C. Hayes

发表

Rh(II)-catalysed room temperature aziridination of homoallyl-carbamates.

C. Hayes, Peter Beavis, Lesley A. Humphries, 2006, Chemical communications.

Synthesis of β-keto esters in-flow and rapid access to substituted pyrimidines.

C. Hayes, Hannah E. Bartrum, D. Blakemore, 2010, The Journal of organic chemistry.

Bridgehead enolate or bridgehead organolithium? DFT calculations provide insights into a difficult bridgehead substitution reaction in the synthesis of the polycyclic polyprenylated acylphloroglucinol (PPAP) nemorosone.

C. Hayes, N. Simpkins, 2013, Organic & biomolecular chemistry.

Bridgehead lithiation-substitution of bridged ketones, lactones, lactams, and imides: experimental observations and computational insights.

A. J. Blake, A. Blake, Claire Wilson, 2009, Journal of the American Chemical Society.

Continuous-flow generation of diazoesters and their direct use in S–H and P–H insertion reactions: synthesis of α-sulfanyl, α-sulfonyl, and α-phosphono carboxylates

C. Hayes, Hannah E. Bartrum, D. Blakemore, 2013 .

Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition

C. Hayes, P. Powalowska, R. D. Alharthy, 2016, Organic & biomolecular chemistry.

Synthesis and preliminary anticancer activity studies of C4 and C8-modified derivatives of catechin gallate (CG) and epicatechin gallate (ECG).

S. Watson, A. Grabowska, C. Hayes, 2006, The Journal of organic chemistry.

Nucleophilic fluorination of β-ketoester derivatives with HBF4.

C. Hayes, Hannah E. Bartrum, C. Moody, 2012, Chemical communications.

Redirection of carotenoid metabolism for the efficient production of taxadiene [taxa-4(5),11(12)-diene] in transgenic tomato fruit

R. Linforth, C. Hayes, R. Fray, 2007, Transgenic Research.

A formal synthesis of (+)-lactacystin from 4-hydroxyproline

W. Lewis, C. Hayes, P. Glossop, 2013 .

Enantioselective total syntheses of (−)-clasto-lactacystin β-lactone and 7-epi-(−)-clasto-lactacystin β-lactone

C. Hayes, M. Selby, A. Sherlock, 2006 .

An enantioselective formal synthesis of the proteasome inhibitor (+)-lactacystin

C. Hayes, M. P. Green, J. Prodger, 2002 .

Accessing low-oxidation state taxanes: is taxadiene-4(5)-epoxide on the taxol biosynthetic pathway?† †Electronic supplementary information (ESI) available: Full experimental procedures and copies of 1H and 13C NMR spectra. CCDC 1030909. For ESI and crystallographic data in CIF or other electronic fo

W. Lewis, G. Seymour, C. Hayes, 2016, Chemical science.

An alkylidene carbene CH insertion strategy for the enantioselective synthesis of α,α-dialkyl-α-amino acids

C. Hayes, R. Gabaitsekgosi, 1999 .

Effects of vinylphosphonate internucleotide linkages on the cleavage specificity of exonuclease III and on the activity of DNA polymerase I.

C. Hayes, P. Soultanas, Zara A. Doddridge, 2003, Biochemistry.

Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus

I. Brown, J. Nguyen-Van-Tam, P. Gershkovich, 2021, Viruses.

Asymmetric organocatalytic formation of protected and unprotected tetroses under potentially prebiotic conditions.

C. Hayes, Laurence Burroughs, P. Clarke, 2012, Organic & biomolecular chemistry.

Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin

P. Gershkovich, C. Hayes, K. Mellits, 2021, Virulence.

Procyanidin B3 synthesis: a study of leaving group and Lewis acid activator effects upon interflavan bond formation

C. Hayes, R. D. Alharthy, 2010 .

Identification of Internal Ribosome Entry Segment (IRES)-trans-Acting Factors for the Myc Family of IRESs

K. Lilley, M. Bushell, C. Hayes, 2007, Molecular and Cellular Biology.

alpha,beta-Unsaturated and cyclopropyl acyl radicals, and their ketene alkyl radical equivalents. Ring synthesis and tandem cyclisation reactions.

C. Hayes, G. Pattenden, Nicole M. Harrington-Frost, 2005, Organic & biomolecular chemistry.

The ‘Hirao reduction’ revisited: a procedure for the synthesis of terminal vinyl bromides by the reduction of 1,1-dibromoalkenes

C. Hayes, S. Abbas, Stephen M. Worden, 2000 .

Efficient asymmetric organocatalytic formation of erythrose and threose under aqueous conditions.

C. Hayes, Laurence Burroughs, P. Clarke, 2010, Chemical communications.

Enantioselective synthesis of the tricyclic core of (−)-FR901483

C. Hayes, Asnuzilawati Asari, P. Angelov, 2007 .

C-H Insertion as a Key Step to Spiro-Oxetanes, Scaffolds for Drug Discovery.

W. Lewis, C. Hayes, Hannah E. Bartrum, 2017, Chemistry.

Diazophosphonates: Effective surrogates for Diazoalkanes in Pyrazole Synthesis.

Michael T. Green, W. Lewis, C. Hayes, 2021, Chemistry.

Enantioselective total syntheses of omuralide, 7-epi-omuralide, and (+)-lactacystin.

A. J. Blake, A. Blake, Claire Wilson, 2008, The Journal of organic chemistry.

Rapid access to α-alkoxy and α-amino acid derivatives through safe continuous-flow generation of diazoesters.

C. Hayes, Hannah E. Bartrum, D. Blakemore, 2011, Chemistry.

Studies on DMDO-mediated benzylidene acetal oxidation

C. Hayes, P. Glossop, David K. Mycock, 2008 .

A convenient method for 3-pyrroline synthesis.

C. Hayes, M. P. Green, J. Prodger, 2001, Organic letters.

Phosphoramidate synthesis via copper-catalysed aerobic oxidative coupling of amines and H-phosphonates.

C. Hayes, R. Blundell, J. Fraser, 2013, Chemical communications.

Electrohydrocyclization of alkoxy tether substituted mixed enone/enoate and bisenone systems: retention versus elimination

S. Handy, C. Hayes, Renuka Manchanayakage, 2007 .

Synthetic studies towards phomactin A. Concise synthesis of the novel tricyclic furanochroman system

C. Hayes, G. Pattenden, K. Foote, 1996 .

Iodoetherification of homoallylic alcohols : A stereoselective approach to tetrahydrofurans

C. Hayes, D. Knight, S. Bedford, 1992 .

Synthetic studies towards the phomactins. Concise syntheses of the tricyclic furanochroman and the oxygenated bicyclo[9.3.1]pentadecane ring systems in phomactin A.

C. Hayes, G. Pattenden, K. Foote, 2003, Organic & biomolecular chemistry.

Towards a total synthesis of (−)-cephalotaxine: construction of the BCDE-tetracyclic core

C. Hayes, Renameditswe Mapitse, Stephen M. Worden, 2002 .

Stereoselective Synthesis of Functionalized Pyrrolidines by the Diverted N-H Insertion Reaction of Metallocarbenes with β-Aminoketone Derivatives.

W. Lewis, C. Hayes, C. Moody, 2016, Angewandte Chemie.

Enantioselective Total Syntheses of Omuralide (I), 7-epi-Omuralide (II), and (+)-Lactacystin (III).

A. Blake, Claire Wilson, C. Hayes, 2008 .

Total synthesis of (-)-aritasone via the ultra-high pressure hetero-Diels-Alder dimerisation of (-)-pinocarvone.

Maliha Uroos, A. Blake, W. Lewis, 2017, Organic & biomolecular chemistry.

Model studies of the overall 5-endo-trig iodocyclization of homoallylic alcohols

C. Hayes, D. Knight, S. Bedford, 1999 .

Alkyl halide-free heteroatom alkylation and epoxidation facilitated by a recyclable polymer-supported oxidant for the in-flow preparation of diazo compounds.

C. Hayes, C. Moody, Simon M. Nicolle, 2015, Chemistry.

Stereoselective Synthesis of Highly Substituted Tetrahydrofurans through Diverted Carbene O-H Insertion Reaction.

W. Lewis, C. Hayes, C. Moody, 2015, Angewandte Chemie.

Unusually high α-proton acidity of prolyl residues in cyclic peptides†

Oliver R. Maguire, C. Hayes, S. Cobb, 2020, Chemical science.

α-ketene alkyl and α,β-unsaturated acyl radical intermediates in ring constructions

C. Hayes, G. Pattenden, 1996 .

Synthesis of the C1-C28 Portion of Spongistatin 1 (Altohyrtin A).

C. Hayes, C. Heathcock, M. M. Claffey, 1999, The Journal of organic chemistry.

Carbene reactivity of 4-diazo-4H-imidazoles toward nucleophiles and aromatic compounds.

M. Stevens, A. Blake, C. Hayes, 2009, The Journal of organic chemistry.

An olefin cross-metathesis approach to vinylphosphonate-linked nucleic acids.

C. Hayes, M. Lera, 2001, Organic letters.

An olefin cross-metathesis approach to vinylphosphonate-linked nucleic acids.

C. Hayes, M. Lera, 2001, Organic letters.

Commercially available 5'-DMT phosphoramidites as reagents for the synthesis of vinylphosphonate-linked oligonucleic acids.

C. Hayes, S. Abbas, R. D. Bertram, 2001, Organic letters.

An improved procedure for the synthesis of vinylphosphonate-linked nucleic acids

C. Hayes, S. Abbas, 2000 .

Stereoselective synthesis of highly functionalised P-stereogenic nucleosides via palladium-catalysed P-C cross-coupling reactions

C. Hayes, M. L. Ruiz, Benjamin Whittaker, 2008 .

A Novel Palladium-Catalysed Coupling Strategy for the Rapid Synthesis of Nucleic Acid Analogues Bearing Modified Backbones

C. Hayes, S. Abbas, 1999 .

An efficient enantioselective synthesis of (2R)-hydroxymethyl glutamic acid and an approach to the (2R)-hydroxymethyl-substituted sphingofungins.

C. Hayes, N. Thomson, D. M. Bradley, 2006, Journal of Organic Chemistry.

RPA alleviates the inhibitory effect of vinylphosphonate internucleotide linkages on DNA unwinding by BLM and WRN helicases.

C. Hayes, P. Janscak, Glyn Bradley, 2004, Nucleic acids research.

Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes.

Alexander Kondrashov, Anne E Willis, Timothy W Gant, 2009, Genes & development.

A novel synthesis and detection method for cap-associated adenosine modifications in mouse mRNA

S. Zhong, M. Alcocer, C. Hayes, 2011, Scientific reports.

Studies on the oxidation of 2,2,4-trisubstituted 3-pyrrolines

C. Hayes, M. P. Green, J. Prodger, 2002 .

Multigram synthesis of the C29-C51 subunit and completion of the total synthesis of altohyrtin C (spongistatin 2).

C. Hayes, M. McLaughlin, C. Heathcock, 2003, Journal of the American Chemical Society.

A formal synthesis of (-)-cephalotaxine.

Claire Wilson, C. Hayes, D. Catterick, 2008, Organic letters.

Linear Viscoelastic Behaviour of Polyacrylate Binders and Bitumen Blends

A. Collop, C. Hayes, G. Airey, 2008 .

Mapping the interaction between eukaryotic initiation factor 4A (eIF4A) and the inhibitor hippuristanol using carbene footprinting and mass spectrometry

J. Lloyd, N. Oldham, G. Seymour, 2021, Proteomics.

Synthesis of β‐Keto Esters In‐Flow and Rapid Access to Substituted Pyrimidines.

C. Hayes, Hannah E. Bartrum, D. Blakemore, 2011 .

The impact of macrocycle conformation on the taxadiene-forming carbocation cascade: Insight gained from sobralene, a recently discovered verticillene isomer.

C. Hayes, G. Pattenden, M. J. Palframan, 2020, The Journal of organic chemistry.

Nicolle, Simon M. and Lewis, William and Hayes, Christopher J. and Moody, Christopher J. (2015) Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion

W. Lewis, C. Hayes, C. Moody, 2017 .

Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O – H insertion reaction

W. Lewis, C. Hayes, C. Moody, 2016 .

Nucleophilic fluorination of b-ketoester derivatives with HBF4w

C. Hayes, Hannah E. Bartrum, C. Moody, 2012 .

Alkyl halide-free heteroatom alkylation and epoxidation facilitated by a recyclable polymer-supported oxidant for the in-flow preparation of diazo compounds.

C. Hayes, C. Moody, Simon M. Nicolle, 2015, Chemistry.

A second generation formal synthesis of (-)-cephalotaxine.

A. Hameed, A. Blake, C. Hayes, 2008, The Journal of organic chemistry.

A formal synthesis of (-)-cephalotaxine.

C. Hayes, D. Catterick, William Esmieu, 2008, Organic letters.

Scope and limitations of the alkylidene carbene 1,5-CH insertion reactions of α-amino acid-derived substrates

C. Hayes, Renameditswe Mapitse, 2002 .

Synthesis of Nemorosone viaa Difficult Bridgehead Substitution Reaction

C. Hayes, N. Simpkins, James D. Taylor, 2010 .