D. Vignali

H. Yano, D. Vignali, C. Workman, 2021, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Non-Cell Autonomous Expression of TNF-α-Converting Enzyme ADAM17 Is Required for Normal Lymphocyte Development1

P. Dempsey, K. Boyd, D. Vignali, 2007, The Journal of Immunology.

Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency.

S. Ziegler, J. Rehg, D. Finkelstein, 2012, Immunity.

T cell regulation

C. Drake, D. Pardoll, J. Powell, 1995 .

Preferential control of induced regulatory T cell homeostasis via a Bim/Bcl-2 axis

D. Green, D. Vignali, C. Workman, 2012, Cell Death and Disease.

Lymphocyte Activation Gene-3 (CD223) Negative Regulation of T Cell Homeostasis by

D. Vignali, C. Workman, 2017 .

Scalable signaling mediated by T cell antigen receptor–CD3 ITAMs ensures effective negative selection and prevents autoimmunity

Harvir Singh, Dario A A Vignali, Paul J Utz, 2008, Nature Immunology.

Negative Regulation of T Cell Homeostasis by Lymphocyte Activation Gene-3 (CD223)1

D. Vignali, C. Workman, 2005, The Journal of Immunology.

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

W. Paul, P. Doherty, J. Ihle, 1996, Nature.

Regulatory T cells and inhibitory cytokines in autoimmunity.

D. Vignali, M. Bettini, 2009, Current opinion in immunology.

People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burden

Janet S. Lee, Jishnu Das, P. Benos, 2021, Cell Reports Medicine.

Intratumoral regulatory T cells: markers, subsets and their impact on anti‐tumor immunity

D. Vignali, C. Workman, H. Yano, 2019, Immunology.

LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes

J. Kolls, D. Normolle, M. Chikina, 2017, Science Immunology.

Interleukin-35 Limits Anti-Tumor Immunity.

Deepali V. Sawant, Greg M. Delgoffe, P. Vogel, 2016, Immunity.

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

D. Finkelstein, Greg M. Delgoffe, P. Vogel, 2013, Nature.

Interleukin-35: A Novel Mediator of Peripheral Tolerance

Greg M. Delgoffe, D. Vignali, 2013, Cytokine Frontiers.

Cutting Edge: Human Regulatory T Cells

D. Vignali, C. Workman, Vandana Chaturvedi, 2011 .

Infectious Tolerance Require IL-35 To Mediate Suppression and Cutting Edge: Human Regulatory T Cells

D. Vignali, C. Workman, Vandana Chaturvedi, 2011 .

Require IL-35 To Mediate Suppression and Cutting Edge : Human Regulatory T Cells

D. Vignali, C. Workman, Vandana Chaturvedi, 2011 .

TIM‐1 Signaling Is Required for Maintenance and Induction of Regulatory B Cells

V. Kuchroo, S. Xiao, C. Brooks, 2015, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

The plasticity and stability of regulatory T cells

Shimon Sakaguchi, Herman Waldmann, Dario A. A. Vignali, 2013, Nature Reviews Immunology.

LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L.

S. Beyaz, M. Sykes, D. Vignali, 2011, Blood.

Membrane Association of the CD3ε Signaling Domain Is Required for Optimal T Cell Development and Function

P. Dash, P. Thomas, K. Wucherpfennig, 2014, The Journal of Immunology.

The battle against immunopathology: infectious tolerance mediated by regulatory T cells

D. Vignali, D. Gravano, 2011, Cellular and Molecular Life Sciences.

Treg-specific LAG3 deletion reveals a key role for LAG3 in regulatory T cells to inhibit CNS autoimmunity

A. Sharpe, D. Vignali, C. Workman, 2018, The Journal of Immunology.

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

P. Doherty, J. Ihle, G. Grosveld, 1996, Nature.

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

J. Keats, P. L. Bergsagel, M. Karin, 2008, Nature Immunology.

Essential Cytoplasmic Translocation of a Cytokine Receptor–Assembled Signaling Complex

M. Karin, Ping-Hui Tseng, Jun-Li Luo, 2008, Science.

Interpreting mixed signals: the cell's cytokine conundrum.

Greg M. Delgoffe, P. Murray, D. Vignali, 2011, Current opinion in immunology.

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses

Stephen J. Turner, Anthony W. Purcell, Peter C. Doherty, 2011, Proceedings of the National Academy of Sciences.

The two membrane proximal domains of CD4 interact with the T cell receptor

J. Strominger, D. Vignali, R. Mittler, 1996, The Journal of experimental medicine.

Lymphocyte Activation Gene-3 (LAG-3) Negatively Regulates Environmentally-Induced Autoimmunity

T. McGaha, M. Monestier, D. Vignali, 2014, PloS one.

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

Deepali V. Sawant, J. Luketich, D. Corry, 2019, Nature Immunology.

Regulatory T Cells in the Tumor Microenvironment.

D. Vignali, C. Workman, Rebekah Dadey, 2020, Advances in experimental medicine and biology.

Cutting Edge: Molecular Analysis of the Negative Regulatory Function of Lymphocyte Activation Gene-31

D. Vignali, C. Workman, K. Dugger, 2002, The Journal of Immunology.

PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells.

C. Klein, K. Welte, D. Vignali, 2011, Blood.

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

M. Karin, Ping-Hui Tseng, D. Vignali, 2010, Nature Immunology.

1049 Reconstruction of gene regulatory networks dissects transcriptional control of intratumoral regulatory T cells

P. Benos, D. Vignali, C. Workman, 2022, Regular and Young Investigator Award Abstracts.

1048 Interplay of IL-12 and IFNg to induce Tregfragility within the tumor microenvironment

D. Vignali, C. Workman, E. Scott, 2022, Regular and Young Investigator Award Abstracts.

Combinatorial Immunotherapy

C. Drake, A. Korman, D. Vignali, 2012, Oncoimmunology.

Microenvironment and Immunology Immune InhibitoryMolecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

C. Liu, C. Drake, G. Netto, 2012 .

STAT heterodimers in immunity

Greg M. Delgoffe, D. Vignali, 2013, JAK-STAT.

Aplp1 and the Aplp1-Lag3 Complex facilitates transmission of pathologic α-synuclein

T. Dawson, V. Dawson, Cong Liu, 2021, bioRxiv.

Diabetes in the Absence of LAG-3 Cutting Edge: Accelerated Autoimmune

C. Drake, A. Korman, M. Selby, 2011 .

T cell-driven initiation and propagation of autoimmune diabetes.

D. Vignali, M. Bettini, 2011, Current opinion in immunology.

A picornaviral 2A-like sequence-based tricistronic vector allowing for high-level therapeutic gene expression coupled to a dual-reporter system.

J. Tolar, R. McIvor, A. Wilber, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Regulatory T cell stability is maintained by a neuropilin-1 : semaphorin-4 a axis

Jody, D. Finkelstein, Greg M. Delgoffe, 2016 .

Inducible T-cell receptor expression in precursor T cells for leukemia control

A. Schambach, D. Wedekind, B. Schiedlmeier, 2015, Leukemia.

Receptors | T-Cell Antigen Receptor

Vivian Kitainda, D. Vignali, L. Jones, 2021, Encyclopedia of Biological Chemistry III.

The interaction between CD4 and MHC class II molecules and its effect on T cell function.

D. Vignali, 1994, Behring Institute Mitteilungen.

The battle against immunopathology: infectious tolerance mediated by regulatory T cells

D. Vignali, D. Gravano, 2012, Cellular and Molecular Life Sciences.

IFNγ-induction of T_H1-like regulatory T cells controls antiviral responses

J. Alcorn, L. Kane, Lyndsay Avery, 2023, Nature Immunology.

A Fox of a different color: FoxA1 programs a new regulatory T cell subset

Greg M. Delgoffe, D. Vignali, 2014, Nature Medicine.

Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves TH1/TFH fate bifurcation in malaria

Neil D. Lawrence, S. Teichmann, O. Stegle, 2017, Science Immunology.

LAG-3 as the third checkpoint inhibitor

D. Vignali, C. Workman, V. Aggarwal, 2023, Nature Immunology.

Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay.

D. Vignali, D. Vignali, R. T. Carson, 1999, Journal of immunological methods.

The composition and signaling of the IL-35 receptor are unconventional

K. Garcia, C. Drake, C. Hunter, 2012, Nature Immunology.

T cell receptor recognition of MHC class II-bound peptide flanking residues enhances immunogenicity and results in altered TCR V region usage.

D. Vignali, D. Woodland, D. Vignali, 1997, Immunity.

Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity

E. Lipson, R. Ferris, D. Normolle, 2020, Nature Immunology.

Régulation des lymphocytes T

C. Drake, D. Pardoll, J. Powell, 2004 .

Regulation par lymphocytes t

C. Drake, D. Pardoll, J. Powell, 2004 .

Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency.

S. Ziegler, J. Rehg, D. Finkelstein, 2012, Immunity.

Essential Cytoplasmic Translocation of a Cytokine Receptor–Assembled Signaling Complex

M. Karin, Ping-Hui Tseng, Jun-Li Luo, 2008, Science.

Expansion of EBV latent membrane protein 2a specific cytotoxic T cells for the adoptive immunotherapy of EBV latency type 2 malignancies: influence of recombinant IL12 and IL15.

H. Heslop, C. Rooney, W. Xie, 2003, Cytotherapy.

LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L.

S. Beyaz, M. Sykes, D. Vignali, 2011, Blood.