M. Morishima-kawashima

发表

Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments

Yasuo Ihara, Masato Hasegawa, K. Titani, 1993, Neuron.

System in Alzheimer Disease Lysosomal - Proteasome System and the Autophagic - The Ubiquitin

A. Fagan, L. Mucke, K. Blennow, 2012 .

The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.

Y. Ihara, R. Nixon, M. Morishima-kawashima, 2012, Cold Spring Harbor Perspectives in Medicine.

Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein.

Y. Ihara, N. Dohmae, C. Haass, 2003, The Journal of biological chemistry.

Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein*

Y. Ihara, N. Dohmae, C. Haass, 2003, Journal of Biological Chemistry.

Gamma-secretase activity is present in rafts but is not cholesterol-dependent.

Y. Ihara, M. Morishima-kawashima, Y. Shimada, 2003, Biochemistry.

Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

Y. Ihara, S. Funamoto, T. Saido, 2004, Biochemistry.

Truncated Carboxyl-Terminal Fragments of β-Amyloid Precursor Protein Are Processed to Amyloid β-Proteins 40 and 42†

Y. Ihara, S. Funamoto, T. Saido, 2004 .

Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein.

Y. Ihara, T. Saido, M. Morishima-kawashima, 2005, FEBS Letters.

Selective Deposition of Mutant Tau in the FTDP‐17 Brain Affected by the P301L Mutation

W. Kamphorst, R. Ravid, Y. Ihara, 2001, Journal of neuropathology and experimental neurology.

Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells.

Y. Ihara, M. Morishima-kawashima, H. Misonou, 2000, Biochemistry.

Molecular aging of tau: disulfide‐independent aggregation and non‐enzymatic degradation in vitro and in vivo

Y. Ihara, N. Dohmae, M. Morishima-kawashima, 2004, Journal of neurochemistry.

Mutant Presenilin 2 Transgenic Mouse: Effect on an Age‐Dependent Increase of Amyloid β‐Protein 42 in the Brain

T. Iwatsubo, Mamoru Ito, Y. Ueyama, 1998, Journal of neurochemistry.

Aβ46 Is Processed to Aβ40 and Aβ43, but Not to Aβ42, in the Low Density Membrane Domains*

Y. Ihara, M. Morishima-kawashima, S. Ishiura, 2008, Journal of Biological Chemistry.

Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains.

Y. Ihara, M. Morishima-kawashima, S. Ishiura, 2008, The Journal of biological chemistry.

Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain.

Y. Ihara, H. Yamaguchi, M. Morishima-kawashima, 2000, The American journal of pathology.

Longer Forms of Amyloid (cid:1) Protein: Implications for the Mechanism of Intramembrane Cleavage by (cid:2) -Secretase

F. Kametani, Y. Ihara, G. Dolios, 2005 .

A possible fetal antigen ofM r70,000 in neurofibrillary tangles

K. Titani, K. Kosik, Y. Ihara, 1991, Brain Research.

Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation.

R. Ravid, P. Heutink, J. V. van Swieten, 2001, The American journal of pathology.

Amyloid β-protein (Aβ) Accumulation in the Putamen and Mammillary Body during Aging and in Alzheimer Disease

Y. Ihara, M. Morishima-kawashima, T. Miyakawa, 1998 .

In vivo phosphorylation sites in fetal and adult rat tau.

K. Titani, K. Kosik, M. Hasegawa, 1993, The Journal of biological chemistry.

Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during aging.

Y. Ihara, D. Schenk, K. Khan, 1999, The American journal of pathology.

Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.

T. Kudo, M. Takeda, Y. Ihara, 2008, The Journal of biological chemistry.

γ-Secretase Associated with Lipid Rafts

Y. Ihara, S. Funamoto, S. Tagami, 2013, The Journal of Biological Chemistry.

γ-Cleavage and ε-cleavage of β-amyloid precursor protein

Y. Ihara, M. Morishima-kawashima, 2003 .

Enhanced amyloid-beta generation by gamma-secretase complex in DRM microdomains with reduced cholesterol levels

Toshiharu Suzuki, M. Nishimura, M. Morishima-kawashima, 2021 .

The presence of amyloid beta-protein in the detergent-insoluble membrane compartment of human neuroblastoma cells.

Y. Ihara, M. Morishima-kawashima, 1998, Biochemistry.

Appearance of Sodium Dodecyl Sulfate-Stable Amyloid β-Protein (Aβ) Dimer in the Cortex During Aging

Y. Ihara, D. Schenk, K. Khan, 1999 .

Amyloid (B-protein (Aß) Accumulation in the Putamen and Mammillary Body during Aging and in Alzheimer Disease

Y. Ihara, M. Morishima-kawashima, T. Miyakawa, 1998 .

Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells.

Y. Ihara, M. Morishima-kawashima, Rie Mitsumori, 2003, Biochemistry.

Effect of Apolipoprotein E Allele ε4 on the Initial Phase of Amyloid β-Protein Accumulation in the Human Brain

Y. Ihara, H. Yamaguchi, M. Morishima-kawashima, 2000 .

Modulation of Lipid Kinase PI4KIIα Activity and Lipid Raft Association of Presenilin 1 Underlies γ-Secretase Inhibition by Ginsenoside (20S)-Rg3*

D. Berman, Y. Ihara, Hyun-Ok Yang, 2013, The Journal of Biological Chemistry.

Successive cleavage of β-amyloid precursor protein by γ-secretase.

S. Funamoto, S. Tagami, M. Okochi, 2020, Seminars in cell & developmental biology.

Alzheimer's disease: β‐Amyloid protein and tau

Y. Ihara, M. Morishima-kawashima, 2002, Journal of neuroscience research.

The pool of map kinase associated with microtubules is small but constitutively active.

K. Kosik, M. Morishima-kawashima, 1996, Molecular biology of the cell.

Longer Forms of Amyloid β Protein: Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase

F. Kametani, Y. Ihara, M. Maeda, 2005, The Journal of Neuroscience.

Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin.

M. Frosch, R. Tanzi, T. Tabira, 2000, Journal of Biological Chemistry.

Proline-directed and Non-proline-directed Phosphorylation of PHF-tau (*)

K. Titani, M. Hasegawa, Y. Ihara, 1995, The Journal of Biological Chemistry.

Amyloid β‐protein deposition in the leptomeninges and cerebral cortex

Yasuo Ihara, Y. Ihara, K. Yanagisawa, 1997 .

Hyperphosphorylation of Tau in PHF

K. Titani, M. Hasegawa, Y. Ihara, 1995, Neurobiology of Aging.

γ-Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of β-Carboxyl Terminal Fragment

Y. Ihara, S. Funamoto, M. Morishima-kawashima, 2009, The Journal of Neuroscience.

Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase

M. Morishima-kawashima, 2014, Front. Physiol..

Accumulation of Amyloid β-Protein in the Low-Density Membrane Domain Accurately Reflects the Extent of β-Amyloid Deposition in the Brain

Y. Ihara, D. Schenk, K. Khan, 2001 .

Independent accumulations of tau and amyloid β-protein in the human entorhinal cortex

Y. Ihara, S. Murayama, M. Morishima-kawashima, 2005, Neurology.

Enhanced amyloid-β generation by γ-secretase complex in DRM microdomains with reduced cholesterol levels

Toshiharu Suzuki, M. Nishimura, S. Murayama, 2020 .

Enhanced amyloid-β generation by γ-secretase complex in detergent-resistant membrane microdomains with reduced cholesterol levels.

Toshiharu Suzuki, M. Nishimura, S. Murayama, 2019, Human molecular genetics.

Amyloid β-protein accumulation in the human brain during aging

Y. Ihara, M. Morishima-kawashima, 2001 .

Presence of sodium dodecyl sulfate-stable amyloid beta-protein dimers in the hippocampus CA1 not exhibiting neurofibrillary tangle formation.

Y. Ihara, M. Morishima-kawashima, M. Yoshimura, 1999, The American journal of pathology.

Effects of human apolipoprotein E isoforms on the amyloid β‐protein concentration and lipid composition in brain low‐density membrane domains

Xianlin Han, S. Fujita, Y. Ihara, 2007, Journal of neurochemistry.

Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.

K. Titani, M. Hasegawa, Y. Ihara, 1992, The Journal of biological chemistry.

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

F. Kametani, Y. Ihara, M. Maeda, 2005, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Posttranslational Modifications of the Tau in PHF: Phosphorylation and Ubiquitination

Y. Ihara, M. Morishima-kawashima, 1995 .

Amyloid beta-protein deposition in the leptomeninges and cerebral cortex.

Y. Ihara, K. Yanagisawa, M. Morishima-kawashima, 1997, Annals of neurology.

Visualization of Newly Deposited tau in Neurofibrillary Tangles and Neuropil Threads

D. Mann, R. Ravid, Y. Ihara, 2005, Journal of neuropathology and experimental neurology.

Blocking the cleavage at midportion between γ‐ and ε‐sites remarkably suppresses the generation of amyloid β‐protein

Y. Ihara, T. Saido, M. Morishima-kawashima, 2005 .

[Recent advances in Alzheimer's disease].

Y. Ihara, M. Morishima-kawashima, 2001, Seikagaku. The Journal of Japanese Biochemical Society.

DAPT-Induced Intracellular Accumulations of Longer Amyloid β-Proteins: Further Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase†

Y. Ihara, M. Morishima-kawashima, S. Ishiura, 2006 .

Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain.

Y. Ihara, D. Schenk, K. Khan, 2001, The American journal of pathology.

DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase.

Y. Ihara, M. Morishima-kawashima, S. Ishiura, 2006, Biochemistry.

Amyloid beta-protein (A beta) accumulation in the putamen and mammillary body during aging and in Alzheimer disease.

Y. Ihara, M. Morishima-kawashima, T. Miyakawa, 1998, Journal of neuropathology and experimental neurology.

Increased levels of plasma p3-alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease.

T. Asada, Toshiharu Suzuki, M. Maeda, 2014, Journal of Alzheimer's disease : JAD.

Dissociation of β‐amyloid from lipoprotein in cerebrospinal fluid from Alzheimer's disease accelerates β‐amyloid‐42 assembly

E. Matsubara, M. Shoji, Y. Ihara, 2011, Journal of neuroscience research.

[Molecular analysis of tau deposited in the FTDP-17 brain].

M. Morishima-kawashima, 2001, Rinsho shinkeigaku = Clinical neurology.

Increased Levels of Plasma p3-Alc alpha 35, a Major Fragment of Alcadein alpha by gamma-Secretase Cleavage, in Alzheimer's Disease

Toshiharu, T. Asada, Toshiharu Suzuki, 2019 .