Kirsten M. Stray

发表

Tsg101 and the Vacuolar Protein Sorting Pathway Are Essential for HIV-1 Budding

Wesley I. Sundquist, David G. Myszka, W. Sundquist, 2001, Cell.

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

William A. Lee, Sina Bavari, Robert Jordan, 2017, Journal of medicinal chemistry.

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

William A. Lee, Mike Flint, Donald K. Nichols, 2016, Nature.

Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid Protein

Wesley I. Sundquist, W. Sundquist, J. Garrus, 2003, Journal of Virology.

Non-Catalytic Site HIV-1 Integrase Inhibitors Disrupt Core Maturation and Induce a Reverse Transcription Block in Target Cells

S. Yant, Luong K. Tsai, T. Cihlar, 2013, PloS one.

Assembly Properties of the Human Immunodeficiency Virus Type 1 CA Protein

Wesley I. Sundquist, W. Sundquist, C. Aiken, 2004, Journal of Virology.

HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein

R. D. Fisher, W. Sundquist, D. Higginson, 2003, The Journal of cell biology.

Evaluation of the Effect of Cobicistat on the In Vitro Renal Transport and Cytotoxicity Potential of Tenofovir

S. Yant, T. Cihlar, Kirsten M. Stray, 2013, Antimicrobial Agents and Chemotherapy.

Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV.

R. Mackman, J. Bilello, T. Cihlar, 2021, Journal of medicinal chemistry.

Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study.

M. Desai, R. Jordan, R. Mackman, 2015, Journal of medicinal chemistry.

Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines.

I. Pichová, R. Pohl, Michal Hocek, 2011, Journal of medicinal chemistry.

Drug Resistance Assessment Following Administration of Respiratory Syncytial Virus (RSV) Fusion Inhibitor Presatovir to Participants Experimentally Infected With RSV

S. Lewis, R. Jordan, T. Cihlar, 2020 .

Intracellular Metabolism of the Nucleotide Prodrug GS-9131, a Potent Anti-Human Immunodeficiency Virus Agent

R. Mackman, T. Cihlar, K. Lin, 2007, Antimicrobial Agents and Chemotherapy.

Tenofovir alafenamide (TAF) does not deplete mitochondrial DNA in human T-cell lines at intracellular concentrations exceeding clinically relevant drug exposures.

T. Cihlar, Kirsten M. Stray, A. Ray, 2017, Antiviral research.

Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors

S. Yant, Luong K. Tsai, T. Cihlar, 2015, Antimicrobial Agents and Chemotherapy.

Discovery of GS-8374, a potent human immunodeficiency virus type 1 protease inhibitor with a superior resistance profile

William A. Lee, M. Hatada, M. Desai, 2011 .

Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring.

William A. Lee, M. Hatada, Xiaohong Liu, 2006, Journal of molecular biology.

Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer.

Yujin Wang, Manoj C Desai, M. Desai, 2010, ACS medicinal chemistry letters.

Structure-activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers, part I: core region.

M. Desai, Luong K. Tsai, Kirsten M. Stray, 2014, Bioorganic & medicinal chemistry letters.

Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile

K. White, Helen Yu, G. Kukolj, 2016, Antimicrobial Agents and Chemotherapy.

A New Point Mutation (P157S) in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Confers Low-Level Resistance to (−)-β-2′,3′-Dideoxy-3′-Thiacytidine

R. Schinazi, G. Klarmann, B. Preston, 1999, Antimicrobial Agents and Chemotherapy.

The Human Endosomal Sorting Complex Required for Transport (ESCRT-I) and Its Role in HIV-1 Budding*♦

W. Sundquist, H. Kräusslich, B. Müller, 2004, Journal of Biological Chemistry.

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

C. Spina, J. Mellors, Helen Yu, 2014, PLoS pathogens.

GS-5806 Inhibits a Broad Range of Respiratory Syncytial Virus Clinical Isolates by Blocking the Virus-Cell Fusion Process

R. Jordan, R. Mackman, T. Cihlar, 2015, Antimicrobial Agents and Chemotherapy.

Nucleotide Prodrug GS-5734 Is a Broad-Spectrum Filovirus Inhibitor That Provides Complete Therapeutic Protection Against the Development of Ebola Virus Disease (EVD) in Infected Non-human Primates

William A. Lee, R. Jordan, R. Mackman, 2015 .

In Vitro Characterization of GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease with a Favorable Resistance Profile

William A. Lee, M. Hatada, Xiaohong Liu, 2011, Antimicrobial Agents and Chemotherapy.

Mutations in Multiple Domains of Gag Drive the Emergence of In Vitro Resistance to the Phosphonate-Containing HIV-1 Protease Inhibitor GS-8374

H. Kräusslich, B. Müller, B. Glass, 2012, Journal of Virology.

Drug resistance assessment following administration of RSV fusion inhibitor presatovir to participants experimentally infected with respiratory syncytial virus.

S. Lewis, R. Jordan, T. Cihlar, 2020, The Journal of infectious diseases.

55Biological Profiling of GS-9350, a Novel Pharmacoenhancer that Lacks Anti-HIV Activity and Exhibits Low Potential for Metabolic Adverse Effects In Vitro

M. Desai, Luong K. Tsai, T. Cihlar, 2010 .

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

William A. Lee, Jeffrey R. Kugelman, G. Palacios, 2016, Nature.

GS-8374, a Prototype Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits Protease Mutants with Amino Acid Insertions

J. Konvalinka, J. Brynda, T. Cihlar, 2013, Journal of Virology.

Prototype Phosphonate-Containing Inhibitor of HIV-1 Protease , Effectively 1 Inhibits Protease Mutants with Amino Acid Insertions 2 3 Running title : HIV-1 Protease Mutants and Phosphonate Inhibitor 4 5

J. Konvalinka, Kirsten M. Stray, M. Kožíšek, 2013 .

The Human Endosomal Complex Required for Transport I (ESCRT-I) and its Role in HIV-1 Budding*

H. Kräusslich, B. Müller, J. Garrus, 2004 .

HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein

R. D. Fisher, W. Sundquist, D. Higginson, 2003, The Journal of cell biology.

Structure-activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers. Part II: P2/P3 region and discovery of cobicistat (GS-9350).

M. Desai, Luong K. Tsai, S. Swaminathan, 2014, Bioorganic & medicinal chemistry letters.

GS-8374, a Novel Phosphonate HIV Protease Inhibitor with Potent In Vitro Antiretroviral Activity, Low Metabolic Toxicity, and Favorable Resistance Profile

William A. Lee, N. Parkin, Luong K. Tsai, 2007 .

Analysis of GS-5806 Resistance Emergence in Human Healthy Adult Subjects Experimentally Infected with Respiratory Syncytial Virus (RSV)

S. Lewis, H. Mo, R. Jordan, 2015 .