D. Crowther

发表

Functional genomics in Drosophila models of human disease.

Ko-Fan Chen, Damian C Crowther, Ko-Fan Chen, 2012, Briefings in functional genomics.

A Drosophila model of Alzheimer's disease.

Damian C Crowther, D. Lomas, D. Crowther, 2006, Methods in enzymology.

Endoplasmic reticulum dysfunction in neurological disease

D. Lomas, S. Marciniak, D. Crowther, 2013, The Lancet Neurology.

Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in a Drosophila model of Alzheimer’s disease

Robert Hider, Huw Lewis, Damian C Crowther, 2009, The European journal of neuroscience.

Unravelling the twists and turns of the serpinopathies

J. Irving, D. Lomas, S. Marciniak, 2011, The FEBS journal.

alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies.

D. Lomas, B. Gooptu, S. Marciniak, 2009, Clinical science.

Polymerisation underlies alpha1-antitrypsin deficiency, dementia and other serpinopathies.

D. Lomas, D. Crowther, E. Miranda, 2004, Frontiers in bioscience : a journal and virtual library.

CCT complex restricts neuropathogenic protein aggregation via autophagy

D. Rubinsztein, M. Jimenez-Sanchez, F. Menzies, 2016, Nature Communications.

Expression of the alternative oxidase mitigates beta-amyloid production and toxicity in model systems.

H. Jacobs, P. Rustin, D. Crowther, 2016, Free radical biology & medicine.

Molecular mousetraps and the serpinopathies.

D. Lomas, D. Crowther, E. Miranda, 2005, Biochemical Society transactions.

Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease.

D. Gubb, D. Lomas, D. Crowther, 2005, Neuroscience.

Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF

Maryam Clausen, D. Rassl, C. Hogaboam, 2021, Scientific Reports.

Endoplasmic Reticulum-associated Degradation (ERAD) and Autophagy Cooperate to Degrade Polymerogenic Mutant Serpins*

D. Lomas, S. Marciniak, D. Crowther, 2009, The Journal of Biological Chemistry.

Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies

D. Lomas, D. Crowther, E. Miranda, 2004, European Journal of Human Genetics.

Animal Models of Amyloid Diseases

Stanislav Ott, D. Crowther, 2013 .

Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB

D. Lomas, P. Lehner, S. Marciniak, 2013, Human molecular genetics.

Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis

D. Lomas, J. Huntington, D. Crowther, 2006, The FEBS journal.

Nucleation of α1-antichymotrypsin polymerization

D. Lomas, L. Serpell, B. Gooptu, 2003 .

Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB.

D. Lomas, J. Johansson, D. Crowther, 2004, European journal of biochemistry.

Serpinopathies and the central nervous system

D. Lomas, D. Crowther, E. Miranda, 2004 .

Mutant Neuroserpin (S49P) That Causes Familial Encephalopathy with Neuroserpin Inclusion Bodies Is a Poor Proteinase Inhibitor and Readily Forms Polymers in Vitro *

D. Lomas, D. Crowther, R. Mahadeva, 2002, The Journal of Biological Chemistry.

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease

Rohan T Ranasinghe, D. Holtzman, D. Klenerman, 2021, bioRxiv.

Progressive myoclonus epilepsy associated with neuroserpin inclusion bodies (neuroserpinosis).

D. Lomas, D. Crowther, B. Roussel, 2016, Epileptic disorders : international epilepsy journal with videotape.

Development of a Novel Recombinant Serpin with Potential Antithrombotic Properties (*)

R. Carrell, D. Crowther, D. Crowther, 1995, The Journal of Biological Chemistry.

The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer’s disease

Ko-Fan Chen, Bernard Possidente, David A. Lomas, 2014, Disease Models & Mechanisms.

Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation*

Kyle L. Morris, D. Lomas, L. Serpell, 2010, The Journal of Biological Chemistry.

Intraneuronal Aβ, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer’s disease

Richard M. Page, D. Gubb, D. Lomas, 2005, Neuroscience.

Prion-induced toxicity in PrP transgenic Drosophila.

J. Spiropoulos, D. Crowther, R. Bujdoso, 2012, Experimental and molecular pathology.

Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response

D. Lomas, H. Ryoo, S. Marciniak, 2010, Journal of Cell Science.

Iron is a specific cofactor for distinct oxidation- and aggregation-dependent Aβ toxicity mechanisms in a Drosophila model

Stanislav Ott, D. Crowther, Nikolas Dziadulewicz, 2015, Disease Models & Mechanisms.

ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism

T. Kawano, M. Zhen, P. S. St George-Hyslop, 2011, Human molecular genetics.

Central and peripheral circadian clocks and their role in Alzheimer's disease

Ko-Fan Chen, Damian C. Crowther, Ruchi Chauhan, 2017, Disease Models & Mechanisms.

TREM2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimer's disease‐associated H157Y variant

P. S. St George-Hyslop, I. Chessell, J. Sévalle, 2017, EMBO molecular medicine.

Utilizing microphysiological systems and induced pluripotent stem cells for disease modeling: a case study for blood brain barrier research in a pharmaceutical setting.

Kristin M. Fabre, D. Crowther, R. Hicks, 2019, Advanced drug delivery reviews.

The TRiC/CCT Chaperone Is Implicated in Alzheimer's Disease Based on Patient GWAS and an RNAi Screen in Aβ-Expressing Caenorhabditis elegans

Julie Williams, D. Sattelle, D. Lomas, 2014, PloS one.

Coordinate regulation of eIF2&agr; phosphorylation by PPP1R15 and GCN2 is required during Drosophila development

D. Lomas, S. Marciniak, D. Crowther, 2013, Journal of Cell Science.

Alzheimer's disease: insights from Drosophila melanogaster models

D. Sattelle, D. Lomas, D. Crowther, 2010, Trends in biochemical sciences.

p53 and Translation Attenuation Regulate Distinct Cell Cycle Checkpoints during Endoplasmic Reticulum (ER) Stress*

D. Lomas, S. Marciniak, D. Crowther, 2013, The Journal of Biological Chemistry.

Familial conformational diseases and dementias

D. Crowther, 2002, Human mutation.

(15) A Drosophila Model of Alzheimer's Disease

D. Lomas, D. Crowther, R. Page, 2006 .

Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity☆

J. Irving, D. Lomas, E. Speretta, 2013, Biochimica et biophysica acta.

Protein misfolding and disease: from the test tube to the organism.

Damian C Crowther, Christopher M Dobson, C. Dobson, 2008, Current opinion in chemical biology.

Systematic In Vivo Analysis of the Intrinsic Determinants of Amyloid β Pathogenicity

Michele Vendruscolo, Fabrizio Chiti, Damian C Crowther, 2007, PLoS biology.

Metabolic changes may precede proteostatic dysfunction in a Drosophila model of amyloid beta peptide toxicity

A. Malmendal, Stanislav Ott, D. Crowther, 2016, Neurobiology of Aging.

Drosophila melanogaster as a Model for Studies on the Early Stages of Alzheimer's Disease.

Stanislav Ott, D. Crowther, J. Lim, 2016, Methods in molecular biology.

Drosophila Melanogaster as a Model Organism for Dementia

M. Giannakou, D. Crowther, 2011 .

Neuroserpin Binds Aβ and Is a Neuroprotective Component of Amyloid Plaques in Alzheimer Disease*

D. Gubb, D. Lomas, J. Johansson, 2006, Journal of Biological Chemistry.

Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response

R. Bürli, N. Brandon, G. López-Doménech, 2021, The EMBO journal.

ANS binding reveals common features of cytotoxic amyloid species.

C. Dobson, G. Favrin, Mark R. Wilson, 2010, ACS chemical biology.

C. Dobson, D. Lomas, D. Crowther, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Ovine PrP transgenic Drosophila show reduced locomotor activity and decreased survival.

M. Landgraf, J. Evers, T. Jahn, 2012, The Biochemical journal.

Characterisation of serpin polymers in vitro and in vivo.

Claire H. Michel, J. Irving, C. Robinson, 2011, Methods.

Methods and models in neurodegenerative and systemic protein aggregation diseases.

C. Dobson, E. Speretta, T. Knowles, 2010, Frontiers in bioscience.

Therapeutic targets from a Drosophila model of Alzheimer's disease.

D. Lomas, D. Crowther, R. Page, 2004, Current opinion in pharmacology.

The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB

Mark J. Davies, D. Lomas, D. Crowther, 2008, Human molecular genetics.

The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster.

Michele Vendruscolo, Damian C Crowther, Christopher M Dobson, 2011, Integrative biology : quantitative biosciences from nano to macro.

Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer’s disease

D. Klenerman, M. Vendruscolo, T. Knowles, 2021, Brain communications.

Retro-inversal of intracellular selected β-amyloid-interacting peptides: implications for a novel Alzheimer's disease treatment.

Stanislav Ott, D. Crowther, N. Kad, 2014, Biochemistry.

Testing the Therapeutic Potential of Doxycycline in a Drosophila melanogaster Model of Alzheimer Disease*

E. Speretta, D. Crowther, I. Cardoso, 2011, The Journal of Biological Chemistry.

Flyglow: Single-fly observations of simultaneous molecular and behavioural circadian oscillations in controls and an Alzheimer’s model

J. O’Neill, Ko-Fan Chen, D. Crowther, 2016, Scientific Reports.

Simultaneous Monitoring of Behavior & Peripheral Clocks in Drosophila Reveals Unstructured Sleep in an Alzheimer’s Model

J. O’Neill, Ko-Fan Chen, D. Crowther, 2015, bioRxiv.

Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a Drosophila model of Alzheimer's disease

J. H. Viles, Ko-Fan Chen, D. Crowther, 2018, The Journal of Biological Chemistry.

The pro-domains of neurotrophins, including BDNF, are linked to Alzheimer's disease through a toxic synergy with Aβ

D. Crowther, J. Lim, C. Reighard, 2015, Human molecular genetics.

The chaperone domain BRICHOS prevents CNS toxicity of amyloid-β peptide in Drosophila melanogaster

B. Winblad, J. Johansson, S. Linse, 2014, Disease Models & Mechanisms.

Aggregation of the amyloid-β peptide (Aβ) into toxic oligomers and amyloid fibrils is linked to the development of Alzheimer’s disease (AD). Mutations of the BRICHOS chaperone domain are associated with amyloid disease and recent in vitro data show that BRICHOS

B. Winblad, J. Johansson, S. Linse, 2014 .

Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide.

C. Dobson, D. Lomas, G. Favrin, 2010, Biophysical journal.

Expression in Drosophila of Tandem Amyloid β Peptides Provides Insights into Links between Aggregation and Neurotoxicity

C. Dobson, D. Lomas, G. Favrin, 2012, The Journal of Biological Chemistry.

Insights into amyloid disease from fly models.

Ko-Fan Chen, D. Crowther, 2014, Essays in biochemistry.

Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies

C. Dobson, K. Reymann, M. Fändrich, 2014, Acta neuropathologica communications.

Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease

Kai J. Kohlhoff, C. Dobson, D. Lomas, 2011, Journal of Neuroscience Methods.

Sequestration of the Aβ Peptide Prevents Toxicity and Promotes Degradation In Vivo

C. Dobson, D. Lomas, T. Härd, 2010, PLoS biology.

Plasma and CSF serpins in Alzheimer disease and dementia with Lewy bodies

K. Blennow, E. Londos, D. Lomas, 2007, Neurology.

Serpins: implications of a mobile reactive centre.

R. Carrell, D. Evans, D. Crowther, 1992, Current opinion in biotechnology.