Glenville Jones

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CYP2U1, a Novel Human Thymus- and Brain-specific Cytochrome P450, Catalyzes ω- and (ω-1)-Hydroxylation of Fatty Acids*

M. Taimi, S. S. Chuang, C. Helvig, 2004, Journal of Biological Chemistry.

Glenville Jones, 2008, The American journal of clinical nutrition.

The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know

J. Manson, S. Mayne, J. Aloia, 2010, The Journal of clinical endocrinology and metabolism.

Structural analysis of CYP2R1 in complex with vitamin D3.

Hee-Won Park, A. Plotnikov, Glenville Jones, 2007, Journal of molecular biology.

CYP24A1 and kidney disease

M. Petkovich, Glenville Jones, 2011, Current opinion in nephrology and hypertension.

Plasma 24,25‐dihydroxyvitamin D3 concentrations in x‐linked hypophosphatemic mice: Studies using mass fragmentographic and radioreceptor assays

J. Cunningham, Glenville Jones, H. Tenenhouse, 1990, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Analysis of Vitamins D, Their Metabolites and Analogues

Glenville Jones, H. Makin, M. Calverley, 2010 .

Insights into Vitamin D metabolism using cyp24 over-expression and knockout systems in conjunction with liquid chromatography/mass spectrometry (LC/MS)

Glenville Jones, R. St-Arnaud, M. Gao, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

Hepatic activation and inactivation of clinically-relevant vitamin D analogs and prodrugs.

R. Mehta, Glenville Jones, S. Strugnell, 2006, Anticancer research.

100 YEARS OF VITAMIN D: Historical aspects of vitamin D

Glenville Jones, 2022, Endocrine connections.

Update on pharmacologically-relevant vitamin D analogues.

Glenville Jones, M. Kaufmann, 2018, British journal of clinical pharmacology.

Chapter 67 – Genetic Defects in Vitamin D Metabolism and Action∗

F. Glorieux, Glenville Jones, R. St-Arnaud, 2016 .

CHAPTER 81 – Analog Metabolism

Glenville Jones, 2005 .

Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada

W. Leslie, S. Atkinson, D. Cole, 2010, Canadian Medical Association Journal.

Interpreting vitamin D assay results: proceed with caution.

Glenville Jones, 2015, Clinical journal of the American Society of Nephrology : CJASN.

Significance of serum 24,25-dihydroxyvitamin D in the assessment of vitamin D status: a double-edged sword?

C. Sempos, A. Hoofnagle, K. Cashman, 2015, Clinical chemistry.

Targeted genomic deletions identify diverse enhancer functions and generate a kidney-specific, endocrine-deficient Cyp27b1 pseudo-null mouse

R. Redfield, Glenville Jones, J. Pike, 2019, The Journal of Biological Chemistry.

A kidney-specific genetic control module in mice governs endocrine regulation of the cytochrome P450 gene Cyp27b1 essential for vitamin D3 activation

Glenville Jones, J. Pike, M. Meyer, 2017, The Journal of Biological Chemistry.

Vitamin D Analogs and Their Clinical Uses

Glenville Jones, 2012 .

Diagnostic Aspects of Vitamin D: Clinical Utility of Vitamin D Metabolite Profiling

Glenville Jones, M. Kaufmann, 2021, JBMR plus.

Controversies in Vitamin D: A Statement From the Third International Conference

John H. White, R. Rizzoli, P. Lips, 2020, JBMR plus.

Prevention of post-cardiac surgery vitamin D deficiency in children with congenital heart disease: a pilot feasibility dose evaluation randomized controlled trial

M. Lawson, K. Menon, D. Fergusson, 2020, Pilot and Feasibility Studies.

PTH suppression by calcitriol does not predict off‐target actions in experimental CKD

M. Petkovich, Glenville Jones, M. Adams, 2020, Pharmacology research & perspectives.

Editorials: Why Dialysis Patients Need Combination Therapy with Both Cholecalciferol and A Calcitriol Analogs

Glenville Jones, 2010, Seminars in dialysis.

Overlapping Phenotypes Associated With CYP24A1, SLC34A1, and SLC34A3 Mutations: A Cohort Study of Patients With Hypersensitivity to Vitamin D

J. Bacchetta, S. Lemoine, Glenville Jones, 2021, Frontiers in Endocrinology.

Vitamin D metabolite profiling using liquid chromatography–tandem mass spectrometry (LC–MS/MS)

Martin Kaufmann, Glenville Jones, Glenville Jones, 2016, The Journal of Steroid Biochemistry and Molecular Biology.

Clinical utility of simultaneous quantitation of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D by LC-MS/MS involving derivatization with DMEQ-TAD.

H. DeLuca, D. Cooper, J. Gallagher, 2014, The Journal of clinical endocrinology and metabolism.

Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1α,25-(OH)2D3-26,23-lactone

Glenville Jones, B. O’Leary, M. Kaufmann, 2007, Proceedings of the National Academy of Sciences.

CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo

H. DeLuca, Glenville Jones, M. Kaufmann, 2013, Proceedings of the National Academy of Sciences.

the Institute of Medicine: What Clinicians Need to Know The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from

J. Manson, J. Aloia, J. Gallagher, 2011 .

The 2011 Dietary Reference Intakes for Calcium and Vitamin D: what dietetics practitioners need to know.

J. Manson, S. Mayne, J. Aloia, 2011, Journal of the American Dietetic Association.

Mutations in CYP24A1 and idiopathic infantile hypercalcemia.

M. Konrad, H. Fehrenbach, J. Hoenderop, 2011, The New England journal of medicine.

CYP24A1 and SLC34A1 Pathogenic Variants Are Uncommon in a Canadian Cohort of Children with Hypercalcemia or Hypercalciuria

M. Pinsk, Glenville Jones, D. Pacaud, 2021, Hormone Research in Paediatrics.

Differential diagnosis of vitamin D–related hypercalcemia using serum vitamin D metabolite profiling

J. Gallagher, M. Uesugi, M. Konrad, 2021, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Vitamin D supplementation in pregnancy: A word of caution. Familial hypercalcaemia due to disordered vitamin D metabolism

Glenville Jones, S. Soule, C. Florkowski, 2020 .

Do the heterozygous carriers of a CYP24A1 mutation display a different biochemical phenotype than wild types?

C. Marcocci, F. Cetani, F. Baldinotti, 2020, The Journal of clinical endocrinology and metabolism.

Improved Screening Test for Idiopathic Infantile Hypercalcemia Confirms Residual Levels of Serum 24,25‐(OH)2D3 in Affected Patients

D. Cooper, J. Gallagher, Glenville Jones, 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Genetic Diseases of Vitamin D Metabolizing Enzymes.

Glenville Jones, K. Schlingmann, M. Kottler, 2017, Endocrinology and metabolism clinics of North America.

Calcium pyrophosphate deposition disease revealing a hypersensitivity to vitamin D.

Glenville Jones, C. Marcelli, M. Kottler, 2017, Joint, bone, spine : revue du rhumatisme.

Vitamin D metabolism in the premature newborn: A randomized trial.

E. Lyden, Glenville Jones, L. Armas, 2016, Clinical nutrition.

Dynamics of Vitamin D Metabolism in Maternal–Fetal Dyads

E. Lyden, Glenville Jones, C. Hanson, 2016, Journal of pediatric gastroenterology and nutrition.

Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations.

R. Nussbaum, E. Hsiao, S. Baumgartner-Parzer, 2015, The Journal of clinical endocrinology and metabolism.

A lifetime of hypercalcemia and hypercalciuria, finally explained.

R. Kumar, J. Bilezikian, S. Shapses, 2014, The Journal of clinical endocrinology and metabolism.

Extrarenal vitamin D activation and interactions between vitamin D₂, vitamin D₃, and vitamin D analogs.

Glenville Jones, 2013, Annual review of nutrition.

Metabolism and biomarkers of Vitamin D

Glenville Jones, 2012, Scandinavian journal of clinical and laboratory investigation. Supplementum.

The Activating Enzymes of Vitamin D Metabolism (25- and 1α-Hydroxylases)

Glenville Jones, D. Prosser, 2011 .

Generation of a homology model for the human cytochrome P450, CYP24A1, and the testing of putative substrate binding residues by site-directed mutagenesis and enzyme activity studies.

Glenville Jones, S. Masuda, M. Kaufmann, 2007, Archives of biochemistry and biophysics.

Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse.

Glenville Jones, R. St-Arnaud, M. Demay, 2005, Endocrinology.

Impact of Vitamin D Supplementation on Gross Motor Development of Healthy Term Infants: A Randomized Dose-Response Trial

A. Majnemer, H. Weiler, Glenville Jones, 2016, Physical & occupational therapy in pediatrics.

Contemporary Diagnosis and Treatment of Vitamin D–Related Disorders

Glenville Jones, G. Carter, H. Makin, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Glenville Jones, E. Yendt, M. Cohanim, 1991, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Secondary hyperparathyroidism in primary osteoporosis and osteopenia: optimizing calcium and vitamin D intakes to levels recommended by expert panels may not be sufficient for correction

Glenville Jones, E. Yendt, K. A. Kovacs, 2008, Clinical endocrinology.

Mineral Homeostasis in Murine Fetuses Is Sensitive to Maternal Calcitriol but Not to Absence of Fetal Calcitriol

Glenville Jones, R. St-Arnaud, M. Kaufmann, 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

IOM committee members respond to Endocrine Society vitamin D guideline.

Christine L. Taylor, J. Manson, S. Mayne, 2012, The Journal of clinical endocrinology and metabolism.

Functional properties and substrate characterization of human CYP26A1, CYP26B1, and CYP26C1 expressed by recombinant baculovirus in insect cells.

M. Taimi, C. Helvig, M. Petkovich, 2011, Journal of pharmacological and toxicological methods.

CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.

M. Taimi, S. S. Chuang, C. Helvig, 2004, The Journal of biological chemistry.

Maternal Vitamin D Status and Gestational Weight Gain as Correlates of Neonatal Bone Mass in Healthy Term Breastfed Young Infants from Montreal, Canada

F. Rauch, H. Weiler, Glenville Jones, 2021, Nutrients.

Oxidation of Vinyl Carbamate and Formation of 1,N6-Ethenodeoxyadenosine in Murine Lung

Glenville Jones, Ashish Sharma, K. Collins, 2007, Drug Metabolism and Disposition.

Randomized trial of two doses of vitamin D3 in preterm infants <32 weeks: Dose impact on achieving desired serum 25(OH)D3 in a NICU population

E. Lyden, Glenville Jones, C. Hanson, 2017, PloS one.

Side-chain hydroxylation of vitamin D3 and its physiological implications

V. Palda, Glenville Jones, D. Lohnes, 1987, Steroids.

Interrelationships Among Vitamin D Status and Body Composition in Mother-Infant Dyads

F. Rauch, H. Weiler, Glenville Jones, 2020, Current Developments in Nutrition.

PHOSPHORUS METABOLISM AND MANAGEMENT IN CHRONIC KIDNEY DISEASE: Expanding Role for Vitamin D in Chronic Kidney Disease: Importance of Blood 25‐OH‐D Levels and Extra‐Renal 1α‐Hydroxylase in the Classical and Nonclassical Actions of 1α,25‐Dihydroxyvitamin D3

Glenville Jones, 2007 .

Vitamin D and Analogues

Glenville Jones, 2008 .

High-Dose Intramuscular Vitamin D Provides Long-Lasting Moderate Increases in Serum 25-Hydroxvitamin D Levels and Shorter-Term Changes in Plasma Calcium.

R. Lucas, M. Clarke, E. Lim, 2017, Journal of AOAC International.

The metabolism of 1,25(OH)2D3 in clinical and experimental kidney disease

M. Petkovich, Glenville Jones, P. Norman, 2022, Scientific Reports.

Vitamin D analogs.

Glenville Jones, 2012, Rheumatic diseases clinics of North America.

Vitamin D analogs.

Glenville Jones, 2001, Endocrinology and metabolism clinics of North America.

Metabolism and Catabolism of Vitamin D, Its Metabolites, and Clinically Relevant Analogs

Glenville Jones, 2010 .

Vitamin D and Analogs

Glenville Jones, 2002 .

Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1α,25-dihydroxyvitamin D3

T. Kensler, S. S. Chuang, Glenville Jones, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

Vitamin D status and functional health outcomes in children aged 2-8 y: a 6-mo vitamin D randomized controlled trial.

F. Rauch, H. Weiler, Glenville Jones, 2018, The American journal of clinical nutrition.

Vitamin Ds: Metabolites and Analogs

Glenville Jones, H. Makin, 2000 .

24(R), 25-dihydroxyvitamin D2 synthesis, determination of absolute configuration by x-ray analysis and identification as a kidney metabolite of vitamin D2

D. Rabinovich, Z. Shakked, F. Frolow, 1979 .

Hepatic osteodystrophy in chronic cholestasis: Evidence for a multifactorial etiology

R. Shulman, C. Langman, Glenville Jones, 2002, Pediatric transplantation.

Vitamin D–Dependent Rickets Type 1B (25‐Hydroxylase Deficiency): A Rare Condition or a Misdiagnosed Condition?

Glenville Jones, G. Weryha, P. Journeau, 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Vitamin D analogs--drug design based on proteins involved in vitamin D signal transduction.

Glenville Jones, S. Masuda, 2003, Current drug targets. Immune, endocrine and metabolic disorders.

Characterization of 3-epi-1α, 25-dihydroxyvitamin D3 involved in 1α, 25-dihydroxyvitamin D3 metabolic pathway in cultured cell lines

J. Rhim, R. Kremer, Glenville Jones, 2000 .

Expression and Activity of Vitamin D-Metabolizing Cytochrome P450s (CYP1α and CYP24) in Human Nonsmall Cell Lung Carcinomas.

H. Ramshaw, Jay A. White, M. Petkovich, 1999, Endocrinology.

Ternary solvent mixtures for improved resolution of hydroxylated metabolites of vitamin D2 and vitamin D3 during high-performance liquid chromatography

Glenville Jones, 1980 .

The discovery and synthesis of the nutritional factor vitamin D.

Glenville Jones, 2018, International journal of paleopathology.

Vitamin D and Diseases of Mineral Homeostasis: A Cyp24a1 R396W Humanized Preclinical Model of Infantile Hypercalcemia Type 1

Glenville Jones, R. St-Arnaud, A. Arabian, 2022, Nutrients.

A High-Calcium and Phosphate Rescue Diet and VDR-Expressing Transgenes Normalize Serum Vitamin D Metabolite Profiles and Renal Cyp27b1 and Cyp24a1 Expression in VDR Null Mice.

Glenville Jones, J. Pike, S. Lee, 2015, Endocrinology.

7 – VITAMIN D

Glenville Jones, M. Calverley, 1992 .

The 1,24,25(OH)3D3 metabolite in clinical and experimental CKD: Impact of calcitriol treatment

M. Petkovich, Glenville Jones, P. Norman, 2022, The Journal of Steroid Biochemistry and Molecular Biology.

Calcioic acid: In vivo detection and quantification of the terminal C24-oxidation product of 25-hydroxyvitamin D3 and related intermediates in serum of mice treated with 24,25-dihydroxyvitamin D3

Glenville Jones, R. St-Arnaud, A. Arabian, 2019, The Journal of Steroid Biochemistry and Molecular Biology.

Serum 24,25-dihydroxyvitamin D3 response to native vitamin D2 and D3 Supplementation in patients with chronic kidney disease on hemodialysis.

E. Lyden, Glenville Jones, M. Kaufmann, 2017, Clinical nutrition.

Evidence for the activation of 1α-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: Delineation of pathways involving 1α,24-dihydroxyvitamin D2 and 1α,25-dihydroxyvitamin D2

Glenville Jones, R. St-Arnaud, S. Strugnell, 2006 .

Preclinical safety and efficacy of 24R,25-dihydroxyvitamin D3 or lactosylceramide treatment to enhance fracture repair

Glenville Jones, R. St-Arnaud, A. Arabian, 2020, Journal of orthopaedic translation.

Isolation and identification of 24,25-dihydroxy vitamin D2 by use of the perfused rat kidney

D. Rabinovich, Z. Shakked, F. Frolow, 1979 .

Clarification of DRIs for calcium and vitamin D across age groups.

J. Manson, S. Mayne, J. Aloia, 2011, Journal of the American Dietetic Association.

Use of vitamin D4 analogs to investigate differences in hepatic and target cell metabolism of vitamins D2 and D3

Glenville Jones, S. Strugnell, H. Makin, 2002 .

1,25(OH)2D, the Preferred Substrate for CYP24

Glenville Jones, H. Tenenhouse, Harriet S. Tenenhouse, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Interlaboratory Comparison for the Determination of 24,25-Dihydroxyvitamin D₃ in Human Serum Using Liquid Chromatography with Tandem Mass Spectrometry.

Johanna E. Camara, C. Sempos, A. Hoofnagle, 2017, Journal of AOAC International.

Hypercalcemic States Associated with Abnormalities of Vitamin D Metabolism

Glenville Jones, K. Schlingmann, 2018 .

Synthesis and CYP24A1 inhibitory activity of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones.

A. Brancale, Glenville Jones, C. Simons, 2010, European journal of medicinal chemistry.

A dialogue on analogues Newer vitamin-D drugs for use in bone disease, psoriasis, and cancer

Glenville Jones, M. Calverley, 1993, Trends in Endocrinology & Metabolism.

HPLC-MS/MS analysis of the products generated from all-trans-retinoic acid using recombinant human CYP26A DOI 10.1194/jlr.M100343-JLR200

M. Petkovich, Glenville Jones, L. Luu, 2002, Journal of Lipid Research.

Two French Families with Vitamin D Dependency Rickets Type 1B Harbor Homozygous Recessive Expression Of CYP2R1 Mutations L99P and G42_L46DEL INSR

S. Brennan, Glenville Jones, F. Feillet, 2016 .

Hypercalcemia due to CYP24A1 mutations: a systematic descriptive review.

C. Marcocci, F. Cetani, F. Baldinotti, 2021, European journal of endocrinology.

ANNALS EXPRESS: Vitamin D supplementation in pregnancy: A word of caution.

Glenville Jones, S. Soule, C. Florkowski, 2019, Annals of clinical biochemistry.

Metabolism of the antiproliferative vitamin D analogue, EB1089, in a cultured human keratinocyte model

Glenville Jones, H. Makin, D. Trafford, 1995 .

The seleno-acetal route to 1α-hydroxy-vitamin D analogues : synthesis of 24-oxa-1α-hydroxy-vitamin D3, a useful vitamin D metabolism probe

Glenville Jones, S. Strugnell, Martin J. Calverleya, 1993 .

Metabolism of 25-hydroxydihydrotachysterol3 in bone cells in vitro

Glenville Jones, H. Makin, F. Qaw, 1992, Steroids.

Chromatographic separation of24(R),25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3-26,23-lactone using a cyanobonded phase packing

Glenville Jones, 1983 .

Expression and Activity of Vitamin D-Metabolizing Cytochrome P450s (CYP1a and CYP24) in Human Nonsmall Cell Lung Carcinomas*

R. Cook, H. Ramshaw, Jay A. White, 1999 .

Selective conversion by microglia of dehydroepiandrosterone to 5-androstenediol—A steroid with inherent estrogenic properties

B. McEwen, K. Bulloch, Glenville Jones, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

Dehydroepiandrosterone (DHEA) metabolism in the brain: Identification by liquid chromatography/mass spectrometry of the delta-4-isomer of DHEA and related steroids formed from androstenedione by mouse BV2 microglia

B. McEwen, K. Bulloch, Gist Croft, 2006, The Journal of Steroid Biochemistry and Molecular Biology.

Hereditary Hypercalcemia Caused by a Homozygous Pathogenic Variant in the CYP24A1 Gene: A Case Report and Review of the Literature

C. Marcocci, F. Cetani, E. Vignali, 2019, Case reports in endocrinology.

25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D.

Glenville Jones, M. Kaufmann, D. Prosser, 2012, Archives of biochemistry and biophysics.

Bioengineering Anabolic Vitamin D-25-Hydroxylase Activity into the Human Vitamin D Catabolic Enzyme, Cytochrome P450 CYP24A1, by a V391L Mutation*

Glenville Jones, M. Kaufmann, D. Prosser, 2011, The Journal of Biological Chemistry.

Vitamin D Toxicity–A Clinical Perspective

Glenville Jones, P. Płudowski, E. Marcinowska-Suchowierska, 2018, Front. Endocrinol..

Cytochrome P450-mediated metabolism of vitamin D

Glenville Jones, M. Kaufmann, D. Prosser, 2014, Journal of Lipid Research.

1,25‐dihydroxyvitamin D3 metabolism in a human osteosarcoma cell line and human bone cells

Glenville Jones, G. Jones, B. Miller, 1990, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Vitamin D and its analogs

Glenville Jones, J. Pike, J. W. Pike, 2020 .

Maternal excess adiposity and serum 25-hydroxyvitamin D < 50 nmol/L are associated with elevated whole body fat mass in healthy breastfed neonates

F. Rauch, H. Weiler, Glenville Jones, 2022, BMC Pregnancy and Childbirth.

Promise of vitamin D analogues in the treatment of hyperproliferative conditions

Glenville Jones, S. Masuda, 2006, Molecular Cancer Therapeutics.

Metabolism of dehydroepiandrosterone by rodent brain cell lines: Relationship between 7-hydroxylation and aromatization

B. McEwen, K. Bulloch, Gist Croft, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Optimal bone fracture repair requires 24R,25-dihydroxyvitamin D3 and its effector molecule FAM57B2

Glenville Jones, R. St-Arnaud, Abdallah Husseini, 2018, The Journal of clinical investigation.

Autosomal-Recessive Mutations in SLC34A1 Encoding Sodium-Phosphate Cotransporter 2A Cause Idiopathic Infantile Hypercalcemia.

M. Konrad, E. Levtchenko, C. Wagner, 2016, Journal of the American Society of Nephrology : JASN.

The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know

JoAnn E. Manson, A. Catharine Ross, Sue A. Shapses, 2010, The Journal of clinical endocrinology and metabolism.

Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations

R. Eastell, R. Jorde, M. Holick, 2018, The Journal of clinical endocrinology and metabolism.

Enzymes involved in the activation and inactivation of vitamin D.

Glenville Jones, Glenville Jones, David E Prosser, 2004, Trends in biochemical sciences.

Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D

H. DeLuca, C. Sempos, J. Bilezikian, 2018, British journal of clinical pharmacology.

Locust retinoid X receptors: 9-Cis-retinoic acid in embryos from a primitive insect

G. R. Wyatt, M. Petkovich, Glenville Jones, 2008, Proceedings of the National Academy of Sciences.

CHARACTERIZATION OF THE LOCUST

G. R. Wyatt, M. Petkovich, Glenville Jones, 2007 .

Influence of 1,25-dihydroxy vitamin D3 on TLR4-induced activation of antigen presenting cells is dependent on the order of receptor engagement.

E. Petrof, Glenville Jones, Sarah Siddiqui, 2011, Immunobiology.

Mouse P450RAI (CYP26) Expression and Retinoic Acid-inducible Retinoic Acid Metabolism in F9 Cells Are Regulated by Retinoic Acid Receptor γ and Retinoid X Receptor α*

P. Chambon, D. Metzger, M. Petkovich, 1998, The Journal of Biological Chemistry.

Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada (summary)

W. Leslie, Glenville Jones, D. Hanley, 2010, Canadian Medical Association Journal.

Pharmacokinetics of vitamin D toxicity 1 – 4

Glenville Jones, 2008 .

Calcitriol Accelerates Vascular Calcification Irrespective of Vitamin K Status in a Rat Model of Chronic Kidney Disease with Hyperphosphatemia and Secondary Hyperparathyroidism

Glenville Jones, M. Adams, R. Holden, 2018, The Journal of Pharmacology and Experimental Therapeutics.

1,25(OH)2D3‐dependent regulation of calbindin‐D28k mRNA requires ongoing protein synthesis in chick duodenal organ culture

B. Komm, M. Galligan, M. Haussler, 1995, Journal of cellular biochemistry.

Use of vitamin D(4) analogs to investigate differences in hepatic and target cell metabolism of vitamins D(2) and D(3).

Glenville Jones, S. Strugnell, H. Makin, 2002, Biochimica et biophysica acta.

Analysis of vitamin D, its metabolites and structural analogues

Glenville Jones, H. Makin, M. Calverley, 1995 .

Methodological issues in assessing plasma 25-hydroxyvitamin D concentration in newborn infants.

H. Weiler, Glenville Jones, M. L’Abbé, 2014, Bone.

UV and dietary predictors of serum 25-hydroxyvitamin D concentrations among young shift-working nurses and implications for bone density and skin cancer

K. Aronson, Q. Miao, Glenville Jones, 2013, Public Health Nutrition.

A chromatin-based mechanism controls differential regulation of the cytochrome P450 gene Cyp24a1 in renal and non-renal tissues

Glenville Jones, J. Pike, M. Meyer, 2019, The Journal of Biological Chemistry.

Structural motif-based homology modeling of CYP27A1 and site-directed mutational analyses affecting vitamin D hydroxylation.

Z. Jia, Glenville Jones, D. Prosser, 2006, Biophysical journal.

Expression of CYP27A, a gene encoding a vitamin D‐25 hydroxylase in human liver and kidney

L. Valiquette, Glenville Jones, G. Jones, 2001, Clinical endocrinology.

Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides.

S. Yee, A. Brancale, Glenville Jones, 2010, Bioorganic & medicinal chemistry.

In Vitro Metabolism of the Vitamin D Analog, 22-Oxacalcitriol, Using Cultured Osteosarcoma, Hepatoma, and Keratinocyte Cell Lines (*)

R. Kremer, Glenville Jones, T. Kobayashi, 1996, The Journal of Biological Chemistry.

Different Mechanisms of Hydroxylation Site Selection by Liver and Kidney Cytochrome P450 Species (CYP27 and CYP24) Involved in Vitamin D Metabolism (*)

F. Dilworth, R. Kremer, Glenville Jones, 1995, The Journal of Biological Chemistry.

Effect of different dosages of oral vitamin D supplementation on vitamin D status in healthy, breastfed infants: a randomized trial.

H. Weiler, Glenville Jones, M. L’Abbé, 2013, JAMA.

1,24(S)-Dihydroxyvitamin D2, a biologically active analogue of vitamin D, is a naturally occurring metabolite in humans

Glenville Jones, E. Mawer, J. Knutson, 1995 .

Importance of cytochrome P450-mediated metabolism in the mechanism of action of vitamin D analogs.

Glenville Jones, M. Gao, S. Masuda, 2003, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Vitamin D status in mothers with pre-eclampsia and their infants: a case–control study from Serbia, a country without a vitamin D fortification policy

M. Glibetić, H. Weiler, Glenville Jones, 2016, Public Health Nutrition.

Vitamin D Toxicity: A Clinical Perspective

Glenville Jones, P. Płudowski, E. Marcinowska-Suchowierska, 2020, Prime Archives in Endocrinology.

Current understanding of the molecular actions of vitamin D.

H. DeLuca, Glenville Jones, G Jones, 1998, Physiological reviews.

Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism.

S. Creighton, M. Taimi, H. Ramshaw, 2000, Proceedings of the National Academy of Sciences of the United States of America.

The ElutionProfileof VitaminD 2 Metabolitesfrom SephadexLH 2 O Columns

Glenville Jones, A. Hay, 2004 .

Long-term efficacy and safety of rifampin in the treatment of a patient carrying a CYP24A1 loss-of-function variant.

C. Marcocci, F. Cetani, F. Baldinotti, 2022, The Journal of clinical endocrinology and metabolism.

Validation of a routine two‐sample iohexol plasma clearance assessment of GFR and an evaluation of common endogenous markers in a rat model of CKD

Glenville Jones, M. Turner, M. Adams, 2017, Physiological reports.

Measurement of Vitamin D metabolites: an international perspective on methodology and clinical interpretation

E. Gunter, Glenville Jones, G. Carter, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

Methodological issues in assessing plasma 25-hydroxyvitamin D concentration in newborn infants.

H. Weiler, Glenville Jones, M. L’Abbé, 2014, Bone.

Vitamin D status in mothers with pre-eclampsia and their infants: a case–control study from Serbia, a country without a vitamin D fortification policy

M. Glibetić, H. Weiler, Glenville Jones, 2016, Public Health Nutrition.

IOM committee members respond to Endocrine Society vitamin D guideline.

Christine L. Taylor, J. Manson, S. Mayne, 2012, The Journal of clinical endocrinology and metabolism.

Structural analysis of CYP2R1 in complex with vitamin D3.

A. Plotnikov, Glenville Jones, Hee-won Park, 2007, Journal of molecular biology.

Bioengineering Anabolic Vitamin D-25-Hydroxylase Activity into the Human Vitamin D Catabolic Enzyme, Cytochrome P450 CYP24A1, by a V391L Mutation*

Glenville Jones, M. Kaufmann, D. Prosser, 2011, The Journal of Biological Chemistry.

Measurements of the Vitamin D Metabolome in the Calgary Vitamin D Study: Relationship of Vitamin D Metabolites to Bone Loss

Glenville Jones, S. Boyd, D. Hanley, 2023, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Significance of serum 24,25-dihydroxyvitamin D in the assessment of vitamin D status: a double-edged sword?

C. Sempos, A. Hoofnagle, K. Cashman, 2015, Clinical chemistry.

Vitamin D–Dependent Rickets Type 1B (25‐Hydroxylase Deficiency): A Rare Condition or a Misdiagnosed Condition?

Glenville Jones, G. Weryha, P. Journeau, 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Contemporary Diagnosis and Treatment of Vitamin D–Related Disorders

Glenville Jones, G. Carter, H. Makin, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Serum 24,25-dihydroxyvitamin D3 response to native vitamin D2 and D3 Supplementation in patients with chronic kidney disease on hemodialysis.

E. Lyden, Glenville Jones, M. Kaufmann, 2017, Clinical nutrition.

Vitamin D status and functional health outcomes in children aged 2-8 y: a 6-mo vitamin D randomized controlled trial.

F. Rauch, H. Weiler, Glenville Jones, 2018, The American journal of clinical nutrition.

Epimeric vitamin D and cardiovascular structure and function in advanced CKD and after kidney transplantation.

T. Hiemstra, Kenneth Lim, T. Lu, 2023, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Effect of high-dose inhaled budesonide on calcium and phosphate metabolism and the risk of osteoporosis.

G. Wells, Glenville Jones, J. Toogood, 1988, The American review of respiratory disease.

Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations.

R. Nussbaum, E. Hsiao, S. Baumgartner-Parzer, 2015, The Journal of clinical endocrinology and metabolism.

Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada

W. Leslie, S. Atkinson, D. Cole, 2010, Canadian Medical Association Journal.

A kidney-specific genetic control module in mice governs endocrine regulation of the cytochrome P450 gene Cyp27b1 essential for vitamin D3 activation

Glenville Jones, M. Meyer, M. Onal, 2017, The Journal of Biological Chemistry.

Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2.

Glenville Jones, R. St-Arnaud, S. Strugnell, 2006, Biochimica et Biophysica Acta.