J. Hempel

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The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold

Yuh-Ju Sun, Zhi-Jie Liu, Bi-Cheng Wang, 1997, Nature Structural Biology.

Class III human liver alcohol dehydrogenase: a novel structural type equidistantly related to the class I and class II enzymes.

H. Jörnvall, B. Vallee, J. Hempel, 1988, Biochemistry.

Cloning and complete nucleotide sequence of a full-length cDNA encoding a catalytically functional tumor-associated aldehyde dehydrogenase.

R. Lindahl, J. Hempel, M. D. Brennan, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Class III aldehyde dehydrogenase from rat liver: super-family relationship to classes I and II and functional interpretations.

R. Lindahl, J. Hempel, 1989, Progress in clinical and biological research.

Human liver alcohol dehydrogenase: amino acid substitution in the beta 2 beta 2 Oriental isozyme explains functional properties, establishes an active site structure, and parallels mutational exchanges in the yeast enzyme.

H. Jörnvall, B. Vallee, J. Hempel, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a segment containing a reactive cysteine residue in human liver cytoplasmic aldehyde dehydrogenase (isoenzyme E1).

H. Jörnvall, J. Hempel, R. Pietruszko, 1982, Biochemistry.

The Big Book of Aldehyde Dehydrogenase Sequences

H. Nicholas, J. Perozich, R. Lindahl, 1999 .

Aldehyde Dehydrogenase Catalytic Mechanism

J. Rose, Bi-Cheng Wang, Zhi-jie Liu, 1999 .

Aldehyde dehydrogenases: Widespread structural and functional diversity within a shared framework

H. Nicholas, R. Lindahl, J. Hempel, 1993, Protein science : a publication of the Protein Society.

Selective chemical modification of human liver aldehyde dehydrogenases E1 and E2 by iodoacetamide.

J. Hempel, R. Pietruszko, 1981, The Journal of biological chemistry.

Characterization of the coenzyme binding site of liver aldehyde dehydrogenase: differential reactivity of coenzyme analogues.

H. Jörnvall, J. Hempel, H. von Bahr-Lindström, 1985, Biochemistry.

Human alcohol dehydrogenase: structural differences between the beta and gamma subunits suggest parallel duplications in isoenzyme evolution and predominant expression of separate gene descendants in livers of different mammals.

H. Jörnvall, B. Vallee, J. Hempel, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of a nonhepatic alcohol dehydrogenase from rat hepatocellular carcinoma and stomach.

F. Becker, A. Cederbaum, R. Pietrusko, 1975, Archives of Biochemistry and Biophysics.

Structural characteristics of a major seed albumin ofPisum sativum

H. Jörnvall, J. Hempel, J. Przybylska, 1985, Bioscience reports.

Structure of the class II enzyme of human liver alcohol dehydrogenase: combined cDNA and protein sequence determination of the pi subunit.

H. Jörnvall, B. Vallee, K. Larsson, 1987, Biochemistry.

Human liver alcohol dehydrogenase

H. Jörnvall, B. Vallee, J. Hempel, 1984 .

Molecular cloning and characterization of a cDNA for the beta subunit of human alcohol dehydrogenase.

G. W. Hatfield, H. Jörnvall, G. Duester, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Aldehyde dehydrogenases: what can be learned from a baker's dozen sequences?

R. Lindahl, J. Hempel, 1991, Advances in experimental medicine and biology.

Rapid modulation of gill Na+ + K+-dependent ATPase activity during acclimation of the killifish Fundulus heteroclitus to salinity change.

J. Hempel, D. Towle, M. E. Gilman, 1977, The Journal of experimental zoology.

Human stomach alcohol dehydrogenase: isoenzyme composition and catalytic properties.

J. Hempel, R. Pietruszko, 1979, Alcoholism, clinical and experimental research.

UDP-Glucose Dehydrogenase

J. Perozich, J. Hempel, John Perozich, 1995 .

Relationships within the aldehyde dehydrogenase extended family

H. Nicholas, J. Perozich, R. Lindahl, 2008, Protein science : a publication of the Protein Society.

Roles of conserved residues in the arginase family.

J. Perozich, J. Hempel, S. Morris, 1998, Biochimica et biophysica acta.

Ethanol utilization regulatory protein: Profile alignments give no evidence of origin through aldehyde and alcohol dehydrogenase gene fusion

H B Nicholas, B. Persson, H. Jörnvall, 1995, Protein science : a publication of the Protein Society.

UDP-glucose dehydrogenase. Structural characteristics.

J. Perozich, J. Hempel, A. Leksana, 1995, Advances in experimental medicine and biology.

UDP‐glucose dehydrogenase from bovine liver: Primary structure and relationship to other dehydrogenases

I. Kuo, J. Perozich, J. Hempel, 1994, Protein science : a publication of the Protein Society.

Thiol proteases and aldehyde dehydrogenases: Evolution from a common thiolesterase precursor?

H. Jörnvall, H. Nicholas, J. Hempel, 1991, Proteins.

Coenzyme specificity in aldehyde dehydrogenase.

I. Kuo, J. Perozich, R. Lindahl, 2001, Chemico-biological interactions.

cDNA to chick lumican (corneal keratan sulfate proteoglycan) reveals homology to the small interstitial proteoglycan gene family and expression in muscle and intestine.

J. Vergnes, J. Hempel, J. Hassell, 1992, The Journal of biological chemistry.

Type XII collagen contributes to diversities in human corneal and limbal extracellular matrices.

J. Hempel, N. Sundarraj, S. Anderson, 1997, Investigative ophthalmology & visual science.

Human liver alcohol dehydrogenase. 2. The primary structure of the gamma 1 protein chain.

H. Jörnvall, J. Hempel, J. von Wartburg, 1984, European journal of biochemistry.

Atypical human liver alcohol dehydrogenase: the β 2‐Bern subunit has an amino acid exchange that is identical to the one in the β 2‐Oriental chain

H. Jörnvall, J. Hempel, J. von Wartburg, 1984 .

By-products as an aid in residue identification during peptide sequence analysis with dimethylaminoazobenzene isothiocyanate

H. Jörnvall, J. Hempel, H. Bahr-Lindström, 1982 .

Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations.

H. Jörnvall, J. Hempel, R. Kaiser, 1985, European journal of biochemistry.

HUMAN LIVER ALCOHOL DEHYDROGENASE: THE PRIMARY STRUCTURE OF THE γ1 PROTEIN CHAIN

H. Jörnvall, J. Hempel, R. Kaiser, 1984 .

Aldehyde dehydrogenase from human liver

H. Jörnvall, J. Hempel, H. Bahr-Lindström, 1984 .

Aldehyde dehydrogenase from human liver. Primary structure of the cytoplasmic isoenzyme.

H. Jörnvall, J. Hempel, H. von Bahr-Lindström, 1984, European journal of biochemistry.

Inducible (class 3) aldehyde dehydrogenase from rat hepatocellular carcinoma and 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated liver: distant relationship to the class 1 and 2 enzymes from mammalian liver cytosol/mitochondria.

R. Lindahl, J. Hempel, K. Harper, 1989, Biochemistry.

cDNA and protein structure for the alpha subunit of human liver alcohol dehydrogenase.

A. Holmgren, K. Larsson, J. Hempel, 1986, Biochemistry.

Cleavage at acyl-proline bonds with sodium in liquid ammonia: application with nanomolar amounts of peptides and separation of products by high-performance liquid chromatography for structural analysis.

H. Jörnvall, J. Hempel, 1985, Analytical biochemistry.

Human liver alcohol dehydrogenase: The unique properties of the “atypical” isoenzyme β2β2-Bern can be explained by a single base mutation

H. Jörnvall, J. Hempel, J. P. Wartburg, 1985 .

Human liver mitochondrial aldehyde dehydrogenase: a C‐terminal segment positions and defines the structure corresponding to the one reported to differ in the Oriental enzyme variant

H. Jörnvall, J. Hempel, R. Kaiser, 1984, FEBS letters.

The cytoplasmic isoenzyme of horse liver aldehyde dehydrogenase. Relationship to the corresponding human isoenzyme.

H. Jörnvall, J. Hempel, H. von Bahr-Lindström, 1984, European journal of biochemistry.

Human aldehyde dehydrogenase: improved purification procedure and comparison of homogeneous isoenzymes E1 and E2.

J. Hempel, R. Pietruszko, D. Reed, 1982, Alcoholism, clinical and experimental research.

The Murine P84 Neural Adhesion Molecule Is SHPS-1, a Member of the Phosphatase-Binding Protein Family

C. Lagenaur, V. Narayanan, S. Çomu, 1997, The Journal of Neuroscience.

Structures of human alcohol and aldehyde dehydrogenases.

H. Jörnvall, B. Vallee, J. Hempel, 1987, Enzyme.

Comparative studies of vertebrate aldehyde dehydrogenase 3: sequences, structures, phylogeny and evolution. Evidence for a mammalian origin for the ALDH3A1 gene.

J. Hempel, R. Holmes, 2011, Chemico-biological interactions.

Aldehyde dehydrogenase from human erythrocytes: structural relationship to the liver cytosolic isozyme.

J. Hempel, D. Agarwal, H. Goedde, 1989, Enzyme.

Biochemical, immunological, and molecular characterization of a "high Km" aldehyde dehydrogenase.

J. Hempel, D. Agarwal, H. Goedde, 1991, Advances in experimental medicine and biology.

Human liver high Km aldehyde dehydrogenase (ALDH4): properties and structural relationship to the glutamic gamma-semialdehyde dehydrogenase.

J. Hempel, D. Agarwal, H. Goedde, 1993, Advances in experimental medicine and biology.

Human liver glutamic γ-semialdehyde dehydrogenase: Structural relationship to the yeast enzyme

J. Hempel, D. Agarwal, H. Goedde, 1992 .

Acetyl‐blocked N‐terminal structures of sorbitol and aldehyde dehydrogenases

H. Jörnvall, J. Hempel, J. Jeffery, 1984, FEBS Letters.

Structural relationships among class I isozymes of human liver alcohol dehydrogenase.

H. Jörnvall, B. Vallee, J. Hempel, 1985, Biochemistry.

Mechanistic implications of the cysteine-nicotinamide adduct in aldehyde dehydrogenase based on quantum mechanical/molecular mechanical simulations.

D. Deerfield, J. Hempel, T. Wymore, 2007, Biochemistry.

Crystal structure of a class 3 aldehyde dehydrogenase at 2.6 A resolution.

J. Rose, B. Wang, Z. J. Liu, 1997, Advances in experimental medicine and biology.

On the interaction of human liver aldehyde dehydrogenase E1 isoenzyme with disulfiram and iodoacetamide.

J. Hempel, R. Pietruszko, R. C. Vallari, 1980, Advances in experimental medicine and biology.

Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.

T. Hu, Eugen Lounkine, Tamara J. Gilbert, 2018, Journal of medicinal chemistry.

ETHANOL-OXIDIZING ENZYMES IN TRANSPLANTABLE HEPATOCELLULAR CARCINOMS

A. Cederbaum, J. Hempel, R. Pietruszko, 1977 .

Alcohol and aldehyde dehydrogenases: structures of the human liver enzymes, functional properties and evolutionary aspects.

H. Jörnvall, B. Vallee, J. Hempel, 1987, Alcohol and alcoholism (Oxford, Oxfordshire). Supplement.

Internal chain cleavage and product heterogeneity during Edman degradation of isosteric peptide analogs lacking the α‐carbonyl function

K. Nilsson, H. Jörnvall, J. Hempel, 1986, FEBS letters.

Molecular recognition of aldehydes by aldehyde dehydrogenase and mechanism of nucleophile activation

Alexander D. MacKerell, Troy Wymore, Hugh B Nicholas, 2004, Proteins.

Initial catalytic events in class 3 aldehyde dehydrogenase: MM and QM/MM simulations.

M. Field, H. Nicholas, D. Deerfield, 2003, Chemico-biological interactions.

Molecular dynamics simulation of class 3 aldehyde dehydrogenase.

H. Nicholas, J. Hempel, T. Wymore, 2001, Chemico-biological interactions.

Identification of zinc proteins in rat parotid saliva.

R. Koepsel, J. Hempel, K. Etzel, 1997, Archives of oral biology.

Shifting the NAD/NADP preference in class 3 aldehyde dehydrogenase.

B. Wang, I. Kuo, J. Perozich, 2000, European journal of biochemistry.

HUMAN LIVER ALCOHOL DEHYDROGENASE: THE PRIMARY STRUCTURE OF THE β1β1 ISOENZYME

H. Jörnvall, B. Vallee, J. Hempel, 1984 .

Aldehyde dehydrogenase. Maintaining critical active site geometry at motif 8 in the class 3 enzyme.

B. Wang, H. Nicholas, I. Kuo, 2001, European journal of biochemistry.

Beyond the catalytic core of ALDH: a web of important residues begins to emerge.

B. Wang, H. Nicholas, I. Kuo, 2001, Chemico-biological interactions.

Preliminary crystallographic analysis of class 3 rat liver aldehyde dehydrogenase

J. Rose, I. Kuo, R. Lindahl, 1990, Proteins.

Chemical modification and site of interaction of human aldehyde dehydrogenase E1 with disulfiram and iodoacetamide.

J. Hempel, R. Pietruszko, R. C. Vallari, 1982, Progress in clinical and biological research.

Evidence for an ambidirectional magnesium- activated, sodium-potassium dependent adenosine triphosphatase

J. Hempel, 1973 .

Primary structure of rat liver D-beta-hydroxybutyrate dehydrogenase from cDNA and protein analyses: a short-chain alcohol dehydrogenase.

W. W. Zhang, S. Churchill, P. Churchill, 1992, Biochemistry.

Mitochondrial aldehyde dehydrogenase Homology of putative targeting sequence to that of carbamyl phosphate synthetase I revealed by correlation of cDNA and protein data

H. Jörnvall, J. Hempel, J. Höög, 1987, FEBS letters.

Progress toward the tertiary structure of (class 3) aldehyde dehydrogenase.

J. Rose, B. Wang, J. Perozich, 1995, Advances in experimental medicine and biology.

Homocyst(e)ine and risk of cardiovascular disease in the Multiple Risk Factor Intervention Trial.

J. Cutler, L. Kuller, J. Hempel, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.

T. Hu, Eugen Lounkine, Tamara J. Gilbert, 2018, Journal of medicinal chemistry.