D. Medaglini

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Characterization of the Antigen-Specific CD4+ T Cell Response Induced by Prime-Boost Strategies with CAF01 and CpG Adjuvants Administered by the Intranasal and Subcutaneous Routes

D. Christensen, A. Ciabattini, Gennaro Prota, 2015, Front. Immunol..

Role of the Microbiota in the Modulation of Vaccine Immune Responses

A. Ciabattini, D. Medaglini, R. Olivieri, 2019, Front. Microbiol..

Computational Analysis of Multiparametric Flow Cytometric Data to Dissect B Cell Subsets in Vaccine Studies

A. Ciabattini, G. Pozzi, D. Medaglini, 2019, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population

C. Franceschi, R. Rappuoli, P. Garagnani, 2020, Seminars in Immunopathology.

CD4+ T Cell Priming as Biomarker to Study Immune Response to Preventive Vaccines

A. Ciabattini, D. Medaglini, E. Pettini, 2013, Front. Immunol..

Peptide-specific T helper cells identified by MHC class II tetramers differentiate into several subtypes upon immunization with CAF01 adjuvanted H56 tuberculosis vaccine formulation.

P. Andersen, D. Christensen, A. Ciabattini, 2015, Vaccine.

Modulation of Primary Immune Response by Different Vaccine Adjuvants

A. Ciabattini, P. Andersen, G. Pozzi, 2016, Front. Immunol..

Transcriptomics of the Vaccine Immune Response: Priming With Adjuvant Modulates Recall Innate Responses After Boosting

G. Gilfillan, D. Kazmin, A. Ciabattini, 2018, Front. Immunol..

Gram-positive commensal bacteria for mucosal vaccine delivery.

V. Fischetti, G. Pozzi, D. Medaglini, 1996, Current opinion in biotechnology.

Expression of foreign proteins on gram-positive commensal bacteria for mucosal vaccine delivery.

V. Fischetti, G. Pozzi, D. Medaglini, 1993, Current opinion in biotechnology.

Vaccination in the elderly: The challenge of immune changes with aging.

Christine Nardini, Paolo Garagnani, Claudio Franceschi, 2018, Seminars in immunology.

Vaccine adjuvants: a priority for vaccine research.

R. Shattock, D. Medaglini, A. Harandi, 2010, Vaccine.

The microbicide cyanovirin-N expressed on the surface of commensal bacterium Streptococcus gordonii captures HIV-1

M. Boyd, J. Mcmahon, Toshiyuki Mori, 2002, AIDS.

Physicochemical Characterization Cascade of Nanoadjuvant–Antigen Systems for Improving Vaccines

L. Calzolai, J. Ponti, S. Gioria, 2021, Vaccines.

The European effort towards the development of mucosal vaccines for poverty-related diseases.

R. Rappuoli, D. Medaglini, O. Olesen, 2009, Vaccine.

Innovation Partnership for a Roadmap on Vaccines in Europe (IPROVE): A vision for the vaccines of tomorrow.

P. Denoel, D. Medaglini, O. Leroy, 2018, Vaccine.

In vivo mucosal delivery of bioactive human interleukin 1 receptor antagonist produced by Streptococcus gordonii

P. Bossù, L. Hammarström, G. Pozzi, 2003, BMC biotechnology.

Immunomonitoring of human responses to the rVSV-ZEBOV Ebola vaccine.

D. Medaglini, C. Siegrist, 2017, Current opinion in virology.

13C-NMR determination of simultaneous xylose and glucose fermentation by a newly isolated strain (G11) of Klebsiella planticola

S. Bastianoni, N. Marchettini, C. Rossi, 1995 .

Immunization with recombinant Streptococcus gordonii expressing tetanus toxin fragment C confers protection from lethal challenge in mice.

A. Ciabattini, G. Pozzi, D. Medaglini, 2001, Vaccine.

Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination

T. Monath, M. Addo, M. Kieny, 2020, npj Vaccines.

Recombinant Streptococcus gordonii as a Live Vehicle for Vaccine Antigens

G. Pozzi, D. Medaglini, M. Oggioni, 1997 .

Immune Memory After Respiratory Infection With Streptococcus pneumoniae Is Revealed by in vitro Stimulation of Murine Splenocytes With Inactivated Pneumococcal Whole Cells: Evidence of Early Recall Responses by Transcriptomic Analysis

G. Pozzi, D. Medaglini, F. Iannelli, 2022, Frontiers in Cellular and Infection Microbiology.

Immunogenicity of a Bivalent Adjuvanted Glycoconjugate Vaccine against Salmonella Typhimurium and Salmonella Enteritidis

F. Mancini, C. MacLennan, D. Medaglini, 2017, Front. Immunol..

A Stochastic Model for CD4+ T Cell Proliferation and Dissemination Network in Primary Immune Response

A. Vicino, Gennaro Prota, D. Medaglini, 2015, PloS one.

A Stochastic Model for CD 4 + T Cell Proliferation and Dissemination Network in Primary Immune

A. Vicino, Gennaro Prota, D. Medaglini, 2015 .

Interferon-γ from Brain Leukocytes Enhances Meningitis by Type 4 Streptococcus pneumoniae

G. Pozzi, D. Medaglini, F. Iannelli, 2015, Front. Microbiol..

Intranasal administration of the synthetic polypeptide from the C-terminus of the circumsporozoite protein of Plasmodium berghei with the modified heat-labile toxin of Escherichia coli (LTK63) induces a complete protection against malaria challenge.

A. Ciabattini, D. Medaglini, G. Del Giudice, 2009, Vaccine.

O:2-CRM197 Conjugates against Salmonella Paratyphi A

D. Medaglini, A. Saul, Laura B Martin, 2012, PloS one.

The role of the vaccines industry in Mission Grand Convergence.

D. Medaglini, J. Almond, 2017, Vaccine.

The third dose of mRNA SARS-CoV-2 vaccines enhances the spike-specific antibody and memory B cell response in myelofibrosis patients

A. Ciabattini, D. Medaglini, G. Pastore, 2022, Frontiers in Immunology.

Human dendritic cells very efficiently present a heterologous antigen expressed on the surface of recombinant gram-positive bacteria to CD4+ T lymphocytes.

P. Ricciardi-Castagnoli, M. Rescigno, G. Girolomoni, 1999, Journal of immunology.

The European research effort for HIV/AIDS, malaria and tuberculosis.

D. Medaglini, A. Hoeveler, 2003, Vaccine.

Editorial: Advanced Immunization Technologies for Next Generation Vaccines

R. Rappuoli, P. Andersen, D. Medaglini, 2020, Frontiers in Immunology.

Characterization of nanoparticles-based vaccines for COVID-19

L. Calzolai, S. Gioria, D. Medaglini, 2022, Nature Nanotechnology.

Surface Display of Recombinant Proteins on Bacillus subtilis Spores

R. Isticato, M. De Felice, E. Ricca, 2001, Journal of bacteriology.

Mucosal and systemic immune responses to a recombinant protein expressed on the surface of the oral commensal bacterium Streptococcus gordonii after oral colonization.

V. Fischetti, G. Pozzi, D. Medaglini, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Genetic engineering of Streptococcus gordonii for the simultaneous display of two heterologous proteins at the bacterial surface.

G. Pozzi, D. Medaglini, M. Oggioni, 2002, FEMS microbiology letters.

Vaginal Immunization with Recombinant Gram‐Positive Bacteria

G. Pozzi, D. Medaglini, M. Oggioni, 1998, American journal of reproductive immunology.

Stimulation of Human Monocytes with the Gram-Positive Vaccine Vector Streptococcus gordonii

A. Ciabattini, G. Pozzi, D. Medaglini, 2006, Clinical and Vaccine Immunology.

Recombinant Gram-positive bacteria as vehicles of vaccine antigens

G. Pozzi, D. Medaglini, M. Oggioni, 1997 .

Long-Term Anti-Bacterial Immunity against Systemic Infection by Salmonella enterica Serovar Typhimurium Elicited by a GMMA-Based Vaccine

A. Ciabattini, G. Pozzi, D. Medaglini, 2021, Vaccines.

Human T-helper cell recognition of an immunodominant epitope of HIV-1 gp120 expressed on the surface of Streptococcus gordonii.

V. Fischetti, G. Pozzi, D. Medaglini, 1994, Vaccine.

Harmonization and qualification of an IFN-γ Enzyme-Linked ImmunoSpot assay (ELISPOT) to measure influenza-specific cell-mediated immunity within the FLUCOP consortium

R. Cox, G. Leroux-Roels, E. Gianchecchi, 2022, Frontiers in Immunology.

Intranasal immunization of mice with recombinant Streptococcus gordonii expressing NadA of Neisseria meningitidis induces systemic bactericidal antibodies and local IgA.

M. Giuliani, L. Santini, A. Ciabattini, 2008, Vaccine.

Human Dendritic Cells Are Superior to B Cells at Presenting a Major Histocompatibility Complex Class II-Restricted Heterologous Antigen Expressed on Recombinant Streptococcus gordonii

G. Girolomoni, G. Pozzi, D. Medaglini, 2000, Infection and Immunity.

Immunogenicity of the B Monomer ofEscherichia coli Heat-Labile Toxin Expressed on the Surface of Streptococcus gordonii

G. Palù, A. Marcello, G. Pozzi, 2000, Infection and Immunity.

Engineering the gram-positive cell surface for construction of bacterial vaccine vectors.

G. Pozzi, D. Medaglini, M. Oggioni, 1999, Methods.

Antigenicity and immunogenicity of the V3 domain of HIV type 1 glycoprotein 120 expressed on the surface of Streptococcus gordonii.

M. Zazzi, F. Peruzzi, G. Pozzi, 1999, AIDS research and human retroviruses.

Immunization with the conjugate vaccine Vi-CRM₁₉₇ against Salmonella typhi induces Vi-specific mucosal and systemic immune responses in mice.

A. Ciabattini, G. Pozzi, D. Medaglini, 2012, Vaccine.

Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2

F. Baldanti, L. Varani, Q. Pan-Hammarström, 2022, bioRxiv.

Harmonization and qualification of intracellular cytokine staining to measure influenza-specific CD4+ T cell immunity within the FLUCOP consortium

R. Cox, G. Leroux-Roels, E. Gianchecchi, 2022, Frontiers in Immunology.

Recombinant Haemagglutinin Derived From the Ciliated Protozoan Tetrahymena thermophila Is Protective Against Influenza Infection

B. Verrier, V. Contreras, D. Busse, 2019, Front. Immunol..

Recombinant Streptococcus gordonii for Mucosal Delivery of a scFv Microbicidal Antibody

G. Teti, G. Pozzi, D. Medaglini, 2001, International reviews of immunology.

Biotechnological Approaches to Fight Pathogens at Mucosal Sites

C. Kelly, G. Pozzi, D. Medaglini, 2001, Biotechnology & genetic engineering reviews.

Expression of measles virus antigens in Streptococcus gordonii.

K. Wiesmüller, C. Muller, G. Pozzi, 2000, The new microbiologica.

Vaginal immunization of Cynomolgus monkeys with Streptococcus gordonii expressing HIV-1 and HPV 16 antigens.

G. Pozzi, D. Medaglini, F. Titti, 1998, Vaccine.

Commensal bacteria as vectors for mucosal vaccines against sexually transmitted diseases: vaginal colonization with recombinant streptococci induces local and systemic antibodies in mice.

P. Sestini, G. Pozzi, D. Medaglini, 1997, Vaccine.

Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis

J. Crump, E. Owusu-Dabo, S. Kariuki, 2022, The Lancet. Infectious diseases.

Primary Activation of Antigen-Specific Naive CD4+ and CD8+ T Cells following Intranasal Vaccination with Recombinant Bacteria

Donata Medaglini, Annalisa Ciabattini, Elena Pettini, 2008, Infection and Immunity.

Bacteria-induced neo-biosynthesis, stabilization, and surface expression of functional class I molecules in mouse dendritic cells.

P. Ricciardi-Castagnoli, C. Théry, M. Rescigno, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Evidence of SARS-CoV-2-Specific Memory B Cells Six Months After Vaccination With the BNT162b2 mRNA Vaccine

A. Ciabattini, D. Medaglini, S. Lucchesi, 2021, Frontiers in Immunology.

Evidence of SARS-Cov-2-specific memory B cells six months after vaccination with BNT162b2 mRNA vaccine

A. Ciabattini, D. Medaglini, S. Lucchesi, 2021, medRxiv.

Vaginal Immunization to Elicit Primary T-Cell Activation and Dissemination

A. Vicino, A. Ciabattini, Gennaro Prota, 2013, PloS one.

Distribution of Primed T Cells and Antigen-Loaded Antigen Presenting Cells Following Intranasal Immunization in Mice

Donata Medaglini, Annalisa Ciabattini, Elena Pettini, 2011, PloS one.

Intranasal immunization with vaccine vector Streptococcus gordonii elicits primed CD4+ and CD8+ T cells in the genital and intestinal tracts.

Donata Medaglini, Annalisa Ciabattini, Elena Pettini, 2010, Vaccine.

In Vivo Activation of Naive CD4+ T Cells in Nasal Mucosa-Associated Lymphoid Tissue following Intranasal Immunization with Recombinant Streptococcus gordonii

Donata Medaglini, Annalisa Ciabattini, Gianni Pozzi, 2006, Infection and Immunity.

Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination

T. Monath, M. Addo, M. Kieny, 2020, npj Vaccines.

Correlates of vaccine-induced protective immunity against Ebola virus disease.

D. Medaglini, C. Siegrist, Francesco Santoro, 2018, Seminars in immunology.

Transcriptomic signatures induced by the Ebola virus vaccine rVSVΔG-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study

T. Monath, H. Nakaya, R. Ahmed, 2021, The Lancet. Microbe.

From Bivariate to Multivariate Analysis of Cytometric Data: Overview of Computational Methods and Their Application in Vaccination Studies

Simone Furini, Simone Lucchesi, Donata Medaglini, 2020, Vaccines.

A dose-dependent plasma signature of the safety and immunogenicity of the rVSV-Ebola vaccine in Europe and Africa

T. Monath, C. Combescure, T. Ottenhoff, 2017, Science Translational Medicine.

Ebola vaccine R&D: Filling the knowledge gaps

Tom H. M. Ottenhoff, Donata Medaglini, T. Ottenhoff, 2015, Science Translational Medicine.

Immunity against HIV/AIDS, Malaria, and Tuberculosis during Co-Infections with Neglected Infectious Diseases: Recommendations for the European Union Research Priorities

A. Thiel, F. Chiodi, U. Steinhoff, 2008, PLoS neglected tropical diseases.

Using IFN-gamma release assay to confirm tuberculin skin test improves the screening of latent tuberculosis infection in Italian healthcare workers

A. Ciabattini, G. Pozzi, D. Medaglini, 2016, Journal of Occupational Medicine and Toxicology.

Profiling the B cell immune response elicited by vaccination against the respiratory virus SARS-CoV-2

A. Ciabattini, D. Medaglini, E. Pettini, 2022, Frontiers in Immunology.

Assessment of mucosal immunity to HIV-1

F. Wegmann, R. Shattock, A. Spetz, 2010, Expert review of vaccines.

Monitoring Anti-PEG Antibodies Level upon Repeated Lipid Nanoparticle-Based COVID-19 Vaccine Administration

L. Calzolai, S. Gioria, A. Ciabattini, 2022, International journal of molecular sciences.

Short or Long Interval between Priming and Boosting: Does It Impact on the Vaccine Immunogenicity?

A. Ciabattini, D. Medaglini, E. Pettini, 2021, Vaccines.

Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein

F. Baldanti, L. Varani, Q. Pan-Hammarström, 2023, Science Immunology.

B cell response after SARS-CoV-2 mRNA vaccination in people living with HIV

A. Ciabattini, D. Medaglini, S. Lucchesi, 2023, Communications Medicine.

Optimized Protocol for the Detection of Multifunctional Epitope-Specific CD4+ T Cells Combining MHC-II Tetramer and Intracellular Cytokine Staining Technologies

A. Ciabattini, D. Medaglini, Emanuele Nolfi, 2019, Front. Immunol..

Human Transcriptomic Response to the VSV-Vectored Ebola Vaccine

H. Nakaya, T. Ottenhoff, G. Pozzi, 2021, Vaccines.

Trajectory of Spike-Specific B Cells Elicited by Two Doses of BNT162b2 mRNA Vaccine

A. Ciabattini, D. Medaglini, S. Lucchesi, 2023, Cells.

The Slower Antibody Response in Myelofibrosis Patients after Two Doses of mRNA SARS-CoV-2 Vaccine Calls for a Third Dose

A. Ciabattini, D. Medaglini, G. Pastore, 2021, medRxiv.

Prime-Boost Strategies in Mucosal Immunization Affect Local IgA Production and the Type of Th Response

A. Ciabattini, G. Pozzi, D. Medaglini, 2013, Front. Immunol..

A third dose of mRNA-1273 vaccine improves SARS-CoV-2 immunity in HCT recipients with low antibody response after 2 doses

A. Ciabattini, D. Medaglini, S. Lucchesi, 2022, Blood Advances.

Heterologous Prime-Boost Combinations Highlight the Crucial Role of Adjuvant in Priming the Immune System

A. Ciabattini, P. Andersen, G. Pozzi, 2018, Front. Immunol..

ADITEC: Joining Forces for Next-Generation Vaccines

Rino Rappuoli, Donata Medaglini, R. Rappuoli, 2012, Science Translational Medicine.

Adoptive transfer of transgenic T cells to study mucosal adjuvants.

Donata Medaglini, Annalisa Ciabattini, Elena Pettini, 2009, Methods.

Maraviroc as a potential HIV-1 latency-reversing agent in cell line models and ex vivo CD4 T cells.

M. Zazzi, A. De Luca, E. Montomoli, 2020, The Journal of general virology.

B Cell Response Six Months after SARS-CoV-2 mRNA Vaccination in People Living with HIV Under Antiretroviral Therapy

A. Ciabattini, D. Medaglini, S. Lucchesi, 2022, SSRN Electronic Journal.

Immunoglobulin-binding domains of peptostreptococcal protein L enhance vaginal colonization of mice by Streptococcus gordonii.

L. Björck, G. Pozzi, D. Medaglini, 2001, Microbial pathogenesis.

Peptide-specific T helper cells identified by MHC class II tetramers differentiate into several subtypes upon immunization with CAF01 adjuvanted H56 tuberculosis vaccine formulation.

P. Andersen, D. Christensen, Gennaro Prota, 2015, Vaccine.

Correlates of vaccine-induced protective immunity against Ebola virus disease.

D. Medaglini, C. Siegrist, Francesco Santoro, 2018, Seminars in immunology.

Predicting humoral responses to primary and booster SARS-CoV-2 mRNA vaccination in people living with HIV: a machine learning approach

M. Augello, D. Medaglini, Giorgio Montesi, 2024, Journal of translational medicine.

Refined innate plasma signature after rVSVΔG-ZEBOV-GP immunization is shared among adult cohorts in Europe and North America

D. Medaglini, C. Siegrist, A. Harandi, 2024, Frontiers in immunology.

Global blood miRNA profiling unravels early signatures of immunogenicity of Ebola vaccine rVSVΔG-ZEBOV-GP

D. Medaglini, C. Siegrist, A. Harandi, 2023, iScience.

Primary T-cell response to mucosal vaccination

Gennaro Prota, G. Pozzi, D. Medaglini, 2010 .