S. Taraviras

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Maximal loading of MCM 2 / 4 in late G 1 1 Multi-step loading of human Mini Chromosome Maintenance proteins in live human cells *

P. Bastiaens, P. Kotsantis, H. Grecco, 2013 .

Multi-step Loading of Human Minichromosome Maintenance Proteins in Live Human Cells*

Zoi Lygerou, Philippe Bastiaens, Vassilis Roukos, 2013, The Journal of Biological Chemistry.

Control over DNA replication in time and space

Zoi Lygerou, Ioanna-Eleni Symeonidou, I. Symeonidou, 2012, FEBS letters.

Dynamic recruitment of licensing factor Cdt1 to sites of DNA damage

P. Bastiaens, E. Stelzer, P. Kotsantis, 2011, Journal of Cell Science.

Geminin prevents DNA damage in vagal neural crest cells to ensure normal enteric neurogenesis

V. Pachnis, S. Taraviras, C. Konstantinidou, 2016, BMC Biology.

The Nucleophosmin-Pin1 interaction links the cell cycle, cancer and pluripotency

Spyridon Champeris Tsaniras, D. Vlachakis, S. Taraviras, 2015 .

In silico analysis of DNA re-replication across a complete genome reveals cell-to-cell heterogeneity and genome plasticity

J. Lygeros, M. Rapsomaniki, S. Taraviras, 2020, bioRxiv.

Concise Review: Geminin—A Tale of Two Tails: DNA Replication and Transcriptional/Epigenetic Regulation in Stem Cells

D. Karamitros, S. Taraviras, Z. Lygerou, 2017, Stem cells.

Chromatin and Nuclear Architecture: Shaping DNA Replication in 3D.

S. Taraviras, Z. Lygerou, Patroula Nathanailidou, 2020, Trends in genetics : TIG.

Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1

T. Ishii, A. Perrakis, Tatsuro S. Takahashi, 2018, Life Science Alliance.

Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1

T. Ishii, A. Perrakis, Tatsuro S. Takahashi, 2018, bioRxiv.

Mature T Cells Proliferation of Thymocytes and Differential Geminin Requirement for

H. Veiga-Fernandes, V. Pachnis, D. Karamitros, 2010 .

Differential Geminin Requirement for Proliferation of Thymocytes and Mature T Cells

D. Kioussis, H. Veiga-Fernandes, V. Pachnis, 2010, The Journal of Immunology.

Life without geminin

D. Kioussis, H. Veiga-Fernandes, V. Pachnis, 2010, Cell cycle.

Cdt1 Is Differentially Targeted for Degradation by Anticancer Chemotherapeutic Drugs

P. Kotsantis, Vassilis Roukos, H. Nishitani, 2012, PloS one.

Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members

J. Livet, A. Genovesio, S. Hippenmeyer, 2019, Neuron.

Mcidas and GemC1 are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche

M. Götz, S. Taraviras, Z. Lygerou, 2015, Development.

CRL4Cdt2: Coupling Genome Stability to Ubiquitination.

H. Nishitani, S. Taraviras, Z. Lygerou, 2020, Trends in cell biology.

Advanced Gene-Targeting Therapies for Motor Neuron Diseases and Muscular Dystrophies

S. Taraviras, Myrsini Chamakioti, Nikolaos Karantzelis, 2022, International journal of molecular sciences.

Reduced Geminin levels promote cellular senescence

D. Karamitros, S. Taraviras, Z. Lygerou, 2013, Mechanisms of Ageing and Development.

Subtype-specific neuronal differentiation of PC12 cells transfected with alpha2-adrenergic receptors.

M. Scheinin, C. Flordellis, A. Lymperopoulos, 2002, European journal of cell biology.

Controlling centriole numbers: Geminin family members as master regulators of centriole amplification and multiciliogenesis

S. Taraviras, Z. Lygerou, Dafni-Eleftheria Pefani, 2018, Chromosoma.

Ras suppressor-1 (RSU1) exerts a tumor suppressive role with prognostic significance in lung adenocarcinoma

H. Kalofonos, V. Zolota, S. Taraviras, 2022, Clinical and Experimental Medicine.

Neural Injury, Repair, and Adaptation in the GI Tract III. Role of the RET signal transduction pathway in development of the mammalian enteric nervous system

V. Pachnis, D. Natarajan, S. Taraviras, 1998 .

III. Role of the RET signal transduction pathway in development of the mammalian enteric nervous system.

V. Pachnis, D. Natarajan, S. Taraviras, 1998, American journal of physiology. Gastrointestinal and liver physiology.

Mast cells mediate malignant pleural effusion formation.

V. Aidinis, O. Eickelberg, Y. Iwakura, 2015, The Journal of clinical investigation.

Posttranslational modification of microtubules by the MATCAP detyrosinase

T. Brummelkamp, A. Perrakis, S. Taraviras, 2022, Science.

Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells

D. Egan, Joe D. Lewis, A. Fish, 2022, Frontiers in Pharmacology.

Intrinsic neural stem cell properties define brain hypersensitivity to genotoxic stress

S. Taraviras, Z. Lygerou, V. Bravou, 2022, Stem cell reports.

Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines.

P. Nurse, G. Xouri, V. Pachnis, 2004, European journal of biochemistry.

Cell Cycle-dependent Subcellular Translocation of the Human DNA Licensing Inhibitor Geminin*

G. Xouri, H. Nishitani, I. Symeonidou, 2013, The Journal of Biological Chemistry.

Mcidas and GemC1/Lynkeas specify embryonic radial glial cells

S. Taraviras, Z. Lygerou, C. Kyrousi, 2016, Neurogenesis.

Title: Mcidas and GemC1/Lynkeas are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche.

M. Götz, S. Taraviras, Z. Lygerou, 2015 .

DNA Replication Inhibitor Geminin and Retinoic Acid Signaling Participate in Complex Interactions Associated With Pluripotency

Spyridon Champeris Tsaniras, D. Vlachakis, S. Taraviras, 2019, Cancer Genomics & Proteomics.

Sustained GRK2-dependent CREB activation is essential for α2-adrenergic receptor-induced PC12 neuronal differentiation.

C. Flordellis, A. Lymperopoulos, S. Taraviras, 2020, Cellular signalling.

Germany Adaptation of the Fluorogenic 5 ′-Nuclease Chemistry to a PCR-Based Reverse Transcriptase Assay

F. Tronche, T. Mantamadiotis, G. Schütz, 1999 .

First case report of Charcot–Marie–Tooth disease type 2CC with a frameshift mutation of NEFH gene in Greece

S. Taraviras, E. Chroni, Dimitra Veltsista, 2021, Neurological Sciences.

McIdas localizes at centrioles and controls centriole numbers through PLK4-dependent phosphorylation

M. Mann, Sihem Zitouni, M. Bettencourt-Dias, 2022, bioRxiv.

A Custom Ultra-Low-Cost 3D Bioprinter Supports Cell Growth and Differentiation

S. Taraviras, Z. Lygerou, S. Champeris Tsaniras, 2020, Frontiers in Bioengineering and Biotechnology.

Replication Licensing Aberrations, Replication Stress, and Genomic Instability.

S. Taraviras, Z. Lygerou, S. Champeris Tsaniras, 2019, Trends in biochemical sciences.

Metabolic regulation of the neural stem cell fate: Unraveling new connections, establishing new concepts

G. Gakis, S. Taraviras, Z. Lygerou, 2022, Frontiers in Neuroscience.

B cell depletion treatment decreases CD4+IL4+ and CD4+CD40L+ T cells in patients with systemic sclerosis

A. Drosos, S. Taraviras, D. Daoussis, 2019, Rheumatology International.

Visualizing the dynamics of histone variants in the S-phase nucleus

S. Taraviras, Z. Lygerou, Stella Maxouri, 2018, Genome Biology.

Canagliglozin extends life span and leads to less weight gain in C57BL6 male mice

G. Lagoumintzis, D. Chartoumpekis, S. Taraviras, 2022, bioRxiv.

Mismatch repair regulates Cdt1 after UV damage

S. Taraviras, Z. Lygerou, Andreas Panagopoulos, 2017, Cell cycle.

Age and Visual Experience-dependent Expression of NMDAR1 Splice Variants in Rat Retina

S. Taraviras, E. Kouvelas, A. Mitsacos, 2011, Neurochemical Research.

Wound healing related agents: Ongoing research and perspectives

Spyridon Champeris Tsaniras, S. Taraviras, Foteini G Skondra, 2018, Advanced drug delivery reviews.

Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors

V. Beneš, D. Kioussis, D. Karamitros, 2015, Development.

Geminin ablation in vivo enhances tumorigenesis through increased genomic instability

V. Gorgoulis, S. Taraviras, Z. Lygerou, 2018, The Journal of pathology.

The Human Licensing Factor for DNA Replication Cdt1 Accumulates in G1 and Is Destabilized after Initiation of S-phase*

Zoi Lygerou, Takeharu Nishimoto, T. Nishimoto, 2001, The Journal of Biological Chemistry.

Running title : Geminin ablation in vivo enhances tumorigenesis Conflicts of Interest

Spyridon Champeris Tsaniras, Lalioti, V. Gorgoulis, 2018 .

Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.

Dimitris Kletsas, Jiri Bartek, Vassilis G Gorgoulis, 2007, Cancer research.

Licensing of DNA replication, cancer, pluripotency and differentiation: an interlinked world?

I. Symeonidou, S. Taraviras, Z. Lygerou, 2014, Seminars in cell & developmental biology.

Self-renewal mechanisms in neural cancer stem cells.

T. Mantamadiotis, S. Taraviras, 2011, Frontiers in bioscience.

Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion

Y. Iwakura, T. Blackwell, S. Taraviras, 2018, Nature Communications.

Licensing regulators Geminin and Cdt1 identify progenitor cells of the mouse CNS in a specific phase of the cell cycle

F. Guillemot, O. Britz, R. Ramsay, 2007, Neuroscience.

Tobacco chemical-induced mouse lung adenocarcinoma cell lines pin the prolactin orthologue proliferin as a lung tumour promoter.

S. Taraviras, S. Champeris Tsaniras, H. Papadaki, 2019, Carcinogenesis.

ILK over‐expression in human colon cancer progression correlates with activation of β‐catenin, down‐regulation of E‐cadherin and activation of the Akt–FKHR pathway

J. Varakis, S. Taraviras, E. Papadaki, 2006, The Journal of pathology.

Mammalian PNLDC1 is a novel poly(A) specific exonuclease with discrete expression during early development

C. Stathopoulos, K. Grafanaki, D. Anastasakis, 2016, Nucleic acids research.

Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis

Gavin Kelsey, G. Kelsey, G. Schütz, 1994, Mechanisms of Development.

T cell proliferation and homeostasis: an emerging role for the cell cycle inhibitor geminin.

D. Kioussis, D. Karamitros, S. Taraviras, 2011, Critical reviews in immunology.

GemC1 is a critical switch for neural stem cell generation in the postnatal brain

K. Kahle, N. Spassky, S. Taraviras, 2019, Glia.

GemC1 governs multiciliogenesis through direct interaction with and transcriptional regulation of p73

V. Beneš, S. Taraviras, Z. Lygerou, 2019, Journal of Cell Science.

Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability--evidence of E2F-1 transcriptional control over hCdt1.

Vassilis G Gorgoulis, Zoi Lygerou, A. Papavassiliou, 2004, The American journal of pathology.

Fanconi anemia proteins and genome fragility: unraveling replication defects for cancer therapy.

S. Taraviras, Z. Lygerou, Nibal Badra Fajardo, 2022, Trends in cancer.

ILK Expression in Colorectal Cancer Is Associated with EMT, Cancer Stem Cell Markers and Chemoresistance.

H. Kalofonos, S. Taraviras, S. Champeris Tsaniras, 2018, Cancer genomics & proteomics.

Three-Dimensional Models for Studying Neurodegenerative and Neurodevelopmental Diseases.

S. Taraviras, C. Kyrousi, G. Lokka, 2020, Advances in experimental medicine and biology.

easyFRAP: an interactive, easy-to-use tool for qualitative and quantitative analysis of FRAP data

Maria Anna Rapsomaniki, Nickolaos-Nikiforos Giakoumakis, Stavros L. Taraviras, 2012, Bioinform..

GemC1 controls multiciliogenesis in the airway epithelium

S. Taraviras, Z. Lygerou, A. Papanastasiou, 2016, EMBO reports.

Geminin Regulates Cortical Progenitor Proliferation and Differentiation

D. Kioussis, F. Guillemot, V. Pachnis, 2011, Stem cells.

Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis.

V. Pachnis, D. Natarajan, S. Taraviras, 2016, Developmental biology.

The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing*

J. Blow, A. Perrakis, P. J. Gillespie, 2013, The Journal of Biological Chemistry.

Idas, a Novel Phylogenetically Conserved Geminin-related Protein, Binds to Geminin and Is Required for Cell Cycle Progression*

A. Perrakis, I. Symeonidou, S. Taraviras, 2011, The Journal of Biological Chemistry.

Geminin Cleavage during Apoptosis by Caspase-3 Alters Its Binding Ability to the SWI/SNF Subunit Brahma*

M. Wilm, Vassilis Roukos, M. Gentzel, 2007, Journal of Biological Chemistry.

Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system.

G. Raisman, V. Pachnis, S. Taraviras, 1999, Development.

Development of the mammalian enteric nervous system.

V. Pachnis, S. Taraviras, 1999, Current opinion in genetics & development.

DNA Replication Control: Liquid-liquid Phase Separation Comes Into Play.

S. Taraviras, Z. Lygerou, Patroula Nathanailidou, 2020, Journal of molecular biochemistry.

Cdt1 and Geminin in cancer: markers or triggers of malignant transformation?

D. Karamitros, S. Taraviras, C. Petropoulou, 2008, Frontiers in bioscience : a journal and virtual library.

Mammalian PNLDC1 is a novel poly(A) specific exonuclease with discrete expression during early development

C. Stathopoulos, K. Grafanaki, D. Anastasakis, 2016, Nucleic acids research.

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing

R. Medema, D. Svergun, J. Blow, 2009, Proceedings of the National Academy of Sciences.

Expression of the licensing factors, Cdt1 and Geminin, in human colon cancer.

J. Varakis, H. Nishitani, S. Taraviras, 2005, International journal of oncology.

Radial glial cells in the adult dentate gyrus : what are they and where do they come from ?

S. Taraviras, 2019 .

Fine‐tuning multiciliated cell differentiation at the post‐transcriptional level: contribution of miR‐34/449 family members

S. Taraviras, Z. Lygerou, S. Grigoriadis, 2021, Biological reviews of the Cambridge Philosophical Society.

Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage

T. Halazonetis, V. Gorgoulis, Vassilis Roukos, 2022, The Journal of pathology.

Aberrant replication licensing drives Copy Number Gains across species

V. Beneš, I. Symeonidou, S. Taraviras, 2020, bioRxiv.

Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin

Maria Dimaki, Zoi Lygerou, Peter J Verveer, 2007, The EMBO journal.

How a radial glial cell decides to become a multiciliated ependymal cell

S. Taraviras, Z. Lygerou, C. Kyrousi, 2017, Glia.

Simple in vitro generation of human leukocyte antigen-G-expressing T-regulatory cells through pharmacological hypomethylation for adoptive cellular immunotherapy against graft-versus-host disease.

A. Sgourou, D. Marioli, S. Taraviras, 2017, Cytotherapy.

EasyFRAP-web: a web-based tool for the analysis of fluorescence recovery after photobleaching data

Maria Anna Rapsomaniki, Grigorios Koulouras, Andreas Panagopoulos, 2018, Nucleic Acids Res..

Canagliflozin extends life span and leads to less weight gain in C57BL6 male mice

G. Lagoumintzis, D. Chartoumpekis, S. Taraviras, 2023, bioRxiv.

Ribosomal DNA and the nucleolus at the heart of aging.

S. Taraviras, Z. Lygerou, Dafni-Eleftheria Pefani, 2022, Trends in biochemical sciences.

Alterations in the spatiotemporal expression pattern of geminin during human epidermal morphogenesis.

S. Taraviras, Z. Lygerou, G. Stamatiou, 2023, Acta dermatovenerologica Alpina, Pannonica, et Adriatica.

The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins

A. Fish, A. Perrakis, S. Taraviras, 2015, Acta crystallographica. Section D, Biological crystallography.

Cortical Development and Brain Malformations: Insights From the Differential Regulation of Early Events of DNA Replication

S. Taraviras, Z. Lygerou, Argyro Kalogeropoulou, 2019, Front. Cell Dev. Biol..

3D Reconstitution of the Neural Stem Cell Niche: Connecting the Dots

G. Gakis, S. Taraviras, Z. Lygerou, 2021, Frontiers in Bioengineering and Biotechnology.

Primary structure, chromosomal mapping, expression and transcriptional activity of murine hepatocyte nuclear factor 4gamma.

P. Lichter, G. Ryffel, T. Drewes, 2000, Biochimica et biophysica acta.

Generation of inhibitory mutants of hepatocyte nuclear factor 4.

S. Taraviras, G. Schütz, G. Kelsey, 1997, European journal of biochemistry.

Adult Neural StemCells an dMulticiliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members Highlights

J. Livet, A. Genovesio, S. Hippenmeyer, 2019 .

Ras suppressor-1 (RSU1) exerts a tumor suppressive role with prognostic significance in lung adenocarcinoma

H. Kalofonos, V. Zolota, S. Taraviras, 2022, Clinical and Experimental Medicine.

Integrin-Linked-Kinase Overexpression Is Implicated in Mechanisms of Genomic Instability in Human Colorectal Cancer

H. Papadaki, S. Taraviras, Z. Lygerou, 2020, Digestive Diseases and Sciences.

PCR-based strategy for genotyping mice and ES cells harboring loxP sites.

F. Tronche, T. Mantamadiotis, S. Taraviras, 1998, BioTechniques.

Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion

Y. Iwakura, T. Blackwell, S. Taraviras, 2018, Nature Communications.

Geminin prevents DNA damage in vagal neural crest cells to ensure normal enteric neurogenesis

V. Pachnis, S. Taraviras, C. Konstantinidou, 2016, BMC Biology.

Alpha 2‐Adrenergic Receptors Decrease DNA Replication and Cell Proliferation and Induce Neurite Outgrowth in Transfected Rat Pheochromocytoma Cells

I. Ilias, C. Flordellis, A. Lymperopoulos, 2006, Annals of the New York Academy of Sciences.

Ribosomal DNA and the nucleolus at the heart of aging.

S. Taraviras, Z. Lygerou, Dafni-Eleftheria Pefani, 2022, Trends in biochemical sciences.

B cell depletion treatment decreases CD4+IL4+ and CD4+CD40L+ T cells in patients with systemic sclerosis

A. Drosos, S. Taraviras, D. Daoussis, 2019, Rheumatology International.

Mast cells mediate malignant pleural effusion formation.

V. Aidinis, O. Eickelberg, Y. Iwakura, 2015, The Journal of clinical investigation.

Seminars in Cell & Developmental Biology

M. Kelley, I. Symeonidou, S. Taraviras, 2013 .

Geminin Participates in Differentiation Decisions of Adult Neural Stem Cells Transplanted in the Hemiparkinsonian Mouse Brain.

S. Taraviras, Z. Lygerou, C. Kyrousi, 2017, Stem cells and development.

Geminin Regulates Cortical Progenitor Proliferation and Differentiation

D. Kioussis, F. Guillemot, V. Pachnis, 2011, Stem cells.

Seminars in Cell & Developmental Biology

I. Symeonidou, S. Taraviras, Z. Lygerou, 2017 .