J. Sai

发表

Effects of flow and diffusion on chemotaxis studies in a microfabricated gradient generator.

J. Wikswo, M. Stremler, A. Richmond, 2005, Lab on a chip.

Microfluidic switching system for analyzing chemotaxis responses of wortmannin-inhibited HL-60 cells

J. Wikswo, A. Richmond, J. Sai, 2008, Biomedical microdevices.

Bimodal analysis reveals a general scaling law governing nondirected and chemotactic cell motility.

Alka A. Potdar, V. Quaranta, P. Cummings, 2010, Biophysical journal.

Study of Chemotaxis and Cell-Cell Interactions in Cancer with Microfluidic Devices.

J. Wikswo, Matthew B. Rogers, A. Richmond, 2016, Methods in enzymology.

Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis.

A. Richmond, L. Lapierre, J. Goldenring, 2004, Molecular biology of the cell.

Drugging an undruggable pocket on KRAS

M. Koegl, S. Fesik, A. Waterson, 2019, Proceedings of the National Academy of Sciences.

The Yin/Yan of CCL2: a minor role in neutrophil anti-tumor activity in vitro but a major role on the outgrowth of metastatic breast cancer lesions in the lung in vivo

Nicole A. Lavender, G. Ayers, A. Richmond, 2017, BMC Cancer.

Adaptor Protein2 (AP2) Orchestrates CXCR2‐Mediated Cell Migration

A. Richmond, J. Sai, Oriana E. Hawkins, 2014, Traffic.

Chemokine receptor internalization and intracellular trafficking.

A. Richmond, J. Sai, E. Schutyser, 2005, Cytokine & growth factor reviews.

Parallel Phosphatidylinositol 3-Kinase (PI3K)-dependent and Src-dependent Pathways Lead to CXCL8-mediated Rac2 Activation and Chemotaxis*

J. Wikswo, A. Richmond, J. Sai, 2008, Journal of Biological Chemistry.

Hsc/Hsp70 Interacting Protein (Hip) Associates with CXCR2 and Regulates the Receptor Signaling and Trafficking*

Wei Yang, A. Richmond, J. Sai, 2002, The Journal of Biological Chemistry.

Phosphorylation-independent Association of CXCR2 with the Protein Phosphatase 2A Core Enzyme*

Wei Yang, A. Richmond, J. Sai, 2001, The Journal of Biological Chemistry.

Discovery and Structure-Based optimization of potent and selective WDR5 inhibitors containing a dihydroisoquinolinone bicyclic core

S. Fesik, R. Coffey, J. Sai, 2020 .

VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis

A. Ham, A. Richmond, J. Sai, 2009, Journal of Cell Science.

RACK1 Regulates Specific Functions of Gβγ*

H. Hamm, J. Sai, F. Lin, 2004, Journal of Biological Chemistry.

RACK1 regulates specific functions of Gbetagamma.

H. Hamm, J. Sai, F. Lin, 2004, The Journal of biological chemistry.

Ikk4a/Arf Inactivation with Activation of the NF-kB/IL-6 Pathway Is Sufficient to Drive the Development and Growth of Angiosarcoma

G. Ayers, A. Lazar, D. Lev, 2012 .

Structural Elucidation of Peptide Binding to KLHL-12, a Substrate Specific Adapter Protein in a Cul3-Ring E3 Ligase Complex.

E. Olejniczak, S. Fesik, J. Sai, 2020, Biochemistry.

Characterization of chemokine receptor CXCR2 interacting proteins using a proteomics approach to define the CXCR2 "chemosynapse".

A. Ham, A. Richmond, J. Sai, 2009, Methods in enzymology.

Reply to Tran et al.: Dimeric KRAS protein–protein interaction stabilizers

M. Koegl, S. Fesik, A. Waterson, 2020, Proceedings of the National Academy of Sciences.

Different circadian oscillators control Ca(2+) fluxes and lhcb gene expression.

C. Johnson, J. Sai, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.

E. Olejniczak, S. Fesik, O. Rossanese, 2018, Journal of medicinal chemistry.

Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods.

E. Olejniczak, S. Fesik, A. Waterson, 2020, Journal of medicinal chemistry.

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.

S. Fesik, A. Waterson, O. Rossanese, 2018, Journal of medicinal chemistry.

Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.

S. Fesik, A. Waterson, O. Rossanese, 2018, Journal of medicinal chemistry.

PI3K Inhibition Reduces Mammary Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 Responses

Andrew C Johnson, Nicole A. Lavender, G. Ayers, 2016, Clinical Cancer Research.

Short tail with skin lesion phenotype occurs in transgenic mice with keratin‐14 promoter‐directed expression of mutant CXCR2

A. Richmond, J. Sai, Yingjun Su, 2008, Journal of leukocyte biology.

INK4a/ARF [corrected] inactivation with activation of the NF-κB/IL-6 pathway is sufficient to drive the development and growth of angiosarcoma.

G. Ayers, A. Lazar, D. Lev, 2012, Cancer research.

Epithelial NF-κB signaling promotes EGFR-driven lung carcinogenesis via macrophage recruitment

L. Gleaves, T. Blackwell, F. Yull, 2016, Oncoimmunology.

Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization.

S. Fesik, J. Sai, Bin Zhao, 2022, Journal of medicinal chemistry.

Discovery and Structure-Based Optimization of Potent and Selective WD repeat domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.

S. Fesik, R. Coffey, M. Inoue, 2019, Journal of medicinal chemistry.

Monomeric and Dimeric CXCL8 Are Both Essential for In Vivo Neutrophil Recruitment

K. Rajarathnam, R. Garofalo, A. Richmond, 2010, PloS one.

LIM and SH3 Protein -1 Modulates CXCR2-Mediated Cell Migration

A. Richmond, J. Sai, C. Chew, 2010, PloS one.

Cell surface heparan sulfate participates in CXCL1-induced signaling.

A. Richmond, J. Sai, D. Wang, 2003, Biochemistry.

Functional characterization of chimpanzee cytomegalovirus chemokine, vCXCL-1(CCMV).

A. Richmond, J. Sai, M. Penfold, 2007, Virology.

Dark-Stimulated Calcium Ion Fluxes in the Chloroplast Stroma and Cytosol Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.000653.

C. Johnson, J. Sai, 2002, The Plant Cell Online.

Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses.

E. Olejniczak, S. Fesik, A. Waterson, 2019, ACS chemical biology.

Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models

S. Fesik, Qi Liu, S. Chowdhury, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Protein-Protein Interaction.

S. Fesik, A. Waterson, O. Rossanese, 2019, Journal of medicinal chemistry.

The C-terminal domain LLKIL motif of CXCR2 is required for ligand-mediated polarization of early signals during chemotaxis

A. Richmond, J. Sai, D. Wang, 2004, Journal of Cell Science.

IQGAP1 Is a Novel CXCR2-Interacting Protein and Essential Component of the “Chemosynapse”

A. Ham, A. Richmond, J. Sai, 2011, PloS one.

The IL Sequence in the LLKIL Motif in CXCR2 Is Required for Full Ligand-induced Activation of Erk, Akt, and Chemotaxis in HL60 Cells*

Ann Richmond, J. Wikswo, A. Richmond, 2006, Journal of Biological Chemistry.

The Yin/Yan of CCL2: a minor role in neutrophil anti-tumor activity in vitro but a major role on the outgrowth of metastatic breast cancer lesions in the lung in vivo

Nicole A. Lavender, G. Ayers, A. Richmond, 2017, BMC Cancer.

Bimodal analysis reveals a general scaling law governing nondirected and chemotactic cell motility.

Alka A. Potdar, A. Richmond, J. Sai, 2010, Biophysical journal.