D. Spratt

发表

RBR E3 ubiquitin ligases: new structures, new insights, new questions

H. Walden, D. Spratt, G. Shaw, 2014, The Biochemical journal.

Calmodulin Binding and Activation of Mammalian Nitric Oxide Synthases

D. Spratt, Donald Eric Spratt, 2008 .

Crystal structure of the catalytic C‐lobe of the HECT‐type ubiquitin ligase E6AP

E. Lowe, S. Lorenz, D. Spratt, 2020, Protein science : a publication of the Protein Society.

LYSINE 48-TETRA-UBIQUITIN SLOWS A SnapShot of Ubiquitin Chain Elongation : Protein Synthesis and Degradation :

Z. Pan, D. Spratt, G. Shaw, 2014 .

A SnapShot of Ubiquitin Chain Elongation

Z. Pan, D. Spratt, G. Shaw, 2014, The Journal of Biological Chemistry.

Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme

D. Spratt, Valerie A. Ivancic, Claire A. Krasinski, 2018, Bioscience reports.

Generation of phospho‐ubiquitin variants by orthogonal translation reveals codon skipping

P. O'Donoghue, D. Spratt, G. Shaw, 2016, FEBS letters.

Binding and activation of nitric oxide synthase isozymes by calmodulin EF hand pairs

D. Spratt, J. G. Guillemette, J. Salerno, 2006, The FEBS journal.

An Angelman syndrome substitution in the HECT E3 ubiquitin ligase C-terminal Lobe of E6AP affects protein stability and activity

D. Spratt, S. A. Beasley, Chloe Kellum, 2020, PloS one.

Suramin inhibits cullin-RING E3 ubiquitin ligases

J. Hurwitz, N. Zheng, Yi Sun, 2016, Proceedings of the National Academy of Sciences.

Exchange Broadening Underlies the Enhancement of IDE-Dependent Degradation of Insulin by Anionic Membranes

D. Spratt, Valerie A. Ivancic, Qiuchen Zheng, 2022, ACS omega.

Redefining the catalytic HECT domain boundaries for the HECT E3 ubiquitin ligase family

D. Spratt, J. M. Schafer, K. Rich, 2022, Bioscience reports.

Structural Insights into Ankyrin Repeat-Containing Proteins and Their Influence in Ubiquitylation

D. Spratt, Emma I. Kane, Emma I Kane, 2021, International journal of molecular sciences.

Structure of the HHARI Catalytic Domain Shows Glimpses of a HECT E3 Ligase

P. Mercier, D. Spratt, G. Shaw, 2013, PloS one.

Rapid and efficient purification of Drosophila homeodomain transcription factors for biophysical characterization.

Jacqueline M. Dresch, R. A. Drewell, J. Dresch, 2019, Protein expression and purification.

A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease

P. Mercier, H. Walden, L. Burchell, 2013, Nature Communications.

HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response

D. Spratt, E. Paparisto, Stephen D. Barr, 2021, Viruses.

HECT E3 ubiquitin ligases – emerging insights into their biological roles and disease relevance

D. Spratt, Yaya Wang, Anning Zhou, 2020, Journal of Cell Science.

Correction: HECT E3 ubiquitin ligases – emerging insights into their biological roles and disease relevance

D. Spratt, Yaya Wang, Anning Zhou, 2020, Journal of Cell Science.

Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination

J. Hurwitz, Lan Huang, Zhijian J. Chen, 2014, Proceedings of the National Academy of Sciences.

Structure and dynamics of calmodulin (CaM) bound to nitric oxide synthase peptides: effects of a phosphomimetic CaM mutation.

T. Dieckmann, K. Futrega, D. Spratt, 2012, Biochemistry.

Exploring the Roles of HERC2 and the NEDD4L HECT E3 Ubiquitin Ligase Subfamily in p53 Signaling and the DNA Damage Response

D. Spratt, Nicholas A. Mathieu, Rafael H. Levin, 2021, Frontiers in Oncology.

Resveratrol Sustains Insulin-Degrading Enzyme Activity toward Aβ42

D. Spratt, Valerie A. Ivancic, Claire A. Krasinski, 2018, ACS omega.

Intersection of Redox Chemistry and Ubiquitylation: Post-Translational Modifications Required for Maintaining Cellular Homeostasis and Neuroprotection

D. Spratt, Emma I. Kane, Kelly L Waters, 2021, Cells.

Codon optimization for enhanced Escherichia coli expression of human S100A11 and S100A1 proteins.

D. Spratt, G. Shaw, N. M. Marlatt, 2010, Protein expression and purification.

Regulation of mammalian nitric oxide synthases by electrostatic interactions in the linker region of calmodulin.

D. Spratt, Valentina Taiakina, J. G. Guillemette, 2008, Biochimica et biophysica acta.

FRET conformational analysis of calmodulin binding to nitric oxide synthase peptides and enzymes.

M. Palmer, D. Spratt, Valentina Taiakina, 2008, Biochemistry.

New Discoveries on the Roles of “Other” HECT E3 Ubiquitin Ligases in Disease Development

D. Spratt, Emma I. Kane, Emma I Kane, 2020, Ubiquitin - Proteasome Pathway.

Selective Recruitment of an E2∼Ubiquitin Complex by an E3 Ubiquitin Ligase*

Z. Pan, D. Spratt, G. Shaw, 2012, The Journal of Biological Chemistry.

Selective Recruitment of an E 2 Ubiquitin Complex by an E 3 Ubiquitin Ligase

Z. Pan, D. Spratt, G. Shaw, 2012 .

A subset of calcium‐binding S100 proteins show preferential heterodimerization

Martin L. Duennwald, D. Spratt, G. Shaw, 2019, The FEBS journal.

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

P. Mercier, H. Walden, R. Toth, 2015, The EMBO journal.

Differential Activation of Nitric-oxide Synthase Isozymes by Calmodulin-Troponin C Chimeras*

D. Spratt, J. G. Guillemette, J. Salerno, 2004, Journal of Biological Chemistry.

Intraprotein electron transfer in inducible nitric oxide synthase holoenzyme

James T. Hazzard, G. Tollin, D. Spratt, 2008, JBIC Journal of Biological Inorganic Chemistry.

Small-Molecule Gankyrin Inhibition as a Therapeutic Strategy for Breast and Lung Cancer.

Snehal K. Shukla, Vivek Gupta, D. Spratt, 2022, Journal of medicinal chemistry.

Mapping the Binding and Calmodulin-Dependent Activation of Nitric Oxide Synthase Isozymes

D. Spratt, Valentina Taiakina, J. G. Guillemette, 2011 .

Calcium-deficient calmodulin binding and activation of neuronal and inducible nitric oxide synthases.

D. Spratt, Valentina Taiakina, J. G. Guillemette, 2007, Biochimica et biophysica acta.

The Longest Amyloid-β Precursor Protein Intracellular Domain Produced with Aβ42 Forms β-Sheet-Containing Monomers That Self-Assemble and Are Proteolyzed by Insulin-Degrading Enzyme.

D. Spratt, Valerie A. Ivancic, Claire A. Krasinski, 2018, ACS chemical neuroscience.

Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme

D. Spratt, Charles E. Jakobsche, Valerie A. Ivancic, 2021, Antioxidants.

Selective labeling of selenomethionine residues in proteins with a fluorescent derivative of benzyl bromide.

M. Palmer, D. Spratt, J. G. Guillemette, 2006, Analytical biochemistry.

Dual-targeted labeling of proteins using cysteine and selenomethionine residues.

M. Palmer, D. Spratt, J. G. Guillemette, 2005, Analytical biochemistry.

Generation of phospho‐ubiquitin variants by orthogonal translation reveals codon skipping

P. O'Donoghue, D. Spratt, G. Shaw, 2016, FEBS letters.

Association of the disordered C-terminus of CDC34 with a catalytically bound ubiquitin.

D. Spratt, G. Shaw, 2011, Journal of molecular biology.

New Discoveries on Protein Recruitment and Regulation during the Early Stages of the DNA Damage Response Pathways

D. Spratt, Kelly L. Waters, 2024, International journal of molecular sciences.