S. Swain

发表

CD4 T Cell-Mediated Protection from Lethal Influenza: Perforin and Antibody-Mediated Mechanisms Give a One-Two Punch1

Deborah M. Brown, Allison M Dilzer, Dana L. Meents, 2006, The Journal of Immunology.

Hallmarks of CD4 T cell immunity against influenza

T. Strutt, S. Swain, K. McKinstry, 2011, Journal of internal medicine.

Memory CD4+ T-cell–mediated protection depends on secondary effectors that are distinct from and superior to primary effectors

L. Bradley, T. Strutt, K. K. McKinstry, 2012, Proceedings of the National Academy of Sciences.

Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms.

T. Strutt, Deborah M. Brown, S. Swain, 2012, The Journal of clinical investigation.

Multipronged CD4+ T‐cell effector and memory responses cooperate to provide potent immunity against respiratory virus

T. Strutt, K. K. McKinstry, S. Swain, 2013, Immunological reviews.

Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful

T. Strutt, S. Swain, R. Dutton, 2013, Archivum immunologiae et therapiae experimentalis.

Intraepithelial T-cell cytotoxicity, induced bronchus-associated lymphoid tissue, and proliferation of pneumocytes in experimental mouse models of influenza.

S. Sell, T. Strutt, K. K. McKinstry, 2014, Viral immunology.

Superantigen-Induced CD4 T Cell Tolerance Mediated by Myeloid Cells and IFN-γ1

L. Cauley, S. Swain, Ellen E. Miller, 2000, The Journal of Immunology.

T Cell Subsets and the Recognition of MHC Class

S. Swain, 1983, Immunological reviews.

Age-associated increase in lifespan of naïve CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects

S. Swain, Hirotake Tsukamoto, K. Clise-Dwyer, 2009, Proceedings of the National Academy of Sciences.

Expanding roles for CD4+ T cells in immunity to viruses

T. Strutt, K. K. McKinstry, S. Swain, 2012, Nature Reviews Immunology.

Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals.

M. Croft, S. Swain, C. Dubey, 1996, Journal of immunology.

Influencing the fates of CD4 T cells on the path to memory: lessons from influenza

T. Strutt, S. Swain, K. McKinstry, 2008, Immunology and cell biology.

The potential of CD4 T‐cell memory

T. Strutt, K. K. McKinstry, S. Swain, 2010, Immunology.

Multifunctional CD4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection

Deborah M. Brown, S. Swain, Sarah Lee, 2012, Journal of Virology.

Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?

S. Swain, P. Devarajan, 2019, Cell host & microbe.

The specific direct interaction of helper T cells and antigen- presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells

S. Singer, A. Kupfer, S. Swain, 1987, The Journal of experimental medicine.

Coclustering of CD4 (L3T4) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells.

C. Janeway, S. Singer, A. Kupfer, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Coclustering of CD 4 ( L 3 T 4 ) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells

C. Janeway, S. Singer, A. Kupfer, 2022 .

Interleukin 18

S. Swain, Susan L. Swain, 2001, The Journal of experimental medicine.

IL4 dictates T-cell differentiation.

S. Swain, S. L. Swain, 1993, Research in immunology.

Environmental and Intrinsic Factors Lead to Antigen Unresponsiveness in CD4+ Recent Thymic Emigrants from Aged Mice1

S. Swain, K. Clise-Dwyer, G. Huston, 2007, The Journal of Immunology.

Two Distinct Stages in the Transition from Naive CD4 T Cells to Effectors, Early Antigen-Dependent and Late Cytokine-Driven Expansion and Differentiation1

S. Swain, Michael Yen, D. Jelley-Gibbs, 2000, The Journal of Immunology.

Short-Lived Antigen Recognition but Not Viral Infection at a Defined Checkpoint Programs Effector CD4 T Cells To Become Protective Memory

T. Strutt, S. Swain, K. McKinstry, 2016, The Journal of Immunology.

To Induce a Cytotoxic CD8 T Cell Response Persistent Depots of Influenza Antigen Fail

T. Strutt, K. K. McKinstry, Deborah M. Brown, 2013 .

The effector to memory transition of CD4 T cells

T. Strutt, K. K. McKinstry, S. Swain, 2008, Immunologic research.

Impact of Post-Thymic Cellular Longevity on the Development of Age-Associated CD4+ T Cell Defects1

Stephen C. Jones, S. Swain, K. Clise-Dwyer, 2008, The Journal of Immunology.

Persistent Depots of Influenza Antigen Fail To Induce a Cytotoxic CD8 T Cell Response1

T. Strutt, Deborah M. Brown, S. Swain, 2007, The Journal of Immunology.

Unique Ability of Activated CD4+ T Cells but Not Rested Effectors to Migrate to Non-lymphoid Sites in the Absence of Inflammation*

Deborah M. Brown, S. Swain, J. Agrewala, 2007, Journal of Biological Chemistry.

Give a One-Two Punch Influenza : Perforin and Antibody-Mediated CD 4 T Cell-Mediated Protection from Lethal

Deborah M. Brown, Allison M Dilzer, Dana L. Meents, 2006 .

CD4+ T‐cell memory: generation and multi‐faceted roles for CD4+ T cells in protective immunity to influenza

Stephen C. Jones, N. Weng, T. Strutt, 2006, Immunological reviews.

IL-7: maintaining T-cell memory and achieving homeostasis.

L. Bradley, S. Swain, L. Haynes, 2005, Trends in immunology.

Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation

Deborah M. Brown, S. Swain, L. Haynes, 2005, The Journal of experimental medicine.

Regulation of the generation and maintenance of T-cell memory: a direct, default pathway from effectors to memory cells.

S. Swain, 2003, Microbes and infection.

CD4 Effector T Cell Subsets in the Response to Influenza

U. V. von Andrian, S. Swain, Ellen E. Miller, 2002, The Journal of experimental medicine.

IL-4 directs the development of Th2-like helper effectors.

A. Weinberg, S. Swain, A. Weinberg, 1990, Journal of immunology.

Characterization of antigen-specific CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB- helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma

L. Bradley, S. Swain, S. Tonkonogy, 1991, The Journal of experimental medicine.

Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells.

M. Croft, L. Bradley, S. Swain, 1994, Journal of immunology.

Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response.

M. Croft, S. Swain, C. Dubey, 1995, Journal of immunology.

Regulation of T cell subsets from naive to memory.

P. Rogers, L. Tsui, S. Swain, 1998, Journal of immunotherapy.

High antigen density and IL-2 are required for generation of CD4 effectors secreting Th1 rather than Th0 cytokines.

P. Rogers, S. Swain, G. Huston, 1998, Journal of immunology.

Interleukin 2, but Not Other Common γ Chain–Binding Cytokines, Can Reverse the Defect in Generation of Cd4 Effector T Cells from Naive T Cells of Aged Mice

S. Swain, P. Linton, L. Haynes, 1999, The Journal of experimental medicine.

Construction of a Single GEM Detector Using Indigenous Anode Plate

P. K. Sahu, S. Swain, A. Tripathy, 2021 .

Measurement of Ion Backflow with GEM-Based Detectors

P. K. Sahu, S. Swain, S. Nayak, 2021 .

Bim Dictates Naive CD4 T Cell Lifespan and the Development of Age-Associated Functional Defects

S. Swain, Hirotake Tsukamoto, G. Huston, 2010, The Journal of Immunology.

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

D. Green, P. Rogers, T. Brunner, 1997, The Journal of experimental medicine.

CD28 and ITK signals regulate autoreactive T cell trafficking

M. Sanderson, Joonsoo Kang, D. Greiner, 2013, Nature Medicine.

Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines.

M. Croft, S. Swain, Michael Croft, 1995, Journal of immunology.

Direct IL-6 Signals Maximize Protective Secondary CD4 T Cell Responses against Influenza

S. Sell, Kunal Dhume, Caroline M. Finn, 2016, The Journal of Immunology.

IL-10 Deficiency Unleashes an Influenza-Specific Th17 Response and Enhances Survival against High-Dose Challenge1

H. Ochs, Jonathan D. Curtis, D. Rawlings, 2009, The Journal of Immunology.

Reciprocal regulation of polarized cytokine production by effector B and T cells

S. Swain, F. Lund, Debra K. Duso, 2000, Nature Immunology.

Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection

S. Swain, S. Khader, A. Cooper, 2006, The Journal of experimental medicine.

Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection

R. Appelberg, T. Strutt, S. Swain, 2012, European journal of immunology.

IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells

A. Marshak‐Rothstein, J. Craft, S. Swain, 2015, The Journal of Immunology.

Age-associated declines in immune system development and function: causes, consequences, and reversal.

S. Swain, K. Dorshkind, 2009, Current opinion in immunology.

Single cell analyses of cytokine production.

S. Swain, L. Carter, 1997, Current opinion in immunology.

This information is current as Thymic Emigrants from Aged Mice Recent + Antigen Unresponsiveness in CD 4 Environmental and Intrinsic Factors Lead to

S. Swain, K. Clise-Dwyer, G. Huston, 2007 .

Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen

T. Randall, S. Swain, L. Haynes, 2005, The Journal of experimental medicine.

Homeostasis and the age-associated defect of CD4 T cells.

S. Swain, K. Clise-Dwyer, L. Haynes, 2005, Seminars in immunology.

CD4 T Cell Immunity to Viral Infection

T. Strutt, K. K. McKinstry, S. Swain, 2016 .

Changes in Naive CD 4 T Cells

S. Swain, P. Linton, L. Haynes, 2002 .

IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age

S. Senju, Y. Nishimura, S. Swain, 2015, Nature Communications.

The significance of T-B collaboration across haplotype barriers.

H. Y. Tse, S. Swain, R. Dutton, 1977, Cold Spring Harbor symposia on quantitative biology.

IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans

G. Kuchel, S. Swain, Chongkai Wang, 2016, Oncotarget.

Why Aging T Cells Fail: Implications for Vaccination

S. Swain, L. Haynes, 2006, Immunity.

Seminars in Immunology

S. Swain, L. Haynes, aura Haynesa, 2012 .

Functional Defects the Development of Age-associated Bim Dictates Naive Cd4 T Cell Lifespan And

S. Swain, Hirotake Tsukamoto, G. Huston, 2022 .

Regulation of CD4+ T‐cell contraction during pathogen challenge

T. Strutt, S. Swain, K. McKinstry, 2010, Immunological reviews.

Consequences of the Direct Interaction of Helper T Cells with B Cells presenting Antigen

S. Swain, R. Dutton, Rjchard W. Dutton, 1987, Immunological reviews.

Regulation of memory CD4 T cells: generation, localization and persistence.

Deborah M. Brown, S. Swain, J. Agrewala, 2002, Advances in experimental medicine and biology.

Interferon γ Eliminates Responding Cd4 T Cells during Mycobacterial Infection by Inducing Apoptosis of Activated Cd4 T Cells

S. Wittmer, S. Swain, D. Dalton, 2000, The Journal of experimental medicine.

CD4 T cells producing IFN‐γ in the lungs of mice challenged with mycobacteria express a CD27‐negative phenotype

A. Apt, S. Swain, I. Lyadova, 2004, Clinical and experimental immunology.

Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful

T. Strutt, S. Swain, R. Dutton, 2013, Archivum Immunologiae et Therapiae Experimentalis.

Functionally Diverse Subsets in CD4 T Cell Responses Against Influenza

T. Strutt, K. K. McKinstry, S. Swain, 2009, Journal of Clinical Immunology.

Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells

S. Swain, R. Budd, T. Krahl, 2007, Proceedings of the National Academy of Sciences.

Bone Marrow Precursor Cells from Aged Mice Generate CD4 T Cells That Function Well in Primary and Memory Responses1

S. Swain, L. Haynes, S. Eaton, 2008, The Journal of Immunology.

Well in Primary and Memory Responses Mice Generate CD4 T Cells That Function Bone Marrow Precursor Cells from Aged

S. Swain, L. Haynes, S. Eaton, 2008 .

CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly

T. Randall, S. Swain, L. Haynes, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Responses at Lower Doses of Antigen Cell Generation: Faster, More Effective Qualitative Changes Accompany Memory T

P. Rogers, S. Swain, C. Dubey, 2000 .

Production of a B cell growth-promoting activity, (DL)BCGF, from a cloned T cell line and its assay on the BCL1 B cell tumor

S. Swain, R. Dutton, 1982, The Journal of experimental medicine.

T-cell memory: new perspectives.

M. Croft, L. Bradley, S. Swain, 1993, Immunology today.

Effect of age on naive CD4 responses: impact on effector generation and memory development

S. Swain, L. Haynes, S. Eaton, 2002, Springer Seminars in Immunopathology.

Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells.

A. Weinberg, S. Swain, W. Hancock, 1988, Journal of immunology.

B cell growth factor interactions.

S. Swain, R. Dutton, 1987, Advances in experimental medicine and biology.

9 – B Cell and T Cell Growth Factors

S. Swain, R. Dutton, 1987 .

Induction of B cell differentiation by T cell factors. I. Stimulation of IgM secretion by products of a T cell hybridoma and a T cell line.

E. Puré, P. Isakson, J. Uhr, 1981, Journal of immunology.

CD4 T cell defects in the aged: Causes, consequences and strategies to circumvent

Wenlian Zhang, S. Swain, V. Brahmakshatriya, 2014, Experimental Gerontology.

Helper T cell differentiation.

S. Swain, Susan L. Swain, 1999, Current opinion in immunology.

SAP Enables T Cells to Help B Cells by a Mechanism Distinct from Th Cell Programming or CD40 Ligand Regulation1

Yongqing Zhang, N. Weng, S. Swain, 2008, The Journal of Immunology.

Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.

S. Swain, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Helper cells activated by allogeneic H-2K or H-2D differences have a Ly phenotype distinct from those responsive to I differences.

S. Swain, P. Panfili, S. L. Swain, 1979, Journal of immunology.

Xenogeneic human anti-mouse T cell responses are due to the activity of the same functional T cell subsets responsible for allospecific and major histocompatibility complex-restricted responses

S. Swain, R. Dutton, J. Yamamoto, 1983, The Journal of experimental medicine.

The Lyt phenotype of a long‐term allospecific T cell line. Both helper and killer activities to IA are mediated by Ly‐1 cells

S. Swain, R. Dutton, G. Dennert, 1981, European journal of immunology.

Interleukin 18: tipping the balance towards a T helper cell 1 response.

S. Swain, 2001 .

New Insights into the Generation of CD4 Memory May Shape Future Vaccine Strategies for Influenza

T. Strutt, K. K. McKinstry, S. Swain, 2016, Front. Immunol..

Attrition, in Response to Acute Virus Differentiation and Expansion, but Not T Cell + Graded Levels of IRF4 Regulate CD8

S. Swain, R. Welsh, Amanda L Prince, 2014 .

CD4 T cell responses to influenza infection CD4 T cell responses to influenza infection

Deborah M. Brown, S. Swain, E. Román, 2019 .

Reliable generation and use of MHC class II:gamma2aFc multimers for the identification of antigen-specific CD4(+) T cells.

N. L. La Gruta, L. Cauley, S. Swain, 2002, Journal of immunological methods.

Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals.

M. Croft, S. Swain, C. Dubey, 1996, International immunology.

CD4+ T cell subsets. Lymphokine secretion of memory cells and of effector cells that develop from precursors in vitro.

A. Weinberg, S. Swain, A. Weinberg, 1990, Journal of Immunology.

Small subunit of I–A subregion antigens determines the allospecificity recognized by a monoclonal antibody

J. J. Hubert, J. Silver, S. Swain, 1980, Nature.

Transferable Anergy: Superantigen Treatment Induces CD4+ T Cell Tolerance That Is Reversible and Requires CD4−CD8− Cells and Interferon γ

L. Cauley, S. Swain, G. Huston, 1997, The Journal of experimental medicine.

Role of BCGFII in the differentiation to antibody secretion normal and tumor B cells.

S. Swain, 1985, Journal of immunology.

Influenza Vaccine-Induced CD4 Effectors Require Ag Recognition at an Effector Checkpoint to Generate CD4 Lung Memory and Ab Production

S. Swain, Y. Kuang, Jingya Xia, 2021 .

Influenza Vaccine–Induced CD4 Effectors Require Antigen Recognition at an Effector Checkpoint to Generate CD4 Lung Memory and Antibody Production

S. Swain, Y. Kuang, Jingya Xia, 2020, The Journal of Immunology.

Strong influenza-induced TFH generation requires CD4 effectors to recognize antigen locally and receive signals from continuing infection

S. Swain, Allen M. Vong, P. Devarajan, 2022, Proceedings of the National Academy of Sciences.

Cytotoxic CD4 Development Requires CD4 Effectors to Concurrently Recognize Local Antigen and Encounter Infection-Induced IL-15

S. Swain, Allen M. Vong, K. Kelly, 2020, bioRxiv.

Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype.

A. Weinberg, S. Swain, G. Huston, 1991, Journal of immunology.

IgD + age‐associated B cells are the progenitors of the main T‐independent B cell response to infection that generates protective Ab and can be induced by an inactivated vaccine in the aged

A. Marshak‐Rothstein, S. Swain, Y. Kuang, 2022, bioRxiv.

Understanding the Heterogeneous Population of Age-Associated B Cells and Their Contributions to Autoimmunity and Immune Response to Pathogens.

S. Swain, P. Devarajan, Olivia Kugler-Umana, 2020, Critical reviews in immunology.

Inflammatory Cytokines Overcome Age-Related Defects in CD4 T Cell Responses In Vivo1

S. Swain, M. Rincón, L. Haynes, 2004, The Journal of Immunology.

T-Cell Subsets: Who does the polarizing?

S. Swain, 1995, Current Biology.

Transcriptional repression of the IL-2 gene in Th cells by ZEB.

T. Kadesch, B. Huber, L. Tsui, 1998, Journal of immunology.

Th Cells by ZEB Transcriptional Repression of the IL-2 Gene in

T. M. Williams, T. Kadesch, B. Huber, 2022 .

Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements

M. Croft, S. Swain, D. D. Duncan, 1992, The Journal of experimental medicine.

Monoclonal antibody to L3T4 blocks the function of T cells specific for class 2 major histocompatibility complex antigens.

S. Swain, F. Fitch, M. English, 1984, Journal of immunology.

current as T Cells + the Induction of Profibrotic CD 8 IL-21 Promotes Pulmonary Fibrosis through

A. Marshak‐Rothstein, J. Craft, S. Swain, 2015 .

TGF-beta1: immunosuppressant and viability factor for T lymphocytes.

A. Cerwenka, S. Swain, 1999, Microbes and infection.

Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression.

M. Kagnoff, S. Swain, P. D. Murray, 1987, Journal of Immunology.

Cytotoxic CD4 T Cells in Antiviral Immunity

S. Swain, N. Marshall, 2011, Journal of biomedicine & biotechnology.

The Role of IL4 and IL5: Characterization of a Distinct Helper T Cell Subset that makes IL4 and IL5 (Th2) and Requires Priming before Induction of Lymphokine Secretion

S. Swain, R. Dutton, S. Tonkonogy, 1988, Immunological reviews.

Visualization of Direct T-B Cell Interaction

S. Swain, 1987 .

Enhanced development of Th2-like primary CD4 effectors in response to sustained exposure to limited rIL-4 in vivo.

L. Bradley, S. Swain, K. Yoshimoto, 1996, Journal of immunology.

IL-15 supports the generation of protective lung-resident memory CD4 T cells

Kunal Dhume, Caroline M. Finn, T. Strutt, 2017, Mucosal Immunology.

Critical role of cognate interactions in the response of small, high-density B cells.

M. Croft, S. Swain, 1990, Research in immunology.

In Vivo Responses Age-Related Defects in CD4 T Cell Inflammatory Cytokines Overcome

S. Swain, M. Rincón, L. Haynes, 2004 .

IFN-γ Acts Directly on Activated CD4+ T Cells during Mycobacterial Infection to Promote Apoptosis by Inducing Components of the Intracellular Apoptosis Machinery and by Inducing Extracellular Proapoptotic Signals1

Xujian Li, K. K. McKinstry, S. Swain, 2007, The Journal of Immunology.

Role of T cells in the B-cell response: glutaraldehyde-fixed T-helper hybridoma cells synergize with the lymphokine IL-4 to induce B-cell activation and proliferation.

S. Swain, R. Dutton, E. Kubota, 1991, Immunology.

Polarized patterns of cytokine secretion

S. Swain, 1993, Current Biology.

Lymphokines and the immune response: the central role of interleukin-2.

S. Swain, Susan L. Swain, 1991, Current opinion in immunology.

Multifunctional CD 4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection

Deborah M. Brown, S. Swain, Sarah Lee, 2012 .

“An Intrinsic Program Determines Key Age-Associated Changes in Adaptive Immunity That Limit Response to Non-Pathogens”

S. Swain, S. Tonkonogy, Olivia Kugler-Umana, 2021, Frontiers in Aging.

The defects in effector generation associated with aging can be reversed by addition of IL-2 but not other related gamma(c)-receptor binding cytokines.

S. Swain, L. Haynes, S. Eaton, 2000, Vaccine.

Pathogen Recognition by CD4 Effectors Drives Key Effector and Most Memory Cell Generation Against Respiratory Virus

S. Swain, Allen M. Vong, P. Devarajan, 2018, Front. Immunol..

Peptide Avidity for TCR on CD4 Effectors Determines the Extent of Memory Generation

S. Swain, L. Stern, E. Huseby, 2022, bioRxiv.

Fine specificity mapping of two allospecific T cell lines: recognition of private specificities in the H‐2 IA subregion

S. Swain, R. Dutton, G. Dennert, 1981, European journal of immunology.

Immune senescence: new insights into defects but continued mystery of root causes.

B. Blomberg, S. Swain, 2013, Current opinion in immunology.

Erratum: CD4+ T-cell memory: Generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza (Immunological Reviews (2006) 211, (8-22))

Stephen C. Jones, N. Weng, T. Strutt, 2006 .

Induction of CD4 T Cell Changes in Murine AIDS Is Dependent on Costimulation and Involves a Dysregulation of Homeostasis1

S. Swain, Michael Yen, N. Lepak, 2002, The Journal of Immunology.

S. Swain, P. Linton, L. Haynes, 1997, Mechanisms of Ageing and Development.

Regulation of the development of helper T cell subsets

S. Swain, 1991, Immunologic research.

B cell stimulatory factor 1 (interleukin 4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors

J. Pfeifer, S. Swain, R. Dutton, 1987, The Journal of experimental medicine.

Regulation of the development of distinct subsets of CD4+ T cells.

S. Swain, 1991, Research in immunology.

Alloreactivity, the Development of the T Cell Repertoire and the Understanding of T Cell Function

S. Swain, R. Dutton, P. Panfili, 1978, Immunological reviews.

Interferon g Eliminates Responding CD 4 T Cells during Mycobacterial Infection by Inducing Apoptosis of Activated CD 4 T Cells

S. Wittmer, S. Swain, D. Dalton, 2000 .

Priming with Cold-Adapted Influenza A Does Not Prevent Infection but Elicits Long-Lived Protection against Supralethal Challenge with Heterosubtypic Virus1

Alan D. Roberts, T. Strutt, S. Swain, 2007, The Journal of Immunology.

CD4 T cell development and cytokine polarization: an overview

S. Swain, 1995, Journal of leukocyte biology.

Involves a Dysregulation of Homeostasis AIDS Is Dependent on Costimulation and Induction of CD4 T Cell Changes in Murine

S. Swain, Michael Yen, N. Lepak, 2002 .

Differentiation Cytokine-Driven Expansion and Antigen-Dependent and Late Naive CD 4 T Cells to Effectors , Early Two Distinct Stages in the Transition from

S. Swain, Michael Yen, D. Jelley-Gibbs, 2000 .

Continuously proliferating allospecific T cells. I. Specificity of cooperation with allogeneic B cells in the humoral antibody response to sheep erythrocytes

S. Swain, R. Dutton, G. Dennert, 1979, The Journal of experimental medicine.

Key research opportunities in immune system aging.

S. Swain, J. Nikolich-Žugich, 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

Mechanism of allosuppression: evidence for direct suppression of responding B cells.

S. Swain, 1978, Journal of immunology.

Mouse T-lymphocyte subpopulations: relationships between function and Lyt antigen phenotype.

S. Swain, R. Dutton, 1980, Immunology today.

Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization.

E. Raz, M. Roman, D. Carson, 1996, Proceedings of the National Academy of Sciences of the United States of America.

ON THE RELATIONSHIP BETWEEN Lyt PHENOTYPES, MHC SUBREGIONS, AND T CELL FUNCTION

S. Swain, R. Dutton, 1980 .

ALLOHELP TO H-2K APPEARS TO DEPEND ONLY ON A MATURE LY123 T CELL

S. Swain, R. Dutton, P. Panfili, 1979 .

T-cell immunosenescence: lessons learned from mouse models of aging

M. Blackman, S. Swain, D. Woodland, 2009, Trends in Immunology.

CD4 T-cell memory can persist in the absence of class II.

S. Swain, 2000, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

IL-2 receptor (Tac antigen) protein expression is down-regulated by the 5'-untranslated region of the mRNA.

A. Weinberg, S. Swain, 1990, Journal of immunology.

CD4 T cells in murine acquired immunodeficiency syndrome: polyclonal progression to anergy

S. Koch, S. Swain, G. Muralidhar, 1992, The Journal of experimental medicine.

Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays

P. Marrack, J. Kappler, J. Watson, 1983, The Journal of experimental medicine.

SAP Is Required for Th Cell Function and for Immunity to Influenza1

P. Schwartzberg, Dana L. Meents, S. Swain, 2006, The Journal of Immunology.

A monoclonal T cell-replacing activity can act directly on B cells to enhance clonal expansion

S. Swain, R. Dutton, G. D. Wetzel, 1982, The Journal of experimental medicine.

B cell response to T helper cell subsets. II. Both the stage of T cell differentiation and the cytokines secreted determine the extent and nature of helper activity.

M. Croft, S. Swain, 1991, Journal of immunology.

Control of innate immunity by memory CD4 T cells.

T. Strutt, S. Swain, K. McKinstry, 2011, Advances in experimental medicine and biology.

Memory CD4+ T cells induce innate responses independently of pathogen

Jonathan D. Curtis, T. Strutt, S. Swain, 2010, Nature Medicine.

NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection

S. Nutt, S. Swain, Y. Kuang, 2017, The Journal of Immunology.

From naive to effector ‐ alterations with aging

L. Tsui, S. Swain, P. Linton, 1997, Immunological reviews.

The cytokines IL-4, IFN-gamma, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro.

L. Bradley, S. Swain, K. Yoshimoto, 1995, Journal of immunology.

From Naive to Memory T Cells

Paul C. Rogers, M. Croft, L. Bradley, 1996, Immunological reviews.

Helper T‐Cell Subsets: Phenotype, Function and the Role of Lymphokines in Regulating their Development

M. Croft, S. Hedrick, A. Weinberg, 1991, Immunological reviews.

B Cell Immunodeficiency Fails to Develop in CD4-Deficient Mice Infected with BM5: Murine AIDS as a Multistep Disease1

S. Koch, S. Swain, D. P. Harris, 2001, The Journal of Immunology.

Negative allogeneic effects in vitro. II. Mapping of histocompatibility differences leading to allosuppression.

S. Swain, R. Dutton, 1977, Journal of immunology.

IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge

R. Locksley, S. Gaffen, T. Randall, 2007, Nature Immunology.

Rapid default transition of CD4 T cell effectors to functional memory cells

N. Weng, S. Swain, G. Huston, 2007, The Journal of experimental medicine.

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles

M. Croft, S. Swain, R. Dutton, 1994, The Journal of experimental medicine.

Location, Location, Location: The Impact of Migratory Heterogeneity on T Cell Function

B. Baaten, L. Bradley, S. Swain, 2013, Front. Immunol..

T Cell Replacing Factors in the B Cell Response to Antigen 1

S. Swain, R. Dutton, G. D. Wetzel, 1982, Immunological reviews.

Qualitative Changes Accompany Memory T Cell Generation: Faster, More Effective Responses at Lower Doses of Antigen1

P. Rogers, S. Swain, C. Dubey, 2000, The Journal of Immunology.

TGF-β1: immunosuppressant and viability factor for T lymphocytes

A. Cerwenka, S. Swain, 1999 .

Distinct lymphokine production by CD4+ T cells isolated from mucosal and systemic lymphoid organs.

S. Swain, S. Tonkonogy, 1993, Immunology.

Culture supernatants of a stimulated T-cell line have helper activity that acts synergistically with interleukin 2 in the response of B cells to antigen.

S. Swain, R. Dutton, G. Dennert, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Negative allogeneic effects in vitro. I. Allogeneic T cells markedly suppress the secondary antibody-forming cell response.

S. Swain, R. Dutton, 1977, Journal of immunology.

Frequency of allogeneic helper T cells responding to whole H-2 differences and to an H-2K difference alone.

S. Swain, R. Dutton, I. Lefkovits, 1979, Journal of immunology.

PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion.

M. Bosenberg, F. Carrette, L. Bradley, 2016, Immunity.

Tc17, a Unique Subset of CD8 T Cells That Can Protect against Lethal Influenza Challenge1

T. Strutt, S. Swain, K. McKinstry, 2009, The Journal of Immunology.

T cell memory.

L. Bradley, S. Swain, R. Dutton, 1998, Annual review of immunology.

Multiple Redundant Effector Mechanisms of CD8+ T Cells Protect against Influenza Infection

T. Strutt, S. Swain, K. McKinstry, 2013, The Journal of Immunology.

T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines

G. Kuchel, S. Swain, L. Haynes, 2016, Front. Immunol..

The properties of the unique age-associated B cell subset reveal a shift in strategy of immune response with age.

Wenlian Zhang, S. Swain, Y. Kuang, 2017, Cellular immunology.

Repeated stimulation of CD4 effector T cells can limit their protective function

S. Swain, R. Kemp, L. Haynes, 2005, The Journal of experimental medicine.

Antigen-independent changes in naive CD4 T cells with aging

S. Swain, P. Linton, L. Haynes, 1996, The Journal of experimental medicine.

Antigen-independ ent Changes in Naive CD4 T Cells with Aging By Phyllis-Jean Linton,* Laura Haynes,¢ Norman R.. Klinman,g

S. Swain, 1996 .

Germinal center B cells in Peyer's patches of aged mice exhibit a normal activation phenotype and highly mutated IgM genes

S. Swain, D. P. Harris, B. Rogerson, 2003, Mechanisms of Ageing and Development.

Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion

S. Swain, X. Zhang, H. Broome, 1995, The Journal of experimental medicine.

Generation and in vivo persistence of polarized Th1 and Th2 memory cells.

S. Swain, 1994, Immunity.

Memory effectors: a potent, IL-4-secreting helper T cell population that develops in vivo after restimulation with antigen.

L. Bradley, S. Swain, K. Yoshimoto, 1993, Journal of immunology.

Entry of naive CD4 T cells into peripheral lymph nodes requires L- selectin

S. Watson, L. Bradley, S. Swain, 1994, The Journal of experimental medicine.

The Biological Outcome of CD40 Signaling Is Dependent on the Duration of CD40 Ligand Expression

T. Randall, S. Swain, L. Haynes, 2002, The Journal of experimental medicine.

IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells

S. Swain, G. Huston, Jichu Li, 2003, The Journal of experimental medicine.

From naive to memory

S. Swain, S L Swain, L L Carter, 1998, Immunologic research.

Transforming growth factor-beta enhances the in vivo effector function and memory phenotype of antigen-specific T helper cells in experimental autoimmune encephalomyelitis.

A. Weinberg, S. Swain, H. Offner, 1992, Journal of immunology.

PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion.

M. Bosenberg, F. Carrette, L. Bradley, 2016, Immunity.

TLR-Activated Dendritic Cells Enhance the Response of Aged Naive CD4 T Cells via an IL-6–Dependent Mechanism

Stephen C. Jones, S. Swain, G. Huston, 2010, The Journal of Immunology.

IL-6 Response of Aged Naive CD 4 T Cells via an TLR-Activated Dendritic Cells Enhance the

Stephen C. Jones, S. Swain, G. Huston, 2010 .

Krüppel‐like factor 4 (KLF4) directly regulates proliferation in thymocyte development and IL‐17 expression during Th17 differentiation

W. Wood, K. Becker, J. An, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Effector CD4+ T Cells Generate Intermediate Caspase Activity and Cleavage of Caspase-8 Substrates1

Ravi S. Misra, S. Swain, R. Budd, 2005, The Journal of Immunology.

IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells.

Deborah M. Brown, Allison M Dilzer, S. Swain, 2009, Cellular immunology.

The specific direct interaction of helper T cells and antigen-presenting B cells.

C. Janeway, S. Singer, A. Kupfer, 1986, Proceedings of the National Academy of Sciences of the United States of America.

CD4+ T cell effectors can become memory cells with high efficiency and without further division

S. Swain, G. Huston, Hui Hu, 2001, Nature Immunology.

Effector CD4 T cell transition to memory requires late cognate interactions that induce autocrine IL-2

Wenlian Zhang, T. Strutt, S. Swain, 2014, Nature Communications.

Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation

F. Alam, S. Sell, T. Strutt, 2019, PLoS pathogens.

Class II-independent generation of CD4 memory T cells from effectors.

S. Swain, G. Huston, H. Hu, 1999, Science.

Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection

Rachel P. J. Lai, Xinchun Chen, D. Zak, 2015, The Journal of experimental medicine.

In vivo persistence of CD8 polarized T cell subsets producing type 1 or type 2 cytokines.

A. Cerwenka, S. Swain, R. Dutton, 1998, Journal of immunology.

CD8+ T cells responding to influenza infection reach and persist at higher numbers than CD4+ T cells independently of precursor frequency.

Deborah M. Brown, S. Swain, R. Dutton, 2004, Clinical immunology.

Role of Ia-positive cells in the production of T cell-replacing factors: blocking of factor production with anti-Ia serum.

S. Swain, 1980, Journal of immunology.

1822 B CELL GROWTH FACTOR : PRODUCTION AND ASSAY chromatography

S. Swain, R. Dutton, 2003 .

B cell response to fresh and effector T helper cells. Role of cognate T-B interaction and the cytokines IL-2, IL-4, and IL-6.

M. Croft, S. Swain, 1991, Journal of immunology.

Both naive and memory CD4 T cell subsets become anergic during MAIDS and each subset can sustain disease.

S. Koch, S. Swain, G. Muralidhar, 1994, Journal of immunology.

Erratum to: Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful

T. Strutt, S. Swain, K. McKinstry, 2013, Archivum Immunologiae et Therapiae Experimentalis.

Antigen presentation and the regulation of CD4 memory generation to influenza

S. Swain, L. Haynes, D. Jelley-Gibbs, 2006, Expert review of clinical immunology.

Effector CD 4 T Cells Generate Intermediate Caspase Activity and Cleavage of Caspase-8 Substrates 1

Ravi S. Misra, S. Swain, R. Budd, 2005 .

Vaccines against pandemic influenza.

S. Swain, R. Dutton, D. Woodland, 2007, Viral immunology.

E2A activity is induced during B‐cell activation to promote immunoglobulin class switch recombination

C. Murre, S. Swain, D. P. Harris, 1999, The EMBO journal.

Graded Levels of IRF4 Regulate CD8+ T Cell Differentiation and Expansion, but Not Attrition, in Response to Acute Virus Infection

Raymond M. Welsh, Keith Daniels, S. Swain, 2014, The Journal of Immunology.

T-cell factors that promote B-cell proliferation and differentiation.

S. Swain, R. Dutton, 1985, Contemporary topics in molecular immunology.

Partial purification and characterization of a BCGFII from EL4 culture supernatants.

S. Swain, R. Dutton, G. D. Wetzel, 1984, Journal of immunology.

Evidence for two distinct activation states available to B lymphocytes.

S. Swain, R. Dutton, J. Kettman, 1984, Journal of immunology.

Role of antigen‐presenting cells in the polarized development of helper T cell subsets: evidence for differential cytokine production by Th0 cells in response to antigen presentation by B cells and macrophages

S. Swain, Susan L. Swain, David D. Duncan, 1994, European journal of immunology.

T cell responses to influenza virus infection: effector and memory cells.

S. Swain, R. Dutton, D. Woodland, 2004, Viral immunology.

CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation

F. Alam, S. Sell, T. Strutt, 2020, The Journal of Immunology.

Effector functions of helper T cells.

S. Swain, 1993, Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy.

Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells.

A. Weinberg, S. Swain, M. English, 1990, Journal of immunology.

Analysis of histocompatibility requirements for proliferative and helper T cell activity. T cell populations depleted of alloreactive cells by negative selection

P. Matzinger, S. Swain, R. Dutton, 1980, The Journal of experimental medicine.

Virus-induced natural killer cell lysis of T cell subsets.

T. Strutt, S. Swain, R. Welsh, 2020, Virology.

CD4 T cell anergy in murine AIDS: costimulation via CD28 and the addition of IL-12 are not sufficient to rescue anergic CD4 T cells.

S. Swain, C. Andrews, G. Muralidhar, 1997, Journal of immunology.

Regulation of the IgM and IgA anti-dextran B1355S response: synergy between IFN-gamma, BCGF II, and IL 2.

S. Swain, S L Swain, P D Murray, 1985, Journal of immunology.

c‐FLIPS reduces activation of caspase and NF‐κB pathways and decreases T cell survival

S. Swain, D. Holoch, R. Budd, 2008 .

Long-term CD4+ memory T cells from the spleen lack MEL-14, the lymph node homing receptor.

L. Bradley, S. Swain, G. G. Atkins, 1992, Journal of Immunology.

Tc 17 , a Unique Subset of CD 8 T Cells That Can Protect against Lethal Influenza Challenge 1

Richard, T. Strutt, S. Swain, 2009 .

CD4 T cell responses to influenza infection.

Deborah M. Brown, S. Swain, E. Román, 2004, Seminars in immunology.

IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo

Wenlian Zhang, S. Swain, Y. Kuang, 2017, The Journal of Immunology.

Role of antigen in the B cell response. Specific antigen and the lymphokine IL-5 synergize to drive B cell lymphoma proliferation and differentiation to Ig secretion.

S. Swain, R. Dutton, S L Swain, 1988, Journal of immunology.

Erratum to: Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful

T. Strutt, S. Swain, R. Dutton, 2013, Archivum Immunologiae et Therapiae Experimentalis.

Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful

T. Strutt, S. Swain, R. Dutton, 2013, Archivum Immunologiae et Therapiae Experimentalis.

I. Specificity of Coopera t ion with Allogeneic B Cells in the Humora l Ant ibody Response to Sheep Erythroeytes*

S. Swain, R. Dutton, G. Dennert, 2003 .

Interleukin 27 R regulates CD 4 + T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection

Rachel P. J. Lai, Xinchun Chen, D. Zak, 2015 .

Helper T cell memory: more questions than answers.

L. Bradley, S. Swain, 1992, Seminars in immunology.

Analysis of CD4+ T cells that provide contact-dependent bystander help to B cells.

M. Croft, S. Swain, 1992, Journal of immunology.

Regulation of the immune response T-cell interactions.

S. Swain, R. Dutton, 1982, CRC Critical reviews in immunology.

Cytotoxic CD4 Development Requires CD4 Effectors to Concurrently Recognize Local Antigen and Encounter Infection-Induced IL-15

J. Luban, S. Swain, Allen M. Vong, 2022, bioRxiv.

Durable CD4 T-Cell Memory Generation Depends on Persistence of High Levels of Infection at an Effector Checkpoint that Determines Multiple Fates.

T. Strutt, S. Swain, K. McKinstry, 2021, Cold Spring Harbor perspectives in biology.

Aging and immune function Summary of a workshop held at Trudeau Institute, Saranac Lake, NY

Laura Haynes, J. Cambier, S. Swain, 2005, Mechanisms of Ageing and Development.

Thanks for the Memory!1

S. Swain, 2005, The Journal of Immunology.

Lymphokine-mediated activation of a T cell-dependent IgA antipolysaccharide response.

M. Kagnoff, S. Swain, L. S. Arner, 1983, Journal of immunology.

Significance of class 1 and class 2 major histocompatibility complex antigens: help to allogeneic K and D antigens does not involve I recognition.

S. Swain, 1981, Journal of immunology.

TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation.

S. Koch, S. Swain, H. Broome, 1996, Journal of immunology.

Regulation of isotype production by IL-4 and IL-5. Effects of lymphokines on Ig production depend on the state of activation of the responding B cells.

S. Swain, S. Tonkonogy, D. McKenzie, 1989, Journal of immunology.

S. Swain, L. Haynes, 2012, Seminars in immunology.

Ly phenotypes and MHC recognition: the allohelper that recognizes K or D is a mature Ly123 cell.

S. Swain, R. Dutton, M. English, 1979, Journal of immunology.

Uneven distribution of MHC class II epitopes within the influenza virus.

David L Woodland, Shannon C Miller, T. Randall, 2006, Vaccine.

Infectionagainst Lethal Influenza Virus Gamma Interferon and Perforin Mediate Multifunctional CD4 Cells Expressing

Deborah M. Brown, S. Swain, M. D. L. Luz, 2012 .

SAP deficiency results in a striking alteration of the protein profile in activated CD4 T cells.

S. Swain, I. Lefkovits, T. Grussenmeyer, 2006, Journal of Proteome Research.

The generation and maintenance of memory T and B cells.

L. Bradley, S. Swain, R. Dutton, 1999, Immunology today.

Peripheral Tissue Homing Receptor Control of Naïve, Effector, and Memory CD8 T Cell Localization in Lymphoid and Non-Lymphoid Tissues

V. Engelhard, M. Sztein, S. Swain, 2013, Front. Immunol..

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

D. Green, P. Rogers, T. Brunner, 1997, The Journal of experimental medicine.

Multipronged CD4+ T‐cell effector and memory responses cooperate to provide potent immunity against respiratory virus

T. Strutt, S. Swain, K. McKinstry, 2013, Immunological reviews.

Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection

R. Appelberg, T. Strutt, S. Swain, 2012, European journal of immunology.

PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion.

M. Bosenberg, F. Carrette, L. Bradley, 2016, Immunity.

IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells.

Deborah M. Brown, Allison M Dilzer, S. Swain, 2009, Cellular immunology.

Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation

Deborah M. Brown, S. Swain, L. Haynes, 2005, The Journal of experimental medicine.

Characterization of T and B antigen-binding cells for beta-galactosidase. II. T antigen-binding cells.

F. Modabber, S. Swain, A. H. Coons, 1976, Journal of immunology.

Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen

T. Randall, S. Swain, L. Haynes, 2005, The Journal of experimental medicine.