I. Tabas

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Free Cholesterol-loaded Macrophages Are an Abundant Source of Tumor Necrosis Factor-α and Interleukin-6

David A. Brenner, R. Schwabe, D. Brenner, 2005, Journal of Biological Chemistry.

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

M. Mongillo, A. Marks, D. Ron, 2009, The Journal of cell biology.

Role of ERO 1-– mediated stimulation of inositol 1 , 4 , 5-triphosphate receptor activity in endoplasmic reticulum stress – induced apoptosis

M. Mongillo, A. Marks, D. Ron, 2009 .

Human Vascular Endothelial Cells Are a Rich and Regulatable Source of Secretory Sphingomyelinase

K. Williams, I. Tabas, S. Schissel, 1998, The Journal of Biological Chemistry.

Physiological Regulation of Phospholipid Methylation Alters Plasma Homocysteine in Mice*

M. Brosnan, J. Brosnan, D. Vance, 2005, Journal of Biological Chemistry.

The synthesis of complex-type oligosaccharides. III. Identification of an alpha-D-mannosidase activity involved in a late stage of processing of complex-type oligosaccharides.

S. Kornfeld, I. Tabas, 1978, The Journal of biological chemistry.

The synthesis of complex-type oligosaccharides. II. Characterization of the processing intermediates in the synthesis of the complex oligosaccharide units of the vesicular stomatitis virus G protein.

S. Kornfeld, I. Tabas, E. Li, 1978, The Journal of biological chemistry.

The synthesis of complex-type oligosaccharides. I. Structure of the lipid-linked oligosaccharide precursor of the complex-type oligosaccharides of the vesicular stomatitis virus G protein.

S. Kornfeld, I. Tabas, E. Li, 1978, The Journal of biological chemistry.

Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair

C. Devlin, E. Schuchman, I. Tabas, 2010, The Journal of cell biology.

Direct Observation of Rapid Internalization and Intracellular Transport of Sterol by Macrophage Foam Cells

F. Maxfield, D. Wüstner, M. Mondal, 2005, Traffic.

Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages

Na Kong, I. Tabas, Arif Yurdagul, 2022, Nature Protocols.

Adaptive Suppression of the ATF4-CHOP Branch of the Unfolded Protein Response by Toll-Like Receptor Signaling

D. Ron, H. Harding, I. Tabas, 2009, Nature Cell Biology.

Preferential ATP-binding Cassette Transporter A1-mediated Cholesterol Efflux from Late Endosomes/Lysosomes*

Carrie M. Welch, A. Tall, Wengen Chen, 2001, The Journal of Biological Chemistry.

Secretory Sphingomyelinase, a Product of the Acid Sphingomyelinase Gene, Can Hydrolyze Atherogenic Lipoproteins at Neutral pH

K. Williams, J. Rapp, I. Tabas, 1998, The Journal of Biological Chemistry.

Macrophage-targeted CTP:phosphocholine cytidylyltransferase (1-314) transgenic mice.

I. Tabas, A. Walsh, W. Tang, 1999, Biochimica et biophysica acta.

The Cytoplasmic Domain of the Low Density Lipoprotein (LDL) Receptor-related Protein, but Not That of the LDL Receptor, Triggers Phagocytosis*

F. Maxfield, D. Strickland, S. Greenberg, 2003, Journal of Biological Chemistry.

Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation.

K. Williams, T. Swenson, I. Tabas, 1993, The Journal of biological chemistry.

Targeted Deletion of Hepatic CTP:phosphocholine Cytidylyltransferase α in Mice Decreases Plasma High Density and Very Low Density Lipoproteins*

D. Vance, C. Devlin, I. Tabas, 2004, Journal of Biological Chemistry.

A Novel High-Throughput Screening Format to Identify Inhibitors of Secreted Acid Sphingomyelinase

I. Tabas, M. Polokoff, R. Mintzer, 2005, Journal of biomolecular screening.

Free Cholesterol Loading of Macrophages Is Associated with Widespread Mitochondrial Dysfunction and Activation of the Mitochondrial Apoptosis Pathway*

P. M. Yao, I. Tabas, 2001, The Journal of Biological Chemistry.

Transforming growth factor-beta 1 inhibits scavenger receptor activity in THP-1 human macrophages.

R. Assoian, I. Tabas, L. Agellon, 1991, The Journal of biological chemistry.

Acid Sphingomyelinase Promotes Lipoprotein Retention Within Early Atheromata and Accelerates Lesion Progression

K. Williams, C. Devlin, E. Schuchman, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Toll-like receptor activation suppresses endoplasmic reticulum stress-induced CHOP and translation inhibition through activation of eIF2B

S. Kimball, I. Tabas, C. W. Woo, 2011, Nature Cell Biology.

Purification and characterization of a rat liver Golgi alpha-mannosidase capable of processing asparagine-linked oligosaccharides.

S. Kornfeld, I. Tabas, 1979, The Journal of biological chemistry.

Biosynthetic intermediates of beta-glucuronidase contain high mannose oligosaccharides with blocked phosphate residues.

S. Kornfeld, I. Tabas, 1980, The Journal of biological chemistry.

Attenuated Free Cholesterol Loading-induced Apoptosis but Preserved Phospholipid Composition of Peritoneal Macrophages from Mice That Do Not Express Group VIA Phospholipase A2*

J. Turk, C. Semenkovich, Yankun Li, 2007, Journal of Biological Chemistry.

Enrichment of Endoplasmic Reticulum with Cholesterol Inhibits Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase-2b Activity in Parallel with Increased Order of Membrane Lipids

J. Freed, F. Maxfield, L. Ciani, 2004, Journal of Biological Chemistry.

Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

R. Mahley, F. Maxfield, J. Mas-Oliva, 1991, The Journal of biological chemistry.

Sphingomyelinase Treatment Induces ATP-independent Endocytosis

F. Maxfield, P. Leopold, I. Tabas, 1998, The Journal of cell biology.

Free Cholesterol Loading of Macrophages Induces Apoptosis Involving the Fas Pathway*

P. M. Yao, I. Tabas, 2000, The Journal of Biological Chemistry.

Evidence That the Initial Up-regulation of Phosphatidylcholine Biosynthesis in Free Cholesterol-loaded Macrophages Is an Adaptive Response That Prevents Cholesterol-induced Cellular Necrosis

I. Tabas, N. Beatini, G. Keesler, 1996, The Journal of Biological Chemistry.

Effect and cellular site of action of cysteine protease inhibitors on the cholesterol esterification pathway in macrophages and Chinese hamster ovary cells.

F. Maxfield, X. Zha, I. Tabas, 1995, Biochemistry.

Extracellular Nampt Promotes Macrophage Survival via a Nonenzymatic Interleukin-6/STAT3 Signaling Mechanism*

Yuan Zhang, C. Wolberger, S. Imai, 2008, Journal of Biological Chemistry.

Sphingomyelinase Converts Lipoproteins From Apolipoprotein E Knockout Mice Into Potent Inducers of Macrophage Foam Cell Formation

I. Tabas, S. Marathe, A. R. Leventhal, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Evidence for prolonged cell-surface contact of acetyl-LDL before entry into macrophages.

F. Maxfield, X. Zha, P. Leopold, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Human plasma cholesteryl ester transfer protein enhances the transfer of cholesteryl ester from high density lipoproteins into cultured HepG2 cells.

A. Tall, I. Tabas, E. Granot, 1987, The Journal of biological chemistry.

Unique Cellular Events Occurring during the Initial Interaction of Macrophages with Matrix-retained or Methylated Aggregated Low Density Lipoprotein (LDL)

F. Maxfield, H. Du, R. Ghosh, 1999, The Journal of Biological Chemistry.

Effects of particle size on cell uptake of model triglyceride-rich particles with and without apoprotein E.

I. Tabas, R. Deckelbaum, T. Vogel, 1994, Biochemistry.

Sitosterol-containing Lipoproteins Trigger Free Sterol-induced Caspase-independent Death in ACAT-competent Macrophages*

D. Landry, Yankun Li, I. Tabas, 2006, Journal of Biological Chemistry.

Lipoproteins activate acyl-coenzyme A:cholesterol acyltransferase in macrophages only after cellular cholesterol pools are expanded to a critical threshold level.

I. Tabas, X. X. Xu, Ira Tabas, 1991, Journal of Biological Chemistry.

The Cellular Trafficking and Zinc Dependence of Secretory and Lysosomal Sphingomyelinase, Two Products of the Acid Sphingomyelinase Gene*

K. Williams, E. Schuchman, I. Tabas, 1998, The Journal of Biological Chemistry.

B-Very Low Density Lipoprotein Is Sequestered in Surface-connected Tubules in Mouse Peritoneal Macrophages

J. Myers, I. Tabas, N. Jones, 2002 .

Beta-very low density lipoprotein is sequestered in surface-connected tubules in mouse peritoneal macrophages

F. Maxfield, J. Myers, I. Tabas, 1993, The Journal of cell biology.

Regulation of the threshold for lipoprotein-induced acyl-CoA:cholesterol O-acyltransferase stimulation in macrophages by cellular sphingomyelin content.

I. Tabas, X. X. Xu, Y. Shiratori, 1994, Journal of lipid research.

Foam cell-forming J774 macrophages have markedly elevated acyl coenzyme A:cholesterol acyl transferase activity compared with mouse peritoneal macrophages in the presence of low density lipoprotein (LDL) despite similar LDL receptor activity.

A. Tall, I. Tabas, G. Boykow, 1987, The Journal of clinical investigation.

The Influence of Particle Size and Multiple Apoprotein E-Receptor Interactions on the Endocytic Targeting of O3VLDL in Mouse Peritoneal Macrophages

F. Maxfield, J. Myers, Xiang-Xi Xu, 2002 .

Inhibition of acyl coenzyme A:cholesterol acyl transferase in J774 macrophages enhances down-regulation of the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase and prevents low density lipoprotein-induced cholesterol accumulation.

A. Tall, I. Tabas, D. Weiland, 1986, The Journal of biological chemistry.

Immunolocalization of Acyl-Coenzyme A:CholesterolO-Acyltransferase in Macrophages*

Robert V Farese, Hong Wang, F. Maxfield, 1998, The Journal of Biological Chemistry.

The Binding Activity of the Macrophage Lipoprotein(a)/Apolipoprotein(a) Receptor Is Induced by Cholesterol via a Post-translational Mechanism and Recognizes Distinct Kringle Domains on Apolipoprotein(a)*

M. Koschinsky, B. Gabel, C. Devlin, 1996, The Journal of Biological Chemistry.

Macrophage foam cell lipoprotein(a)/apoprotein(a) receptor. Cell-surface localization, dependence of induction on new protein synthesis, and ligand specificity.

I. Tabas, Y. Li, G. Fless, 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

Cholesterol loading of macrophages leads to marked enhancement of native lipoprotein(a) and apoprotein(a) internalization and degradation.

I. Tabas, G. Fless, G. Keesler, 1993, The Journal of biological chemistry.

Endocytosed/ -VLDL and LDL Are Delivered to Different Intracellular Vesicles in Mouse Peritoneal Macrophages

Xiang-Xi Xu, I. Tabas, Sungtae Lira, 2002 .

Interferon-gamma down-regulates the lipoprotein(a)/apoprotein(a) receptor activity on macrophage foam cells. Evidence for disruption of ligand-induced receptor recycling by interferon-gamma.

I. Tabas, G. Keesler, P. Skiba, 1994, The Journal of biological chemistry.

Sphingomyelinase, an enzyme implicated in atherogenesis, is present in atherosclerotic lesions and binds to specific components of the subendothelial extracellular matrix.

K. Williams, I. Tabas, S. Marathe, 1999, Arteriosclerosis, thrombosis, and vascular biology.

Acid Sphingomyelinase-deficient Macrophages Have Defective Cholesterol Trafficking and Efflux*

A. Tall, Wengen Chen, I. Tabas, 2001, The Journal of Biological Chemistry.

Macrophages deficient in CTP:Phosphocholine cytidylyltransferase-alpha are viable under normal culture conditions but are highly susceptible to free cholesterol-induced death. Molecular genetic evidence that the induction of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is

P. M. Yao, I. Tabas, S. Jackowski, 2000, The Journal of biological chemistry.

Brief Report: Increased Apoptosis in Advanced Atherosclerotic Lesions of Apoe−/− Mice Lacking Macrophage Bcl-2

E. Fisher, Yankun Li, P. M. Yao, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Studies of the synthesis, structure and function of the phosphorylated oligosaccharides of lysosomal enzymes

A. Varki, M. Reitman, S. Kornfeld, 1983, Journal of Biosciences.

Free cholesterol loading of macrophages stimulates phosphatidylcholine biosynthesis and up-regulation of CTP: phosphocholine cytidylyltransferase.

I. Tabas, Y. Shiratori, A. Okwu, 1994, The Journal of biological chemistry.

Unmodified low density lipoprotein causes cholesteryl ester accumulation in J774 macrophages.

A. Tall, I. Tabas, D. Weiland, 1985, Proceedings of the National Academy of Sciences of the United States of America.

InsP3 Receptor Regulates Hepatic Gluconeogenesis in Fasting and Diabetes

M. Montminy, W. Fischer, J. Goode, 2012, Nature.

OLIGOSACCHARIDE PROCESSING DURING GLYCOPROTEIN BIOSYNTHESIS

S. Kornfeld, I. Tabas, E. Li, 1979 .

Cholesterol esterification as a limiting factor in accumulation of cell cholesterol: a comparison of two J774 macrophage cell lines.

W. Rosoff, I. Tabas, J. Khoo, 1989, Biochimica et biophysica acta.

Minimally Oxidized LDL Offsets the Apoptotic Effects of Extensively Oxidized LDL and Free Cholesterol in Macrophages

J. Witztum, O. Quehenberger, Yankun Li, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Sphingomyelinase enhances low density lipoprotein uptake and ability to induce cholesteryl ester accumulation in macrophages.

I. Tabas, X. X. Xu, Xiangxi Xu, 1991, The Journal of biological chemistry.

Stimulation of CTP:Phosphocholine Cytidylyltransferase by Free Cholesterol Loading of Macrophages Involves Signaling through Protein Dephosphorylation (*)

M. Houweling, I. Tabas, Xiaohui Zha, 1995, The Journal of Biological Chemistry.

Enrichment of acyl coenzyme A:cholesterol O-acyltransferase near trans-golgi network and endocytic recycling compartment.

F. Maxfield, O. Quehenberger, T. T. Soe, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Mechanism of the association of HDL3 with endothelial cells, smooth muscle cells, and fibroblasts. Evidence against the role of specific ligand and receptor proteins.

A. Tall, I. Tabas, 1984, The Journal of biological chemistry.

Creation of a mouse model for non-neurological (type B) Niemann-Pick disease by stable, low level expression of lysosomal sphingomyelinase in the absence of secretory sphingomyelinase: relationship between brain intra-lysosomal enzyme activity and central nervous system function.

C. Devlin, E. Schuchman, I. Tabas, 2000, Human molecular genetics.

Macrophages Use Apoptotic Cell-Derived Methionine and DNMT3A During Efferocytosis to Promote Tissue Resolution

A. Tall, I. Tabas, J. Koomen, 2022, Nature Metabolism.

The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver

R. Schwabe, Céline Hernandez, P. Huebener, 2022, Science Translational Medicine.

Processing of high mannose oligosaccharides to form complex type oligosaccharides on the newly synthesized polypeptides of the vesicular stomatitis virus G protein and the IgG heavy chain.

S. Kornfeld, S. Schlesinger, I. Tabas, 1978, The Journal of biological chemistry.

N-asparagine-linked oligosaccharides: processing.

S. Kornfeld, I. Tabas, 1982, Methods in enzymology.

Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.

K. Williams, J. Rapp, I. Tabas, 1996, The Journal of clinical investigation.

Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization.

I. Tabas, C. Watson, T. Peng, 1998, Biochimica et biophysica acta.

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

George Kuriakose, E. Fisher, A. Marks, 2003, Nature Cell Biology.

Interleukin 8 Is Induced by Cholesterol Loading of Macrophages and Expressed by Macrophage Foam Cells in Human Atheroma (*)

A. Tall, I. Tabas, S. Ravalli, 1996, The Journal of Biological Chemistry.

Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesis.

M. Wong, J. Licinio, K. Williams, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Transcriptional activation of the murine CTP:phosphocholine cytidylyltransferase gene (Ctpct): combined action of upstream stimulatory and inhibitory cis-acting elements.

D. Vance, K. Waite, M. Bakovic, 1999, Biochimica et biophysica acta.

The Structure of the Gene for Murine CTP:Phosphocholine Cytidylyltransferase, Ctpct

I. Tabas, G. Keesler, Wei-Bing Tang, 1997, The Journal of Biological Chemistry.

Macrophages Deficient in CTP:Phosphocholine Cytidylyltransferase-α Are Viable under Normal Culture Conditions but Are Highly Susceptible to Free Cholesterol-induced Death

P. M. Yao, I. Tabas, S. Jackowski, 2000, The Journal of Biological Chemistry.

The Distal Pathway of Lipoprotein-induced Cholesterol Esterification, but Not Sphingomyelinase-induced Cholesterol Esterification, Is Energy-dependent*

F. Maxfield, I. Tabas, Xiaohui Zha, 1996, The Journal of Biological Chemistry.

The Uptake and Degradation of Matrix-bound Lipoproteins by Macrophages Require an Intact Actin Cytoskeleton, Rho Family GTPases, and Myosin ATPase Activity*

F. Maxfield, R. Eddy, S. Greenberg, 2001, The Journal of Biological Chemistry.

Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis.

R. Schwabe, D. Brenner, A. Tall, 2005, The Journal of biological chemistry.

Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase.

A. Tall, H. Pownall, X. Jiang, 1998, The Journal of clinical investigation.

Accelerated transfer of cholesteryl esters in dyslipidemic plasma. Role of cholesteryl ester transfer protein.

A. Tall, M. Denke, K. Williams, 1987, The Journal of clinical investigation.

The UPR in atherosclerosis

I. Tabas, I. Tabas, Alex-Xianghua Zhou, 2013, Seminars in Immunopathology.

Cholesteryl ester loading of mouse peritoneal macrophages is associated with changes in the expression or modification of specific cellular proteins, including increase in an alpha-enolase isoform.

N. Kendrick, I. Tabas, Y. Li, 1993, Arteriosclerosis and thrombosis : a journal of vascular biology.

Pivotal Advance: Macrophages become resistant to cholesterol‐induced death after phagocytosis of apoptotic cells

A. Tall, Yankun Li, I. Tabas, 2007, Journal of leukocyte biology.

Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog.

F. Maxfield, X. Zha, S. Mukherjee, 1998, Biophysical journal.

Improvement in Lipid and Protein Trafficking in Niemann‐Pick C1 Cells by Correction of a Secondary Enzyme Defect

F. Maxfield, C. Devlin, E. Schuchman, 2010, Traffic.

Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

Yibin Wang, R. Flavell, Roger J. Davis, 2005, The Journal of cell biology.

Protein synthesis inhibition in mouse peritoneal macrophages results in increased acyl coenzyme A:cholesterol acyl transferase activity and cholesteryl ester accumulation in the presence of native low density lipoprotein.

I. Tabas, G. Boykow, 1987, The Journal of biological chemistry.

TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells.

A. Tall, Marie-Christine Gerbod-Giannone, Yankun Li, 2006, Proceedings of the National Academy of Sciences of the United States of America.

The role of efferocytosis‐fueled macrophage metabolism in the resolution of inflammation

I. Tabas, M. Schilperoort, Hong-Ping Shi, 2023, Immunological reviews.

A Genome-wide CRISPR Screen Identifies WDFY3 as a Novel Regulator of Macrophage Efferocytosis

John G Doench, J. Doench, Katherine R. Croce, 2022, bioRxiv.

PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages

D. Power, M. Katerelos, I. Tabas, 2023, Nature Metabolism.

Cholesterol and phospholipid metabolism in macrophages.

I. Tabas, I. Tabas, I Tabas, 2000, Biochimica et biophysica acta.

The response-to-retention hypothesis of early atherogenesis.

K. Williams, I. Tabas, I. Tabas, 1995, Arteriosclerosis, thrombosis, and vascular biology.

Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

R. Flavell, Yibin Wang, Yankun Li, 2005, The Journal of cell biology.

Intracellular tPA–PAI-1 interaction determines VLDL assembly in hepatocytes

Jieqing Zhu, R. Silverstein, H. Ginsberg, 2023, Science.