S. Lam

发表

The CCN family of angiogenic regulators: the integrin connection.

L. Lau, S. Lam, S. C. Lam, 1999, Experimental cell research.

C. Naus, R. Goldschmeding, H. Yeger, 2003, Molecular pathology : MP.

The Angiogenic Factor Cysteine-Rich 61 (CYR61, CCN1) Supports Vascular Smooth Muscle Cell Adhesion and Stimulates Chemotaxis through Integrin α6β1 and Cell Surface Heparan Sulfate Proteoglycans.

L. Lau, S. Lam, V. Lindner, 2002, Endocrinology.

Adhesion of Human Umbilical Vein Endothelial Cells to the Immediate-Early Gene Product Cyr61 Is Mediated through Integrin αvβ3 *

L. Lau, S. Lam, M. Kireeva, 1998, The Journal of Biological Chemistry.

Identification of a Novel Integrin α6β1 Binding Site in the Angiogenic Inducer CCN1 (CYR61)*

L. Lau, S. Lam, Chih-Chiun Chen, 2003, Journal of Biological Chemistry.

Activation-dependent Adhesion of Human Platelets to Cyr61 and Fisp12/Mouse Connective Tissue Growth Factor Is Mediated through Integrin αIIbβ3 *

L. Lau, S. Lam, M. Kireeva, 1999, The Journal of Biological Chemistry.

Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3).

L. Lau, S. Lam, M. Kireeva, 1999, The Journal of biological chemistry.

Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61).

Y. Liu, L. Lau, S. Lam, 2003, The Journal of biological chemistry.

The P2Y12 Antagonists, 2-Methylthioadenosine 5′-Monophosphate Triethylammonium Salt and Cangrelor (ARC69931MX), Can Inhibit Human Platelet Aggregation through a Gi-independent Increase in cAMP Levels*

S. Srinivasan, G. L. Le Breton, S. Lam, 2009, The Journal of Biological Chemistry.

Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies.

A. Frelinger, S. Lam, M. Ginsberg, 1990, Blood.

Platelet membrane glycoprotein IIb heavy chain forms a complex with glycoprotein IIIa that binds Arg-Gly-Asp peptides.

S. Lam, M. Ginsberg, E. Plow, 1989, Blood.

Identification of a Novel Integrin αvβ3 Binding Site in CCN1 (CYR61) Critical for Pro-angiogenic Activities in Vascular Endothelial Cells*

L. Lau, S. Lam, N. Chen, 2004, Journal of Biological Chemistry.

Chemical cross-linking of arginyl-glycyl-aspartic acid peptides to an adhesion receptor on platelets.

S. Lam, M. Ginsberg, E. Plow, 1988, The Journal of biological chemistry.

Pro-angiogenic Activities of CYR61 (CCN1) Mediated through Integrins αvβ3 and α6β1 in Human Umbilical Vein Endothelial Cells*

L. Lau, S. Lam, S. Leu, 2002, The Journal of Biological Chemistry.

Purification of the human blood platelet thromboxane A2/prostaglandin H2 receptor protein.

G. L. Le Breton, S. O. Kim, S. Hall, 1992, Biochemical pharmacology.

Evidence that arginyl-glycyl-aspartate peptides and fibrinogen gamma chain peptides share a common binding site on platelets.

S. Lam, M. Ginsberg, A. Andrieux, 1987, The Journal of biological chemistry.

Effect of cAMP Phosphodiesterase Inhibitors on ADP-Induced Shape Change, cAMP and Nucleoside Diphosphokinase Activity of Rabbit Platelets

S. Lam, J. Mustard, M. Packham, 1982, Thrombosis and Haemostasis.

Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells.

L. Lau, S. Lam, S. Leu, 2002, The Journal of biological chemistry.

Direct binding of the platelet integrin alphaIIbbeta3 (GPIIb-IIIa) to talin. Evidence that interaction is mediated through the cytoplasmic domains of both alphaIIb and beta3.

S. Lam, T. Leisner, I. Knezevic, 1996, The Journal of biological chemistry.

A molecular basis for integrin alphaMbeta 2 ligand binding promiscuity.

T. Ugarova, S. Lam, V. Yakubenko, 2002, The Journal of biological chemistry.

The inhibitory effects of exogenous arachidonic acid on rabbit platelet aggregation and the release reaction.

S. Lam, J. Mustard, R. Kinlough-Rathbone, 1982, Blood.

Isolation and characterization of a chymotryptic fragment of platelet glycoprotein IIb-IIIa retaining Arg-Gly-Asp binding activity.

S. Lam, 1992, The Journal of biological chemistry.

A directional switch of integrin signaling and a new anti-thrombotic strategy

Xiaoping Du, S. Lam, Kyungho Kim, 2013, Nature.

Tyrosine Phosphorylation of the Integrin β3 Subunit Regulates β3 Cleavage by Calpain*

P. Flevaris, Aleksandra Stojanovic, A. Chishti, 2006, Journal of Biological Chemistry.

TA205, an anti‐talin monoclonal antibody, inhibits integrin–talin interaction

Xiaoping Du, S. Lam, A. Jedsadayanmata, 2006, FEBS letters.

Immunolocalization of beta 1 integrins in platelets and platelet-derived microvesicles.

S. Lam, J. D. Wencel-Drake, M. G. Dieter, 1993, Blood.

Identification of a Talin-binding Site in the Integrin β3 Subunit Distinct from the NPLY Regulatory Motif of Post-ligand Binding Functions

S. Lam, A. Jedsadayanmata, J. D. Wencel-Drake, 1999, The Journal of Biological Chemistry.

Isolation and characterization of a platelet membrane protein related to the vitronectin receptor.

D. Cheresh, A. Frelinger, S. Lam, 1989, The Journal of biological chemistry.

Effect of cellular and receptor activation on the extent of integrin αIIbβ3 internalization

J. Schober, S. Lam, J. Schober, 2003, Journal of thrombosis and haemostasis : JTH.

Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion.

A. Frelinger, S. Lam, M. Ginsberg, 1988, The Journal of biological chemistry.

Identification of a novel integrin alphavbeta3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells.

L. Lau, S. Lam, N. Chen, 2004, The Journal of biological chemistry.

CIB1 is an endogenous inhibitor of agonist-induced integrin αIIbβ3 activation

Weiping Yuan, L. Parise, S. Lam, 2006, The Journal of cell biology.

Adhesion-induced unclasping of cytoplasmic tails of integrin alpha(IIb)beta3.

J. Fox, T. Ugarova, S. Lam, 2009, Biochemistry.

Arg-Gly-Asp-dependent occupancy of GPIIb/IIIa by applaggin: evidence for internalization and cycling of a platelet integrin.

A. Frelinger, S. Lam, J. D. Wencel-Drake, 1993, Blood.

Critical roles for the COOH-terminal NITY and RGT sequences of the integrin β3 cytoplasmic domain in inside-out and outside-in signaling

R. Bodnar, Xiaoping Du, S. Lam, 2003, The Journal of cell biology.

VITAMIN B6 AS AN ANTITHROMBOTIC AGENT

S. Lam, J. Mustard, M. Packham, 1981, The Lancet.

Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers.

A. Frelinger, S. Lam, M. Ginsberg, 1990, The Journal of biological chemistry.

G Protein Subunit Gα13 Binds to Integrin αIIbβ3 and Mediates Integrin “Outside-In” Signaling

T. Voyno-Yasenetskaya, P. Flevaris, Haixia Gong, 2010, Science.

Rapid dissociation of platelet-rich fibrin clots in vitro by a combination of plasminogen activators and antiplatelet agents.

G. Muscolino, G. L. Le Breton, S. Lam, 1991, The Journal of pharmacology and experimental therapeutics.

Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor.

S. Lam, M. Ginsberg, E. Plow, 1988, Science.

The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans.

L. Lau, S. Lam, V. Lindner, 2002, Endocrinology.

The role of integrin alpha D beta2 (CD11d/CD18) in monocyte/macrophage migration.

T. Ugarova, S. Lam, N. Belevych, 2008, Experimental cell research.

Isolation and kinetic studies of nucleoside diphosphokinase from human platelets and effects of cAMP phosphodiesterase inhibitors.

S. Lam, M. Packham, 1986, Biochemical pharmacology.

Direct Binding of the Platelet Integrin αIIbβ3 (GPIIb-IIIa) to Talin

Tina M. Leisner, S. Lam, T. Leisner, 1996, The Journal of Biological Chemistry.

Localization of an Integrin Binding Site to the C Terminus of Talin*

S. Lam, A. Jedsadayanmata, Baodong Xing, 2001, The Journal of Biological Chemistry.

Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail.

S. Lam, A. Jedsadayanmata, S. Patil, 1999, The Journal of biological chemistry.

immediate-early gene products expressed in atherosclerotic lesions monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): as an adhesion receptor on peripheral blood 2 β M α Identification of integrin

L. Lau, R. Ye, T. Ugarova, 2014 .

Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions.

L. Lau, R. Ye, T. Ugarova, 2002, Blood.

immediate-early gene products expressed in atherosclerotic lesions monocytes for Cyr 61 ( CCN 1 ) and connective tissue growth factor ( CCN 2 ) : as an adhesion receptor on peripheral blood 2

L. Lau, R. Ye, T. Ugarova, 2002 .

Anti-peptide antibodies against the human blood platelet thromboxane A2/prostaglandin H2 receptor. Production, purification and characterization.

G. L. Le Breton, S. Lam, D. Komiotis, 1993 .

Targeted Mutagenesis of the Angiogenic Protein CCN1 (CYR61)

Y. Liu, L. Lau, S. Lam, 2004, Journal of Biological Chemistry.

Investigation of possible mechanisms of pyridoxal 5'-phosphate inhibition of platelet reactions.

S. Lam, J. Mustard, M. Packham, 1980, Thrombosis research.

Identification of a novel integrin alphaMbeta2 binding site in CCN1 (CYR61), a matricellular protein expressed in healing wounds and atherosclerotic lesions.

L. Lau, T. Ugarova, J. Schober, 2003, The Journal of biological chemistry.

Supporting Online Material Materials and Methods Fig. S1 References Movies S1 to S3

M. Hartman, T. Voyno-Yasenetskaya, P. Flevaris, 2022 .

A Molecular Basis for Integrin αMβ2 Ligand Binding Promiscuity*

T. Ugarova, S. Lam, V. Yakubenko, 2002, The Journal of Biological Chemistry.

INTEGRIN-MEDIATED CCN FUNCTIONS

L. Lau, S. Lam, 2005 .

The Fibrinogen γ Chain Dodecapeptide Inhibits Agonist-induced Aggregation of Rabbit Platelets and Fibrinogen Binding to Rabbit Glycoprotein IIb-IIIa

S. Lam, M. Packham, C. Gemmell, 1999, Thrombosis and Haemostasis.

Bidirectional Transmembrane Modulation of Integrin αIIbβ3 Conformations*

S. Lam, T. Leisner, Wei Wang, 1999, The Journal of Biological Chemistry.

Tyrosine phosphorylation of the integrin beta 3 subunit regulates beta 3 cleavage by calpain.

P. Flevaris, Aleksandra Stojanovic, A. Chishti, 2006, The Journal of biological chemistry.

G Protein Subunit G a 13 Binds to Integrin a IIb b 3 and Mediates Integrin “ Outside-In ” Signaling

T. Voyno-Yasenetskaya, P. Flevaris, Haixia Gong, 2010 .