Wayland Yeung

发表

Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases

N. Kannan, K. Rasheed, Liang-Chin Huang, 2020, eLife.

Quantitative Structure–Mutation–Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction

N. Kannan, K. Rasheed, Liang-Chin Huang, 2020, BMC bioinformatics.

Mutual antagonism between Hippo signaling and cyclin E drives intracellular pattern formation

N. Kannan, J. Frankel, Wayland Yeung, 2020, The Journal of cell biology.

Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases

N. Kannan, K. Rasheed, Liang-Chin Huang, 2019, bioRxiv.

In Vitro Selection of Diversely Functionalized Aptamers.

R. Hili, Wayland Yeung, Dehui Kong, 2017, Journal of the American Chemical Society.

Modularity of the hydrophobic core and evolution of functional diversity in fold A glycosyltransferases

N. Kannan, K. Moremen, Rahil Taujale, 2022, The Journal of biological chemistry.

Foulkes, D. M. et al. (2018) Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer

D. Drewry, P. Eyers, N. Kannan, 2018 .

Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases

R. Joseph, A. Andreotti, N. Kannan, 2019, Proceedings of the National Academy of Sciences.

Quantitative Structure–Mutation–Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction

N. Kannan, K. Rasheed, Liang-Chin Huang, 2020, BMC bioinformatics.

Tree visualizations of protein sequence embedding space enable improved functional clustering of diverse protein superfamilies

Sheng Li, N. Kannan, W. Lanzilotta, 2023, Briefings Bioinform..

An explainable unsupervised framework for alignment-free protein classification using sequence embeddings

Sheng Li, N. Kannan, W. Lanzilotta, 2022, bioRxiv.

Enzymatic Synthesis of Sequence-Defined Synthetic Nucleic Acid Polymers with Diverse Functional Groups.

R. Hili, Wayland Yeung, Dehui Kong, 2016, Angewandte Chemie.

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

A. Koide, S. Koide, N. Kannan, 2021, Nature Communications.

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues

W. Patrick, N. Kannan, J. Sandow, 2020, Nature Communications.

mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif

Susan S. Taylor, A. Newton, N. Kannan, 2021, Science Signaling.

Mapping the glycosyltransferase fold landscape using interpretable deep learning

N. Kannan, K. Moremen, Rahil Taujale, 2021, Nature Communications.

Mapping the glycosyltransferase fold landscape using deep learning

N. Kannan, K. Moremen, Rahil Taujale, 2021, bioRxiv.

Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells

D. Drewry, W. Zuercher, P. Eyers, 2018, Science Signaling.

Emerging roles of the αC‐β4 loop in protein kinase structure, function, evolution, and disease

Wayland Yeung, Zheng Ruan, Natarajan Kannan, 2020, IUBMB life.

Quantitative Structure–Mutation–Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction

Ye Wang, Natarajan Kannan, Liang-Chin Huang, 2019, BMC Bioinformatics.

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues

N. Kannan, J. Sandow, Cheree Fitzgibbon, 2020, Nature Communications.

The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region

N. Kannan, Lijun Liu, N. Jura, 2019, The Journal of Biological Chemistry.

Dark kinase annotation, mining and visualization using the Protein Kinase Ontology

K. Kochut, N. Kannan, Liang-Chin Huang, 2022, bioRxiv.

Repurposing covalent EGFR/HER2 inhibitors for on-target degradation of human Tribbles 2 (TRIB2) pseudokinase

D. Drewry, W. Zuercher, P. Eyers, 2018, bioRxiv.

Tracing the origin and evolution of pseudokinases across the tree of life

Krys J. Kochut, Wayland Yeung, Rahil Taujale, 2019, Science Signaling.

Evolution of Functional Diversity in the Holozoan Tyrosine Kinome

N. Kannan, Annie Kwon, Rahil Taujale, 2021, bioRxiv.

KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases

P. Eyers, N. Kannan, Liang-Chin Huang, 2021, BMC Bioinformatics.

Functional classification and validation of yeast prenylation motifs using machine learning and genetic reporters

N. Kannan, Zhongliang Zhou, Wayland Yeung, 2021, bioRxiv.

Evolutionary Outcomes of Diversely-Functionalized Aptamers Isolated from In Vitro Evolution.

R. Hili, Wayland Yeung, Dehui Kong, 2019, ACS synthetic biology.

Phosformer: an explainable transformer model for protein kinase-specific phosphorylation predictions

N. Kannan, Zhongliang Zhou, Wayland Yeung, 2023, Bioinformatics.

Generation of Synthetic Copolymer Libraries by Combinatorial Assembly on Nucleic Acid Templates.

R. Hili, Wayland Yeung, Dehui Kong, 2016, ACS combinatorial science.

Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases

P. Eyers, N. Kannan, D. Byrne, 2023, bioRxiv.

A comprehensive in vivo screen of yeast farnesyltransferase activity reveals broad reactivity across a majority of CXXX sequences

N. Kannan, Wayland Yeung, Junehyung Kim, 2023, bioRxiv.

Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases

P. Eyers, N. Kannan, D. Byrne, 2023, bioRxiv.

Alignment-free estimation of sequence conservation for identifying functional sites using protein sequence embeddings

Sheng Li, N. Kannan, Zhongliang Zhou, 2023, Briefings Bioinform..

An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function

N. Kannan, M. Llimargas, I. Muñoz, 2022, bioRxiv.

Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases

P. Eyers, N. Kannan, D. Byrne, 2023, eLife.

Redox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms

P. Eyers, N. Kannan, D. Byrne, 2024, bioRxiv.