journal of immunology.

Corticoresistant nephrotic syndrome associated with T-cell deficiency in two sisters.

L. Moretta, M. Jeannet, J. Guignard, 1983, Pediatrics.

The effects of IgM rheumatoid factor on EAM and EAG rosette formation with Fc receptor-bearing lymphoid cells.

L. Moretta, R. Emmons, J. Davis, 1983, Arthritis and rheumatism.

PMN-MDSC are a new target to rescue graft-versus-leukemia activity of NK cells in haplo-HSC transplantation

N. Tumino, F. Locatelli, E. Munari, 2019, Leukemia.

Different effects of NK cells and NK-derived soluble factors on cell lines derived from primary or metastatic pancreatic cancers

S. Scaglione, N. Tumino, E. Munari, 2022, Cancer Immunology, Immunotherapy.

TCRαβ/CD19 depleted hematopoietic stem cell transplantation from haploidentical donors: dissecting the GvL/GvHD conundrum

N. Tumino, F. Locatelli, L. Moretta, 2020, Bone Marrow Transplantation.

Activating NK cell receptor expression/function (NKp30, NKp46, DNAM‐1) during chronic viraemic HCV infection is associated with the outcome of combined treatment

D. Olive, I. Hirsch, L. Moretta, 2011, European journal of immunology.

Increasing LFA-1 Expression Enhances Immune Synapse Architecture and T Cell Receptor Signaling in Jurkat E6.1 Cells

M. D’Elios, C. Baldari, L. Moretta, 2021, Frontiers in Cell and Developmental Biology.

Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation.

L. Moretta, M. Mingari, G. Spaggiari, 2006, Blood.

Erratum: Methylprednisolone induces preferential and rapid differentiation of CD34+ cord blood precursors toward NK cells (International Immunology (2008) vol. 20 (565-575))

L. Moretta, M. Mingari, C. Vitale, 2008 .

HO-1 up-regulation: a key point in high-risk neuroblastoma resistance to bortezomib.

M. Nitti, L. Moretta, N. Traverso, 2014, Biochimica et biophysica acta.

An Anti-inflammatory microRNA Signature Distinguishes Group 3 Innate Lymphoid Cells From Natural Killer Cells in Human Decidua

N. Tumino, L. Moretta, M. Mingari, 2020, Frontiers in Immunology.

PD-1 is expressed by and regulates human group 3 innate lymphoid cells in human decidua

D. Olive, E. Fulcheri, E. Munari, 2019, Mucosal Immunology.

Generation of a Novel Regulatory NK Cell Subset from Peripheral Blood CD34+ Progenitors Promoted by Membrane-Bound IL-15

S. Chouaib, S. Ferrini, S. Negrini, 2008, PloS one.

Natural Killer (NK)/melanoma cell interaction induces NK-mediated release of chemotactic High Mobility Group Box-1 (HMGB1) capable of amplifying NK cell recruitment

L. Moretta, M. Parodi, S. Sivori, 2015, Oncoimmunology.

Induction of anti-tumor immune response by bispecific monoclonal antibodies (bimAbs).

S. Canevari, S. Ferrini, L. Moretta, 1992, Pharmacological research.

Immunoregulatory subpopulations of human T lymphocytes.

L. Moretta, A. Moretta, M. Mingari, 1979, Biomedicine / [publiee pour l'A.A.I.C.I.G.].

Presence of innate lymphoid cells in pleural effusions of primary and metastatic tumors: Functional analysis and expression of PD‐1 receptor

N. Tumino, E. Munari, L. Moretta, 2019, International journal of cancer.

The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity

R. Biassoni, L. Moretta, A. Moretta, 1999, European journal of immunology.

Recent Progress in Human Natural Killer Cell Ontogeny

R. Biassoni, L. Moretta, A. Poggi, 1994 .

Identification of PVR ( CD 155 ) and Nectin-2 ( CD 112 ) as Cell Surface Ligands for the Human DNAM-1 ( CD 226 ) Activating Molecule

L. Moretta, N. Reymond, A. Moretta, 2003 .

Comparison of three validated PD-L1 immunohistochemical assays in urothelial carcinoma of the bladder: interchangeability and issues related to patient selection

G. Netto, F. Ciompi, C. Luchini, 2022, Frontiers in Immunology.

The roles of different forms of IL-15 in human melanoma progression

N. Tumino, S. Chouaib, I. Caruana, 2023, Frontiers in Immunology.

Differential NKp30 Inducibility in Chimpanzee NK Cells and Conserved NK Cell Phenotype and Function in Long-Term HIV-1-Infected Animals1

J. Heeney, R. Biassoni, L. Moretta, 2007, The Journal of Immunology.

Increased expression of the natural killer cell inhibitory receptor CD85j/ILT2 on antigen‐specific effector CD8 T cells and its impact on CD8 T‐cell function

J. Lieberman, M. Lederman, Sang-Kyung Lee, 2004, Immunology.

Familial hemophagocytic lymphohistiocytosis: a model for understanding the human machinery of cellular cytotoxicity

V. Cetica, L. Moretta, M. Aricò, 2011, Cellular and Molecular Life Sciences.

CD8+ NK cells are predominant in chimpanzees, characterized by high NCR expression and cytokine production, and preserved in chronic HIV‐1 infection

J. Heeney, R. Biassoni, L. Moretta, 2010, European journal of immunology.

Erratum: Selective increase of a subset of T cell receptor γδT lymphocytes in the peripheral blood of patients with human immunodeficiency virus type 1 infection (J Infect Dis (1992) 165 (917-919))

E. Ciccone, S. Ferrini, L. Moretta, 1992 .

Interleukin-2 production in response to phytohemagglutinin is not necessarily dependent upon the T3-mediated pathway of T-cell activation.

L. Moretta, M. Mingari, F. Gerosa, 1986, Clinical immunology and immunopathology.

Cyclosporin-A inhibits IL-2 production by all human T-cell clones having this function, independent of the T4/T8 phenotype or the coexpression of cytolytic activity.

A. Nicolin, R. Biassoni, S. Ferrini, 1986, Clinical immunology and immunopathology.

MicroRNA analysis of Natural Killer cell-derived exosomes: the microRNA let-7b-5p is enriched in exosomes and participates in their anti-tumor effects against pancreatic cancer cells

N. Tumino, L. Moretta, L. Quatrini, 2023, Oncoimmunology.

Treatment of stage IIIB non-small-cell lung cancer with surgery followed by infusion of tumor infiltrating lymphocytes and recombinant interleukin-2: a pilot study.

L. Moretta, L. Santi, Giorgio Reggiardo, 1996, Journal of Immunotherapy with Emphasis on Tumor Immunology.

p40 molecule regulates NK cell activation mediated by NK receptors for HLA class I antigens and TCR-mediated triggering of T lymphocytes.

L. Moretta, A. Poggi, A Poggi, 1997, International immunology.

HLA Haploidentical Stem Cell Transplantation After Removal of αβ + T Lymphocytes and B Lymphocytes Is an Effective Treatment for Children with Life-Threatening, Non-Malignant Disorders

S. Rutella, F. Locatelli, L. Moretta, 2012 .

NK-cell phenotype at interruption underlies widely divergent duration of CD4+-guided antiretroviral treatment interruption.

C. Mussini, L. Moretta, A. Cossarizza, 2011, International immunology.

Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 surface receptors.

L. Moretta, C. Romagnani, M. Mingari, 2001, Advances in experimental medicine and biology.

Effect of human natural killer and gammadelta T cells on the growth of human autologous melanoma xenografts in SCID mice.

F. Lozupone, F. Belardelli, G. Parmiani, 2004, Cancer research.

Selective increase of a subset of T cell receptor gamma delta T lymphocytes in the peripheral blood of patients with human immunodeficiency virus type 1 infection.

E. Ciccone, S. Ferrini, L. Moretta, 1992, The Journal of infectious diseases.

Signal transducing mechanisms involved in human T cell activation via surface T44 molecules. Comparison with signals transduced via the T cell receptor complex

D. Olive, G. Pantaleo, L. Moretta, 1986, European journal of immunology.

MULTIPLE RELAPSES OF VISCERAL LEISHMANIASIS IN AN ADOLESCENT WITH IDIOPATHIC CD4+ LYMPHOCYTOPENIA ASSOCIATED WITH NOVEL IMMUNOPHENOTYPIC AND MOLECULAR FEATURES

A. Fischer, U. Dianzani, A. Plebani, 2009, The Pediatric infectious disease journal.

AATF/Che-1 RNA polymerase II binding protein overexpression reduces the anti-tumor NK-cell cytotoxicity through activating receptors modulation

N. Tumino, G. Piaggio, S. Iezzi, 2023, Frontiers in Immunology.

Receptor modulation and functional activation of human CD34+Lin−‐derived immature NK cells in vitro by Mycobacterium bovis Bacillus Calmette‐Guerin (BCG)

R. Biassoni, L. Moretta, F. Bozzano, 2012, European journal of immunology.

Revisited function of human NK cell subsets

L. Moretta, A. De Maria, 2011, Cell cycle.

Molecular classification of mature aggressive B-cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens

F. Locatelli, S. Mboup, L. Moretta, 2017 .

Inherent transcriptional signatures of NK cells are associated with response to IFNα + rivabirin therapy in patients with Hepatitis C Virus

F. Marincola, D. Bedognetti, K. Matsuura, 2015, Journal of Translational Medicine.

PROLIFERATIVE RESPONSIVENESS OF TWO DISTINCT HUMAN T-CELL SUBPOPULATIONS TO CON A, PHA AND ALLOANTIGENS

P. Lydyard, M. Ferrarini, M. Cooper, 1977 .

Lymphocyte effector mechanisms in innate and adaptive immunity.

L. Moretta, 2005, Current opinion in immunology.

Human toll-like receptor 8 (TLR8) in NK cells: implication for cancer immunotherapy.

L. Moretta, E. Maggi, I. Veneziani, 2023, Immunology letters.

Differential NKp30 inducibility in chimpanzee NK cells and conserved NK cell phenotype and function in long-term HIV-1-infected animals

J. Heeney, R. Biassoni, L. Moretta, 2007, The Journal of Immunology.

TGFβ1 inhibits the surface expression of the NKp30 and NKG2D triggering NK receptors: consequences for the NK-mediated killing of dendritic cells

R. Biassoni, L. Moretta, A. Moretta, 2003 .

Innate immune effectors in cancer.

L. Moretta, P. Vacca, 2023, Seminars in immunology.

Selective Preservation of Bone Marrow Mature Recirculating but Not Marginal Zone B Cells in Murine Models of Chronic Inflammation

L. Leng, R. Bucala, F. Sanvito, 2010, PloS one.

T-Cell Depleted HLA-Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (haplo-HSCT) Followed By Donor Lymphocyte Infusion with T Cells Transduced with the Inducible Caspase 9 (iC9) Suicide Gene in Children with Hematological Malignancies

I. Caruana, F. Locatelli, L. Moretta, 2016 .

Transplantation of T-Cell Depleted Peripheral Blood Haematopoietic Stem Cells from an HLA-Disparate Family Donor for Children with Hematological Malignancies.

F. Locatelli, P. Comoli, L. Moretta, 2007 .

Expression and function of NKRP1A molecule on human monocytes and dendritic cells

L. Moretta, A. Poggi, M. Zocchi, 1997, European journal of immunology.

Human NK cells

L. Moretta, 2015 .

Molecular Cloning of NKp46: A Novel Member of the Immunoglobulin Superfamily Involved in Triggering of Natural Cytotoxicity

R. Biassoni, L. Moretta, A. Malaspina, 1998, The Journal of experimental medicine.

NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis

L. Moretta, A. Moretta, S. Sivori, 1998, The Journal of experimental medicine.

Perilymphatic injections of recombinant interleukin‐2 (rIL‐2) partially correct the immunologic defects in patients with advanced head and neck squamous cell carcinoma

L. Moretta, G. Margarino, M. Scala, 1992, The Laryngoscope.

Cytokine-induced expression of killer inhibitory receptors in human T lymphocytes.

R. Bellomo, L. Moretta, M. Mingari, 1998, European cytokine network.

Identification of four subsets of human CD3-CD16+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition

E. Ciccone, L. Moretta, A. Moretta, 1990, The Journal of experimental medicine.

Increased proportion of CD16+ NK cells in the colonic lamina propria of inflammatory bowel disease patients, but not after azathioprine treatment

M. Altfeld, B. Gazzard, G. Nuovo, 2010, Alimentary pharmacology & therapeutics.

Structure of the Ly49 family of natural killer (NK) cell receptors and their interaction with MHC class I molecules

R. Biassoni, L. Moretta, N. Dimasi, 2004, Immunologic research.

SpecificRecognitionofHuman CD3 -CD16+ Natural KillerCellsRequirestheExpressionofan Autosomic RecessiveGene on TargetCells

J. Guardiola, E. Ciccone, R. Biassoni, 1990 .

, function of NKp 46-and NKG 2 D-activating receptors and regulates NK-cell The tryptophan catabolite l-kynurenine inhibits the surface expression

L. Moretta, M. Vitale, C. Cantoni, 2006 .

Expression of HLA class l‐specific inhibitory receptors by chronically activated cytolytic T lymphocytes: useful or harmful to the host?

L. Moretta, M. Mingari, C. Vitale, 1997, Melanoma research.

The C gamma 1-encoded disulphide-linked and the C gamma 2-encoded nondisulphide-linked forms of the gamma/delta heterodimer use different gamma and delta variable regions.

B. Falini, P. Pelicci, M. Fagioli, 1990, Blood.

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

J. Paul Robinson, Jonathan A. Rebhahn, B. Becher, 2017, European journal of immunology.

MSC and innate immune cell interactions: A lesson from human decidua.

L. Moretta, M. Mingari, P. Vacca, 2015, Immunology letters.

NCR+ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures

L. Moretta, M. Truini, M. Mingari, 2015, Nature Communications.

Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion.

F. Locatelli, R. Masetti, R. Handgretinger, 2017, Blood.

Killer Ig-like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation.

F. Locatelli, L. Moretta, A. Moretta, 2011, Blood.

Phenotypic and functional heterogeneity of human NK cells developing after umbilical cord blood transplantation: a role for human cytomegalovirus?

F. Locatelli, F. Frassoni, L. Moretta, 2012, Blood.

CD56brightCD16− Killer Ig-Like Receptor− NK Cells Display Longer Telomeres and Acquire Features of CD56dim NK Cells upon Activation1

A. Thiel, M. Dlakić, B. Shenker, 2007, The Journal of Immunology.

Human NK cells directly recognize Mycobacterium bovis via TLR2 and acquire the ability to kill monocyte-derived DC.

L. Moretta, A. Moretta, M. Falco, 2008, International immunology.

Removal Of Alpha/Beta+ T Cells and Of CD19+ B Cells From The Graft Translates Into Rapid Engraftment, Absence Of Visceral Graft-Versus-Host Disease and Low Transplant-Related Mortality In Children With Acute Leukemia Given HLA-Haploidentical Hematopoietic Stem Cell Transplantation

S. Rutella, F. Locatelli, M. Andreani, 2013 .

Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells.

R. Biassoni, L. Moretta, A. Moretta, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Molecular de ﬁ nition of group 1 innate lymphoid cells in the mouse uterus

L. Moretta, I. Filipovic, M. Mingari, 2022 .

E. Ciccone, L. Moretta, A. Moretta, 1990, The Journal of experimental medicine.

Analysis of the molecular mechanism involved in 2B4‐mediated NK cell activation: evidence that human 2B4 is physically and functionally associated with the linker for activation of T cells

R. Biassoni, L. Moretta, A. Moretta, 2000, European journal of immunology.

p75/AIRM1 and CD33, two sialoadhesin receptors that regulate the proliferation or the survival of normal and leukemic myeloid cells

L. Moretta, C. Romagnani, M. Mingari, 2001, Immunological reviews.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Amit A. Patel, F. Ginhoux, D. Busch, 2021, European journal of immunology.

Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison

E. Reinherz, M. Cooper, L. Moretta, 1980, The Journal of experimental medicine.

Functional characterization of human thymocytes: a limiting dilution analysis of precursors with proliferative and cytolytic activities.

M. López-Botet, L. Moretta, 1985, Journal of immunology.

A novel KIR-associated function: evidence that CpG DNA uptake and shuttling to early endosomes is mediated by KIR3DL2.

E. Romeo, A. Viola, C. Soldani, 2010, Blood.

Differential NKp30 inducibility in chimpanzee NK cells and conserved NK cell phenotype and function in long-term HIV-1-infected animals (Journal of Immunology (2007) 178, (1702-1712))

R. Biassoni, L. Moretta, M. Mingari, 2007 .