T. Skarzynski

发表

Structure of holo-glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus at 1.8 A resolution.

P C Moody, A. Wonacott, T. Skarzynski, 1987, Journal of molecular biology.

X-ray diffraction from crystals in crystallization plates

T. Skarzynski, 2009 .

The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X‐ray crystallography.

C V Smith, C. V. Smith, D. Wigley, 1996, The EMBO journal.

Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.

N R Taylor, P. Colman, A. Wonacott, 1998, Journal of medicinal chemistry.

Novel inhibitors of influenza sialidases related to GG167 structure-activity, crystallographic and Molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides

Paul W Smith, P. Colman, J. Varghese, 1996 .

Bonding of molecular oxygen to T state human haemoglobin

R. Liddington, E. Dodson, A. Brzozowski, 1984, Nature.

The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate.

G. Hardy, T. Skarzynski, O. Singh, 2001, Bioorganic & medicinal chemistry letters.

Crystal structures of ASK1‐inhibtor complexes provide a platform for structure‐based drug design

I. Wall, P. Rowland, R. Tanner, 2013, Protein science : a publication of the Protein Society.

Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 protease.

Z. Ni, P. Rowland, S. Baker, 2010, Bioorganic & medicinal chemistry letters.

Crystallization of inhibitor complexes of an N-terminal 24 kDa fragment of the DNA gyrase B protein.

C. V. Smith, D. Wigley, R. Lewis, 1994, Journal of molecular biology.

Crystal structure of alpha-dendrotoxin from the green mamba venom and its comparison with the structure of bovine pancreatic trypsin inhibitor.

T. Skarzynski, 1992, Journal of molecular biology.

Crystallization and preliminary X-ray analysis of porcine synovial collagenase.

A. Wonacott, T. Skarzynski, I. Clark, 1989, Journal of molecular biology.

Structure of r-1-isopropyl-t-2,t-3-diphenylaziridine

T. Skarzynski, T. Olszak, G. Mlostoń, 1988 .

Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease.

Paul Bamborough, Martin R Johnson, Martin R. Johnson, 2003, Organic letters.

Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams.

G. Hardy, D. Belton, T. Skarzynski, 2001, Bioorganic & medicinal chemistry letters.

STRUCTURE OF UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE

T. Skarzynski, 1997 .

Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin.

A. Wonacott, T. Skarzynski, V. Kelly, 1996, Structure.

Crystal structure of α-dendrotoxin from the green mamba venom and its comparison with the structure of bovine pancreatic trypsin inhibitor

T. Skarzynski, T. Skarzynski, 1992 .

Probing the coenzyme specificity of glyceraldehyde-3-phosphate dehydrogenases by site-directed mutagenesis.

P. Billard, C. Corbier, A. Wonacott, 1990, Biochemistry.

The X-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 Å resolution

R. Hubbard, G. Davies, A. Wonacott, 1996, Nature Structural Biology.

Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed beta-propeller.

B. Hazleman, P. Brick, B. Hazleman, 1995, Structure.

Crystal structure of the ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA.

T. Sixma, C. Oubridge, K. Nagai, 2000, Structure.

Coenzyme-induced conformational changes in glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus.

A. Wonacott, T. Skarzynski, 1988, Journal of molecular biology.

The high‐resolution crystal structure of a 24‐kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin

A. Breeze, D. Wigley, J. Ladbury, 1997, Proteins.

The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution.

R. Hubbard, G. Davies, A. Wonacott, 1996, Nature structural biology.

Stereochemical course of enzymatic enolpyruvyl transfer and catalytic conformation of the active site revealed by the crystal structure of the fluorinated analogue of the reaction tetrahedral intermediate bound to the active site of the C115A mutant of MurA.

C. Walsh, D. Kim, T. Skarzynski, 1998, Biochemistry.

c-4,t-5-Bis(p-methoxyphenyl)-t-3-methyl-r-2-phenyl-1,3-oxazolidine, C24H25NO3

Z. Derewenda, T. Skarzynski, G. Mlostoń, 1983 .

Industrial perspective on X-ray data collection and analysis.

T. Skarzynski, Tadeusz Skarzynski, James Thorpe, 2006, Acta crystallographica. Section D, Biological crystallography.

Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates.

William McDowell, Yang Liu, Dazhong Fan, 2010, Bioorganic & medicinal chemistry letters.